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| 1 | Current Trends of the Prevalence of Childhood Asthma in Three Chinese Cities: A Multicenter Epidemiological Survey显示文摘Objective To analyze the prevalence of asthma and asthma related symptoms among children aged 0-14 years in three Chinese cities and to obtain a crude estimation of the trend of childhood asthma prevalence in China. Methods A cross-sectional, population-based survey of prevalence of asthma was conducted in children aged from 0 to 14 years in 3 major cities of China (Beijing, Chongqing, and Guangzhou) with different geographic locations. All the subjects were randomly selected by a multi-stage sampling method. Three to five schools and kindergartens in 2 urban districts in each city were randomly selected for the survey, and a validated questionnaire that included the core questions of the International Study of Asthma and Allergies in Childhood, Phase Ⅲ questionnaire and several additional questions were used. All questionnaires were completed by parents or guardians of the selected children. Children whose parents responded affirmatively to the question' Has your child ever been diagnosed as asthma by a doctor' were recognized as victims of asthma. Results The prevalence of asthma in Beijing, Chongqing, and Guangzhou was 3.15%, 7.45%, and 2.09%, respectively. These values were significantly higher than those obtained 10 years ago in the national epidemiological survey in 2000 which used the same method of investigation and the same diagnotic criteria (χ2 =3.938, P=0.047; χ2 =73.506, P≤0.001; χ2 =11.956, P=0.001, in each city). Of the asthmatic children 57.21%, 69.91%, and 60.00% had their first attack before the age of 3 in Beijing, Chongqing, and Guangzhou, respectively. Wheezing was the primary clinical manifestation for all asthmatic children , followed by persistent cough and repeated respiratory infections. Both the prevalence of asthma and asthma-related symptoms were statistically higher in males than in females. Conclusion The prevalence of childhood asthma is statistically higher than that 10 years ago in the three Chinese cities. | JUAN BAI JiNG ZHAO KUN-LING SHEN LI XIANG AI-HUAN CHEN SUI HUANG YING HUANG JIAN-SHENG WANG RONG-WEI YE | 2010 | Biomedical and Environmental Sciences2010，23，6： | 37 |
| 2 | Molecular Cloning and Expression of Squalene Epoxidase from a Medicinal Plant, Bupleurum chinense显示文摘Objective In plant, squalene epoxidase(SE) catalyzes the first oxygenation step in the biosynthetic pathway of triterpenoid and phytosterol, representing one of the rate-limiting enzymes in this pathway. Bupleurum chinense is an important medicinal herb with its major active constituents such as triterpenoid saponins and saikosaponins. In order to obtain the series of enzymatic genes involved in saikosaponin biosynthesis, a c DNA of SE, designated Bc SE1, was cloned from B. chinense. Methods The Bc SE1 gene was cloned by homology-based PCR and 5'/3' RACE methods from the adventitious roots of B. chinense. The physical and chemical parameters of Bc SE1 protein were predicted by protparam. In order to discover hints in amino acid sequences on the dominant functions in the biosynthesis of saponin or phytosterol, sequences of SE from other plants were downloaded from NCBI for sequences alignment and phylogenetic analysis. Bc SE1 was cloned into a yeast mutant KLN1(MATa, erg1::URA3, leu2, ura3, and trp1) to verify the enzyme activity of Bc SE1. Additionally, the tissue-specific expression and methyl jasmonate(Me JA) inducibility of Bc SE1 were investigated using quantitative real-time PCR. Results The predicted protein of Bc SE1 is highly similar to SEs from other plants sharing amino acid sequence identities of up to 88%. The Bc SE1 can functionally complement with yeast SE gene(ERG1) when