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| 1 | Relationship between the parent charge transfer gap and maximum transition temperature in cuprates显示文摘One of the biggest puzzles concerning the cuprate high temperature superconductors is what determines the maximum transition temperature(Tc,max), which varies from less than 30 to above 130 K in different compounds.Despite this dramatic variation, a robust trend is that within each family, the double-layer compound always has higher Tc,maxthan the single-layer counterpart. Here we use scanning tunneling microscopy to investigate the electronic structure of four cuprate parent compounds belonging to two different families. We find that within each family, the double layer compound has a much smaller charge transfer gap size(DCT), indicating a clear anticorrelation between DCTand Tc,max. These results suggest that the charge transfer gap plays a key role in the superconducting physics of cuprates, which shed important new light on the high Tc mechanism from doped Mott insulator perspective. | Wei Ruan Cheng Hu Jianfa Zhao Peng Cai Yingying Peng Cun Ye Runze Yu Xintong Li Zhenqi Hao Changqing Jin Xingjiang Zhou Zheng-Yu Weng Yayu Wang | 2016 | Science Bulletin2016，61，23： | 3 |
| 2 | Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms:relevance to excitotoxic neurodegeneration显示文摘Background:Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis,which converts glutamine into glutamate.Glutamate is the major neurotransmitter of excitatory synapses,executing important physiological functions in the central nervous system.There are two isoforms of glutaminase 1,KGA and GAC,both of which are generated through alternative splicing from the same gene.KGA and GAC both transcribe 1–14 exons in the N-terminal,but each has its unique C-terminal in the coding sequence.We have previously identified that KGA and GAC are differentially regulated during inflammatory stimulation and HIV infection.Furthermore,glutaminase 1 has been linked to brain diseases such as amyotrophic lateral sclerosis,Alzheimer’s disease,and hepatic encephalopathy.Core enzyme structure of KGA and GAC has been published recently.However,how other coding sequences affect their functional enzyme activity remains unclear.Methods:We cloned and performed serial deletions of human full-length KGA and GAC from the N-terminal and the C-terminal at an interval of approximately 100 amino acids(AAs).Prokaryotic expressions of the mutant glutaminase 1 protein and a glutaminase enzyme activity assay were used to determine if KGA and GAC have similar efficiency and efficacy to convert glutamine into glutamate.Results:When 110 AAs or 218 AAs were deleted from the N-terminal or when the unique portions of KGA and GAC that are beyond the 550 AA were deleted from the C-terminal,KGA and GAC retained enzyme activity comparable to the full length proteins.In contrast,deletion of 310 AAs or more from N-terminal or deletion of 450 AAs or more from C-terminal resulted in complete loss of enzyme activity for KGA/GAC.Consistently,when both Nand C-terminal of the KGA and GAC were removed,creating a truncated protein that expressed the central 219 AA-550 AA,the protein retained enzyme activity.Furthermore,expression of the core 219 AA-550 AA coding sequence in cells increased extracellular glutamate concentrations to levels comparable to those of full-length KGA and GAC expressions,suggesting that the core enzyme activity of the protein lies within the central 219 AA-550 AA.Full-length KGA and GAC retained enzyme activities when kept at 4°C.In contrast,219 AA-550 AA truncated protein lost glutaminase activities more readily compared with full-length KGA and GAC,suggesting that the Nterminal and C-terminal coding regions are required for the stability KGA and GAC.Conclusions:Glutaminase isoforms KGA and GAC have similar efficacy to catalyze the conversion of glutamine to glutamate.The core enzyme activity of glutaminase 1 protein is within the central 219 AA-550 AA.The N-terminal and C-terminal coding regions of KGA and GAC help maintain the long-term activities of the enzymes. | Yuju Li Justin Peer Runze Zhao Yinghua Xu Beiqing Wu Yi Wang Changhai Tian Yunlong Huang Jialin Zheng | 2017 | Translational Neurodegeneration2017，6，1： | 1 |
