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| 1 | Improving analytic hierarchy process applied to fire risk analysis of public building显示文摘The structure importance in Fault Tree Analysis(FTA) reflects how important Basic Events are to Top Event.Attribute at alternative level in Analytic Hierarchy Process(AHP) also reflect its importance to general goal.Based on the coherence of these two methods,an improved AHP is put forward.Using this improved method,how important the attribute is to the fire safety of public building can be analyzed more credibly because of the reduction of subjective judgment.Olympic venues are very important public buildings in China.The fire safety evaluation of them will be a big issue to engineers.Improved AHP is a useful tool to the safety evaluation to these Olympic venues,and it will guide the evaluation in other areas. | SHI Long ZHANG RuiFang XIE QiYuan FU LiHua | 2009 | Chinese Science Bulletin2009，54，8： | 7 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | MULTI-TILLERING DWARF1, a new allele of BRITTLE CULM 12, affects plant height and tiller in rice显示文摘Plant height and tillering are crucial factors determining rice plant architecture and influencing rice grain production. In this study, multi-tillering dwarf1(mtd1), a stable multi-tiller and dwarf mutant, was screened from the ethylmethane sulfonate-treated japonica rice variety Wuyunging7. Compared with the wild type, mtd1 mutant exhibited pleiotropic phenotypes, including dwarfism, more tillers, brittle culms and delayed heading date.By employing map-based cloning strategy, the gene MTD1 was finally mapped to an approximately 66-kb region on the short arm of chromosome 9. Sequencing results showed that the gene LOC_Os09g02650(BC12) in mtd1 mutant had a single nucleotide substitution(G to A), which generated a premature translation stop. Over-expressing MTD1/BC12 coding sequence rescued all the phenotypes of mtd1 mutants including plant height and tillers, which confirms that BC12 is the mutated gene in mtd1 mutant.Quantitative reverse transcription-PCR analysis showed that MTD1/BC12 could negatively regulate the expression of MONOCULM 1, IDEAL PLANT ARCHITECTURE1 and Tillering and Dwarf 1, and control rice tillering. Remarkably, a-amylase activity analysis and gibberellic acid(GA)treatment showed that the dwarf phenotype of mtd1 mutant was dependent on GA biosynthesis pathway. These results facilitated to further uncover the molecular mechanism of the growth and development in rice. | Haiping Yu Deyong Ren Yangzhou Zhu Jiangmin Xu Yuexing Wang Ruifang Liu Yunxia Fang Zhenyuan Shi Jiangjie Pan Mei Lu Bojun Ma Jiang Hu Yuchun Rao | 2016 | Science Bulletin2016，61，23： | 3 |
| 4 | Effects of salinity on embryonic and larval development of Chinese mitten crab Eriocheir sinensis(Decapoda: Brachyura) and salinity-induced physiological changes显示文摘To investigate the effects of salinity on early development of Chinese mitten crab ( Eriocheir sinensis ), and the salinity tolerance mechanism of embryos, different developmental stages of embryos (gastrula, eyespot and pre-hatching stage), and hatched stage I zoea and megalopa, were exposed to a range of salinities (1, 5, 10, 15 (control), 20, 25, 30, 35 and 40). Hatching, survival and molting were monitored. Effects of 24-hour hypersaline (35) and hyposaline (1) stress on egg diameter, water content, Na +/K +-ATPase (NKA) activity, and crustacean hyperglycemic hormone (CHH) gene mRNA expression in embryos and megalopa, are reported. Embryos are more tolerant of low (≤ 5) than high (≥25) salinities, with optimum ranges for gastrula and pre-hatching stage embryos being 5-20, and for eyespot embryo and stage I zoea, 10-20. Most megalopa can molt to the first juvenile instar by day 5 at salinities between 1 and 40, whereas molting of megalopa stages was delayed at 40. Hypersaline conditions resulted in a loss of moisture, reduction of egg volume, and a signifi cant increase in NKA activity and CHH mRNA expression at some developmental stages. Hyposaline conditions did not affect moisture content or egg volume, but resulted in decreased NKA activity and CHH mRNA expression in