expressed in the KLN1 mutant(MATa, erg1::URA3, leu2, ura3, and trp1). Using as controls with β-amyrin synthase(β-AS) which is presumed to catalyze the first committed step in saikosaponin biosynthesis and a cycloartenol synthase(CAS) relating to the phytosterol biosynthesis, the transcript of Bc SE1 was significantly elevated by Me JA in adventitious roots of B. chinense and the transcript of Bc SE1 was most abundant in the fruits and flowers of plants, followed by that in the leaves and roots, and least in stems. Conclusion It is the first time to illustrate the molecular information of SE in B. chinense and to clone the full-length SE gene in plants of genus Bupleurum L. | Ke Gao Jie-sen Xu Jing Sun Yan-hong Xu Jian-he Wei Chun Sui | 2016 | Chinese Herbal Medicines2016，8，1： | 10 |
| 3 | Origin of Baotoudong syenites in North China Craton:Petrological, mineralogical and geochemical evidence显示文摘Baotoudong 正长岩 pluton 被定位到 Baotou 城市的东方,内部蒙古,沿着北方中国 Craton (NCC ) 的北边缘的三叠纪的碱的 magmatic 带的最西的部分。锆石 U-Pb 年龄, petrological,矿物学并且 pluton 的 geochemical 数据在这份报纸被获得,抑制它的起源和披风来源特征。pluton 由 nepheline-clinopyroxene 正长岩和碱长石正长岩组成,与 214.7 ? 的锆石 U-Pb 年龄 ?????????? 潡潴摵湯 ????? 甠瑬慲潰慴獳捩 ???????????????????? | NIU Xiao Lu YANG Jing Sui LIU Fei ZHANG Hong Yu YANG Ming Chun | 2016 | Science China Earth Sciences2016，59，1： | 10 |
| 4 | Distribution of wall shear stress in carotid plaques using magnetic resonance imaging and computational fluid dynamics analysis: a preliminary study显示文摘背景墙砍应力是在动脉粥样硬化患者匾的 destabilization 的一个重要因素。这研究的目的是估计墙的分发砍在使用高分辨率的先进颈动脉匾强调磁性的回声成像和计算液体 dynamics.Methods 八 diseased 在七个病人的内部颈动脉动脉被评估。高分辨率磁性的回声成像被用来设想匾结构,并且在匾的技工压力被把脉管的成像 processing 以后与计算液体 dynamics.Results 墙相结合获得砍在在所有情况中的匾的压力比在控制的那些高组。最大砍在匾的压力在匾的匾山,以及肩膀的顶被观察。在他们之中,最大砍在破裂的匾的应力在二种情况中在三种情况中并且在含纤维的帽子的肩膀在破裂地点被观察。最大砍应力也在石灰化的区域被看见在血栓区域并且在在另外的三个盒子中的匾的最厚的区域, respectively.Conclusion 决心最大砍在匾的应力可能为预言匾的破裂地点是有用的并且可以在估计匾危险起一个重要作用。 | JING Li-na GAO Pei-yi LIN Yan SUI Bin-bin QIN Hai-qiang MA Li XUE Jing | 2011 | Chinese Medical Journal2011，，10： | 10 |
| 5 | Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation显示文摘AIM: To investigate the effect of different dietary fatty acids on hepatic inflammasome activation.METHODS: Wild-type C57BL/6 mice were fed either a high-fat diet or polyunsaturated fatty acid(PUFA)-enriched diet. Primary hepatocytes were treated with either saturated fatty acids(SFAs) or PUFAs as well as combined with lipopolysaccharide(LPS). The expression of NOD-like receptor protein 3(NLRP3) inflammasome, peroxisome proliferator-activated receptor-γ and nuclear factor-kappa B(NF-κB) was determined by real-time PCR and Western blot. The activity of Caspase-1 and interleukine-1β production were measured.RESULTS: high-fat diet-induced hepatic steatosis was sufficient to induce and activate hepatic NLRP3 inflammasome. SFA palmitic acid(PA) directly activated NLRP3 inflammasome and increased sensitization to LPS-induced inflammasome activation in hepatocytes. In contrast, PUFA docosahexaenoic acid(Dh A) had thepotential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation. Furthermore, a highfat diet increased but PUFA-enriched diet decreased sensitization to LPS-induced hepatic NLRP3 inflammasome activation in vivo. Moreover, PA increased but Dh A decreased phosphorylated NF-κB p65 protein expression in hepatocytes.CONCLUSION:Hepatic NLRP 3 inflammasome activation played an important role in the development of non-alcoholic fatty liver disease. Dietary SFAs and PUFAs oppositely regulated the activity of NLRP3 inflammasome through direct activation or inhibition of NF-κB. | Yong-heng Sui Wen-jing Luo Qin-Yu Xu jing hua | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 6 | Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer’s disease显示文摘Melatonin can attenuate cardiac microvascular ischemia/reperfusion