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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Regulation of TH17 cell differentiation by innate immune signals显示文摘在抗原刺激之上,天真的 T 助手房间区分进不同的系达到专业化性质和受动器功能。T H 17 房间, CD4 + 受动器 T 房间的一个最近识别的系,对真菌和细胞外的细菌在有免疫力的防卫起一个关键作用,而且贡献许多自体免疫的条件的致病。T H 17 房间被在 T 房间表明小径和 transcriptional 管理者的一个复杂网络安排。当 T 房间内在的小径的参与广泛地被描述了时,我们开始就正在欣赏怎么 T H 17 房间开发被外来的小径塑造,特别天生的有免疫力的信号。树枝状的房间(DC ) ,到天生的桥牌的最重要的房间类型和适应免疫,驱动器 T 由提供 antigenic, costimulatory 和 cytokine 的 H 17 房间区别发信号。这被 DC 被天生、煽动性的信号的识别经由模式识别受体, cytokine 受体和接着激活细胞内部的发信号网络的另外的 immunomodulatory 受体调停。特别地, p38α地图 kinase 作为一条批评小径出现了编程序 DC 依赖的 T 由在 DC 集成多重有启发性的信号的 H 17 房间区别。这里,我们在导出 DC 的天生的有免疫力的信号由驾驶 T H 17 房间区别。 | Gonghua Huang Yanyan Wang Hongbo Chi | 2012 | Cellular & Molecular Immunology2012，9，4： | 24 |
| 3 | LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125显示文摘 | Linlin Li Mengna Zhang Weizhen Chen Ruirui Wang Zi Ye Yanyan Wang Xiao Li Cheguo Cai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 20 |
| 4 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 5 | Volume fractal dimension of soil particles and relationships with soil physical-chemical properties and plant species diversity in an alpine grassland under different disturbance degrees显示文摘Fractal geometry is an important method in soil science,and many studies have used fractal theory to examine soil properties and the relationships with other eco-environmental factors.However,there have been few studies examining soil particle volume fractal dimension in alpine grasslands.To study the volume fractal dimension of soil particles(D) and its relationships with soil salt,soil nutrient and plant species diversity,we conducted an experiment on an alpine grassland under different disturbance degrees:non-disturbance(N 0),light disturbance(L),moderate disturbance(M) and heavy disturbance(H).The results showed that(1) Ds varied from 2.573 to 2.635 among the different disturbance degrees and increased with increasing degrees of disturbance.(2) Shannon-Wiener diversity index,Pielou's evenness index and Margalef richness index reached their highest values at the M degree,indicating that moderate disturbance is beneficial to the increase of plant species diversity.(3) In the L and M degrees,there was a significant positive correlation between D and clay content and a significant negative correlation between D and soil organic matter(SOM).In the H degree,D was significantly and positively correlated with total salt(TS).The results suggested that to a certain extent,D can be used to characterize the uniformity of soil texture in addition to soil fertility characteristics.(4) For the L degree,there was a significant negative correlation between D and the Shannon-Wiener diversity index;while for the M degree,there was a significant negative correlation between D and Pielou's evenness index. | YanYan LIU YanMing GONG Xin WANG YuKun HU | 2013 | Journal of Arid Land2013，5，4： | 18 |
| 6 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 7 | Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis显示文摘Recent studies have revealed that osthole,an active constituent isolated from the fruit of Cnidium monnieri(L.) Cusson,a traditional Chinese medicine,possesses anticancer activity.However,its effect on breast cancer cells so far has not been elucidated clearly.In the present study,we evaluated the effects of osthole on the proliferation,cell cycle and apoptosis of human breast cancer cells MDA-MB 435.We demonstrated that osthole is effective in inhibiting the proliferation of MDA-MB 435 cells,The mitochondrion-mediated apoptotic pathway was involved in apoptosis induced by osthole,as indicated by activation of caspase-9 and caspase-3 followed by PARP degradation.The mechanism underlying its effect on the induction of G1 phase arrest was due to the up-regulation of p53 and p21 and down-regulation of Cdk2 and cyclin D1 expression.Were observed taken together,these findings suggest that the anticancer efficacy of osthole is mediated via induction of cell cycle arrest and apoptosis in human breast cancer cells and osthole may be a potential chemotherapeutic agent against human breast cancer. | Lintao Wang Yanyan Peng Kaikai Shi Haixiao Wang Jianlei Lu Yanli Li Changyan Ma | 2015 | The Journal of Biomedical Research2015，29，2： | 12 |
