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| 1 | Effect of early enteral nutrition on postoperative nutritional status and immune function in elderly patients with esophageal cancer or cardiac cancer显示文摘Objective: To explore the effect of early enteral nutrition (EN) on postoperative nutritional status, intestinal permeability, and immune function in elderly patients with esophageal cancer or cardiac cancer. Methods: A total of 96 patients with esophageal cancer or cardiac cancer who underwent surgical treatment in our hospital from June 2007 to December 2010 were enrolled in this study. They were divided into EN group (n=50) and parenteral nutrition (PN) group (n=46) based on the nutrition support modes. The body weight, time to first flatus/defecation, average hospital stay, complications and mortality after the surgery as well as the liver function indicators were recorded and analyzed. Peripheral blood samples were collected on the days 1, 4 and 7 after surgery. The plasma diamine oxidase (DAO) activity and D-lactate level were determined to assess the intestinal permeability. The plasma endotoxin levels were determined using dynamic turbidimetric assay to assess the protective effect of EN on intestinal mucosal barrier. The postoperative blood levels of inflammatory cytokines and immunoglobulins were determined using enzyme- linked immunosorbent assay (ELISA). Results: After the surgery, the time to first flatus/defecation, average hospital stay, and complications were significantly less in the EN group than those in the PN group (P<0.05), whereas the EN group had significantly higher albumin levels than the PN group (P<0.05). On the 7th postoperative day, the DAO activity, D-lactate level and endotoxin contents were significantly lower in the EN group than those in the PN group (all P<0.05). In addition, the EN group had significantly higher IgA, IgG, IgM, and CD4 levels than the PN group (P<0.05) but significantly lower IL-2, IL-6, and TNF-α levels (P<0.05). Conclusions: In elderly patients with esophageal cancer or cardiac cancer, early EN after surgery can effectively improve the nutritional status, protect intestinal mucosal barrier (by reducing plasma endoxins), and enhance the immune | Guiping Yu Guoqiang Chen Bin Huang Wenlong Shao Guangqiao Zeng | 2013 | Chinese Journal of Cancer Research2013，25，3： | 67 |
| 2 | Dynamic Weapon Target Assignment Based on Intuitionistic Fuzzy Entropy of Discrete Particle Swarm显示文摘Aiming at the problems of convergence-slow and convergence-free of Discrete Particle Swarm Optimization Algorithm(DPSO) in solving large scale or complicated discrete problem, this article proposes Intuitionistic Fuzzy Entropy of Discrete Particle Swarm Optimization(IFDPSO) and makes it applied to Dynamic Weapon Target Assignment(WTA). First, the strategy of choosing intuitionistic fuzzy parameters of particle swarm is defined, making intuitionistic fuzzy entropy as a basic parameter for measure and velocity mutation. Second, through analyzing the defects of DPSO, an adjusting parameter for balancing two cognition, velocity mutation mechanism and position mutation strategy are designed, and then two sets of improved and derivative algorithms for IFDPSO are put forward, which ensures the IFDPSO possibly search as much as possible sub-optimal positions and its neighborhood and the algorithm ability of searching global optimal value in solving large scale 0-1 knapsack problem is intensified. Third, focusing on the problem of WTA, some parameters including dynamic parameter for shifting firepower and constraints are designed to solve the problems of weapon target assignment. In addition, WTA Optimization Model with time and resource constraints is finally set up, which also intensifies the algorithm ability of searching global and local best value in the solution of WTA problem. Finally, the superiority of IFDPSO is proved by several simulation experiments. Particularly, IFDPSO, IFDPSO1~IFDPSO3 are respectively effective in solving large scale, medium scale or strict constraint problems such as 0-1 knapsack problem and WTA problem. | Yi Wang Jin Li Wenlong Huang Tong Wen | 2017 | China Communications2017，14，1： | 15 |
