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| 1 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 2 | Assessing the Effectiveness of a Cervical Cancer Screening Program in a Hospital-based Study显示文摘This study compared HPV testing and liquid-based cytology(LCT)as performance indicators for cervical cancer screening in a hospital-based study.A total of 61,193 outpatients were screened initially by LCT.Samples with screening results showing atypical squamous cells of undetermined significance(ASC-US)or worse were referred for colposcopy,and some | YANG Yi LANG Jing He WANG You Fang CHENG Xue Mei CAI Yu Pin LI Hui ZHU Bao Li ZHANG Rui Fen | 2015 | Biomedical and Environmental Sciences2015，28，1： | 10 |
| 3 | Effects of Jian Pi Qu Shi Formula on intestinal bacterial flora in patients with idiopathic membranous nephropathy:A prospective randomized controlled trial显示文摘Background:The incidence of idiopathic nlembranous nephropathy(IMN)has recently increased remarkably.Immune dysfunction caused by disordered intestinal flora might be an important factor affecting IMN.The Jian Pi Qu Shi Formula(JPQSF)shows promise in treating IMN.Here,we sequenced 16S rRNA genes to compare intestinal flora between patients with IMN and healthy persons.We also conducted a randomized controlled clinical trial to further compare the intestinal flora of patients with IMN treated with traditional Chinese medicine(TCM)and western medicine(WM).Methods:Among 40 patie nls with IMN treated at Department of Nephrology in Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine between July 2016 and December 2018,we compared 30 of them with 10 healthy persons(controls).The IMN group was randomly assigned to receive JPQSF(TCM)or immunosuppressant WM therapy in(n=15 per group)for 6 months.Intestinal microbiota diversity was analyzed using alpha diversity and beta diversity.Intestinal flora that significantly differed between the groups was analyzed using MetaStat.The effects and safety of the therapies were determined based on the values for plasma albumin,24-h urine protein excretion,serum creatinine,urea nitrogen,estimate glomerular filtration rate(eGFR),complete blood count,and liver enzymes.All data were statistically analyzed using Statistical Package for the Social Sciences(SPSS)20.0 statistical software.Results:Baseline characteristics did not significanlly differ between the IMN and healthy groups,or the TCM and WM groups.After six months of treatment,24-h urinary protein significantly declined in the TCM and WM groups(before and after treatment:3.24±1.74 vs.1.73±1.85 g,P<0.05 and 3.94±1.05 vs.1.91±1.18 g,P<0.05,respectively).Plasma albumin was significantly increased in the TCM group(before vs.after treatment:32.44±9.04 vs.39.99±7.03 g/L,P<0.05),but did not significantly change in the WM group(31.55±4.23 vs.34.83±9」4 g/L,P>0.05).Values for urea nitrogen,serum creatinine,and eGFR did not significanlly change in either group.The alpha diversity index for intestinal flora differed between the IMN and healthy groups,and the TCM and WM groups.Comparisons of multiple samples(beta diversity)revealed differences in intestinal flora between the IMN and healthy groups,and the TCM and WM groups.The Metastat analysis findings showed that the main genera that differed between the IMN group before treatment and the healthy group were Christensenellaceae_R-7_group,Bifidobacterium(77),Dorea,Escherichia-Shigella,Parabacteroides,Bifidobacterium,and Coprococcus_3.AfterTCM therapy,the main differential genera were Butyricimonas,Bacteroides,Alistipes,and Lachnospira,and after WM therapy,these were Ruminococcus_2,Lachnospiraceae_ND3007_group,Lachnospira,Bifidobacterium,Alistipes,and[Eubacterium]_ventriosum_group.Conclusion:Patients with IMN might have disordered intestinal flora,and JPQSF can regulate intestinal flora in patienls with IMN. | Rui Lang Xin-Hui Wang Ai-Feng Li Ying Liang Bao-Chen Zhu Bin Shi Yong-Qiu Zheng Ren-Huan Yu | 2020 | Chronic Diseases and Translational Medicine2020，6，2： | 8 |
| 4 | EBV-Induced Human CD8^+ NKT Cells Synergise CD4^+ NKT Cells Suppressing EBV-Associated Tumours upon Induction of Thl-Bias显示文摘 | Wei Xiao Li Li Rui Zhou Ruijing Xiao Yujuan Wang Xiang Ji Mengjun Wu Lan Wang Wei Huang Xiaoling Zheng Xinti Tan Lang Chen Tao Xiong Jie Xiong Youxin Jin Jinquan Tan Yuling He | 2009 | Cellular & Molecular Immunology2009，6，5： | 5 |