embryos. For megalopa stages, NKA activity was significantly upregulated following both hypo- and hypersaline stress. Our results suggest high salinity will inhibit development and hatching of E. sinensis embryos, and low salinity will affect the survival of their stage I zoea. Increased NKA activity in embryos and megalopa stages might indicate a hyporegulation response under hypersaline conditions. These findings provide useful information for spawning ground protection of indigenous E . sinensis and enrich the knowledge of embryonic tolerance mechanisms of hyperregulating crustaceans following osmotic stress. | WANG Ruifang HUANG Xiaorong WANG Haihua LU Jianxue SHI Xiaotao FENG Guangpeng ZHUANG Ping | 2019 | Journal of Oceanology and Limnology2019，37，5： | 2 |
| 5 | Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells显示文摘Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction'(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4 | Jie Liang Keman Cheng Yao Li Jiaqi Xu Yiwei Chen Nana Ma Qingqing Feng Fei Zhu Xiaotu Ma Tianjiao Zhang Yale Yue Guangna Liu Xinjing Guo Zhiqiang Chen Xinwei Wang Ruifang Zhao Ying Zhao Jian Shi Xiao Zhao Guangjun Nie | 2022 | Fundamental Research2022，2，1： | 2 |
| 6 | Epithelial-Mesenchymal Transitions and the Expression of Twist in MCF-7/ADR, Human Multidrug-Resistant Breast Cancer Cells显示文摘0BJECTIVE To study the expression levels of Twist and epithelialmesenchymal transitions in multidrug-resistant MCF-7/ADR breast cancer cells, and to study the relationship between multidrug resistance (MDR) and metastatic potential of the cells. METHODS RT-PCR, immunohistochemical and Western blotting methods were used to examine the changes of expression levels of the transcription factor Twist, E-cadherin and N-cadherin in the MCF-7 breast cancer cell line and its multidrug-resistant variant, MCF-7/ADR. RESULTS In MCF-7 cells, the expression of E-cadherin can be detected, but there is no expression of Twist or N-cadherin. In MCF-7/ADR cells, E-cadherin expression is lost, but the expression of two other genes was significantly positive. CONCLUSION Epithelial-mesenchymal transitions induced by Twist, may have a relationship with enhanced invasion and metastatic potential during the development of multidrug-resistant MCF-7/ADR breast cancer cells. | Fei Zhang Yurong Shi Lin Zhang Bin Zhang Xiyin Wei Yi Yang Rui Wang Ruifang Niu | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 2 |
| 7 | Adjunctive sepsis therapy with aminophylline(STAP):a randomized controlled trial显示文摘Background:Sepsis is a serious disease caused by infection.Aminophylline has anti-asthma and anti-inflammatory effects.We aimed to explore the safety and effect of aminophylline in sepsis.Methods:We conducted a clinical randomized controlled trial involving 100 patients diagnosed with sepsis within 48 h after intensive care unit(ICU)admission in two sites.All patients were randomized in a 1:1 ratio to receive standard therapy with or without aminophylline.The primary clinical outcome was all-cause mortality at 28 days.Results:From September 27,2018 to February 12,2020,we screened 277 septic patients and eventually enrolled 100 patients,with 50 assigned to the aminophylline group and 50 to the usual-care group.At 28 days,7 of 50 patients(14.0%)in the aminophylline group had died,compared with 16 of 50(32.0%)in the usual-care group(P=0.032).Cox regression showed that the aminophylline group had a lower hazard of death(hazard ratio=0.312,95%confidence interval:0.129–0.753).Compared with the usual-care group,patients in the aminophylline group had a longer survival time(P=0.039 by the log-rank test).The effects of aminophylline on vasopressor dose,oxygenation index,and sequential organ failure assessment score were timedependent with treatment.There were no significant differences in total hospitalization days,ICU hospitalization days,and rates of serious adverse events(all P>0.05).No adverse events were observed in the trial.Conclusions:Aminophylline as an adjunct therapy could significantly reduce the risk of death and prolong the survival time of patients with sepsis.Trial registration:ChiCTR.org.cn,ChiCTR1800019173. | Ruifang Zhang Huan Liu Dongmei Dai Xianfei Ding Dong Wang Yan Wang Xuexiu Shi Shuguang Zhang Xiaoguang Duan Haixu Wang Yonggang Luo Shaohua Liu Bing Han Xiaojuan Zhang Yu Fang Jing Yang Wangbin Xu Tongwen Sun | 2022 | Chinese Medical Journal2022，135，23： | 2 |
