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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 3 | The cost of obsessive- compulsive disorder (OCD) in China: a multi- center cross- sectional survey based on hospitals显示文摘Background Obsessive-compulsive disorder(OCD)is considered a very debilitating disorder with severe loss of quality of life and income.Aims This study estimates the quality of life and economic consequences of OCD in China.Methods The research team interviewed 639 patients with OCD in 13 hospitals in 12 cities in China.The direct method was used to get the direct cost of OCD.Indirect costs associated with OCD were estimated using the human capital approach.Linear regression analysis was conducted for quality of life and generalised linear model analysis was conducted for total cost.Sensitivity analysis was used to analyse the uncertainty of total cost.Results The mean quality of life score for OCD was 52.78(20.46).The annual total cost of OCD per capita was 24503.78(95%CI:22621.53 to 26386.03)renminbi(RMB)(US$3465.88(95%CI:US$3199.65 to US$3732.11)).The annual cost of OCD in China was estimated to be 37.74 billion(95%CI:34.95 billion to 40.53 billion)RMB(equal to US$5.34 billion(95%CI:US$4.94 billion to US$5.73 billion)).Sensitivity analysis showed that the total annual cost of OCD in China was between 23.15 billion RMB(US$3.27 billion)and 370.00 billion RMB(US$52.33 billion).Worse social function status,more psychiatric symptoms and higher Yale Brown Obsessive-Compulsive Scale(Y-BOCS)score were associated with worse quality of life.The numbers of clinic visits and hospitalisations,socioeconomic status,education,Y-BOCS scores and age were found to be significantly associated with total cost.Conclusions OCD is associated with low quality of life and high costs in China.The findings call for concerted efforts to improve services for patients with OCD.Improvements may include early detection and diagnosis,the provision of evidence-based treatments and relapse prevention strategies. | Weili Yang Zhen Tang Xijin Wang Xiancang Ma Yuqi Cheng Bin Wang Ping Sun Wenxin Tang Jia Luo Changhong Wang Ping Li Guiyun Xu Jun Yan Vlasios Brakoulias Zhen Wang | 2021 | General Psychiatry2021，34，6： | 3 |
| 4 | Epigenetic silencing of WIF - 1 in hepatocellular carcinomas显示文摘 | Yun Deng Bin Yu Qin Cheng Jie Jin Haiyan You Ronghu Ke Ning Tang Qiujin Shen Huiqun Shu Genfu Yao Zhigang Zhang Wenxin Qin | 2010 | Journal of Cancer Research and Clinical Oncology2010，，8： | 1 |
| 5 | Down-regulating annexin gene GhAnn2 inhibits cotton fiber elongation and decreases Ca 2+ influx at the cell apex显示文摘 | Wenxin Tang Yonghui He Lili Tu Maojun Wang Yang Li Yong-Ling Ruan Xianlong Zhang | 2014 | Plant Molecular Biology2014，，6： | 1 |
| 6 | The COVID‐19 vaccine: Attitudes and vaccination in patients with autoimmune inflammatory rheumatic diseases显示文摘Background:We examined attitudes toward the COVID‐19 vaccine,potential factors underlying these attitudes,and ways to increase vaccination willingness in autoimmune inflammatory rheumatic diseases(AIIRD)patients.Methods:A multicenter,web‐based,observational survey using an online questionnaire was conducted among AIIRD patients aged≥18 years from May 24,2021,to June 3,2021.Participants were 3104 AIIRD patients(2921 unvaccinated and 183 vaccinated).Results:Of the unvaccinated patients,32.9%were willing to receive the COVID‐19 vaccine,45.0%were uncertain,and 14.8%were unwilling.When vaccination was recommended by physicians,patients'willingness increased to 93.8%.Participants'main concerns were that the vaccine may aggravate AIIRD disease(63.0%)and may cause vaccine‐related adverse events(19.9%).Female patients were less likely to be vaccinated.However,patients who had children aged≤18 years were more willing to be vaccinated.In addition,vaccination willingness was higher in patients with trust in the safety and efficacy of the COVID‐19 vaccine.Notably,183(5.9%)patients