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| 1 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | Antibacterial applications of graphene oxides: structure-activity relationships, molecular initiating events and biosafety显示文摘Bacterial infections may lead to diverse acute or chronic diseases(e.g., inflammation, sepsis and cancer).New antibiotics against bacteria are rarely discovered in recent years, which necessitates the exploration of new antibacterial agents. Engineered nanomaterials(ENMs) have been extensively studied for antibacterial use because of their long lasting killing effects in wide spectra of bacteria. Graphene oxide(GO) is one of the most widely studied ENMs and exhibit strong bactericidal effects. The physicochemical properties of GO play important roles in bacterial killing by triggering a cascade of toxic events. Many studies have explored the signaling pathways of GO in bacteria. Although molecular initiating events(MIEs) of GO in bacteria dominate its killing efficiency as well as toxicity mechanisms, they have been rarely reviewed. In this report, we discussed the structure–activity relationships(SARs) involved in GOinduced bacterial killing and the MIEs including redox reaction with biomolecules, mechanical destruction of membranes and catalysis of extracellular metabolites. Furthermore, we summarized the clinical or commercial applications of GO-based antibacterial products and discussed their biosafety in mammal.Finally, we reviewed the remaining challenges in GO for antibacterial applications, which may offer new insights for the development of nano antibacterial studies. | Huizhen Zheng Ronglin Ma Meng Gao Xin Tian Yong-Qiang Li Lingwen Zeng Ruibin Li | 2018 | Science Bulletin2018，63，2： | 8 |
| 4 | A User Differential Range Error Calculating Algorithm Based on Analytic Method显示文摘提高完整,有更少的执行时间的一个分析方法(AM ) 被建议计算微分范围错误(UDRE ) 由用户过去常检测潜在的风险的用户。位置推算历和钟修正计算方法首先被介绍。它证明计算 UDRE 的最重要的事情是在服务体积发现最糟的用户地点(WUL ) 。然后,用 AM 的一个 UDRE 算法被描述解决这个问题。由使用错误向量的协变性矩阵,寻找 WUL 被变换成一个分析几何学问题。WUL 的地点能被数学推导直接获得。实验被进行比较在建议 AM 算法和在主人车站使用的彻底的格子搜索(EGS ) 方法之间的表演。AM 算法的正确性能被 EGS 方法和 AM 算法证明的结果表演能在超过 90% 减少计算时间。这个建议算法的计算复杂性从而比 EGS. 的好这个算法对在主人车站计算 UDRE 更合适。 | SHAO Bo LIU Jiansheng ZHAO Ruibin HUANG Zhigang LI Rui | 2011 | Chinese Journal of Aeronautics2011，24，6： | 7 |
| 5 | Expansion of CRISPR/Cas9 genome targeting sites in zebrafish by Csy4-based RNA processing显示文摘 | Wei Qin Fang Liang Yan Feng Haipeng Bai Ruibin Yan Song Li Shuo Lin | 2015 | Cell Research2015，25，9： | 6 |
| 6 | Study of latch-up immunization in bulk CMOS integrated circuits exposed to transient ionizing radiation显示文摘This paper presents experimental results of transient gamma irradiation effects on two kinds of circuits.One is a two-stage circuit consisting of a bipolar power device L7805CV and a bulk complementary metal-oxide-semiconductor(CMOS) device IDT6116,the other is a two-stage circuit consisting of a bipolar power device L7805CV and the equivalent circuit of the parasitic P-N-P-N structure in bulk CMOS devices.The results show that the L7805CV's output interruption after transient irradiation can prevent latch-up from occurring on the second stage circuit.The demanded minimum interruption duration to avoid latch-up varies with dose rate,and this is confirmed by the experimental results. | LI RuiBin CHEN Wei LIN DongSheng YANG ShanChao BAI XiaoYan WANG GuiZhen LIU Yan QI Chao MA Qiang | 2012 | Science China(Technological Sciences)2012，55，11： | 5 |
| 7 | On the Response of Subduction in the South Pacific to an Intensification of Westerlies and Heat Flux in an Eddy Permitting Ocean Model显示文摘Based on an eddy permitting ocean general circulation model, the response of water masses to two distinct climate scenarios in the South Pacific is assessed in this paper. Under annually repeating atmospheric forcing that is characterized by different westerlies and associated heat flux, the response of Subantarctic Mode Water(SAMW) and Antarctic Intermediate Water(AAIW) is quantitatively estimated. Both SAMW and AAIW are found to be warmer, saltier and denser under intensified westerlies and increased heat loss. The increase in the subduction volume of SAMW and AAIW is about 19.8 Sv(1 Sv =10~6m^3s^(-1)). The lateral induction term plays a dominant role in the changes in the subduction volume due to the deepening of the mixed layer depth(MLD). Furthermore, analysis of the buoyancy budget is used to quantitatively diagnose the reason for the changes in the MLD. The deepening of the MLD is found to be primarily caused by the strengthening of heat loss from the ocean to the atmosphere in the formation region of SAMW and AAIW. | Chengyan LIU Zhaomin WANG Bingrui LI Chen CHENG Ruibin XIA | 2017 | Advances in Atmospheric Sciences2017，34，4： | 5 |