| 5 | A Foodborne Bongkrekic Acid Poisoning Incident--Heilongjiang Province,2020显示文摘What is already known on this topic?Poisoning incidents caused by bongkrekic acid(BA),one of the metabolites of Burkholderia gladioli pathovar cocovenenans(B.cocovenenans),have been reported in Indonesia,Mozambique,and China.The reported case fatality rates averaged 60%,32%,and 26.5%,respectively.In China,B.cocovenenans is often called Pseudomonas cocovenenans subsp.farinofermentans.What is added by this report?In October 2020,9 persons in Jidong County,Heilongjiang Province died after consuming a homemade fermented corn flour product—sour soup—with a case fatality rate of 100%.BA was detected in both food samples and biological samples with a content of 330 mg/kg and 3 mg/L,respectively.The doses of BA consumed by the cases were approximately 22-33 times the lethal dose in human.What are the implications for public health practice?The consumption of fermented corn flour products,deteriorated fresh tremella,or black fungus and metamorphic starch products may cause BA poisoning.Health education should be strengthened so that homemade-starch-fermented food should be avoided and foods that have been kept for a long time should not be consumed.Meanwhile,training and emergency capacity building for primary healthcare workers should be strengthened to provide timely diagnosis and response. | Yuan Yuan Rui Gao Qiang Liang Li Song Jun Huang Nan Lang Jing Zhou | 2020 | China CDC weekly2020，2，51： | 5 |
| 6 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 7 | Extracts from cotton over the whole growing season induce Orobanche cumana(sunflower broomrape) germination with significant cultivar interactions显示文摘Five cotton cultivars and their parents were tested for induction of germination of Orobanche cumana Wallr.(sunflower broomrape) seeds in pot and field experiments. Germination rates induced by cotton root extracts were the highest followed by stem extracts then leaf extracts. Cotton seedlings at the six-leaf stage induced higher germination than seedling at the two-and four-leaf stage, in all five cotton cultivars and their parents. In the field, the highest concentration of cotton root extracts gave the highest germination rate of O. cumana, and the lowest concentration of cotton root extracts gave the lowest germination rate. Methanol extracts of cotton rhizosphere soil gave the highest germination of O. cumana. In general,the root, stem and leaf extracts were more active at the sixleaf stage than other seedling stages. In conclusion,extracts of cotton rhizosphere soil and tissues have high activity in the seedling stage. Extracts of cotton across the whole growing season were able to induce O. cumana germination but displayed significant cultivar interactions. | Ming LANG Rui YU Yongqing MA Wei ZHANG Christopher S.P.McErlean | 2017 | Frontiers of Agricultural Science and Engineering2017，4，2： | 3 |
| 8 | Systemic autoimmune diseases and recurrent pregnancy loss:research progress in diagnosis and treatment显示文摘To the Editor:Recurrent pregnancy loss(RPL)is defined as the loss of two or more pregnancies before 24 weeks of gestation,and it affects about 1%to 2%of couples.[1]The etiology of RPL includes metabolic/endocrinological abnormalities,genetic factors,anatomical factors,immune disorders,thrombophilia,male factors,and psychological factors.[1,2]Systemic autoimmune diseases like antiphospholipid syndrome(APS),[3]undifferentiated connective tissue disease(UCTD),[4]and systemic lupus erythematosus(SLE)[5]have been found to be important causes of RPL in recent years.Understanding the associations between different systemic autoimmune diseases and RPL,as well as being able to provide suitable diagnoses and treatments,is of great significance. | Rui Gao Xun Zeng Lang Qin | 2021 | Chinese Medical Journal2021，，17： | 2 |