| 3 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 4 | Oxidative stress, nutritional antioxidants and beyond显示文摘Free radical-induced oxidative stress contributes to the development of metabolic syndromes(Mets), including overweight,hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain;under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress status.Natural antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and antiinflammatory effect of polyphenols as potential nutritional therapy. | Qiuping Guo Fengna Li Yehui Duan Chaoyue Wen Wenlong Wang Lingyu Zhang Ruilin Huang Yulong Yin | 2020 | Science China(Life Sciences)2020，63，6： | 10 |
| 5 | Hydrophilic bismuth sulfur nanoflower superstructures with an improved photothermal efficiency for ablation of cancer cells显示文摘Nanomaterials 与强烈在红外线附近(NIR ) 吸收展览有效 photon-to-thermal 精力转移能力和罐头产生热切除癌症房间,因此在 photothermal 癌症治疗学起一个枢轴的作用。此处,吸水的象花的铋硫(双性人 2 有一致尺寸的 S 3) 上层建筑和改进 NIR 吸收 controllably 经由 polyvinylpyrrolidone (PVP ) 帮助的一个灵巧的 solvothermal 过程被综合,它能调整产品形态学。由 808-nm 激光导致了,同样准备的双性人 2 S 3 nanoflowers 比双性人 2 当 PVP 不在时准备的 S 3 nanobelts (36.5%) 。这能被归因于双性人 2 与一个更低的乐队一起与 NIR 光而且到非结晶的结构的改进反射率和吸收用作许多激光洞镜子的 3-dimensional crumpled-paper-like nanosheets 装配的 S 3 nanoflower 上层建筑豁开。因此,当使用双性人 2 与相比的 S 3 nanoflowers 用双性人 2 S 3 nanobelts,它由于减少的毒性在治疗为使用使他们更有利。而且,这些双性人 2 S 3 nanoflowers 有效地在 vitro 并且在 vivo 完成了癌症房间的 photothermal 脱离。这些结果不仅支持了双性人 2 是的 S 3 nanoflowers 为癌症治疗的一个有希望的 photothermal 代理人而且铺了一条途径与改进 photothermal 效率利用新代理人。 | Zhiyin Xiao Chaoting Xu Xiaohong Jiang Wenlong Zhang Yuxuan Peng Rujia Zou Xiaojuan Huang Qian Liu Zongyi Qin Junqing Hu | 2016 | Nano Research2016，9，7： | 7 |
| 6 | Synthesis of low-cost porous ceramic microspheres from waste gangue for dye adsorption显示文摘Low-cost porous ceramic microspheres from waste gangue were prepared by simple spray drying and subsequent calcination. Effects of calcination temperature on phase and microstructure evolution, specific surface area, pore structure, and dye adsorption mechanism of the microspheres were investigated systematically. Results showed that the microspheres were spherical, with some mesopores both on the surface and inside the spheres. The phase kept kaolinite after calcined at 800 and 900 ℃ and transformed into mullite at 1000 ℃. The microspheres calcined at 800 ℃ showed larger adsorption capacity and removal efficiency than those calcined at higher temperatures. Methylene blue(MB) and basic fuchsin(BF) removal efficiency reached 100% and 99.9% with the microsphere dosage of 20 g/L, respectively, which was comparable to that of other low-cost waste adsorbents used to remove dyes in the literature. Adsorption kinetics data followed the pseudosecond-order kinetic model, and the isotherm data fit the Langmuir isotherm model. The adsorption process was attributed to multiple adsorption mechanisms including physical adsorption, hydrogen bonding, and electrostatic interactions between dyes and gangue microspheres. The low-cost porous microspheres with excellent cyclic regeneration properties are promising absorbent for dyes in wastewater filtration and adsorption treatment. | Shu YAN Yiming PAN Lu WANG Jingjing LIU Zaijuan ZHANG Wenlong HUO Jinlong YANG Yong HUANG | 2018 | Journal of Advanced Ceramics2018，7，1： | 6 |
