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| 1 | Infective viruses produced from full-length complementary DNA of swine vesicular disease viruses HK/70 strain显示文摘The full-length cDNA clone of swine vesicular disease virus HK/70 strain named pSVOK12 was constructed in order to study the antigenicity, replication, maturation and pathogenicity of swine vesicular disease virus. In vitro transcription RNA from pSVOK12 transfected IBRS-2 cells and the re- covered virus RNA were isolated and sequenced, then indirect hemagglutination test, indirect im- munofluorescence assays, eleectron microscope test, 50% tissue culture infecting dose (TCID50) assays and mouse virulence studies were performed to study the antigenicity and virulence of the recovered virus. The result showed that the infectious clones we ob- tained and the virus derived from pSVOK12 had the same biological properties as the parental strain HK/70. The full-length infectious cDNA clone, pSVOK12, will be very useful in studies of the anti- genicity, virulence, pathogenesis, maturation and replication of SVDV. | ZHENG Haixue LIU Xiangtao SHANG Youiun WU Jinyan BAI Xingwen JIN Ye SUN Shiqi GUO Huichen TIAN Hong FENG Xia YIN Shuanghui GUO Jianhong CONG Guozheng LIU Zaixin CHANG Huiyun MA Junwu XIE Qingge | 2006 | Chinese Science Bulletin2006，51，17： | 6 |
| 2 | Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblasti显示文摘B-cell precursor acute lymphoblastic leukemia(BCP-ALL)is characterized by genetic alterations with high heterogeneity.Precise subtypes with distinct genomic and/or gene expression patterns have been recently revealed using high-throughput sequencing technology.Most of these profiles are associated with recurrent non-overlapping rearrangements or hotspot point mutations that are analogous to the established subtypes,such as DUX4 rearrangements,MEF2D rearrangements,ZNF384/ZNF362 rearrangements,NUTM1 rearrangements,BCL2/MYC and/or BCL6 rearrangements,ETV6-RUNX1-like gene expression,PAX5alt(diverse PAX5 alterations,including rearrangements,intragenic amplifications,or mutations),and hotspot mutations PAX5(p.Pro80Arg)with biallelic PAX5 alterations,IKZF1(p.Asn159Tyr),and ZEB2(p.His1038Arg).These molecular subtypes could be classified by gene expression patterns with RNA-seq technology.Refined molecular classification greatly improved the treatment strategy.Multiagent therapy regimens,including target inhibitors(e.g.,imatinib),immunomodulators,monoclonal antibodies,and chimeric antigen receptor T-cell(CAR-T)therapy,are transforming the clinical practice from chemotherapy drugs to personalized medicine in the field of risk-directed disease management.We provide an update on our knowledge of emerging molecular subtypes and therapeutic targets in BCP-ALL. | Jianfeng Li Yuting Dai Liang Wu Ming Zhang Wen Ouyang Jinyan Huang Saijuan Chen | 2021 | Frontiers of Medicine2021，15，3： | 6 |
| 3 | Environmental cost and pollution risk caused by the industrial transfer in Qinghai Province显示文摘由于精力与升起迫使环境保护和恢复的消费和费用,工业转移从对中央、西方的区域东方在中国澎湃。然而,极其易碎的生态的条件和严重的水缺乏是为在西方的中国的工业开发的重要障碍。污染从东方中国由转移工业引起了的脆弱的环境罐头熊是否成为一个重要问题。这研究第一在中国的不同区域估计精力和环境费用,并且估计必要性升级 Qinghai 省的工业结构。然后,转移工业引起的浪费水,浪费气体,和烟的排出物被输入产量模型计算。根据环境上的浪费排放的效果分析, Qinghai 省的污染风险被估计。结果说明当环境费用在西方的中国是更高的时,在中国的环境保护和恢复的费用有坡度分布,精力效率是更低的。工业结构调整在不同部门的污染上有不同影响。尽管机械和设备,宾馆和迎合的服务的发展,和房地产,租借,并且企业服务增加了污染物质的排放,它是由象建设和金属产品那样的另外的工业引起的减少的排出物的偏移量。因此,尽管经济开发将增加环境污染,工业调整有效地装减少浪费水和浪费气体排出物减少污染风险。仍然为在 Qinghai 省的工业转移有巨大的挑战协调环境和工业开发,这应该被注意。 | Qun'ou JIANG Chengcai TANG Jinyan ZHAN Wei ZHANG Feng WU | 2014 | Frontiers of Earth Science2014，8，3： | 2 |
| 4 | Development of a hamster kidney cell line expressing stably T7 RNA polymerase using retroviral gene transfer technology for efficient rescue of infectious foot-and-mouth disease virus显示文摘 | Haixue Zheng Hong Tian Ye Jin Jinyan Wu Youjun Shang Shuanghui Yin Xiangtao Liu QingGe Xie | 2008 | Journal of Virological Methods2008，，1： | 1 |