were vaccinated.The major vaccination side effects were injection reaction,myalgia,and fatigue.At a median follow‐up of 88(38,131)days,patients'disease activities were stable.Conclusions:The findings show that AIIRD patients were unwilling to receive the COVID‐19 vaccine because of fears of potential disease exacerbation and additional adverse events.Sociodemographic characteristics and concerns about COVID‐19 disease and vaccines had a significant effect on vaccination willingness. | Jiali Chen Wenxin Cai Tian Liu Yunshan Zhou Yuebo Jin Yue Yang Shi Chen Kun Tang Chun Li | 2022 | Rheumatology & Autoimmunity2022，2，2： | 1 |
| 7 | Comprehensive assessment of heavy metal pollution in river and lake sediments using face graph and index of geoaccumulation显示文摘Surface sedimental samples were collected from(1)Le An River in Jiangxi Province,south of China,and(2)several lakes located in southwest of Germany.Concentrations of heavymetals in these samples were determined.Moreover,the situations of heavy metal pollution in tworegions were comprehensively assessed by combined index of geoaccumulation with visualized multi-variate graphical method——modified Chernoff Face Graph.Face graphs intuitively demonstratedstrong heavy metal contamination in Le An River,especially copper pollution.However,in lakes’sedimental samples,contamination of other heavy metals showed mild or clean except cadmium andchromium. | Liu Wenxin Tang Hongxiao Luan Zhaokun Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China | 1997 | Journal of Environmental Sciences1997，9，1： | 1 |
| 8 | A Fast-Fractional Flow Reserve Simulation Method in A Patient with Coronary Stenosis Based on Resistance Boundary Conditions显示文摘Fractional flow reserve(FFR)is the gold standard to identify individual stenosis causing myocardial ischemia in catheter laboratory.The purpose of this study is to present a fast simulation method to estimate FFR value of a coronary artery,which can evaluate the performance of vascular stenosis,based on resistance boundary conditions.A patient-specific 3-dimensional(3D)model of the left coronary system with intermediate diameter stenosis was reconstructed based on the CTA images.The resistance boundary conditions used to simulate the coronary microcirculation were computed based on anatomical reconstruction of coronary 3D model.This study was performed by coupling the 3D coronary tree model with the lumped parameter model(0D model).The flow rate and pressure of coronary tree were calculated in twenty minutes.In addition,the effect of inlet pressure and myocardial mass on FFRss values has been investigated.The results showed that the effect of myocardial mass was greater than the effect of inlet pressure on FFRss.This FFRss simulation method can quickly and accurately assess the influence of coronary stenosis in aid clinical diagnosis. | Wenxin Wang Dalin Tang Boyan Mao Bao Li Xi Zhao Jian Liu Youjun Liu | 2018 | Computer Modeling in Engineering & Sciences2018，，8： | 1 |
| 9 | A neural network model and algorithm for the hybrid flow shop scheduling problem in a dynamic environment显示文摘 | Lixin Tang Wenxin Liu Jiyin Liu | 2005 | Journal of Intelligent Manufacturing2005，，3： | 1 |
| 10 | Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells显示文摘 | Haiyan You Jie Jin Huiqun Shu Bin Yu Angelo De Milito Francesco Lozupone Yun Deng Ning Tang Genfu Yao Stefano Fais Jianren Gu Wenxin Qin | 2009 | Cancer Letters2009，，1： | 1 |
| 11 | Summer atmospheric polybrominated diphenyl ethers in urban and rural areas of northern China显示文摘 | Chen Wang Wei Li Jiwei Chen Hongqijie Wang Tongchao Li Guofeng Shen Huizhong Shen Ye Huang Rong Wang Bin Wang Yanyan Zhang Jianhui Tang Wenxin Liu Xilong Wang Shu Tao | 2012 | Environmental Pollution2012，，： | 1 |