| 7 | Flow Instability of a Centrifugal Pump Determined Using the Energy Gradient Method显示文摘The stability of the centrifugal pump has not been well revealed because of the complexity of internal flow. To analyze the flow characteristics of a centrifugal pump operating at low capacity, methods of numerical simulation and experimental research were adopted in this paper. Characteristics of the inner flow were obtained. Standard k–ε turbulence models were used to calculate the inner flow of the pump under off-design conditions. The distribution of the energy gradient function K was obtained by three-dimensional numerical simulation at different flow rates. The relative velocity component was acquired from the absolute velocity obtained in particle image velocimetry. By comparing with experimental results, it was found that flow instability occurs at the position of maximum K. The flow stability reduces with an increasing flow rate. The research results provide a theoretical basis for the optimization design of a centrifugal pump. | Li Yi Dong Wenlong He Zhaohui Huang Yuanmin Jiang Xiaojun | 2015 | Journal of Thermal Science2015，24，1： | 5 |
| 8 | Facile fabrication of MoP nanodots embedded in porous carbon as excellent anode material for potassium-ion batteries显示文摘Molybdenum phosphide(MoP),owing to its abundant reserve and high theoretical capacity,is regarded as a promising anode material for potassium-ion batteries.However,it still suffers from the problems of acute volume expansion and weak diffusion kinetics.This study reports a simple method to synthesize a composite of molybdenum phosphide and porous carbon(MoP@PC)through simple mixing and annealing treatment.In the MoP@PC,lots of MoP nanodots with an average diameter of about 4 nm uniformly embedded in the petal-like porous carbon.The MoP@PC shows reversible capacities of 330 mAh g^(-1) at100 mA g^(-1) after 100 cycles,and ultra-long cycling stability with a capacity of 240 mAh g^(-1) after 1000 cycles at 1 A g^(-1) and 161 mAh g^(-1) after 1000 cycles at 5 A g^(-1).The structure of MoP@PC after charging-discharging cycles is also investigated by high resolution transmission electron microscope(HRTEM)and the result shows that MoP can still maintain the nanodot morphology without any agglomeration after 1000 cycles at 5 A g^(-1).The storage mechanism of potassium ions was studied as well,which reveals that MoP and potassium ion have a conversion reaction. | Zhanheng Yan Zhongyuan Huang Haihui Zhou Xinxin Yang Songlin Li Wenlong Zhang Fei Wang Yafei Kuang | 2021 | Journal of Energy Chemistry2021，30，3： | 5 |
| 9 | Rb Protein is Essential to the Senescence-Associated Heterochromatic Foci Formation Induced by HMGA2 in Primary WI38 Cells显示文摘细胞的老朽是提供一个障碍给肿瘤的转变的房间周期拘捕的一张不可逆的表格。Rb (Retinoblastoma ) 小径的正直为为衰老的状态的稳定性提供一个分子的基础的联系老朽的 heterochromatin foci (SAHF ) 的形成是必要的。令人惊讶地,尽管高活动性组 A2 蛋白质(HMGA2 ) 能支持 tumorigenesis 并且在肿瘤房间禁止 Rb 功能, HMGA2 的高级表示是足够的在主要房间导致 SAHF 形成。决定 Rb 蛋白质是否在导致 HMGA2 的 SAHF 形成是必要的因此变得重要。在这研究,我们由 HMGA2,典型衰老的标记在被看见的宫外的表示建立了细胞的老朽和 SAHF 汇编 WI38 房间模型,包括 p53, p21 和 p16 的著名 upregulation,并且提高了 SA -- 和 E2F 目标基因的 downregulation 染色的牛乳糖。我们然后证明 Rb 小径禁止者 E7 蛋白质能部分在 WI38 房间在 HMGA2 表示以后废除 SAHF 形成的能力,显示 Rb 是为导致 HMGA2 的 SAHF 形成的一个关键因素。然而, Rb 弄空完全没救 HMGA2 导致的房间生长拘捕,建议 Rb 不是为在 WI38 房间的导致 HMGA2 的老朽的一条独占的小径。 | Xi Shi Baoqing Tian Lingxia Liu Yanyan Gao Chi Ma Namusamba Mwichie Wenlong Ma Liping Han Baiqu Huang Jun Lu Yu Zhang | 2013 | Journal of Genetics and Genomics2013，40，8： | 4 |
| 10 | Initial scalar lithospheric magnetic anomaly map of China and surrounding regions derived from CSES satellite data显示文摘The China Seismo-Electromagnetic Satellite(CSES),China’s first satellite to measure geophysical fields with scientific goals in both space and solid earth physics,was launched successfully in February 2018.It carries high-precision magnetometers to measure the geomagnetic field.In this study,the CSES magnetic data were used to extract the signal of the lithospheric magnetic field caused by magnetized rocks in the crust and uppermost mantle.First,an along-track analysis of the CSES magnetic data was undertaken near the Bangui magnetic anomaly in central Africa and the Tarim magnetic anomaly in China,demonstrating that the CSES magnetic data are indeed sensitive to the lithospheric magnetic anomaly field.Then a lithospheric magnetic anomaly map over China and surrounding regions was derived.This map is consistent with the lithospheric part of