| 5 | Evaluatingimpacts of industrial transformation on water consumptionin the Heihe River Basin of Northwest China 显示文摘 | WU Feng ZHAN Jinyan ZHANG Qian | 2014 | Sustainability2014，6，11： | 1 |
| 6 | Orbital-regulated interfacial electronic coupling endows Ni3N with superior catalytic surface for hydrogen evolution reaction显示文摘The interstitial structure and weak Ni-N interaction of Ni3N lead to high unoccupied d orbital energy and unsuitable orbital orientation,which consequently results in weak orbital coupling with H2O and slow water dissociation kinetics for alkaline hydrogen evolution catalysis.Herein,we successfully lower the unoccupied d orbital energy of Ni3N to strengthen the interfacial electronic coupling by employing the strong electron pulling capability of oxygen dopants.The prepared O-Ni3N catalyst delivers an overpotential of 55 mV at 10 mA cm−2,very close to the commercial Pt/C.Refined structural characterization indicates the oxygen incorporation can decrease the electron densities around the Ni sites.Moreover,density functional theory calculation further proves the oxygen incorporation can create more unoccupied orbitals with lower energy and superior orientation for water adsorption and dissociation.The concept of orbital-regulated interfacial electronic coupling could offer a unique approach for the rational design of hydrogen evolution catalysts and beyond. | Yanyan Fang Da Sun Shuwen Niu Jinyan Cai Yipeng Zang Yishang Wu Linqin Zhu Yufang Xie Yun Liu Zixuan Zhu Amirabbas Mosallanezhad Di Niu Zheng Lu Junjie Shi Xiaojing Liu Dewei Rao Gongming Wang Yitai Qian | 2020 | Science China Chemistry2020，63，11： | 1 |
| 7 | Rapid Detection Co-infections of Classical Swine Fever Virus and Porcine Reproductive and Respiratory Syndrome Virus by One-step Multiplex RT-PCR显示文摘Classical swine fever virus(CSFV) and porcine reproductive and respiratory syndrome virus(PRRSV) have caused immense economic loss in the pig industry and are considered to be the two most important infectious diseases of pigs in the world. A multiplex reverse transcription polymerase chain reaction(multiplex RT-PCR) was developed for CSFV and PRRSV co-infections or infections,respectively. A set of two pairs of primer was designed based on the sequence of nonstructural protein NS54B of CSFV and ORF7 gene of PRRSV. The diagnostic accuracy of multiplex RT-PCR assay was evaluated by using 56 field clinical samples by multiplex RT-PCR,single RT-PCR and sequence analysis;and the specificity of multiplex PCR was verified by using constructed plasmids containing the specific viral target fragments of PRRSV and CSFV,respectively. The results indicated that this assay could reliably differentiate PRRSV and CSFV in co-infection samples. The multiplex RT-PCR developed in this study might provide a new avenue to the rapid the detection of CSFV and PRRSV in one reaction. | TIAN Hong WU Jinyan YAN Chen SHANG Youjun YIN Shuanghui LIU Xiangtao | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，4： | 1 |
| 8 | Younger patients with chronic lymphocytic leukemia benefit from rituximabtreatment: A single center study in China显示文摘 | Zhenshu Xu Jinyan Zhang Shunquan Wu Zhihong Zheng Zhizhe Chen Rong Zhan | 2013 | Oncology Letters2013，，4： | 1 |
| 9 | Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats显示文摘 | Yonghui Zhang Jinyan Cai Hanli Ruan Huifang Pi Jizhou Wu | 2007 | Journal of Ethnopharmacology2007，，： | 1 |
| 10 | Characterization of a single recessive yield trait mutant with elevated endogenous ABA concentration and deformed grains, spikelets and leaves显示文摘 | Kun Wu Jinyan Wang Zhongxin Kong Zheng-Qiang Ma | 2010 | Plant Science2010，，2： | 1 |
| 11 | Impacts of Vegetation Change on the Regional Surface Climate: A Scenario-Based Analysis of Afforestation in Jiangxi Province, China显示文摘 | Enjun Ma Anping Liu Xing Li Feng Wu Jinyan Zhan Xiangzheng Deng | 2013 | Advances in Meteorology2013，，： | 1 |