injury,but it remains unclear whether melatonin can also ameliorate cerebral microvascular abnormalities.Rat models of Alzheimer’s disease were established by six intracerebroventricular injections of amyloidbeta 1–42,administered once every other day.Melatonin(30 mg/kg)was intraperitoneally administered for 13 successive days,with the first dose given 24 hours prior to the first administration of amyloid-beta 1–42.Melatonin ameliorated learning and memory impairments in the Morris water maze test,improved the morphology of microvessels in the cerebral cortex and hippocampus,increased microvessel density,alleviated pathological injuries of cerebral neurons,and decreased the expression of vascular endothelial growth factor and vascular endothelial growth factor receptors 1 and 2.These findings suggest that melatonin can improve microvessel abnormalities in the cerebral cortex and hippocampus by lowering the expression of vascular endothelial growth factor and its receptors,thereby improving the cognitive function of patients with Alzheimer’s disease.This study was approved by the Animal Care and Use Committee of Jinzhou Medical University,China(approval No.2019015)on December 6,2018. | Pan Wang Hai-Juan Sui Xiao-Jia Li Li-Na Bai Jing Bi Hong Lai | 2021 | Neural Regeneration Research2021，16，4： | 8 |
| 7 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 8 | Smart CU1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release显示文摘Thermosensitive 药交货系统(DDS ) 面对主要挑战,例如遥远、可重复的控制在 vivo 温度,尽管这些能增加药的治疗学的功效。处理这个问题,我们涂在红外线附近(NIR ) photothermal Cu 1.75 有 pH/thermos-sensitive 聚合物由的 S nanocrystals 在 situ 聚合。装载内容的 doxorubicine (纪录影片) 直到 40 wt.% ,与纪录影片在正常生理的条件下面正在被漏的不到 8.2 wt.%(pH = 7.4, 37 吗? | Sheng Huang Jing Liu Qian He Hongli Chen Jiabin Cui Suying Xu Yuliang Zhao Chunying Chen Leyu Wang | 2015 | Nano Research2015，8，12： | 7 |
| 9 | Integrated transcriptome and proteome analysis provides insight into chilling-induced dormancy breaking in Chimonanthus praecox显示文摘Chilling has a critical role in the growth and development of perennial plants.The chilling requirement(CR)for dormancy breaking largely depends on the species.However,global warming is expected to negatively affect chilling accumulation and dormancy release in a wide range of perennial plants.Here,we used Chimonanthus praecox as a model to investigate the CR for dormancy breaking under natural and artificial conditions.We determined the minimum CR(570 chill units,CU)needed for chilling-induced dormancy breaking and analyzed the transcriptomes and proteomes of flowering and non-flowering flower buds(FBs,anther and ovary differentiation completed)with different CRs.The concentrations of ABA and GA3 in the FBs were also determined using HPLC.The results indicate that chilling induced an upregulation of ABA levels and significant downregulation of SHORT VEGETATIVE PHASE(SVP)and FLOWERING LOCUS T(FT)homologs at the transcript level in FBs when the accumulated CR reached 570 CU(IB570)compared to FBs in November(FB.Nov,CK)and nF16(non-flowering FBs after treatment at 16℃for−300 CU),which suggested that dormancy breaking of FBs could be regulated by the ABA-mediated SVP-FT module.Overexpression in Arabidopsis was used to confirm the function of candidate genes,and early flowering was induced in 35S::CpFT1 transgenic lines.Our data provide insight into the minimum CR(570 CU)needed for chilling-induced dormancy breaking and its underlying regulatory mechanism in C.praecox,which provides a new tool for the artificial regulation of flowering time and a rich gene resource for controlling chilling-induced blooming. | Zhineng Li Ning Liu Wei Zhang Chunyu Wu Yingjie Jiang Jing Ma Mingyang Li Shunzhao Sui | 2020 | Horticulture Research2020，7，1： | 6 |