| 8 | QTL mapping of quality traits in peanut using whole-genome resequencing显示文摘Oil and protein content and fatty acid composition are quality traits in peanut.Elucidating the genetic mechanisms underlying these traits may help researchers to obtain improved cultivars by molecular breeding.Whole-genome resequencing of a recombinant inbred population of 318 lines was performed to construct a high-density linkage map and identify QTL for peanut quality.The map,containing 4561 bin markers,covered 2032 c M with a mean marker density of 0.45 c M.A total of 110 QTL for oil and protein content,and fatty acid composition were mapped on the 18 peanut chromosomes.The QTL q A05.1 was detected in four environments and showed a major phenotypic effect on the contents of oil,protein,and six fatty acids.The genomic region spanned by q A05.1,corresponding to a physical interval of approximately 1.5 Mb,contains two SNPs polymorphic between the parents that could cause missense mutations.The two SNP sites were employed as KASP markers and validated using lines with extremely high and low oil contents.These sites may be useful in the marker-assisted breeding of peanut cultivars with high oil contents. | Ziqi Sun Feiyan Qi Hua Liu Li Qin Jing Xu Lei Shi Zhongxin Zhang Lijuan Miao Bingyan Huang Wenzhao Dong Xiao Wang Mengdi Tian Jingjing Feng Ruifang Zhao Xinyou Zhang Zheng Zheng | 2022 | The Crop Journal2022，10，1： | 2 |
| 9 | An Investigation of a Confirmed Imported Case of COVID-19 Infected Abroad—Qingpu District,Shanghai Municipality,China,November 15,2020显示文摘Summary What is already known about this topic?A passenger who was from the United States was taken to the hotel for the required isolation on November 13,2020.During the quarantine she was diagnosed as the COVID-19 patient on November 15,2020.Controlling the importation of COVID-19 remains a major challenge.What is added by this report? | Hongrang Zhou Xiaoling Wang Qiufang Xu Xiaoming Wang Yadong Ma Yiru Shi Zhouli Wu Peifeng Zhu Jinjiang Zhao Ruifang Xu Changpo Lin Ning Xiao | 2021 | China CDC weekly2021，3，10： | 1 |
| 10 | Identifying and annotating human bifunctional RNAs reveals their versatile functions显示文摘Bifunctional RNAs that possess both protein-coding and noncoding functional properties were less explored and poorly understood. Here we systematically explored the characteristics and functions of such human bifunctional RNAs by integrating tandem mass spectrometry and RNA-seq data. We first constructed a pipeline to identify and annotate bifunctional RNAs,leading to the characterization of 132 high-confidence bifunctional RNAs. Our analyses indicate that bifunctional RNAs may be involved in human embryonic development and can be functional in diverse tissues. Moreover, bifunctional RNAs could interact with multiple miRNAs and RNA-binding proteins to exert their corresponding roles. Bifunctional RNAs may also function as competing endogenous RNAs to regulate the expression of many genes by competing for common targeting miRNAs. Finally,somatic mutations of diverse carcinomas may generate harmful effect on corresponding bifunctional RNAs. Collectively,our study not only provides the pipeline for identifying and annotating bifunctional RNAs but also reveals their important gene-regulatory functions. | Geng Chen Juan Yang Jiwei Chen Yunjie Song Ruifang Cao Tieliu Shi Leming Shi | 2016 | Science China(Life Sciences)2016，59，10： | 1 |