| 12 | Effectively deploying services on virtualization infrastructure显示文摘虚拟化技术提供一个机会给 acieve 计算资源的有效用法。然而,虚拟化基础结构上的服务的管理仍然在初步的阶段。Contstructing 用户服务环境快速并且高效地仍然是挑战。这份报纸论述为创造并且设置虚拟器具跑的面向的 multiple-VM 推广系统(SO-MVDS ) 满足的一种服务按需。系统提供所有虚拟机与软件环境基于模板被创造的一个模板管理模型预先准备。改进推广表演,我们探索一些策略因为增长机制和 deployment.We 也设计服务推广机制到动态地并且自动地在虚拟器具以内部署多重服务。我们用建议增长机制评估推广时间和 I/O 性能。试验性的结果证明增长机制超过克隆一个。 | Wei GAO Hai JIN Song WU Xuanhua SHI Jinyan YUAN | 2012 | Frontiers of Computer Science2012，6，4： | 1 |
| 13 | Accelerating water dissociation kinetics of Ni3N by tuning interfacial orbital coupling显示文摘The high unoccupied d band energy of Ni_(3)N basically results in weak orbital coupling with water molecule,consequently leading to slow water dissociation kinetics.Herein,we demonstrate Cr doping can downshift the unoccupied d orbitals and strengthen the interfacial orbital coupling to boost the water dissociation kinetics.The prepared Cr-Ni_(3)N/Ni displays an impressive overpotential of 37 mV at 10 mA·cmgeo-2,close to the benchmark Pt/C in 1.0 M KOH solution.Refined structural analysis reveals the Cr dopant exists as the Cr-N_(6)states and the average d band energy of Ni_(3)N is also lowered.Density functional theory calculation further confirms the downshifted d band energy can strengthen the orbital coupling between the unpaired electrons in O 2p and the unoccupied state of Ni 3d,which thus facilitates the water adsorption and dissociation.The work provides a new concept to achieve on-demand functions for hydrogen evolution catalysis and beyond,by regulating the interfacial orbital coupling. | Yishang Wu Yufang Xie Shuwen Niu Yipeng Zang Jinyan Cai Zenan Bian Xuanwei Yin Yanyan Fang Da Sun Di Niu Zheng Lu Amirabbas Mosallanezhad Huijuan Wang Dewei Rao Hongge Pan Gongming Wang | 2021 | Nano Research2021，14，10： | 1 |
| 14 | Selenium Suppresses Lipopolysaccharide-Induced Fibrosis in Peritoneal Mesothelial Cells Through Inhibition of Epithelial-to-Mesenchymal Transition显示文摘 | Jinyan Liu Lingling Zeng Yuliang Zhao Bin Zhu Wanjun Ren Chunling Wu | 2014 | Biological Trace Element Research2014，，2： | 1 |
| 15 | Parallel execution time prediction of the multitask parallel programs 显示文摘 | WU RONGTENG SUN JIZHOU CHEN JINYAN | 2008 | Performance Evaluation2008，65，10： | 1 |
| 16 | Effect of heat treatment on the potential allergenicity and conformational structure of egg allergen ovotransferrin显示文摘 | Ping Tong Jinyan Gao Hongbing Chen Xin Li Yin Zhang Shan Jian Harry Wichers Zhihua Wu Anshu Yang Fahui Liu | 2011 | Food Chemistry2011，，2： | 1 |
| 17 | Superior surface electron energy level endows WP_(2) nanowire arrays with N_(2) fixation functions显示文摘Nitrogen reduction reaction(NRR)under ambient conditions is always a long-standing challenge in science,due to the extreme difficulty in breaking the strong N≡N triple bond.The key to resolving this issue undoubtedly lies in searching superior catalysts to efficiently activate and hydrogenate the stable nitrogen molecules.We herein evaluate the feasibility of WP_(2) for N2 activation and reduction,and first demonstrate WP_(2) with an impressive ammonia yield rate of 7.13 lg h^(-1)cm^(-2),representing a promising W-based catalyst for NRR.DFT analysis further reveals that the NRR catalysis on WP_(2) proceeds in a distal reaction pathway,and the exceptional NRR activity is originated from superior surface electron energy level matching between WP_(2) and NRR potential which facilitates the interfacial proton-coupled electron transfer dynamics.The successfully unraveling the intrinsic catalytic mechanism of WP_(2) for NRR could offer a powerful platform to manipulate the NRR activity by tuning the electron energy levels. | Dongdong Han Xiaojing Liu Jinyan Cai Yufang Xie Shuwen Niu Yishang Wu Yipeng Zang Yanyan Fang Fengqi Zhao Wengang Qu Minghua Chen Gongming Wang Yitai Qian | 2021 | Journal of Energy Chemistry2021，30，8： | 0 |