| 10 | Rapid Assessment on Potential Risks of Schistosomiasis Transmission—7 PLADs,China,2019 and 2021显示文摘Summary What is already known about this topic?Oncomelania hupensis(O.hupensis)and livestock are main infection sources of schistosomiasis.The schistosome infected O.hupensis and livestock’s feces are important risk factors in the transmission of schistosomiasis.What is added by this report?The potential risks of schistosomiasis transmission remain prevalent,giving an early warning to local government with information on existing transmission risks.It is expected that the effectiveness and efficiency of schistosomiasis surveillance could be improved by conducting rapid risk assessment at the beginning of transmission season. | Junyi He Hongqing Zhu Ziping Bao Lijuan Zhang Yinlong Li Ting Feng Suying Guo Wangping Deng Can Wang Hui Dang Tiewu Jia Chao Lyu Zhiqiang Qin Chunli Cao Jing Xu Shizhu Li Xiaonong Zhou | 2021 | China CDC weekly2021，3，51： | 5 |
| 11 | Extremely high-rate aqueous supercapacitor fabricated using doped carbon nanoflakes with large surface area and mesopores at near-commercial mass loading显示文摘在基于所有碳电极并且在良性的水的媒介操作而不是常规器官的电解质的 supercapacitor 完成令人满意的精力力量联合是主要挑战。为这个目的,我们制作了碳 nanoflakes (在厚度的 20-100 nm,在宽度的 5-m ) 包含一个大表面区域的无匹的联合(3,000 m 2sible 光活动被发现是 29.23 和 58.82 摩尔 ?? 挠潲獳氭湩敫 ? 牧灡敨敮 ?????? ?? 吗?? | Nan Mao Huanlei Wang Yang Sui Yongpeng Cui Jesse Pokrzywinski Jing Shi Wei Liu Shougang Chen Xin Wang David Mitlin | 2017 | Nano Research2017，10，5： | 5 |
| 12 | Joint Analysis Method for Major Genes Controlling Multiple Correlated Quantitative Traits显示文摘Based on the major gene and polygene mixed inheritance model for multiple correlated quantitative traits, the authorsproposed a new joint segregation analysis method of major gene controlling multiple correlated quantitative traits, whichinclude major gene detection and its effect and variation estimation. The effect and variation of major gene are estimatedby the maximum likelihood method implemented via expectation-maximization (EM) algorithm. Major gene is tested withthe likelihood ratio (LR) test statistic. Extensive simulation studies showed that joint analysis not only increases thestatistical power of major gene detection but also improves the precision and accuracy of major gene effect estimates. Anexample of the plant height and the number of tiller of F2 population in rice cross Duonieai × Zhonghua 11 was used in theillustration. The results indicated that the genetic difference of these two traits in this cross refers to only one pleiotropicmajor gene. The additive effect and dominance effect of the major gene are estimated as -21.3 and 40.6 cm on plant height,and 22.7 and -25.3 on number of tiller, respectively. The major gene shows overdominance for plant height and close tocomplete dominance for number of tillers. | XIAO Jing WANG Xue-feng HU Zhi-qiu TANG Zai-xiang SUI Jiong-ming LI Xin XU Chen-wu | 2006 | Agricultural Sciences in China2006，5，3： | 5 |
| 13 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 14 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 15 | Analysis of three types of triterpenoids in tetraploid white birches(Betula platyphylla Suk.) and selection of plus trees显示文摘Betulin, oleanolic acid, and betulinic acid are naturally occurring pentacyclic triterpenoids that have significant medicinal value. Considerable amounts of these triterpenoids are available in the outer bark of white birch.In this study, we used ultrasound-assisted extraction(UAE)to extract triterpenoids from birch bark rapidly and with high efficiency. Using high performance liquid chromatography(HPLC), three types of triterpenoids were separated and detected. We examined the differences among triterpenoids extracted from diploid versus tetraploid white birch. Then, we used factor analysis to screen out tetraploid white birches with comprehensively excellent performance. The