| 11 | Distribution of non-spherical nanoparticles in turbulent flow of ventilation chamber considering fluctuating particle number density显示文摘The Reynolds-averaged general dynamic equation(RAGDE)for the nanoparticle size distribution function is derived,including the contribution to particle coagulation resulting from the fluctuating concentration.The equation together with that of a turbulent gas flow is solved numerically in the turbulent flow of a ventilation chamber with a jet on the wall based on the proposed model relating the fluctuating coagulation to the gradient of mean concentration.Some results are compared with the experimental data.The results show that the proposed model relating the fluctuating coagulation to the gradient of mean concentration is reasonable,and it is necessary to consider the contribution to coagulation resulting from the fluctuating concentration in such a flow.The changes of the particle number concentration M_(0) and the geometric mean diameter dg are more obvious in the core area of the jet,but less obvious in other areas.With the increase in the initial particle number concentration m00,the values of M_(0) and the standard deviation of the particle sizeσdecrease,but the value of d_(g) increases.The decrease in the initial particle diameter leads to the reduction of M_(0) andσand the increase in d_(g).With the increase in the Reynolds number,particles have few chances of collision,and hence the coagulation rate is reduced,leading to the increase in M_(0) andσand the decrease in d_(g). | Ruifang SHI Jianzhong LIN Hailin YANG MingzhouYU | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，3： | 1 |
| 12 | Yangtze River Delta Aerosol liquid water in PM_(2.5)and its roles in secondary aerosol formation at a regional site of Yangtze River Delta显示文摘Aerosol liquid water content(ALWC)plays an important role in secondary aerosol formation.In this study,a whole year field campaign was conducted at Shanxi in north Zhejiang Province during 2021.ALWC estimated by ISORROPIA-Ⅱ was then investigated to explore its characteristics and relationship with secondary aerosols.ALWC exhibited a highest value in spring(66.38μg/m^(3)),followed by winter(45.08μg/m^(3)),summer(41.64μg/m^(3)),and autumn(35.01μg/m^(3)),respectively.It was supposed that the secondary inorganic aerosols(SIA)were facilitated under higher ALWC conditions(RH>80%),while the secondary organic species tended to form under lower ALWC levels.Higher RH(>80%)promoted the NO_(3)^(-)formation via gas-particle partitioning,while SO_(4)^(2-)was generated at a relative lower RH(>50%).The ALWC was more sensitive to NO_(3)^(-)(R=0.94)than SO_(4)^(2-)(R=0.90).Thus,the self-amplifying processes between the ALWC and SIA enhanced the particle mass growth.The sensitivity of ALWC and OX(NO_(2)+O_(3))to secondary organic carbon(SOC)varied in different seasons at Shanxi,more sensitive to aqueous-phase reactions(daytime R=0.84;nighttime R=0.54)than photochemical oxidation(daytime R=0.23;nighttime R=0.41)in wintertime with a high level of OX(daytime:130-140μg/m^(3);nighttime:100-140μg/m^(3)).The self-amplifying process of ALWC and SIA and the aqueous-phase formation of SOC will enhance aerosol formation,contributing to air pollution and reduction of visibility. | Ruifang Shi Fei Zhang Yemin Shen Jiasi Shen Bingye Xu Binyu Kuang Zhengning Xu Lingling Jin Qian Tang Xudong Tian Zhibin Wang | 2024 | Journal of Environmental Sciences2024，，4： | 1 |
| 13 | Gekko gecko's chromosome and fission federation complex research显示文摘 | Wang Ruifang Ma Kun Shi Liming | 1989 | Zoology research1989，10，4： | 1 |
| 14 | Redistribution process of precipitation in ecological restoration activity of Pinus sylvestris var.mongolica in Mu Us Sandy Land,China显示文摘Precipitation is the most important water resource in semi-arid regions of China.The redistribution of precipitation among atmospheric water,soil water and groundwater are related to the land surface afforested ecological system.The study took widely replanted Pinus sylvestris var.Mongolica(PSM)in Mu Us Sandy Land(MUSL)as a research object and monitored precipitation,soil moisture,sap flow,and deep soil recharge(DSR)to find out moisture distribution in shallow soil layers.Results showed that the restoration process of PSM in MUSL changed the distribution of precipitation,with part of it infltrating downward as DsR and part of it being stored in the shallow soil.Consequently,evapotranspiration increased and DsR significantly decreased,resulting in up to 466.9 mm of precipitation returning to the atmosphere through evapotranspiration in 2016.Vegetation increased soil water storage(SwS)capacity,with