the CHAOS-7 model.In particular,it clearly reveals four major magnetic anomalies containing long-wavelength signals at the altitude of lowearth-orbiting satellites.Three magnetic highs are located over the Tarim,Sichuan and Songliao basin,the origins of which could be related to large-scale tectonic-magmatic activities during geological history.A prominent magnetic low is otherwise found in the southern Himalayan-Tibetan plateau,possibly caused by the shallow Curie depth in this region.To further improve the precision of the lithospheric magnetic field model,more detailed data processing and multi-source data merging are needed. | WANG Jie SHEN XuHui YANG YanYan ZEREN ZhiMa HULOT Gauthier OLSEN Nils ZHOU Bin MAGNES Werner DE SANTIS Angelo HUANG JianPing GUO Feng LIU WenLong YU JingBo | 2021 | Science China(Technological Sciences)2021，64，5： | 4 |
| 11 | Artificial immune kernel clustering network for unsupervised image segmentation显示文摘An immune kernel clustering network (IKCN) is proposed based on the combination of the artificial immune network and the sup- port vector domain description (SVDD) for the unsupervised image segmentation. In the network, a new antibody neighborhood and an adaptive learning coeffcient, which is inspired by the long-term memory in cerebral cortices are presented. Starting from IKCN algo- rithm, we divide the image feature sets into subsets by the antibodies, and then map each subset into a high dimensional feature space by a mercer kernel, where each antibody neighborhood is represented as a support vector hypersphere. The clustering results of the local support vector hyperspheres are combined to yield a global clustering solution by the minimal spanning tree (MST), where a predfined number of clustering is not needed. We compare the proposed methods with two common clustering algorithms for the artificial synthetic data set and several image data sets, including the synthetic texture images and the SAR images, and encouraging experimental results are obtained. | Wenlong Huang Licheng Jiao | 2008 | Progress in Natural Science:Materials International2008，18，4： | 4 |
| 12 | Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway显示文摘There is a need for synthetic grafts to reconstruct large bone defects using minimal invasive surgery.Our previous study showed that incorporation of Sr into bioactive borate glass cement enhanced the osteogenic capacity in vivo.However,the amount of Sr in the cement to provide an optimal combination of physicochemical properties and capacity to stimulate bone regeneration and the underlying molecular mechanism of this stimulation is yet to be determined.In this study,bone cements composed of bioactive borosilicate glass particles substituted with varying amounts of Sr(0 mol%to 12 mol%SrO)were created and evaluated in vitro and in vivo.The setting time of the cement increased with Sr substitution of the glass.Upon immersion in PBS,the cement degraded and converted more slowly to HA(hydroxyapatite)with increasing Sr substitution.The released Sr2+modulated the proliferation,differentiation,and mineralization of hBMSCs(human bone marrow mesenchymal stem cells)in vitro.Osteogenic characteristics were optimally enhanced with cement(designated BG6Sr)composed of particles substituted with 6mol%SrO.When implanted in rabbit femoral condyle defects,BG6Sr cement supported better peri-implant bone formation and bone-implant contact,comparing to cements substituted with 0mol%or 9mol%SrO.The underlying mechanism is involved in the activation of Wnt/β-catenin signaling pathway in osteogenic differentiation of hBMSCs.These results indicate that BG6Sr cement has a promising combination of physicochemical properties and biological performance for minimally invasive healing of bone defects. | Xu Cui Yadong Zhang Jianyun Wang Chengcheng Huang Yudong Wang Hongsheng Yang Wenlong Liu Ting Wang Deping Wang Guocheng Wang Changshun Ruan Dafu Chen William W.Lu Wenhai Huang Mohamed N.Rahaman Haobo Pan | 2020 | Bioactive Materials2020，5，2： | 3 |