| 9 | Utilizing modified ubi1 introns to enhance exogenous gene expression in maize(Zea mays L.) and rice(Oryza sativa L.)显示文摘The phenomenon of intron-mediated enhancement(IME) was discovered in 1990 based on the observation that plant introns can stimulate gene expression,particularly in monocots.However,the intrinsic mechanism of IME remains unclear because many studies have yielded various results depending on the promoter,reporter gene,flanking sequences of the intron,and target cell or tissue.In this study,the effect of the first intron of the maize ubiquitin gene(ubi1 intron) was investigated by changing insertion sites,deleting specific regions and mutating individual motifs in maize(Zea mays L.)and rice(Oryza sativa L.) using ubi1 intron-containing GUS(β-glucuronidase) constructs.In maize callus,the integration of the full-length ubi1 intron into the GUS coding sequence at the +13,+115 and +513 positions by particle bombardment increased GUS activity approximately five-,four- and two-fold,respectively.Eight truncated ubi1 introns in the pSG(13i)N construct significantly influenced GUS gene expression to different degrees in transient assays.Notably,the 3' region deletions significantly reduced the IME effect,whereas a 142-nt deletion,pSG(13i-P5)N,in the 5' region caused a 1.5-fold enhancement relative to pSG(13i)N.Furthermore,four site-directed mutageneses were performed in pSG(13i-P5)N;these constructs resulted in the up-regulation of GUS gene expression to different levels.The most effective modified ubi1 intron,pSG(13i-M4)N,was further evaluated and proved in rice using transient experiments.In addition,the sequences flanking the GUS insertion significantly influenced the IME effect of the vectors that were constructed.The modified ubi1 intron had the potential application on crop genetic engineering. | PAN Yang-yang CHEN Rui ZHU Li WANG Hai HUANG Da-fang LANG Zhi-hong | 2016 | Journal of Integrative Agriculture2016，15，8： | 1 |
| 10 | Flower- like Bi202CO3: Facile synthesis and their photocatalytic application in treatment of dye-containing wastewater显示文摘 | Chen Lang Huang Rui Yin Shuang-Feng | 2009 | Chemical Engineering Journal2009，193，： | 1 |
| 11 | InvasionDB: A genome and gene database of invasive alien species显示文摘Invasive alien species(IAS) are species whose introduction to areas outside of their native range cause harm to economics, biodiversity, and the environment. Understanding the genetic basis of invasiveness is critical for preventing invasion by an alien species and managing IAS with eco-friendly control methods. In addition, uncovering the genomic features of IAS is essential for accurately predicting invasiveness. However, even though increasing efforts have been devoted to sequencing the genomes of IAS, there is still not an integrated genome database for the invasive biology community. Here, we first determined a list of invasive plants and animals by mining references and databases. Then, we retrieved the genomic and gene data of these IAS, and constructed a database, Invasion DB. Invasion DB encompasses 131 IAS genomes, 76 annotated IAS assemblies, and links these data to conventional functions such as searching for gene coding sequences and Pfam, KEGG, NR annotations, BLAST server, JBrowse, and downloads services. Next, we analyzed 19 invasivenessrelated gene families which confer invasiveness in insects. To study the roles of noncoding RNA in invasiveness, we also annotated 135 494 mi RNAs, 89 294 r RNAs, and 2 671 941 t RNAs from these IAS. In summary, Invasion DB is useful for studying the invasiveness at the genomic level, and thus helps to develop novel management strategies to control IAS. | HUANG Cong LANG Kun QIAN Wan-qiang WANG Shu-ping CAO Xiao-mei HE Rui ZHAN An-ran CHEN Meng-yao YANG Nian-wan LI Fei | 2021 | Journal of Integrative Agriculture2021，20，1： | 1 |
| 12 | Optical image encryption based on the multiple parameter fractional Fourier transform 显示文摘 | Tao Rui Lang Jun Wang Yue | 2008 | Optics Letters2008，33，6： | 1 |
| 13 | pH- responsive N-heterocyclic carbene copper(I) complexes: syntheses and recoverable applications in the carboxyla- tion of arylboronic esters and benzoxazole with carbon di- oxide 显示文摘 | Wenlong Wang Guodong Zhang Rui Lang | 2013 | Green Chemistry2013，15，： | 1 |