results indicate that the optimum conditions for extraction include the use of ethanol as an extraction solvent, a solid-to-liquid ratio of 0.1 g/10 ml,ultrasonic power set at 100 W, a temperature of 60 °C and an extraction time of 15 min. A reversed-phase C18 column(4.6 mm × 250 mm × 5 lm) with a column temperature of 30 °C and the mobile phase composed of A(acetonitrile) and B(0.1 % aqueous phosphoric acid, v/v)at a flow rate of 0.5 ml/min were used, and the detection wavelength was 195 nm. No significant difference was observed between diploid and tetraploid white birch in terms of the content of three types of triterpenoids(at a confidence level of 0.05). As triterpenoid content, height,and DBH(diameter at breast height) are strongly interrelated, we used factor analysis to evaluate all individuals,and we screened out six plus trees with excellent comprehensive characters. | Sui Wang Hui Zhao Jing Jiang Guifeng Liu Chuanping Yang | 2015 | Journal of Forestry Research2015，26，3： | 4 |
| 16 | TiO2/EDTA-rich carbon composites: Synthesis, characterization and visible-light-driven photocatalytic reduction of Cr(Ⅵ)显示文摘Ti02/EDTA-rich carbon composites(TiO_2/EDTA-RC) have been successfully synthesized via a low temperature carbonization process. TiO_2/EDTA-RC exhibits marked absorption of visible light and excellent photoreduction of Cr(Ⅵ) activity under visible light irradiation(λ>420 nm). Due to the high carboxyl group content and strong coordination ability of EDTA, TiO_2-EDTA complex can be easily fabricated between EDTA incorporated in carbon sheet and titanol group on the surface of TiO_2. TiO_2-EDTA complexes on the surface of TiO_2/EDTA-RC, the LMCT complex, are responsible for the prominent photoreduction of Cr(Ⅵ) properties of Ti02/EDTA-RC under visible light irradiation. In addition, the unique structure ofTiO_2/EDTA-RC is also propitious to the visible-light photocatalytic reduction of Cr(Ⅵ).Carbon sheet of TiO_2/EDTA-RC acts as a supporter. TiO_2 nanoparticles and EDTA homogeneously disperse into the carbon sheet supporter and form the TiO_2-EDTA complexes, which can avoid the aggregation of TiO_2 nanoparticles in the aqueous solution and provide more photocatalytic reaction points for the reduction of Cr(Ⅵ). | Zhijun Luo Lingling Qu Jianzhong Ji Jing wang Suying Jiang Zhiren WU Xiangyang Wu | 2018 | Chinese Chemical Letters2018，29，3： | 3 |
| 17 | Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice显示文摘Flaxseed has displayed the potential beneficial as functional foods.However,most studies focused on effects of flaxseed extracts or ingredients in flaxseed.Besides,few studies showed that flaxseed extracts contributed to anti-type 1 diabetes(T1D),yet the underlying mechanism is still unknown.In the present study,16.7% of milled flaxseed(MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks.The results showed that MF feeding 1)slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test,2)decreased liver tumor necrosis factor-αlevels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways,3)and significantly altered some beneficial bacteria in gut microbiota.In conclusion,the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice. | Hui Xia Xiangling Shi Beijia Zhou Jing Sui Chao Yang Hechun Liu Ligang Yang Shaokang Wang Guiju Sun | 2022 | Food Science and Human Wellness2022，11，1： | 3 |