| 12 | Distribution of various aluminum fractions in surface water of the Le An River显示文摘Distribution of various aluminum fractions in surface water of the Le An RiverResearchCenterforEco-EnvironmentalSciences,Beijing100085,ChinaAbstract—Totalcon... | Liu Wenxin, Tang Hongxiao, Luan Zhaokun Research Center for Eco-Environmental Sciences, Beijing 100085, China | 1997 | Journal of Environmental Sciences1997，9，3： | 1 |
| 13 | Use of the Sediment Quality Triad to Assess Metal Contamination in Freshwater Superficial Sediments from the Le An River, China显示文摘 | Wenxin Liu Zhaokun Luan Hongxiao Tang | 1999 | Water Air and Soil Pollution (-)1999，，1： | 1 |
| 14 | A Neural Network Model and Algorithm for the Hybrid Flow Shop Scheduling Problem in a Dynamic Environment显示文摘 | Liu Wenxin Liu Jiyin | 2005 | Journal of Intelligent Manufacturing (Accepted)2005，，： | 1 |
| 15 | Thioredoxin-1 phosphorylated at T100 is needed for its anti-apoptotic activity in HepG2 cancer cells显示文摘 | Xiaoping Chen Wenxin Tang Shan Liu Longjiang Yu Zhengwang Chen | 2010 | Life Sciences2010，，7： | 1 |
| 16 | Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells显示文摘 | Haiyan You Jie Jin Huiqun Shu Bin Yu Angelo De Milito Francesco Lozupone Yun Deng Ning Tang Genfu Yao Stefano Fais Jianren Gu Wenxin Qin | 2009 | Cancer Letters2009，，1： | 1 |
| 17 | A neural network model and algorithm for the hybrid flow shop scheduling problem in a dynamic environment显示文摘 | Lixin Tang Wenxin Liu Jiyin Liu | 2005 | Journal of Intelligent Manufacturing2005，，3： | 1 |
| 18 | Insight in obsessive-compulsive disorder:conception,clinical characteristics,neuroimaging,and treatment显示文摘Obsessive-compulsive disorder(OCD)is a chronic disabling disease with often unsatisfactory therapeutic outcomes.The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders(DSM-5)has broadened the diagnostic criteria for OCD,acknowledging that some OCD patients may lack insight into their symptoms.Previous studies have demonstrated that insight can impact therapeutic efficacy and prognosis,underscoring its importance in the treatment of mental disorders,including OCD.In recent years,there has been a growing interest in understanding the influence of insight on mental disorders,leading to advancements in related research.However,to the best of our knowledge,there is dearth of comprehensive reviews on the topic of insight in OCD.In this review article,we aim to fill this gap by providing a concise overview of the concept of insight and its multifaceted role in clinical characteristics,neuroimaging mechanisms,and treatment for OCD. | Yueqi Huang Yazhu Weng Lan Lan Cheng Zhu Ting Shen Wenxin Tang Hsin-Yi Lai | 2023 | Psychoradiology2023，3，1： | 0 |
| 19 | A current-splitting method applied to 3-dimensional shallow-sea hydrodynamical model显示文摘The current-splitting method (CSM) for the study of ultra-shallow water storm surges proposed by the second author of the present paper is extended in this study to solve time-dependent problems. In the previous method the zero-order horizontal currents in the 3-dimensional storm surge model are split into two components: the wind-driven one and the gradient one, while the component generated by in- | Tang YongmingZhongshar University, guangzhou, ChinaSun Wenxin and Feng ShizuoOcean University of Qingdao,Qingdao,266003,China | 1991 | Acta Oceanologica Sinica1991，10，2： | 0 |
| 20 | Combating inconsistent evaluation of intra-tumor immune status by a novel transcriptomic signature in hepatocellular carcinoma显示文摘Dear Editor,Harnessing the power of the immune system via immune checkpoint inhibition has revolutionized the treatment paradigm of many malignancies,including hepatocellular carcinoma(HCC).1 Despite encouraging efficacy seen with the immune checkpoint blockade(ICB)agents in a subset of patients with HCC,however,there remain a large number of HCC patients experience ICB resistance and failed to derive durable benefit from these agents. | Linmeng Zhang Ning Tang Chen Yang Haigang Geng Hualian Hang Wenxin Qin Cun Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
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