maximum SWS in PSM plot and bare sandy land(BSL)being 260 mm and 197 mm per unit horizontal area,respectively in 2016.DSR decreased from 54%of precipitation in the BSL plot to 0.2%of precipitation in the PSM plot in 2016.A great portion of infiltrated water was stored in the PSM ecosystem,resulting in a time lag of infiltration to reach the deep soil layer,and the infiltration rate in the BSL plot was 11 times of that in the PSM plot.SWS decreased 16 mm and 7.6 mm per unit horizontal area over a one-year period(from March to October,non-freezing time)in 2017 and 2019,respectively.The PSM annual sap flow was maintained at a relatively constant level of 154 mm/yr.Through in-situ measurement and comparative analysis of the precipitation redistribution of the BSL plot and the PSM plot,we find that PSM can significantly reduce the shallow soil water storage and DSR.However,substantial reduction of shallow soil water storage and DsR is detrimental for the long-term development of PSM forest.Therefore,it is necessary to reduce PSM density to cut the water consumption by PSM per unit area,thus to augment the shallow SWS and DSR,which will be beneficial for the PSM to survive under extreme drought conditions in the future.This study helps us understand the role of precipitationinduced groundwater recharge in the process of vegetation restoration in semi-arid regions and explains thepossiblecauses of PSM forest degradation. | Yiben Cheng Hongbin Zhan Wenbin Yang Wei Feng Qi Lu Yunqi Wang Qunou Jiang Bin Wang Mingchang Shi Tao Wang Zhiming Xin Ruifang Hao | 2023 | International Soil and Water Conservation Research2023，11，3： | 0 |
| 15 | Separation of gibberellic acid (GA3) by macroporous adsorption resins显示文摘The adsorption effects of several macroporousadsorption resins for gibberellic acid (GA3) were investigated.The dynamic adsorption capacity is 58.38 mg/g drybeads for resin R4 and 96.46 mg/g dry beads for resin R5which is consistent with the surface area. Aqueous methanol(50%, V/V) is a good eluent and the yield of GA3 isabove 95%. The concentration of GA3 could increase fivefoldafter an adsorption-elution cycle and this is importantwhen considering further crystallization of GA3 in anindustrial process. | Ruifang WANG Jialing YANG Zuoqing SHI Lailiang OU | 2008 | Frontiers of Chemical Science and Engineering2008，2，2： | 0 |
| 16 | Down-Regulation of CXCR4 Expression by siRNA Inhibits Invasive Ability of Breast Cancer Cells显示文摘OBJECTIVE To investigate the efficiency of gene silencing by CXCR4- siRNAs (small interfering RNA), and to examine the invasive ability and the expression of other metastatic-associated genes in siRNA-treated breast cancer cells. METHODS Three siRNAs were designed and cloned into the pSilenc ? 3.1-H1 neo vector. The reconstructed plasmids were purified and trans- fected into the T47D breast cancer cell line, which highly expressed CXCR4. The amount of CXCR4 expression in the transfected cells was measured by flow cytometry and Real-time PCR. Cell invasive ability was evaluated us- ing 24-well Matrigel invasion chambers. In addition, the expression of other metastatic-associated genes, such as E-cad, IGFBP-5, FN and MMP-2, was assessed by Real-time PCR. RESULTS The suppression rates of CXCR4 mRNA expression reached 95.7%, 85.9% and 98.3%compared with control-siRNA cells in the 3 CXCR4- siRNA T47D cells respectively. FCM assays for CXCR4 protein expression showed a similar inhibitory effect. The invasion indexes of these CXCR4- siRNA cells were 0.037, 0.290 and 0.188 respectively compared with control- siRNA cells. After treatment of the cells with CXCR4-siRNA, the expression of E-cad showed an upward tendency and that of IGFBP-5 had a downward trend, while alteration in expression of FN and MMP2 varied without a con- sistant effect. CONCLUSION CXCR4 plays an important role in modulating migra- tion of human breast cancer cells. Small interfering RNA can significantly silence the CXCR4 gene in the human T47D breast cancer cell line. The results of this study strengthen the need for further research on novel gene therapy against breast cancer metastasis. | Lin Zhang Rui Wang Yurong Shi Yi Yang Xiyin Wei Zhi Yao Ruifang Niu | 2007 | Chinese Journal of Clinical Oncology2007，4，4： | 0 |
