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| 1 | Differentiation of Human Bone Marrow Stromal Cells into Neural-Like Cells Induced by Sodium Ferulate in vitro显示文摘Human marrow stromal cells (hMSCs) are multipotential stem cells, capable of differentiating into bone, cartilage,fat and muscle. Several recent reports demonstrated that hMSCs have been also differentiated into neural cells.However, only a few reported inducers are applicable for clinical use. This work is to explore the effects of sodium ferulate (SF) on differentiation of hMSCs into neural cells in vitro. We found that hMSCs could be induced to the cells with typical neural morphology when cultured with SF. The cells express neural proteins, such as nestin,neuron-specific enolase (NSE) and glial fibrillary acidic protein (GFAP). About 30% of the hMSC-derived cells expressed nestin when cultured with SF for 3 h, but no expression was detected after 24 h. The percentages of positive cells for NSE or GFAP were about 67% and 39% separately at 6 h, and reached the plateau phage after treatment with SF for 3 days. The data suggest that SF can induce hMSCs to differentiate into neural-like cells in vitro. | Yang Wang Zhifeng Deng Xianliang Lai Wei Tu | 2005 | Cellular & Molecular Immunology2005，2，3： | 21 |
| 2 | Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial显示文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients. | Wang Xianliang Hou Yazhu Mao Jingyuan Zhao Yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 15 |
| 3 | Mapping Heterotic Loci for Yield and Agronomic Traits Using Chromosome Segment Introgression Lines in Cotton显示文摘在现在的学习,一套染色体片断基因渗入排队(CSIL ) 使用 Gossypium hirsutum L。TM-1 作为接受者父母和 G。施主父母被用来为种间的混血儿探索杂种优势的基因基础的 barbadense Hai7124。个别地从与两个父母一起交叉的 CSIL 导出的 F1 人口的二个集合被设置调查 heterotic loci (HL ) 和替换效果 loci (SL ) 。58 HL 和 39 SL 的一个总数在 3 年里被识别。一稳定的 HL, hLP-A4-3,能在所有 3 年里被检测。三 HL, hBS-A8-1, hLP-D6-1,和 hSI-D7-11,能在 2 年里被检测。四 SL, sBS-D7-1, sLP-A8-1, sLP-D7-1,和 sLP-D12-1,能在 2 年里被检测。HL 和 SL 趋于在有靠近的位置的一些 HL 富有的染色体片断分布式。与在以前的研究检测的 QTL 相比, HL 与 QTL 显示出很少重叠,显示特点显型和杂种优势可能被 loci 的不同集合控制。基因效果的所有三种形式(部分 -- ,完整 -- ,在主导上) 被识别,当在主导上的效果做了主要贡献到杂种优势时。这些结果可以帮助为在棉花澄清杂种优势的遗传机制打了基础。 | Xian Guo Yuping Guo Jun Ma Fang Wang Mizhen Sun Lijuan Gui Jiajia Zhou Xianliang Song Xuezhen Sun Tianzhen Zhang | 2013 | Journal of Integrative Plant Biology2013，55，8： | 13 |
| 4 | Improvements on radiation-hardened performance of static induction transistor显示文摘The radiation-hardened performances of static induction transistor (SIT) have been studied in depth in this paper. The effects of radiation of electron beam on the I-V characteristics, carrier distribution and potential distribution in the channel of SIT have been represented. A large number of electron-hole pairs are generated in the depletion region of reversely biased gate-channel PN junction. The radiation-generated electrons drift towards the drain region at high positive potential, while generated holes flow into gate region biased to the lowest potential. With the accumulation of holes in gate region, the gate potential is boosted, resulting in a decrease in the height of potential barrier in channel, and an increase in drain current. I-V characteristics of SIT in the presence of radiation have been theoretically derived, and compared with experimental results. With the increase in thickness of epitaxial layer, the radiation-hardened capability of SIT is continuously improved until the optimum thickness of 26 μm is reached. The optimum matching relationship among geometric, material and technological parameters has been represented to acquire excellent radiation-hardened performances of SIT. | WANG YongShun LUO XianLiang LI HaiRong WANG ZiTing WU Rong ZHANG CaiZhen LI SiYuan | 2010 | Science China(Information Sciences)2010，53，5： | 6 |