| 3 | Heat transfer and grain refining mechanism during melt treatment by cooling sloping plate显示文摘Heat transfer of flow melt and grain refining mechanism during melt treatment by the cooling sloping plate were investigated.The results show that the cooling sloping plate can refine not only grains of alloys but also can obviously refine pure metal.Cooling ability of the plate is the key factor that induces grain refining,the plate material and the flow amount can affect cooling rate of the melt and thus affect refining effectiveness.The cooling rate of the melt on the cooling sloping plate is much faster than that of the conventional casting process,which can reach 1000 K/s and belongs to meta-rapid solidification scope.The thickness of the temperature boundary layer is much larger than that of the velocity boundary layer on the sloping plate,but the temperature gradient is small in the temperature boundary layer.Under strong cooling action by the cooling plate,most parts of the melt on the plate surface can form undercooling,which causes continuous eruptive nucleation,this is the main grain refining mechanism,and the heterogeneous nucleation on the plate surface is a helpful supplement for the nucleation. | Renguo GUAN Zhanyong ZHAO Runze CHAO Hongqian HUANG Chunming LIU | 2012 | Acta Metallurgica Sinica(English Letters)2012，25，4： | 1 |
| 4 | Engineering the viscoelasticity of gelatin methacryloyl(GelMA)hydrogels via small“dynamic bridges”to regulate BMSC behaviors for osteochondral regeneration显示文摘The dynamic extracellular matrix(ECM)constantly affects the behaviors of cells.To mimic the dynamics of ECM with controllable stiffness and energy dissipation,this study proposes a strategy in which a small molecule,3,4-dihydroxybenzaldehyde(DB),was used as fast'dynamic bridges'to construct viscoelastic gelatin methacryloyl(GelMA)-based hydrogels.The storage modulus and loss modulus of hydrogels were independently adjusted by the covalent crosslinking density and by the number of dynamic bonds.The hydrogels exhibited self-healing property,injectability,excellent adhesion and mechanical properties.Moreover,the in vitro results revealed that the viscous dissipation of hydrogels favored the spreading,proliferation,osteogenesis and chondrogenesis of bone marrow mesenchymal stem cells(BMSCs),but suppressed their adipogenesis.RNA-sequencing and immunofluorescence suggested that the viscous dissipation of hydrogels activated Yes-associated protein(YAP)by stabilizing integrinβ1,and further promoted nuclear translocation of smad2/3 andβ-catenin to enhance chondrogenesis and osteogenesis.As a result,the viscoelastic GelMA hydrogels with highest loss modulus showed best effect in cartilage and subchondral bone repair.Taken together,findings from this study reveal an effective strategy to fabricate viscoelastic hydrogels for modulating the interactions between cells and dynamic ECM to promote tissue regeneration. | Changjiang Liu Qifan Yu Zhangqin Yuan Qianping Guo Xiting Liao Feng Han Tao Feng Guoping Liu Runze Zhao Zhuang Zhu Haijiao Mao Caihong Zhu Bin Li | 2023 | Bioactive Materials2023，，7： | 1 |
| 5 | Morphology development of PC/PE blends during compounding in a twin-screw extruder显示文摘 | Yin Bo Zhao Yin Yu Runze | 2007 | Polym Eng Sei2007，47，1： | 1 |
| 6 | Efficient evaluation model including interconnect resistance effect for large scale RRAM crossbar array matrix computing显示文摘Crossbar architecture has been considered as an efficient means to execute a matrix-vector multiplication computation. An efficient evaluation model for this computation including the interconnect resistance effect on the high density resistive random access memmory(RRAM) crossbar array is proposed in this paper. The proposed model considers the interconnect resistance impacts on the columns and rows separately. The simulation results indicate that the computing speed of the proposed model can be boosted by over three orders of magnitude with the computation deviation of 7.7% in comparison with the precise comprehensive model in the 64 kb crossbar array fabricated at the 14 nm technology node. Based on the proposed evaluation model, the impacts of the parameters including nonlinearity and load resistance, on the computation are discussed along with solutions to improve the computational performance. | Runze HAN Peng HUANG Yudi ZHAO Xiaole CUI Xiaoyan LIU Jinfeng KANG | 2019 | Science China(Information Sciences)2019，62，2： | 1 |
| 7 | Revenue-sharing contract models for logistics service supply chains with mass customization service显示文摘 | Liu Weihua Zhao Xuan Wu Runze | 2015 | Mathematical Problems in Engineering2015，40，7： | 1 |