| 8 | Immunotherapeutical Potential of Mycobacterium Vaccae on M. Tuberculosis Infection in Mice显示文摘Tuberculosis remains the worldwide infectious disease. To identify the therapeutic potential of M. vaccae in treating tuberculosis,M. vaccae was injected into Mycobacterium tuberculosis(M. tuberculosis) infected mice. The optimal dose of M. vaccae(22.5 μg/mouse) treated mice showed lower pathological change index,spleen weight index,lung weight index and vital M. tuberculosis count than those of the untreated group. Treatment with M. vaccae enhanced the percentages of CD3+ and CD4+ T cells,IFN-γ+CD4+ T cells,innate immune cells including NK cells,NK1.1+ T cells and γδ T cells,and reduced the percentage of IL-4+CD4+ T cells. Therefore,M. vaccae could protect the mice from M. tuberculosis infection and improved mouse innate and adaptive cell-mediated immunity,suggesting that M. vaccae is a potential immunotherapeutic agent in pulmonary tuberculosis. | Lijun Xu Yanyan Wang Xiaodong Zheng Xiangdong Gui Lifeng Tao Haiming Wei | 2009 | Cellular & Molecular Immunology2009，6，1： | 11 |
| 9 | Brown adipose tissue transplantation improves whole-body energy metabolism显示文摘 | Qingsheng Chi Dehua Wang Zhaoyun Zhang Chenzhong Li Yiming Li Yaoming Xue John R Speakma Wanzhu Jin Xiaomeng Liu Zongji Zhen Xiaoming Zhu Minghui Meng Lan Li Yanyan Shen | 2013 | Cell Research2013，23，6： | 11 |
| 10 | Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals显示文摘尽管 myocyte 房间移植研究为心肌的梗塞建议了一个有希望的治疗学的潜力,到为心肌的修理的临床的治疗的发展的一个主要障碍是与为移植获得相对同类的室的 myocytes 联系的困难。人的胚胎的干细胞(hESCs ) 是 cardiomyocytes 的有希望的来源。这里,我们报导发信号的 retinoid 在 hESCs 的心脏的区别期间调整 atrial 对室的 myocytes 的命运说明。我们发现少量和 pan-retinoic 酸受体对手 BMS-189453 (RAi ) 显著地增加了 hESCs 的心脏的区别效率。为了调查 retinoid,工作,我们把对待 Noggin+RAi 的文化与对待 Noggin+RA 的文化作比较。我们的结果证明室特定的基因 IRX-4 的表示层次极端地在对待 Noggin+RAi 的文化被提高。MLC-2V,另一个室特定的标记,在对待 Noggin+RAi 的文化,然而并非在对待 Noggin+RA 的文化的 cardiomyocytes 在 cardiomyocytes 的多数被表示。流动 cytometry 分析和 electrophysiological 研究与 64.7 | Qiangzhe Zhang Junjie Jiang Pengcheng Han Qi Yuan Jing Zhang Xiaoqian Zhang Yanyan Xu Henghua Cao Qingzhang Meng Li Chen Tian Tian Xin Wang Pu Li Jurgen Hescheler Guangju Ji Yue Ma | 2011 | Cell Research2011，21，4： | 10 |
| 11 | Early evaluation of growth traits of Larix kaempferi clones显示文摘Early selection is an important method to shorten the breeding cycle for tree species, which may differ in the time for early selection.To evaluate the early selected time for Larix kaempferi, tree height and diameter at breast height of 57 L.kaempferi clones were measured over many different growth years.The results indicated that, except for age × clone interaction for diameter at breast height(P = 0.741), there were significant differences among all variation sources(P < 0.01).The coefficient of phenotypic variation ranged from 14.89 to 35.65%for height and from 19.17 to 23.86% for diameter at breast height in different growth years.The repeatability of height and of diameter at breast height among clones was high,ranging from 0.6181 to 0.8531(height) and from 0.8443 to0.8497(diameter at breast height), in different growth years.There were significant positive correlations between all pairs of growth traits except between height in the 2 nd growth year and height in the 30 th growth year; and between height in the 2 nd growth year × diameter at breast height in the 30 th growth year.With a comprehensive evaluation method and a selection ratio of 10%, L65,L1, L62, L9, L15, and L78 were selected as excellent clones in the 30 th growth year.Their average values of height and diameter at breast height were 9.81 and 16.57%higher than the overall average, representing genetic gains of 6.46 and 13.99%, respectively.This study provides a theoretical foundation for the genetic improvement of L.kaempferi. | Yanyan Pan Shuchun Li Chenglu Wang Wenjun Ma Guiyou Xu Lili Shao Kailong Li Xiyang Zhao Tingbo Jiang | 2018 | Journal of Forestry Research2018，29，4： | 10 |