| 5 | Traditional Chinese Medicine syndrome patterns and Qi-regulating,chest-relaxing and blood-activating therapy on cardiac syndrome X显示文摘OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastered and the TCM intervention programs were determined by clinical investigations for TCM syndrome patterns characteristics of CSX patients.Then,the clinical efficacy studies on TCM intervention for CSX were carried out through randomized controlled trials.RESULTS:CSX is a clinical syndrome with the main manifestations of chest pain and chest stuffiness,and Qi stagnation,phlegm retention and blood stasis are the basic symptoms of CSX.As a result,the Qi-regulating,chest-relaxing and blood-activating therapy integrated with some Western Medicines was adopted for treatment.The effect of Qi-regulating,chest-relaxing and blood-activating therapy can reduce the frequency and degree of angina,improve the symptoms and exercise the tolerance of patients,inhibit the inflammatory response of vascular walls and protect the function of vascular endothelial cells,which is better than that of the simple and conventionalWestern Medicine alone.CONCLUSION:A good effect was achieved in the integration of Chinese and Western Medicines for CSX.The therapy is worthy to be applied further in clinical practice.On the other hand,more long-term and randomised controlled studies with large samples are still required to further determine the clinical efficacy and safety of the therapy. | Yingfei Bi Jingyuan Mao Xianliang Wang Yongbin Ge Henghe Wang Zhenpeng Zhang | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 6 |
| 6 | Influences of wide-narrow seeding on soil properties and winter wheat yields under conservation tillage in North China Plain显示文摘In order to promote the winter wheat yield and guarantee seeding quality in double-cropping system,no-tillage or reduced tillage planting modes with different row spacing have been implemented to result in different levels of yield.A three-year(2012-2015)field experiment was conducted on the experimental farm at Zhuozhou of Hebei Province in North China Plain to compare winter wheat yield from the two planting modes:wide-narrow row space planting mode(WN)and uniform row space planting mode(UR)Both planting modes were performed under reduced tillage conditions with straw mulching.The results showed that in North China Plain WN had positive impacts on crop yield,yield components,leaf area index(LAI)and intercepted photosynthetically active radiation(IPAR)index.Comparing with the UR,IPAR and LAI index for WN were enhanced by 4.8%and 5.2%,respectively.The average yield for WN was 7.2%,significantly greater than that of UR under the same quantity and density.In addition,for WN mode,machinery could pass through with less blocking under large amount of straw mulching,which largely improved tillage efficiency and potentially popularized the conservation tillage technology in North China plain.It is therefore recommended that wide-narrow row space planting mode(WN)combined with reduced tillage and straw mulching be more suitable for conservation tillage in double-cropping pattern areas in North China Plain. | Hongnan Hu Caiyun Lu Qingjie Wang Hongwen Li Jin He Dijuan Xu Xianliang Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 4 |
| 7 | Enhancement of the mechanical properties of polylactic acid/basalt fiber composites via in-situ assembling silica nanospheres on the interface显示文摘A valid strategy to tailor the properties of polylactic acid for more extensive applications was introducing filler.In this work,basalt fiber assembled with in-situ SiO_(2) nanoparticles on the surface was successfully prepared via hydrothermal method and it was further treated with coupling agent KH-550 to improve interfacial interaction between polylactic acid(PLA)and basalt fibers(BF).It was demonstrated that the introduction of BFS could increase the crystallization of PLA and resulted in forming trans-crystallization based on TG and DSC results.The tensile strength of PLA/BF composites raised from 39 MPa to 62.5 MPa with increasing the fiber loading from 1 wt%to 10 wt%.Furthermore,the interfacial interaction could be effectively improved by assembling SiO_(2)(especially with 250 nm in diameter)on BF surface to build mechanical locking,which could keep the PLA matrix in place during the mechanical deformation with the