| 8 | Effect of magnetic field on dislocation morphology and precipitation behaviour in ultrafine-grained 7075 aluminium alloy显示文摘The influence of magnetic field(1 T)on dislocation morphology and precipitation behaviour of ultrafinegrained(UFG)Al 7075 alloy was investigated after ageing from 90 to 200℃ via wide angle X-ray scattering(WAXS),small angle X-ray scattering(SAXS),and transmission electron microscopy(TEM).Experimental results reveal that the improved precipitation kinetics of alloys in the thickness plane(denoted as sample II)as compared to those in the rolling plane(denoted as sample I),which arises due to a higher dislocation density(morphology of dislocation cells)of the thickness plane than that of the rolling plane(morphology of dislocations and dislocation tangles).Specifically,because of different dislocation morphologies,the magnetic field positively and negatively affects the dislocation activity in samples I and II,leading to enhanced and suppressed precipitation behaviors,respectively.Interestingly,nucleation of theηphase is facilitated in the UFG alloy at the critical temperature(140℃)because it affords a faster rate of atom diffusion and a higher dislocation density as compared to those exhibited by its coarse-grained alloy.This systematic and comprehensive study provides new insights into dislocation morphology and precipitation behaviour of the UFG 7075 Al alloy,while enabling the optimization of precipitation kinetics. | Jun Luo Hongyun Luo Tianshu Zhao Runze Wang | 2021 | Journal of Materials Science & Technology2021，，34： | 1 |
| 9 | Associations of genome-wide structural variations with phenotypic differences in cross-bred Eurasian pigs显示文摘Background During approximately 10,000 years of domestication and selection,a large number of structural variations(SVs)have emerged in the genome of pig breeds,profoundly influencing their phenotypes and the ability to adapt to the local environment.SVs(≥50 bp)are widely distributed in the genome,mainly in the form of insertion(INS),mobile element insertion(MEI),deletion(DEL),duplication(DUP),inversion(INV),and translocation(TRA).While studies have investigated the SVs in pig genomes,genome-wide association studies(GWAS)-based on SVs have been rarely conducted.Results Here,we obtained a high-quality SV map containing 123,151 SVs from 15 Large White and 15 Min pigs through integrating the power of several SV tools,with 53.95%of the SVs being reported for the first time.These high-quality SVs were used to recover the population genetic structure,confirming the accuracy of genotyping.Potential functional SV loci were then identified based on positional effects and breed stratification.Finally,GWAS were performed for 36 traits by genotyping the screened potential causal loci in the F2 population according to their corresponding genomic positions.We identified a large number of loci involved in 8 carcass traits and 6 skeletal traits on chromosome 7,with FKBP5 containing the most significant SV locus for almost all traits.In addition,we found several significant loci in intramuscular fat,abdominal circumference,heart weight,and liver weight,etc.Conclusions We constructed a high-quality SV map using high-coverage sequencing data and then analyzed them by performing GWAS for 25 carcass traits,7 skeletal traits,and 4 meat quality traits to determine that SVs may affect body size between European and Chinese pig breeds. | Wencheng Zong Jinbu Wang Runze Zhao Naiqi Niu Yanfang Su Ziping Hu Xin Liu Xinhua Hou Ligang Wang Lixian Wang Longchao Zhang | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 10 | Harvesting net power and desalinating water by pressure-retarded membrane distillation显示文摘Pressure-retarded membrane distillation(PRMD)can convert low-grade heat to useful work by harvesting the pressure energy of the condensation liquid on the cold side.In this study,a new type of PRMD system for combined freshwater and power production was proposed.For this configuration,the thermal energy of the phase change is transported to the interface mainly by conduction rather than convection,which significantly reduces the pump power loss of the liquid flow.In addition,it also utilizes a multistage structure to regenerate heat with low pump power loss.The experimental results showed that,for a module with a heating area of 1.0 m^(2),this system can produce 188 L of freshwater and 27.8 kJ of power each day when operating between 80℃ and 40℃.The water and power densities of the PRMD configuration would be affected by saline ions in the feed liquid,air resistance in the evaporation chamber,membrane wetting,and membrane compaction.The experimental and molecular dynamics simulation results indicated that a higher temperature difference or working temperature will significantly improve the desalination and power generation rates because of the increased mass transfer driving force of the vapor gradient.This study proved that it is possible for a PRMD system to simultaneously obtain net power and freshwater using low-grade heat as the only energy input.Nevertheless,the liquid supply,working pressure,and membrane properties should be improved to achieve better performance. | ZHAO RunZe LI Ji ZHANG ZiKang LONG Rui LIU Wei LIU ZhiChun | 2022 | Science China(Technological Sciences)2022，65，1： | 0 |