| 8 | The outbreak of rabbit hemorrhagic virus type 2 in the interior of China may be related to imported semen显示文摘Dear Editor,Rabbit hemorrhagic disease(RHD)is a fatal infectious disease that primarily affects adult rabbits and causes great economic losses in the rabbit industry(Mitro and Krauss,1993).The causative pathogen is rabbit hemorrhagic disease virus(RHDV),which belongs to the genus Lagovirus and the family Calicivirus(Moussa et al.,1992).In 1984,RHDV was first documented in China. | Ruibin Qi Chunchun Meng Jie Zhu Hang Li Qiuhong Miao Jingyu Tang Aoxing Tang Hongyuan Guo Chuncao Liu Chuanfeng Li Zongyan Chen Fang Wang Qinwen Zhang Guangqing Liu | 2022 | Virologica Sinica2022，37，4： | 3 |
| 9 | Closed form algorithm of double-satellite TDOA+AOA localization based on WGS-84 model显示文摘In this paper,we consider the double-satellite localization under the earth ellipsoid model of the Wideband Geodetic System(WGS-84)using the Time Difference of Arrival(TDOA)and the Angle-of-Arrival(AOA).Several closed-form solution algorithms via the pseudolinearization of the measurement equations are presented to efficiently estimate the location.These algorithms include the Weighted Least Squares(WLS),the Constrained Total Least Squares(CTLS),and the Taylor-Series Iteration(TSI).Performance comparison of the proposed methods with the Cramér-Rao Lower Bound(CRLB)in the simulation is shown to demonstrate that the proposed algorithms are feasible and have stable performance. | Wanchun LI Ruibin CHEN Yuning GUO Caixia FU | 2019 | Chinese Journal of Aeronautics2019，32，10： | 3 |
| 10 | Response of the mixed layer depth and subduction rate in the subtropical Northeast Pacific to global warming显示文摘The response of the mixed layer depth(MLD)and subduction rate in the subtropical Northeast Pacific to global warming is investigated based on 9 CMIP5 models.Compared with the present climate in the 9 models,the response of the MLD in the subtropical Northeast Pacific to the increased radiation forcing is spatially nonuniform,with the maximum shoaling about 50 m in the ensemble mean result.The inter-model differences of MLD change are non-negligible,which depend on the various dominated mechanisms.On the north of the MLD front,MLD shallows largely and is influenced by Ekman pumping,heat flux,and upper-ocean cold advection changes.On the south of the MLD front,MLD changes a little in the warmer climate,which is mainly due to the upper-ocean warm advection change.As a result,the MLD front intensity weakens obviously from 0.24 m/km to0.15 m/km(about 33.9%)in the ensemble mean,not only due to the maximum of MLD shoaling but also dependent on the MLD non-uniform spatial variability.The spatially non-uniform decrease of the subduction rate is primarily dominated by the lateral induction reduction(about 85%in ensemble mean)due to the significant weakening of the MLD front.This research indicates that the ocean advection change impacts the MLD spatially non-uniform change greatly,and then plays an important role in the response of the MLD front and the subduction process to global warming. | Ruibin Xia Bingrui Li Chen Cheng | 2021 | Acta Oceanologica Sinica2021，40，4： | 2 |
| 11 | Engineering vascularized skeletal muscle tissue with transcriptional factor ETV2-induced autologous endothelial cells显示文摘Dear Editor,Newly engineered tissues often fail to function due to insufficient blood vessels formation.Autologous vascular endothelial cells are ideal sources for tissue engineering but are often of limited availability.We first identified that transcriptional factor Etv2(ets variant 2,initially named as Etsrp)was specifically expressed in the zebrafish vascular endothelial cells and was required for vascular development in zebrafish(Sumanas and Lin,2006). | Guanrong Yan Ruibin Yan Cheng Chen Yanqiu Zhao Wei Qin Matthew B.Veldman Song Li Shuo Lin | 2019 | Protein & Cell2019，10，3： | 2 |