| 13 | Accumulation of carotenoids and expression of carotenoid biosynthesis genes in fruit flesh during fruit development in two Cucurbita maxima inbred lines显示文摘Mesocarp color is an important agronomic trait of Cucurbita maxima and is determined mainly by the contents and compositions of the carotenoids.The two inbred lines with significant differences in fruit flesh color were used in the study,the orange’312-1’and white’98-2’.Changes in seven carotenoid contents and compositions in the flesh of fruit produced by inbred lines’312-1’and’98-2’were analyzed during fruit development.The expression of eight key carotenoid biosynthesis genes in the fruit flesh were investigated during five fruit development stage in two inbred lines.As the flesh color intensified,the orange flesh color of’312-1’was determined mainly by the increased contents of lutein,β-carotene and zeaxanthin and the lack of carotenoid accumulation led to the formation of white flesh in’98-2’fruit.The expression of the LCY-e and CHYb genes was significantly stronger in’312-1’than in’98-2’,and their expression was strongly correlated with lutein andβ-carotene contents during fruit development.This study provides a deep understanding of the molecular mechanism of carotenoid biosynthesis in fruit flesh and provides a basis for additional studies on the highly refined improvement of squash quality. | Yusong Luo Chaojie Wang Manman Wang Yunli Wang Wenlong Xu Hongyu Han Zhichao Wang Yujuan Zhong Hexun Huang Shuping Qu | 2021 | Horticultural Plant Journal2021，7，6： | 3 |
| 14 | 3D hierarchical microspheres constructed by ultrathin MoS2-C nanosheets as high-performance anode material for sodium-ion batteries显示文摘MoS2/C composites are considered to have great application potential in sodium-ion batteries(SIBs).It is a challenging and meaningful subject that developing high-performance anode materials via combining MoS2 and carbon effectively to give free rein to their advantages in sodium ion storage.In this work,a novel MoS2-C material was designed by using cellulose nanocrystals(CNCs)as low-cost and green carbon source.3 D hierarchical microspheres(200-250 nm)constructed by ultrathin MoS2-C nanosheets were synthesized by synchronizing the pre-carbonization of CNCs with the formation of MoS2 in hydrothermal reaction and subsequent pyrolysis process.It is found that the ultrathin MoS2-C nanosheets were composed of CNCs-derived short-range ordered carbon and few-layered MoS2.Benefiting from the unique structure and robust combination of MoS2 and CNCs-derived carbon,the ultrathin MoS2-C nanosheets composite was proved to have excellent cycling stability and superior rate performance in sodium-ion half-cell test and have high first reversible specific capacity of 397.9 m Ah/g in full-cell test.This work provides a significant and effective pathway to prepare MoS2-C materials with excellent electrochemical performance for the application in large-scale energy storage systems. | Wenlong Zhang Haihui Zhou Zhongyuan Huang Songlin Li Chuqing Wang Huanxin Li Zhanheng Yan Teng Hou Yafei Kuang | 2020 | Journal of Energy Chemistry2020，29，10： | 3 |
| 15 | In-situ TEM investigation of MoS2 upon alkali metal intercalation显示文摘Phase transition in two dimensional molybdenum disulfide (MoS_2) can be induced by several methods and has been investigated for decades. Alkali metal insertion of MoS_2 had been proved an effective method to cause phase transition early in 1970s, and has been gaining renewed interest recently, due to the possible application of MoS_2 in energy storage. The alkali metal intercalation of MoS_2 has been studied by various techniques, among which in-situ transmission electron microscopy (TEM) provides unique capability of real time resolving the structural evolution of the materials at high spatial resolutions. Here by in-situ TEM technique we investigated the structural evolution of MoS_2 upon lithium and sodium intercalation, along with transformation of the nanosheet and variation of the electron diffraction patterns. The intercalation process is accompanied by emergence of superstructures, which exist in several forms. The ion intercalation results in phase transition of MoS_2 from 2H to 1T, and the driving mechanism of the phase transition are discussed. The work provides a more comprehensive understanding of ion intercalation induced phase transition of MoS_2. | Qianming Huang Lifen Wang Zhi Xu Wenlong Wang Xuedong Bai | 2018 | Science China Chemistry2018，61，2： | 3 |