| 14 | Facile synthesis of BiOC1 nano-flowers of narrow band gap and their visible- light-induced photocatalytic property 显示文摘 | Chen Lang Yin Shuangfeng Huang Rui | 2012 | Catalysis Commu- nications2012，23，： | 1 |
| 15 | An Analysis on Mental Health Education of College Students with Financial Difficulties显示文摘With the enrollment expansion of college and continuous reform of college education system and college charging system,the number of college students with financial difficulties is increasing. The college students with family financial difficulties not only bear the huge economic burden,but also bear the huge pressure of learning and mental stress,and they have many kinds of psychological problems including psychological distress of tension and anxiety,psychological conflict of self-respect and self-abasement,conflict of desire for interpersonal interaction and self-containment and strong vanity and dependence mentality. This paper puts forward the corresponding recommendations to solve these problems. | Shuzhen WANG Ling NI Chaoqiong LI Rui LANG Dan FU | 2017 | Asian Agricultural Research2017，9，6： | 1 |
| 16 | Facile Syn- thesis of BiOCI Nano-Flowers of Narrow Band Gap and Their Visible-Light-Induced Photocatalytie Property 显示文摘 | Chen Lang Yin Shuangfeng Huang Rui | 2012 | Catal Com- mun2012，23，： | 1 |
| 17 | HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner显示文摘The p53 pathway is a highly complex signaling network including several key regulators.HAUSP is a critical component of the p53 pathway acting as a deubiquitinase for both p53 and its key repressor Mdm2.Here,we identified a novel HAUSP-interacting protein,HLA-B-associated transcript 3(Bat3)and found it to be capable of inducing p53 stabilization and activation via a HAUSP-dependent mechanism,resulting in cell growth inhibition.Surprisingly,the deubiquitylating enzymatic activity of HAUSP was not required for this phenomenon.Co-immunoprecipitation showed that p53 coexisted in a complex with Bat3 and HAUSP in vivo,and HAUSP may serve as a binding mediator to enhance the interaction between p53 and Bat3.Further studies revealed that formation of this three-protein complex interfered with the binding of p53 to its proteasome receptor S5a and promoted the accumulation of p53 in nucleus.Notably,Mdm2 protein abundance is also regulated by Bat3 in the presence of HAUSP.Overexpression of Bat3 and HAUSP increases Mdm2 protein levels without influencing the p53–Mdm2 interaction and Mdm2-mediated p53 ubiquitination,indicating that Bat3–HAUSP-mediated protein stabilization is not specific to p53 and different mechanisms may be involved in Bat3-mediated regulation of p53–Mdm2 pathway.Together,our study unravels a novel mechanism by which p53 is stabilized and activated by HAUSP-mediated interaction with Bat3 and implies that Bat3 might function as a tumor suppressor through the stabilization of p53. | Rui Zhang Di Cui TengXue Yue Lang Yunfan Zhang Lianjie Li Haili Sun Yu Kuang Gebin Li Jun Tang | 2020 | Journal of Molecular Cell Biology2020，12，2： | 0 |
| 18 | Direct synthesis of a disinfectant with fresh scent of green plants by semi-hydrogenation of alkynol on Pd single-atom catalysts显示文摘Alcohol-based disinfectants have protected people in the coronavirus disease 2019(COVID-19)pandemic,but olfactory stimuli of ethanol may evoke unpleasant memories associated with stressful situations in the devastating infectious disease.The smell of ethanol in household cleaning and disinfectant products can be covered up by the fragrance additives,and 3-hexenol is especially appreciated for the characteristic,strong odor of green plants.Industrial production of 3-hexenol relies on the selective hydrogenation of 3-hexyn-1-ol,where Lindlar catalyst is normally used for the superior selectivity.Although achieving such catalytic transformation in ethanol solution seems as a direct way to produce a disinfectant with green aroma,a popular consumer product in the post-COVID era,severe leaching of toxic Pb hinders Lindlar catalyst as a promising candidate.We find that the Fe_(2)O_(3) supported Pd single-atom catalyst is highly selective to fulfill semi-hydrogenation of 3-hexyn-1-ol in 75%ethanol,and the aforementioned household product is readily generated after filtrating the stable,solid catalyst out of reaction solution.Single-atom catalysts have been frequently utilized for fine-chemical synthesis,while in this work they make stunning debut in practical manufacture of daily used products. | Yan Jiang Xuetong Yu Yuxia Ji Xunzhu Jiang Yalin Guo Tianbo Li Liang Gao Rui Lang Yanxiong Fang Botao Qiao Jinxiang Dong | 2024 | Nano Research2024，17，5： | 0 |