| 12 | Secure Big Data Storage and Sharing Scheme for Cloud Tenants显示文摘The Cloud is increasingly being used to store and process big data for its tenants and classical security mechanisms using encryption are neither sufficiently efficient nor suited to the task of protecting big data in the Cloud.In this paper,we present an alternative approach which divides big data into sequenced parts and stores them among multiple Cloud storage service providers.Instead of protecting the big data itself,the proposed scheme protects the mapping of the various data elements to each provider using a trapdoor function.Analysis,comparison and simulation prove that the proposed scheme is efficient and secure for the big data of Cloud tenants. | CHENG Hongbing RONG Chunming HWANG Kai WANG Weihong LI Yanyan | 2015 | China Communications2015，12，6： | 10 |
| 13 | LMM5.1 and LMM5.4,two eukaryotic translation elongation factor 1Alike gene family members,negatively affect cell death and disease resistance in rice显示文摘Lesion mimic mutant(LMM) genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed light-dependent spontaneous lesions. Additionally, lmm5 plants exhibited enhanced resistance to all of the tested races of Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae(Xoo) by increasing the expression of defense-related genes and the accumulation of hydrogen peroxide. Genetic analysis showed that the lesion mimic phenotype of lmm5 was controlled by two genes, lmm5.1 and lmm5.4, which were isolated with a map-based cloning strategy. Remarkably, LMM5.1 and LMM5.4 share a 97.4% amino acid sequence identity, and they each encode a eukaryotic translation elongation factor 1A(e EF1A)-like protein. Besides, LMM5.1 and LMM5.4 were expressed in a tissue-specific and an indicaspecific manner, respectively. In addition, high-throughput m RNA sequencing analysis confirmed that the basal immunity was constitutively activated in the lmm5 mutant. Taken together, these results suggest that the homologous e EF1A-like genes, LMM5.1 and LMM5.4, negatively affect cell death and disease resistance in rice. | Jiying Zhao Pengcheng Liu Chunrong Li Yanyan Wang Lequn Guo Guanghuai Jiang Wenxue Zhai | 2017 | Journal of Genetics and Genomics2017，44，2： | 10 |
| 14 | A quantification model of Traditional Chinese Medicine syndromes in children with idiopathic precocious puberty and early puberty显示文摘OBJECTIVE:To establish a quantification model of Traditional Chinese Medicine(TCM)syndromes by sampling patients undergoing idiopathic precocious puberty(IPP)and early puberty.METHODS:A questionnaire for classifying and quantifying TCM syndromes was designed and administered.All the results were analyzed;the relationship between 3 types of syndrome and 47symptoms were summated.Meanwhile,the frequency distribution of each symptom or sign was aggregated.Fuzzy mathematics was used to develop a quantification model ofTCM syndromes.RESULTS:We found that precocious puberty had 3types of syndrome,including hyperactivity of fire due to Yin deficiency(Syndrome I),depressed liver Qi transforming into fire(Syndrome II),and end retention of damp heat(Syndrome III).In the IPP group,Syndrome I was the most common principal syndrome(100%).Forty-six patients(43.81%)werediagnosed with Syndrome I accompanied by Syndrome II and 11(10.48%)were diagnosed with Syndrome I accompanied by Syndrome III.In the early puberty group,Syndrome I was also the main syndrome(98.39%).The degrees of most symptoms were mild to moderate.Reddened tongue was the most common tongue manifestation(62.86%prevalence)in the IPP group.The most common pulse manifestations were slippery pulse,thread pulse,and taut pulse.The Asymptotic Normalization Coefficient(ANC)method was used to quantify the TCM syndromes in 167 cases.Diagnostic accuracy rate reached 91%,comparable to expert diagnosis.CONCLUSION:We find that there are 3 types of syndrome in the IPP group and in the early puberty group.Syndrome I(hyperactivity of fire due to Yin deficiency)is the main syndrome in the two groups.ANC may be an appropriate for quantification model ofTCM syndromes. | Yanyan Lin Yuanyuan Xue Jian Yu Yonghong Wang Wen Sun Yanyan Sun Yumin Shi Yiqun Zhang Hong Hu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 9 |