| 16 | Synthesis, Characterization and Adsorption Properties of Low-cost Porous Calcined Dolomite Microspheres for Removal of Dyes显示文摘Low-cost porous calcined dolomite microspheres were prepared by simple spray drying and subsequent calcination. Effects of calcination temperature on phase evolution and adsorption properties of MB were investigated systematically. Results showed that microspheres treated at 400 ℃ kept mainly calcium carbonate (CaMg (CO3)) phase with some small pores, showing better removal efficiency for MB. With the dosage of 20 g/L under the starting concentration of 100 mg/L, the removal efficiency of the microspheres reached 95.6%. The adsorption kinetics data followed the pseudo-second-order kinetic model, and the isotherm data fit the Langmuir isotherm model. The low-cost microsphere could be applied as a promising absorbent for dyes in wastewater filtration and adsorption treatment. | 闫姝 WANG Qinggang LIU Jingjing HUO Wenlong 杨金龙 HUANG Yong | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，3： | 3 |
| 17 | Electrochemical solid-state amorphization in the immiscible Cu-Li system显示文摘As a typical immiscible binary system, copper (Cu) and lithium (Li) show no alloying and chemical intermixing under normal circumstances. Here we show that, when decreasing Cu nanoparticle sizes into ultrasmall range, the nanoscale size effect can play a subtle yet critical role in mediating the chemical activity of Cu and therefore its miscibility with Li, such that the electrochemical alloying and solidstate amorphization will occur in such an immiscible system. This unusual observation was accomplished by performing in-situ studies of the electrochemical lithiation processes of individual CuO nanowires inside a transmission electron microscopy (TEM). Upon lithiation, CuO nanowires are first electrochemically reduced to form discrete ultrasmall Cu nanocrystals that, unexpectedly, can in turn undergo further electrochemical lithiation to form amorphous Cu Lixnanoalloys. Real-time TEM imaging unveils that there is a critical grain size (ca. 6 nm), below which the nanocrystalline Cu particles can be continuously lithiated and amorphized. The possibility that the observed solid-state amorphization of Cu-Li might be induced by electron beam irradiation effect can be explicitly ruled out; on the contrary, it was found that electron beam irradiation will lead to the dealloying of as-formed amorphous Cu Lixnanoalloys. | Muhua Sun Jiake Wei Zhi Xu Qianming Huang Yu Zhao Wenlong Wang Xuedong Bai | 2018 | Science Bulletin2018，63，18： | 3 |
| 18 | Nonlinear Seismic Response of Rock Tunnels Crossing Inactive Fault under Obliquely Incident Seismic P Waves显示文摘The failure mechanism of tunnels crossing faults is a critical issue for tunnels located in seismically active regions. This study aims to investigate the nonlinear response of rock tunnels crossing inactive faults under obliquely incident seismic P waves. Based on the equivalent nodal force method together with the viscous-spring boundary, an incident method for the site, which contains fault and is subjected to obliquely incident seismic P waves, is developed first. Then, based on the proposed incident method, the nonlinear response and the failure process of the tunnel crossing inactive fault are numerically studied. The numerical results show that the failure mechanism of the tunnel