| 18 | Storage and Remobilization of Nitrogen by Chinese Jujube(Z. jujuba Mill. var. inermis Rehd) Seedling as Affected by Timing of ^(15)N Supply显示文摘Winter jujube orchard nitrogen (N) management aims at increasing N reserves to meet the tree’s growth requirements. Fertilization strategies should maximize the efficiency of fertilizers, including the choice of the optimal timing of N supply. 15N-urea was applied to winter jujubes on Jinsixiaozao jujubes rootstock to evaluate the effect of application timing on N- storage and remobilization in mature trees in pot culture. The treatments consisted of ground application before budding (BB), during fruit core-hardening stage (FCH), and fruit rapid-swelling stage (FRS). Nitrogen-use efficiency of treatments were significantly different, which were 2.42% (BB), 9.77% (FCH), and 9.01% (FRS) in the dormant and 5.20% (BB), 16.16% (FCH), and 10.30% (FRS) in the following full-bloom. N supply in the pre-harvest helped to increase N-reserves of trees and then translocate to the new growth organs the following year. The largest amount of 15N was detected in the roots and trunks. In all the treatments, the partition rates were highest in coarse roots, which were 30.43% (BB), 38.61% (FCH), and 40.62% (FRS), respectively. 15N stored in roots and trunks was used by jujube trees to sustain new growth in the following full-bloom. 15N applied before budding resulted in lower Ndff% in perennial organs (trunks and coarse roots) sampled in the following full-bloom, but fine roots had highest Ndff% (1.28%). Other organs recovered similar amount of Ndff%. In contrast, FCH and FRS treatments led to higher Ndff% (4.01-5.15%) in the new growth organs (new growth branches, deciduous spurs, leaves and flowers), but lower Ndff% in perennial branches (1.49-2.89%). With the delay of 15N-urea application time, 15N increased the partitioning to roots. FCH treatment increased N-storage in perennial organ during winter, which should be remobilized to sustain new growth the following spring. | ZHAO Deng-chao JIANG Yuan-mao PENG Fu-tian ZHANG Jin ZHANG Xu SUI Jing HE Nai-bo | 2006 | Agricultural Sciences in China2006，5，10： | 3 |
| 19 | Visual Attention Model Based Regions of Interest Detection in Compressed Domain显示文摘 | SUI Lei ZHANG Jing ZHUO Li YANG Yuncong | 2012 | Chinese Journal of Electronics2012，21，4： | 2 |
| 20 | Effects of Antiretroviral Therapy and HIV Exposure in Utero on Adverse Pregnancy and Infant Outcomes:A Prospective Cohort Study in Guangzhou, China显示文摘Objective This study aimed to evaluate the effects of in-utero exposure to HIV and ART on pregnancy outcome and early growth of children.Methods This cohort study enrolled 802 HIV-infected pregnant women between October 2009 and May 2018 in Guangzhou, China. The women were assigned to receive combination ART(c ART) or mono/dual ART or no treatment. The primary outcomes were the combined endpoints of any adverse pregnancy outcome [including ectopic pregnancy, spontaneous abortion, stillbirth, preterm birth, small for gestational age(SGA)] and adverse early growth outcome(including infant death, HIV infection of mother-to-child transmission, and underweight, wasting and stunting of infants at 4 weeks of age).Results Adverse pregnancy outcomes occurred in 202(35.1%) of all enrolled HIV-infected women, and121(31.3%) of all infants exhibited adverse effects on early growth at 4 weeks of age. The rates of adverse pregnancy outcomes, spontaneous abortion, ectopic pregnancy, stillbirth, infant death and perinatal HIV infection were higher among women not receiving ART, compared to those treated with c ART or mono/dual ART(P < 0.05). However, women treated with c ART had a higher rate of SGA,compared to untreated women(P < 0.05). No differences in early infant growth were observed among the different treatment regimens.Conclusion Our findings underscore the essentiality of prioritizing HIV-positive pregnant women for ART, as even mono/dual ART available in resource-limited countries could improve pregnancy outcomes and infant survival. | HU Fang LIANG Jing Jing LU Jian Jun HU Yi Fei HU Yan YU Jia ZOU Xing Wen MA Ying Hua LIN Sui Fang | 2019 | Biomedical and Environmental Sciences2019，32，10： | 2 |
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