| 15 | Synthesis and Application of Novel Triazine-Based Charring-Foaming Agents in Intumescent Flame Retardant Polypropylene显示文摘Three novel triazine-based charring-foaming agents (M2-CFA,M4-CFA,and M6-CFA) were synthesized successfully with only water as the solvent and were characterized by FT-IR and thermal gravimetric analysis (TGA).These three charring-foaming agents and the byproduct 944-by were employed to study the effectiveness of the novel intumescent flame retardant dopant on the fire retardancy of polypropylene (PP) investigated through UL-94 and limiting oxygen index (LOI) tests.TGA results showed that the M4-CFA presented good char formation ability (char residue: 26.8% at 700 ℃).It was found that the sample with a 2/1 mass ratio of APP to M4-CFA exhibited the best flame retardancy among all the PP composites: 35.5% LOI and a V-0 rating of UL-94.Additionally,the microstructure and morphology of char residues were further studied by XRD,Raman spectroscopy and SEM. | Ligong Chen Yanyan Yuan Bowei Wang Na Liu Yuzhi Xing Yang Li | 2017 | Transactions of Tianjin University2017，23，3： | 9 |
| 16 | Lactate metabolism in human health and disease显示文摘The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism,as identified by studies on the Warburg effect.The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells,organs and tissues.Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019.Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation,neural excitation,inflammation and other biological processes.An indispensable substance for various physiological cellular functions,lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.Therefore,a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research.This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes,as well as a comprehensive overview of the effects of lactylation in various diseases,particularly inflammation and cancer. | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 9 |
| 17 | Effect of Different Rootstocks on the Salt Stress Tolerance in Watermelon Seedlings显示文摘The selection of salt-tolerant watermelon rootstocks requires the evaluation of its underlying mechanism. The present study investigated the effect of applying 200 mmol·L-1 NaCl on various physiological and biochemical parameters of Citrullus lanatus ‘Jingxin No.2'(abbreviated as W) seedlings grafted onto W, Cucurbita moschata ‘Quanneng Tiejia'(P1), ‘Kaijia No.1'(P2), and Lagenaria siceraria ‘Hanzhen No.3'(G), which were grown hydroponically. All the measured growth parameters were significantly inhibited by salt stress, with W/P2 exhibiting superior growth. Salt stress increased Na+uptake, which in turn disrupted K+/Na+homeostasis in all grafting combinations. The photosynthetic capacity, chlorophyll concentration, and photochemical efficiency of photosystem II of all grafts significantly decreased with salt stress. However, W grafted onto G and P2 showed higher resistance than W grafted onto W and P1. Electrolyte leakage(EL) superoxide dismutase, catalase, peroxidase, and ascorbate peroxidase activity were significantly affected by both grafting and salt stress. Minimum EL was observed in W/P2, which also exhibited superior antioxidative capacity. Physiological and biochemical assessment indicated that W grafted onto the P2 rootstock displayed the greatest salt tolerance. Plants grafted onto salt-resistant P2 accumulated less Na+and reactive oxygen species(ROS) and exhibited superior growth,photosynthesis, and ROS-scavenging capacity compared to those grafted onto the other rootstocks. | YAN Yanyan WANG Shuoshuo WEI Min GONG Biao SHI Qinghua | 2018 | Horticultural Plant Journal2018，4，6： | 9 |
| 18 | Shale Gas Formation and Occurrence in China: An Overview of the Current Status and Future Potential显示文摘Shale gas is one of the most promising unconventional resources both in China and abroad. It is known as a form of self-contained source-reservoir system with large and continuous dimensions. Through years of considerable exploration efforts, China has identified three large shale gas fields in the Fuling, Changning and Weiyuan areas of the Sichuan Basin, and has announced more than 540 billion m^3 of proven shale gas reserves in marine shale systems. The geological theories for shale gas development have progressed rapidly in China as well. For example, the new depositional patterns have been introduced for deciphering the paleogeography and sedimentary systems of the Wufeng shale and Longmaxi shale in the Sichuan Basin. The shale gas storage mechanism has been widely accepted as differing from conventional natural gas in