crossing inactive fault can be attributed to the combined action of the seismic waves and its associated fault slippage. Finally, parameter studies are conducted to investigate the effects of the wave impedance ratio of the fault to the surrounding rock and the incident angle of P waves. By the parameter analysis, it can be concluded that:(1) with decreasing the wave impedance ratio of the fault to the surrounding rock, the seismic response of the tunnel increases significantly;(2) the seismic response of the tunnel increases first and then decreases with the increasing of the incident angle of P waves. This study offers the insight for further research on the seismic stability of tunnels crossing inactive faults. | Hongyun Jiao Xiuli Du Mi Zhao Jingqi Huang Xu Zhao Wenlong Ouyang | 2021 | Journal of Earth Science2021，32，5： | 3 |
| 19 | Design,synthesis and antitumor activities of fluoroquinolone C-3 heterocycles(Ⅳ):s-triazole Schiff-Mannich bases derived from of loxacin显示文摘The aim of this research was to produce novel antitumor fluoroquinolones from antibacterial analogs by introduction of a heterocyclic ring as a bioisostere of the C-3 carboxylic acid group.To this end,two series of eleven s-triazole derivatives bearing functionalized side chains of Schiff bases and Schiff Mannich bases were designed and synthesized.Structures were characterized by elemental analysis and spectral data after which in vitro antitumor activity against L1210,CHO and HL60 cell lines was evaluated in the MTT assay.Compounds posssing a free phenol group were particularly active and warrant further development. | Guoqiang Hu Guoqiang Wang Nannan Duan Xiaoyi Wen Tieyao Cao Songqiang Xie Wenlong Huang | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 3 |
| 20 | The therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3',5'-monophosphate(Epac)for central nervous system trauma显示文摘Millions of people worldwide are affected by traumatic spinal cord injury,which usually results in permanent sensorimotor disability.Damage to the spinal cord leads to a series of detrimental events including ischaemia,haemorrhage and neuroinflammation,which over time result in further neural tissue loss.Eventually,at chronic stages of traumatic spinal cord injury,the formation of a glial scar,cystic cavitation and the presence of numerous inhibitory molecules act as physical and chemical barriers to axonal regrowth.This is further hindered by a lack of intrinsic regrowth ability of adult neurons in the central nervous system.The intracellular signalling molecule,cyclic adenosine 3′,5′-monophosphate(cAMP),is known to play many important roles in the central nervous system,and elevating its levels as shown to improve axonal regeneration outcomes following traumatic spinal cord injury in animal models.However,therapies directly targeting cAMP have not found their way into the clinic,as cAMP is ubiquitously present in all cell types and its manipulation may have additional deleterious effects.A downstream effector of cAMP,exchange protein directly activated by cAMP 2(Epac2),is mainly expressed in the adult central nervous system,and its activation has been shown to mediate the positive effects of cAMP on axonal guidance and regeneration.Recently,using ex vivo modelling of traumatic spinal cord injury,Epac2 activation was found to profoundly modulate the post-lesion environment,such as decreasing the activation of astrocytes and microglia.Pilot data with Epac2 activation also suggested functional improvement assessed by in vivo models of traumatic spinal cord injury.Therefore,targeting Epac2 in traumatic spinal cord injury could represent a novel strategy in traumatic spinal cord injury repair,and future work is needed to fully establish its therapeutic potential. | Alba Guijarro-Belmar Dominik Mateusz Domanski Xuenong Bo Derryck Shewan Wenlong Huang | 2021 | Neural Regeneration Research2021，16，3： | 3 |
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