| 11 | Economic Policy Uncertainty and Stock Risk Features显示文摘In this paper,we introduce economic policy uncertainty by using a stochastic discount model.Via parameter calibration and static analysis,we investigate the dynamic characteristics of stock risk on different policy uncertainty.On this basis,we test the channel through policy uncertainty affects stock risk by empirical simulation,and the effect of policy uncertainty on stock risk formation by portfolio analysis,in order to verify the applicability of the theoretical model in China.Finally,the panel model is used to quantitatively analyze the relationship between policy uncertainty and stock risk.The results show that policy uncertainty can inereuse stock risk through enterprise cash flow,discounting factors and correlation coefficient.The effect is still significant after controlling traditional risk factors,corporate heterogeneity,and external environmental factors.Companies that are non-state-owned,have lower returns on invested capital and lower asset growth rate manifest greater stock risk when policy uncertainty is higher.The magnitude of the effect of policy uncertainty on stock risk is larger when the economy is weaker and the policy environment is more unstable. | Guojin Chen Runze Zhang Xiangqin Zhao | 2019 | Frontiers of Economics in China-Selected Publications from Chinese Universities2019，14，3： | 0 |
| 12 | Genomic prediction of yield performance among single-cross maize hybrids using a partial diallel cross design显示文摘Genomic prediction(GP)in plant breeding has the potential to predict and identify the best-performing hybrids based on the genotypes of their parental lines.In a GP experiment,34 elite inbred lines were selected to make 285 single-cross hybrids in a partial-diallel cross design.These lines represented a mini-core collection of Chinese maize germplasm and comprised 18 inbred lines from the Stiff Stalk heterotic group and 16 inbred lines from the Non-Stiff Stalk heterotic group.The parents were genotyped by sequencing and the 285 hybrids were phenotyped for nine yield and yield-related traits at two locations in the summer sowing area(SUS)and three locations in the spring sowing area(SPS)in the main maizeproducing regions of China.Multiple GP models were employed to assess the accuracy of trait prediction in the hybrids.By ten-fold cross-validation,the prediction accuracies of yield performance of the hybrids estimated by the genomic best linear unbiased prediction(GBLUP)model in SUS and SPS were 0.51 and 0.46,respectively.The prediction accuracies of the remaining yield-related traits estimated with GBLUP ranged from 0.49 to 0.86 and from 0.53 to 0.89 in SUS and SPS,respectively.When additive,dominance,epistasis effects,genotype-by-environment interaction,and multi-trait effects were incorporated into the prediction model,the prediction accuracy of hybrid yield performance was improved.The ratio of training to testing population and size of training population optimal for yield prediction were determined.Multiple prediction models can improve prediction accuracy in hybrid breeding. | Ping Luo Houwen Wang Zhiyong Ni Ruisi Yang Fei Wang Hongjun Yong Lin Zhang Zhiqiang Zhou Wei Song Mingshun Li Jie Yang Jianfeng Weng Zhaodong Meng Degui Zhang Jienan Han Yong Chen Runze Zhang Liwei Wang Meng Zhao Wenwei Gao Xiaoyu Chen Wenjie Li Zhuanfang Hao Junjie Fu Xuecai Zhang Xinhai Li | 2023 | The Crop Journal2023，11，6： | 0 |
| 13 | Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms显示文摘Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon rupture.Currently,there is no approved drug therapy for AAA.Surgical repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed cases.It is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA progression.We contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery methods.There is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and progression.In this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic target.Indeed,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in vivo.In parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug delivery.This NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of AAA.In summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA. | Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang | 2023 | Bioactive Materials2023，，8： | 0 |