tensile strength value raised from 62.5 MPa to 74.0 MPa.It is noticeable that the impact and flexural properties were effectively increased with the incorporation of in-situ SiO_(2) nanoparticles.The further KH-550 treatment made a positive impact as well.For instance,the impact strength and flexural strength of the sample with SiO_(2) and KH-550 modification were improved to 22.49 k J/m^(2) and 146.83 MPa and it enhanced about 42.16%and 41.04%than those of neat PLA,respectively.Therefore,an efficient enhancement of mechanical performance was achieved and this concept of assembling in-situ SiO_(2) on silica-based fiber as a modifier was a novel and simple path to design the interfacial construction and properties of the polymer composites. | Xianliang Hou Shun Yao Zhen Wang Changqing Fang Tiehu Li | 2021 | Journal of Materials Science & Technology2021，，25： | 4 |
| 8 | Tropospheric Wet Refractivity Tomography Based on the BeiDou Satellite System显示文摘This paper presents a novel approach for assessing the precision of the wet refractivity field using BDS(BeiDou navigation satellite system) simulations only, GPS, and BDS+GPS for the Shenzhen and Hongkong GNSS network. The simulations are carried out by adding artificial noise to a real observation dataset. Instead of using the δ and σ parameters computed from slant wet delay, as in previous studies, we employ the Bias and RMS parameters, computed from the tomography results of total voxels, in order to obtain a more direct and comprehensive evaluation of the precision of the refractivity field determination. The results show that:(1) the precision of tropospheric wet refractivity estimated using BDS alone(only 9 satellites used) is basically comparable to that of GPS;(2) BDS+GPS(as of current operation) may not be able to significantly improve the data's spatial density for the application of refractivity tomography; and(3) any slight increase in the precision of refractivity tomography, particularly in the lower atmosphere, bears great significance for any applications dependent on the Chinese operational meteorological service. | WANG Xiaoying WANG Xianliang DAI Ziqiang KE Fuyang CAO Yunchang WANG Feifei SONG Lianchun | 2014 | Advances in Atmospheric Sciences2014，31，2： | 3 |
| 9 | Facilities for Centralized Isolation and Quarantine for the Observation and Treatment of Patients with COVID-19显示文摘The coronavirus disease 2019(COVID-19)pandemic increased the burden on many healthcare systems and in the process,exposed the need for medical resources and physical space.While few studies discussed the efficient utilization of medical resources and physical space so far.Therefore,this study aimed to summarize experiences related to facilities used for centralized isolation for medical observation and treatment during the COVID-19 pandemic in China and to provide suggestions to further improve the management of confirmed cases,suspected cases,and close contacts.In China,three types of facilities for centralized isolation(Fangcang shelter hospitals,refitted non-designated hospitals,and quarantine hotels)underwent retrofitting for the treatment and isolation of confirmed and suspected cases.These facilities mitigated the immediate high demand for space.Moreover,in order to minimize infection risks in these facilities,regulators and governmental agencies implemented new designs,management measures,and precautionary measures to minimize infection risk.Other countries and regions could refer to China’s experience in optimally allocating social resources in response to the COVID-19 pandemic.As a conclusion,government should allocate social resources and construct centralized isolation and quarantine facilities for an emergency response,health authorities should issue regulations for centralized isolation facilities and pay strict attention to the daily management of these facilities,a multidisciplinary administration team is required to support the daily operation of a centralized isolation facility,in-depth studies and international collaboration on the centralized isolation policy are encouraged. | Xianliang Wang Jiao Wang Jin Shen John SJi Lijun Pan Hang Liu Kangfeng Zhao Li Li Bo Ying Lin Fan Liubo Zhang Lin Wang Xiaoming Shi | 2021 | Engineering2021，7，7： | 3 |