| 17 | The Effect of Twist Expression on Angiogenesis in Hepatocellular Carcinoma显示文摘OBJECTIVE Hepatocellular carcinoma (HCC) is a hypervascular tumor for which angiogenesis plays an important role in its progression. The aim of this study was to investigate the expression of TWIST and VEGF and determine their roles in angiogenesis of HCC. METHODS Expression Twist and VEGF mRNA was determined by real-time RT-PCR in 30 pairs of hepatocellular carcinoma and matched non-cancerous tissues. Immunohistochemistry was carried out to analyze the protein expression of Twist and VEGF in 40 hepatocellular carcinoma cases. Staining of endothelial cells for CD34 was used to evaluate the microvessel density (MVD). RESULTS We found that the HCC specimens showing positive Twist expression in tumor cells had a higher microvessel density than those without Twist expression. Furthermore, we found that overexpression of the Twist protein positively correlated with up-regulation of VEGF in the HCC tissues (r=0.479, P=0.002). CONCLUSION Our results demonstrate that Twist may play an important role in the angiogenesis of HCC and a high-level of Twist expression may be related to the malignant potential of tumor cells. | Gangmin Xi Lin Zhang Zhongli Zhan Lihua Zhang Xiyin Wei Yi Yang Yurong Shi Fei Zhang Ruifang Niu | 2006 | Chinese Journal of Clinical Oncology2006，3，6： | 0 |
| 18 | Proteasome Inhibitors Sensitize Hepatocellular Carcinoma Cells to TRAIL显示文摘OBJECTIVE To investigate the effect of proteasome inhibition on the sensitivity of carcinoma cells to TRAIL-inducing apoptosis, and to study the mechanism of the response. METHODS Human hepatocellular carcinoma cells, pretreated with the proteasome inhibitor, MG132, were cotreated with TRAIL. Western blot assays, immunoprecipitation and RT-PCR were performed to test the expression of the Bcl-2 family proteins and Bax mRNA. RESULTS We found that (i) proteasome inhibition sensitized the human hepatocellular carcinoma cells to TRAIL; and (ii) resulted in Bax accumulation before release of cytochrome C and induction of apoptosis. These results were associated with the ability of proteasome inhibitors to overcome Bcl-2-mediated antiapoptotic function; (iii) Bax is regulated by an ubiquitin/proteasome-dependent degradation pathway. CONCLUSION Proteasome inhibition sensitized hepatocellular carcinoma cells to TRAIL by the inhibition of the ubiquitin/proteasome-mediated Bax degradation pathway. | Qingfeng Sheng Yurong Shi Qiang Li Jihui Hao Ruifang Niu Xiyin Wei Yi Yang Lin Zhang | 2006 | Chinese Journal of Clinical Oncology2006，3，6： | 0 |
| 19 | Clinical Research of Acupuncture Therapy on Children with Cerebral Palsy显示文摘 | Bingpei Shi Huaidi Bu Wei Shi Hong Yang Sujuan Wang Zhen Zhu Ruifang Zhao | 2005 | Journal of US-China Medical Science2005，2，6： | 0 |
| 20 | Molecular dynamics simulation study onπ-πstacking of Gemini surfactants in oil/water systems显示文摘Whereas theπ-πstacking interactions at oil/water interfaces can affect interfacial structures hence the interfacial properties,the underlying microscopic mechanism remains largely unknown.We reported an all-atom molecular dynamics(MD)simulation study to demonstrate how the Gemini surfactants with pyrenyl groups affect the interracial properties,structural conformations,and the motion of molecules in the water/n-octane/surfactant ternary systems.It is found that the pyrenyl groups tend to be vertical to the interface owing to theπ-πstacking interaction.Besides,a synergistic effect between theπ-πinteraction and steric hindrance is found,which jointly affects the coalescence of liquid droplets.Therefore,the existence of aromatic groups and a moderate number of surfactants helps to form microemulsion.This work provides a molecular understanding of Gemini surfactants with aromatic groups in microemulsion preparation and applications. | Jule Ma Peiwen Xiao Pingmei Wang Xue Han Jianhui Luo Ruifang Shi Xuan Wang Xianyu Song Shuangliang Zhao | 2022 | Chinese Journal of Chemical Engineering2022，，10： | 0 |
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