| 19 | Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis显示文摘Metastasis of colorectal cancer(CRC)is a leading cause of mortality among CRC patients.Elevated COX-2 and PD-L1 expression in colon cancer tissue has been linked to distant metastasis of tumor cells.Although cox-2 inhibitors and immune checkpoint inhibitors demonstrate improved anti-tumor efficacy,their toxicity and variable therapeutic effects in individual patients raise concerns.To address this challenge,it is vital to identify traditional Chinese medicine components that modulate COx-2 and PD-1/PD-L1:rosmarinic acid(RA)exerts striking inhibitory effect on COX-2,while ginsenoside Rg1(GR)possesses the potential to suppress the binding of PD-1/PD-L1.In this study we investigated whether the combination of RA and GR could exert antimetastatic effects against CRC.MC38 tumor xenograft mouse model with lung metastasis was established.The mice were administered RA(100 mg·kg^(-1)·d^(-1),i.g.)alone or in combination with GR(100 mg·kg^(-1)·d^(-1),i.p.).We showed that RA(50,100,150μM)or a COX-2 inhibitor Celecoxib(1,3,9μM)concentration-dependently inhibited the migration and invasion of MC38 cells in vitro.We further demonstrated that RA and Celecoxib inhibited the metastasis of MC38 tumors in vitro and in vivo via interfering with the COX-2-MYO10 signaling axis and inhibiting the generation of flopodia.In the MC38 tumor xenograft mice,RA administration significantly decreased the number of metastatic foci in the lungs detected by Micro CT scanning;RA in combination with GR that had inhibitory effect on the binding of PD-1 and PD-L1 further suppressed the lung metastasis of colon cancer.Compared to COX-2 inhibitors and immune checkpoint inhibitors,RA and GR displayed better safety profiles without disrupting the tissue structures of the liver,stomach and colon,offering insights into the lower toxic effects of clinical traditional Chinese medicine against tumors while retaining its efficacy. | Huan Liu Rui Deng Cheng-wei Zhu Hong-kuan Han Gang-fan Zong Lang Ren Peng Cheng Zhong-hong Wei Yang Zhao Su-yun Yu Yin Lu | 2024 | Acta Pharmacologica Sinica2024，45，1： | 0 |
| 20 | Domain structure and dielectric diffusion-relaxation characteristics of ternary Pb(In_(1/2)Nb_(1/2))O_(3)-Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)ceramics显示文摘Relaxor-based ternary Pb(In1/2Nb1/2)O_(3)-Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)(PIN-PMN-PT)single crystals and ceramics are promising candidates for high-performance electromechanical conversion devices.It is known that the domain structure and dielectric diffusion-relaxation characteristics are crucial to the excellent performances of relaxor ferroelectrics.In this work,we prepared the PIN-PMN-PT ceramics with various PIN/PMN proportions and systematically investigated their domain structure and dielectric diffusion-relaxation properties.The effect of PIN/PMN proportion on the domain size and dielectric diffusion-relaxation characteristics was also studied.The investigations showed that PIN-PMN-PT ceramics presented multi-type domain patterns comprising irregular island domains and regular lamellar domains.Moreover,the dependent relations of PIN/PMN proportions on the dielectric diffusion and domain size indicated that the PIN composition has a stronger lattice distortion than PMN composition;increasing the PIN proportion can enhance the dielectric diffusion and decrease the domain size.Our results could deepen the understanding of structure-property relationships of multicomponent relaxor ferroelectrics and guide the design and exploration of new high-performance ferroelectric materials. | Xudong Qi Kai Li Lang Bian Enwei Sun Limei Zheng Rui Zhang | 2022 | Journal of Advanced Dielectrics2022，12，6： | 0 |
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