| 10 | Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms显示文摘 | Ying Fan Jinfeng Hu Jing Li Zhao Yang Xianliang Xin Jia Wang Jian Ding Meiyu Geng | 2006 | 中国生物学文摘2006，20，3： | 2 |
| 11 | Distribution and sources of polycyclic aromatic hydrocarbons from urban to rural soils: A case study in Dalian, China显示文摘 | Zhen Wang Jingwen Chen Xianliang Qiao Ping Yang Fulin Tian Liping Huang | 2007 | Chemosphere2007，，5： | 2 |
| 12 | A new phosphidation route for the synthesis of NiPx and their cocatalytic performances for photocatalytic hydrogen evolution over g-C3N4显示文摘Ni-based phosphides(NiPx)composed of earth-abundant elements are promising cocatalysts to replace noble metals for photocatalytic H2 evolution reaction(HER).A safe,energy-saving,and compositioncontrollable synthesis of NiPx is still highly desired.A facile and mild solvothermal process was developed for the first time for selective synthesis of a series of NiPx,including Ni,Ni12P5,Ni2P/Ni12P5,Ni/Ni2P and Ni2P,through controlling the dosage of NaBH4 and NaH2PO2.The phosphidation process was mainly composed of(1)a sequential reduction of Ni2+to Nj0 and(H2PO2)-to P(around the formed Ni0)triggered by NaBH4,and(2)a final phosphidation between Nj0 and the in situ generated P atoms.The photocatalytic HER performance of g-C3N4 can be substantially improved with the decoration of NiPx(3 wt%)as the separation of photoinduced charge carriers can be promoted and some active sites with low over-potential for HER can be introduced.The cocatalytic efficiency of NiPx is mainly determined by P content.Ni2P with a high ratio of P consequently exhibits the highest HER performance(215.1 umol g-1 h-1),which is almost six times higher than that of the pristine g-C3N4(35.6 umol g-1 h-1).Thus,as for the cocatalyst based on Ni phosphides,Ni2P is the preferable crystal phase and more efforts should be devoted to Ni2P to further optimize its structure,texture,and morphology in future works. | Ziqun Wang Longfeng Li Mingzhu Liu Tifang Miao Xiangju Ye Sugang Meng Shifu Chen Xianliang Fu | 2020 | Journal of Energy Chemistry2020，29，9： | 2 |
| 13 | Arsenic retention and transport behavior in the presence of typical anionic and nonionic surfactants显示文摘The massive production and wide use of surfactants have resulted in a large amount of surfactant residuals being discharged into the environment,which could have an impact on arsenic behavior.In the present study,the influence of the anionic surfactant sodium dodecyl benzene sulfonate(SDBS) and nonionic surfactant polyethylene glycol octylphenyl ether(Triton X-100) on arsenic behavior was investigated in batch and column tests.The presence of SDBS and Triton X-100 reduced arsenic retention onto ferrihydrite(FH),enhanced arsenic transport through FH coated sand(FH-sand) columns and promoted arsenic release from the FH surface.With coexisting surfactants in solution,the equilibrium adsorbed amount of arsenic on FH decreased by up to 29.7% and the adsorption rate decreased by up to 52.3%.Pre-coating with surfactants caused a decrease in the adsorbed amount and adsorption rate of arsenic by up to 15.1% and 58.3%,respectively.Because of the adsorption attenuation caused by surfactants,breakthrough of As(Ⅴ) and As(Ⅲ) with SDBS in columns packed with FH-sand was 23.8% and 14.3%faster than that in those without SDBS,respectively.In columns packed with SDBS-coated FH-sand,transport of arsenic was enhanced to a greater extent.Breakthrough of As(Ⅴ) and As(Ⅲ) was 52.4% and 43.8% faster and the cumulative retention amount was 44.5% and 57.3% less than that in pure FH-sand column systems,respectively.Mobilization of arsenic by surfactants increased with the increase of the initial adsorbed amount of arsenic.The cumulative release amount of As(Ⅴ) and As(Ⅲ) from the packed column reached 10.8% and 36.0%,respectively. | Chuan Liang Xianliang Wang Xianjia Peng | 2016 | Journal of Environmental Sciences2016，28，1： | 2 |