that it is adsorbed on organic matter or a mineral surface or occurs as free gas trapped in pores and fractures of the shale. Significant advances in the techniques of microstructural characterization have provided new insights on how gas molecules are stored in micro- and nano-scale porous shales. Furthermore, newly-developed concepts and practices in the petroleum industry, such as hydraulic fracturing, microseismic monitoring and multiwell horizontal drilling, have made the production of this unevenly distributed but promising unconventional natural gas a reality. China has 10–36 trillion m^3 of promising shale gas among the world's whole predicted technically recoverable reserves of 206.6 trillion m^3. China is on the way to achieving its goal of an annual yield of 30–50 billion m^3 by launching more trials within shale gas projects. | ZOU Caineng YANG Zhi PAN Songqi CHEN Yanyan LIN Senhu HUANG Jinliang WU Songtao DONG Dazhong WANG Shufang LIANG Feng SUN Shasha HUANG Yong WENG Dingwei | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 9 |
| 19 | Magnetic field data processing methods of the China Seismo-Electromagnetic Satellite显示文摘The High Precision Magnetometer(HPM) on board the China Seismo-Electromagnetic Satellite(CSES) allows highly accurate measurement of the geomagnetic field; it includes FGM(Fluxgate Magnetometer) and CDSM(Coupled Dark State Magnetometer)probes. This article introduces the main processing method, algorithm, and processing procedure of the HPM data. First, the FGM and CDSM probes are calibrated according to ground sensor data. Then the FGM linear parameters can be corrected in orbit, by applying the absolute vector magnetic field correction algorithm from CDSM data. At the same time, the magnetic interference of the satellite is eliminated according to ground-satellite magnetic test results. Finally, according to the characteristics of the magnetic field direction in the low latitude region, the transformation matrix between FGM probe and star sensor is calibrated in orbit to determine the correct direction of the magnetic field. Comparing the magnetic field data of CSES and SWARM satellites in five continuous geomagnetic quiet days, the difference in measurements of the vector magnetic field is about 10 nT, which is within the uncertainty interval of geomagnetic disturbance. | Bin Zhou YanYan Yang YiTeng Zhang XiaoChen Gou BingJun Cheng JinDong Wang Lei Li | 2018 | Earth and Planetary Physics2018，2，6： | 9 |
| 20 | Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer显示文摘Objective: To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma and reveal the molecular mechanism of carcinogenesis. Methods: Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases of primary hepatic cancer were constructed in SD rats. Rats were respectively sacrificed at d 14, d 28, d 56, d 77, d 105 and d 112 after the rats received DENA by gavage, then the livers were harvested. One part of the livers was classified according to their pathological changes, while the other was reserved for molecular mechanism studies on hepatocarcinogenesis. The differentially expressed genes were isolated from both normal and morbid tissues by mRNA differential display technique (DDRT-PCR). After the fragments were sequenced, bioinformatics were used to analyze the results. Results: Twelve differentially expressed cDNA fragments were obtained. Nine fragments had the homology with known cDNA clones, especially EST-7 was similar to BN/SsNHsdMCW mitochondrion gene and the identity was 100% which suggested EST-7 may be the part of BN/SsNHsdMCW mitochondrion gene. In contrast, other three fragments (EST-1, EST-3 and EST-5) had extremely low identity to any genes registered in GENBANK databases. Conclusions: BN/SsNHsdMCW mitochondrion gene was expressed in different periods of hepatocarcinogenesis. Moreover, EST-1, EST-3 and EST-5 were suggested to contribute to the development of rat hepatocarcinogenesis, and thus may be candidates of new targets of oncogenes or cancer suppressor genes. | Dandan Liu Lijuan Zhi Mingxia Ma Dan Qiao Meijuan Wang Yawei Wang Baijie Jin Anqi Li Guting Liu Yiqing Zhang Yanyan Song Hongxu Zhang | 2013 | Chinese Journal of Cancer Research2013，25，1： | 9 |
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