| 14 | Lanchester equation for cognitive domain using hesitant fuzzy linguistic terms sets显示文摘Intelligent wars can take place not only in the physical domain and information domain but also in the cognitive domain.The cognitive domain will become the key domain to win in the future intelligent war.A Lanchester equation considering cognitive domain is proposed to fit the development tendency intelligent wars in this paper.One party is considered to obtain the exponential enhancement advantage on combat forces in combat if it can gain an advantage in the cognitive domain over the other party according to the systemic advantage function.The operational effectiveness of the cognitive domain in war is considered to consist of a series of indicators.Hesitant fuzzy sets and linguistic term sets are powerful tools when evaluating indicators,hence the indicators are scored by experts using hesitant fuzzy linguistic terms sets here.A unique hesitant fuzzy hybrid arithmetical averaging operator is used to aggregate the evaluation. | HAN Qi LI Weimin XU Qiling ZHAO Minrui HUO Runze ZHANG Tao | 2022 | Journal of Systems Engineering and Electronics2022，33，3： | 0 |
| 15 | Microfluidic field strategy for enhancement and scale up of liquid-liquid homogeneous chemical processes by optimization of 3D spiral baffle structure显示文摘Due to the scale effect, the uniform distribution of reagents in continuous flow reactor becomes bad when the channel is enlarged to tens of millimeters. Microfluidic field strategy was proposed to produce high mixing efficiency in large-scale channel. A 3D spiral baffle structure(3SBS) was designed and optimized to form microfluidic field disturbed by continuous secondary flow in millimeter scale Y-shaped tube mixer(YSTM). Enhancement effect of the 3SBS in liquid-liquid homogeneous chemical processes was verified and evaluated through the combination of simulation and experiment. Compared with 1 mm YSTM, 10 mm YSTM with 3SBS increased the treatment capacity by 100 times, shortened the basic complete mixing time by 0.85 times, which proves the potential of microfluidic field strategy in enhancement and scale-up of liquid-liquid homogeneous chemical process. | Shuangfei Zhao Yingying Nie Wenyan Zhang Runze Hu Lianzhu Sheng Wei He Ning Zhu Yuguang Li Dong Ji Kai Guo | 2023 | Chinese Journal of Chemical Engineering2023，56，4： | 0 |
| 16 | Superconductivity of a cuprate with compressed local octahedron显示文摘Since the historical discovery of high Tc superconductivity(HTS)of La2CuO4 in 1986[1],the superconductivity me chanism of copper oxides remains one of the biggest mysteries in the field of condensed matter physics[2-10].High-Tc cuprates crystallize into layered perovskite structure,as well as copper oxygen octahedron coordination.In octahedron symmetry,the 3d orbitals of Cu^2+with a 3d^9 configuration degenerate into two top eg and three lower t2g orbitals. | WenMin Li LiPeng Cao JianFa Zhao XianCheng Wang RunZe Yu YouWen Long QingQing Liu ChangQing Jin | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 0 |
| 17 | Orbital selection of the double [CuO2] layer compound Ca3Cu2O4Cl2显示文摘The discovery of high-temperature copper oxide superconductors(HTS)by Bednorz and Muller[1]in 1986 opened up a new field of superconductivity.Since then,several different families of materials have been discovered with greatly increased superconducting critical temperature(Tc)[2].Oxychloride cuprates,Can+1CunO2wCl2,are one such type of parent compound of high Tc cuprate superconductors.There are two members in this family known so far that can exist at ambient pressure:Ca2CuO2Cl2(single[Cu02]layer CCOC)and Ca3Cu2O4Cl2(double[CuO2]layer CCOC).Both are composed of a[CuO2]plane with the apical oxygen replaced by chlorine atoms. | JianFa Zhao LiPeng Cao WenMin Li Jun Zhang GuangYang Dai Shuang Yu QingQing Liu XianCheng Wang GuoQiang Zhao YaTing Jia Lei Duan YouWen Long Hong-Ji Lin Chien-Te Chen Liu-Hao Tjeng ZhiWei Hu RunZe Yu ChangQing Jin | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，10： | 0 |
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