| 14 | Current status,prospect and policy and institutional support for Conservation Agriculture in the Asia-Pacific region显示文摘The current growing demand for Conservation Agriculture(CA)at the national level in the countries of the Asia-Pacific region presents an opportunity to promote its widespread adoption and up-scaling through national policy and institutional support that appears necessary.Despite the obvious benefits of CA,it does not spread automatically unless the constraints that hinder adoption are understood and addressed in specific situations.These can include a combination of intellectual,social,financial,biophysical,technical,infrastructure constraints,or policy related support.Knowing what the bottlenecks are is important in developing strategies to overcome them.This paper presents:(a)some of the generic policy opportunities that exist for the adoption and uptake of CA;(b)a summary proceedings and outcome of the Regional Expert Consultation Workshop held in Beijing and sponsored by FAO Regional Office for Asia-Pacific which describes the status of CA in the Asia-Pacific region;(c)the challenges to CA adoption and uptake in the Asia-Pacific region;and(d)the conditions that need to be taken into account in designing and promoting policy and institutional support strategies for up-scaling CA. | A.Kassam Li Hongwen Y.Niino Theodor Friedrich He Jin Wang Xianliang | 2014 | International Journal of Agricultural and Biological Engineering2014，7，5： | 2 |
| 15 | Distribution and sources ofpolycyclic aromatic hydrocarbons from urban to rural soils: a case study in Dalian, China显示文摘 | WANG Zhen CHEN Jingwen QIAO Xianliang | 2007 | Chemosphere2007，68，： | 1 |
| 16 | Hydroxide ZnSn(OH)6:A promising new photocatalyst for benzene degradation显示文摘 | Fu Xianliang Wang Xuxu Ding Zhengxin | 2009 | Applied Catalysis B : Environmental2009，91，12： | 1 |
| 17 | Association study between methylenetetrahydrofolate reductase polymorphisms and unexplained recurrent pregnancy loss: A meta-analysis显示文摘 | Yunlei Cao Jianhua Xu Zhaofeng Zhang Xianliang Huang Aiping Zhang Jian Wang Qiupeng Zheng Lingyuan Fu Jing Du | 2013 | Gene2013，，2： | 1 |
| 18 | Modeling photoinduced toxicity of PAHs based on DFT-calculated descriptors显示文摘 | Ying Wang Jingwen Chen Fei Li Hong Qin Xianliang Qiao Ce Hao | 2009 | Chemosphere2009，，7： | 1 |
| 19 | Characteristics, development and mapping of Gossypium hirsutum derived EST-SSRs in allotetraploid cotton显示文摘 | Zhiguo Han Changbiao Wang Xianliang Song Wangzhen Guo Jinying Gou Chunhong Li Xiaoya Chen Tianzhen Zhang | 2006 | Theoretical and Applied Genetics2006，，3： | 1 |
| 20 | Effect of UBR5 on the tumor microenvironment and its related mechanisms in cancer显示文摘Objective UBR5,recently identified as a potential target for cancer therapeutics,is overexpressed in multiple malignant tumors.In addition,it is closely associated with the growth,prognosis,metastasis,and treatment response of multiple types of cancer.Although emerging evidence supports the relationship between UBR5 and cancer,there are limited cancer analyses available.Methods In this study,online databases(TIMER2,GEPIA2,UALCAN,c-BioPortal,STRING)were employed to comprehensively explore expression levels and prognostic values of the UBR5 gene in cancer,using bioinformatic methods.Results We found that various characteristics of the UBR5 gene such as gene expression,survival value,genetic mutation,protein phosphorylation,immune infiltration,and pathway activities in the normal tissue were remarkably different from those in the primary tumor.Furthermore,“protein processing in spliceosome”and“ubiquitin mediated proteolysis”have provided evidence for their potential involvement in the development of cancer.Conclusion Our findings may provide insights for the selection of novel immunotherapeutic targets and prognostic biomarkers for cancer. | Guangyu Wang Sutong Yin Justice Afrifa Guihong Rong Shaofeng Jiang Haonan Guo Xianliang Hou | 2021 | Oncology and Translational Medicine2021，7，6： | 1 |
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