| 12 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://links.lww.com7CM9/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 13 | Formation and Optical Properties of ZnO:ZnFe_(2)O_(4) Superlattice Microwires显示文摘Pure ZnO hexagonal microwires and Fe(Ⅲ)-doped ZnO microwires(MWs)with a novel rectangular cross section were synthesized in a confined chamber by a convenient one-step thermal evaporation method.An oriented attachment mechanism is consistent with a vapor-solid growth process.Photoluminescence(PL)and Raman spectroscopy of the Fe(Ⅲ)-doped ZnO MWs and in situ spectral mappings indicate a quasi-periodic distribution of Fe(Ⅲ)along a one-dimensional(1-D)superlattice ZnO:ZnFe_(2)O_(4) wire,while PL mapping shows the presence of optical multicavities and related multimodes.The PL spectra at room temperature show weak near-edge doublets(376 nm and 383 nm)and a broad band(450-650 nm)composed of strong discrete lines,due to a 1-D photonic crystal structure.Such a 1-D coupled optical cavity material may find many applications in future photonic and spintronic devices. | Yun Li Guozhang Dai Chunjiao Zhou Qinglin Zhang Qiang Wan Limin Fu Jianping Zhang Ruibin Liu Chuanbao Cao Anlian Pan Yunhong Zhang Bingsuo Zou | 2010 | Nano Research2010，3，5： | 2 |
| 14 | Initial velocity field for solution to strip rolling process by rigid plastic FEM 显示文摘 | Mei Ruibin Li Changsheng Liu Xianghua | 2009 | Journal of Northeastern University2009，30，4： | 1 |
| 15 | Research of Signal-in-Space Integrity Monitoring Based on Inter-satellite Links显示文摘Using the Inter-satellite links(ISLs) to enhance the GNSS's positioning accuracy and integrity is attracting much more attentions. In order to ensure the autonomous positioning accuracy and stability based on ISLs, a satellite and ground joint positioning mode is presented in this paper, which is constrained by quality grade of position error. Spatial error ellipsoid is applied to calculate parameters and achieve Signal-in-space(SIS) integrity monitoring. To check the accuracy of the mode and performance of monitoring, mixed constellation of Beidou system is simulated to support the analysis and investigate the impact of the high-low ISLs. The orbit determination results verify that the introduced integrity monitoring method can satisfy the integrity risk of 10-5/h and achieve the SIS integrity monitoring. | WANG Yuechen LI Rui ZHAO Ruibin | 2015 | Chinese Journal of Electronics2015，24，2： | 1 |
| 16 | Somatic mutations in renal cell carcinomas from Chinese patients revealed by targeted gene panel sequencing and their associations with prognosis and PD-L1 expression显示文摘Dear Editor, Renal cell carcinoma (RCC) is among the most common human cancers in the United States, with approximately 63,990 new patients and 14,400 deaths annually [1]. However, RCC is not among the top 10 malignancies in China in terms of incidence and mortality [2]. The clini-cal and molecular features of RCC differ among distinct pathological types, mainly clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (PRCC), and chromophobe renal cell carcinoma (ChRCC). The most common subtype of RCC is ccRCC worldwide. Accord-ing to The Cancer Genome Atlas (TCGA), the somatic mutation landscape of RCC has been revealed by whole- exome sequencing (WES) or whole-genome sequencing (WGS). In our previous WES study, we validated most of the significantly mutated genes reported by the TCGA and identified several novel somatically altered genes [3]. The TCGA study showed that only somatic mutations in BRCA1-associated protein 1 (BAP1) were associated with patients’ poor survival outcomes among all significantly mutated genes [4]. In our previous WES study, BAP1 was somatically mutated in 2 of 15 ccRCC samples [3]. Never-theless, all of these RCC patients lacked follow-up infor-mation. Hence, further analysis is needed to determine whether there are any somatically mutated genes associ-ated with the prognosis of Chinese patients with RCC. However, WES or WGS is time-consuming and costly. Furthermore, compared with targeted sequencing, WES was more likely to generate false positives and false nega-tives due to insufficient base coverage [5]. | Jie Wang Jianzhong Xi Hanshuo Zhang Juan Li Yuchao Xia Ruibin Xi Zhijun Xi | 2019 | Cancer Communications2019，39，1： | 1 |
| 17 | Surface inter- action with compartmentalized cellular phosphates explain rare earth oxide nanoparticle hazard and provide opportu- nities for safer design显示文摘 | Li Ruibin Ji Zhaoxia Chong Hyun Chang | 2014 | ACS Nano2014，8，2： | 1 |
| 18 | Multidrug resist- ance protein P-glycoprotein does not recognize nanoparti- cle C60: experiment and modeling 显示文摘 | XU Xue LI Ruibin MA Ming | 2012 | Soft Matter2012，8，： | 1 |
| 19 | Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen activation protein kinase pathways in imidazoline receptor antisera selected-protein显示文摘 | Li Fei Wu Ning Su Ruibin | 2006 | J Cell Biochem2006，，： | 1 |
| 20 | Biphasic opioid function modulator:agmatine显示文摘 | Su Ruibin Li Jin Qin Boyi | 2003 | Acta Pharmacol Sin2003，24，7： | 1 |
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