| 18 | USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia显示文摘T-cell acute lymphoblastic leukemia(T-ALL)is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway.Recent studies have revealed that posttranslational modifications,such as ubiquitination,regulate NOTCH1 stability,activity,and localization.However,the specific deubiquitinase that affects NOTCH1 protein stability remains unestablished.Here,we report that ubiquitin-specific protease 7(USP7)can stabilize NOTCH1.USP7 deubiquitinated NOTCH1 in vivo and in vitro,whereas knockdown of USP7 increased the ubiquitination of NOTCH1.USP7 interacted with NOTCH1 protein in T-ALL cells,and the MATH and UBL domains of USP7 were responsible for this interaction.Depletion of USP7 significantly suppressed the proliferation of T-ALL cells in vitro and in vivo,accompanied by downregulation of the NOTCH1 protein level.Similarly,pharmacologic inhibition of USP7 led to apoptosis of T-ALL cells.More importantly,we found that USP7 was significantly upregulated in human T-ALL cell lines and patient samples,and a USP7 inhibitor exhibited cell cytotoxicity toward primary T-ALL cells,indicating the clinical relevance of these findings.Overall,our results demonstrate that USP7 is a novel deubiquitinase that stabilizes NOTCH1.Therefore,USP7 may be a promising therapeutic target in the currently incurable T-ALL. | Huizhuang Shan Xiangyun Li Xinhua Xiao Yuting Dai Jinyan Huang Junjun Song Meng Liu Li Yang Hu Lei Yin Tong Li Zhou Hanzhang Xu Yingli Wu | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 19 | Solving quantified constraint satisfaction problems with value selection rules显示文摘Solving a quantified constraint satisfaction problem(QCSP)is usually a hard task due to its computational complexity.Exact algorithms play an important role in solving this problem,among which backtrack algorithms are effective.In a backtrack algorithm,an important step is assigning a variable by a chosen value when exploiting a branch,and thus a good value selection rule may speed up greatly.In this paper,we propose two value selection rules for existentially and universally quantified variables,respectively,to avoid unnecessary searching.The rule for universally quantified variables is prior to trying failure values in previous branches,and the rule for existentially quantified variables selects the promising values first.Two rules are integrated into the state-of-the-art QCSP solver,i.e.,QCSP-Solve,which is an exact solver based on backtracking.We perform a number of experiments to evaluate improvements brought by our rules.From computational results,we can conclude that the new value selection rules speed up the solver by 5 times on average and 30 times at most.We also show both rules perform well particularly on instances with existentially and universally quantified variables occurring alternatively. | Jian Gao Jinyan Wang Kuixian Wu Rong Chen | 2020 | Frontiers of Computer Science2020，14，5： | 0 |
| 20 | Some Domestic Strontium Carbonate Producers Will Be Beaten out显示文摘1 Surplus capacity and decreasing profit in 2007 With negative impacts from the recession of the color TV picture tube production and the elimination of the export rebate,China’s strontium carbonate manufacturing sector suffered from oversupply in 2007.Many domestic producers cut their operation rates or shifted to producing other chemicals in order to deal with the slack demand,but the price of strontium carbonate still dropped from around RMB4 200 per ton at the be-ginning of 2007 to around RMB3 200 per ton at the end of the year.As the require-ments for saving energy and reducing pol-lutants get higher and higher,producers | Wu Weidong Xu Qing Nanjing Jinyan Strontium Industry Co.,Ltd. | 2008 | China Chemical Reporter2008，，10： | 0 |
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