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| 1 | A 16000-year pollen record of Qinghai Lake and its paleoclimate and paleoenvironment显示文摘The paleoclimate and paleoenvironment of Qinghai Lake indicated by a 16000-year pollen record are as follows. It was very cold and dry before 15200 years. During the Late Glacial, the climate varied from colder and semiarid to cool and semi-humid and fluctuated frequently but with little amplitude. Three cold events in the periods of 13400-13000, 11600-12000, and 11000-10400 aBP respectively correspond to the Oldest Dryas, Older Dryas and Younger Dryas events, whereas the two warm periods between them, 12000-13000 and 11600-11000 aBP, respectively correspond to Boiling and Allerod periods. The temperature increased abruptly after the Younger Dryas event, and then the climate gradually turned to be warm and wet from warm and semiarid. In the Holocene, the largest amplitude of cold event that occurred at ca. 8200 aBP is quite prominent. The Holocene climatic optimum culminated at 6700 aBP. After 2100 aBP, the climate tended to be cold and dry, keeping on up to now. Palaeoclimatic evolution and events of | LIU Xingqi SHEN Ji WANG Sumin YANG Xiangdong TONG Guobang ZHANG Enlou | 2002 | Chinese Science Bulletin2002，47，22： | 33 |
| 2 | Assessment of heavy metal enrichment and its human impact in lacustrine sediments from four lakes in the mid-low reaches of the Yangtze River, China显示文摘Sediments from four lakes in the mid-low reaches of the Yangtze River, Taibai Lake, Longgan Lake, Chaohu Lake and Xijiu Lake, were chosen to evaluate their enrichment state and history. The state of heavy metal enrichment was at a low level in the sediment of Taibai Lake and Longgan Lake. The enrichment state of Co, Cr and Ni was also low in the sediment of Chaohu Lake and Xijiu Lake, while Cu, Pb and Zn enrichment reached a higher level. Mass accumulation fluxes were calculated to quantitatively evaluate the anthropogenic contribution to heavy metals in the sediment. The anthropogenic accumulation fluxes were lower in the sediment of Taibai Lake and Longgan Lake compared with the other two lakes, where heavy metals, especially Cu, Pb and Zn, were mainly from anthropogenic sources. Heavy metal accumulation did not vary greatly in the sediment of Taibai Lake and Longgan Lake, while that in Chaohu Lake and Xijiu Lake increased since the 1950s and substantially increased since the 1980s, although a decrease occurred since 2000 AD in Xijiu Lake. Heavy metal enrichment was strongly related to human activities in the catchment. The development of urbanization and industrialization was much more rapid in the catchments of Chaohu Lake and Xijiu Lake than of the other two lakes, and thus large amounts of anthropogenically sourced heavy metals were discharged into the lakes, which resulted in a higher contamination risk. However, human activities in the Longgan Lake and Taibai Lake catchments mainly involved agriculture, which contributed a relatively small portion of heavy metals to the lakes. | Haijian Bing Yanhong Wu Enfeng Liu Xiangdong Yang | 2013 | Journal of Environmental Sciences2013，25，7： | 14 |
| 3 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://bigd.big.ac.cn/gsa or http://gsa.big.ac.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 4 | Extraction of heavy metals from e-waste contaminated soils using EDDS显示文摘Environmental contamination due to uncontrolled e-waste recycling activities is drawing increasing attention in the world. Extraction of these metals with biodegradable chelant [S,S]-ethylenediaminedisuccinic acid (EDDS) and the factors influencing extraction efficacy were investigated in the present study. Results showed that the addition of EDDS at low pH (5.5) produced higher metal extraction than that at high pH (8.0) solution. Metal speciation analysis indicated that Cu was completely complexed with EDDS at different pH conditions with various amounts of EDDS applied. For Pb and Zn, at low EDDS dose of 0.304 mol/kg soil, they were present as Pb- and Zn-EDDS. However, at high EDDS dose of 1.26 mol/kg soil, most of Pb was bound with dissolved organic matter. Ca and Al were found to be strong competitors for trace metals to EDDS at low application dose and low pH condition. | Renxiu Yang Chunling Luo Gan Zhang Xiangdong Li Zhenguo Shen | 2012 | Journal of Environmental Sciences2012，24，11： | 12 |
| 5 | Timing and splitting of nitrogen fertilizer supply to increase crop yield and efficiency of nitrogen utilization in a wheat–peanut relay intercropping system in China显示文摘Agronomically optimizing the timing and rates of nitrogen(N) fertilizer application can increase crop yield and decrease N loss to the environment. Wheat(Triticum aestivum L.)–peanut(Arachis hypogaea L.) relay intercropping systems are a mainstay of economic and food security in China. We performed a field experiment to investigate the effects of N fertilizer on N recovery efficiency, crop yield, and N loss rate in wheat–peanut relay intercropping systems in the Huang-Huai-Hai Plain, China during 2015–2017. The N was applied on the day before sowing, the jointing stage(G30) or the booting stage(G40) of winter wheat, and the anthesis stage(R1) of peanut in the following percentage splits: 50-50-0-0(N1), 35-35-0-30(N2), and 35-0-35-30(N3), using 300 kg N ha-1, with 0 kg N ha-1(N0) as control. ^(15)N-labeled(20.14 atom %) urea was used to trace the fate of N in microplots. The yields of wheat and peanut increased by 12.4% and 15.4% under the N2 and N3 treatments, relative to those under the N1 treatment. The ^(15)N recovery efficiencies( ^(15)NRE) were 64.9% and 58.1% for treatments N2 and N3, significantly greater than that for the N1 treatment(45.3%). The potential N loss rates for the treatments N2 and N3 were23.7% and 7.0%, significantly lower than that for treatment N1(30.1%). Withholding N supply until the booting stage(N3) did not reduce the wheat grain yield; however, it increased the N content derived from ^(15)N-labeled urea in peanuts, promoted the distribution of ^(15)N to pods, and ultimately increased pod yields in comparison with those obtained by topdressing N at jointing stage(N2). In comparison with N2, the N uptake and N recovery efficiency(NRE) of N3 was increased by 12.0% and 24.1%,respectively, while the apparent N loss decreased by 16.7%. In conclusion, applying N fertilizer with three splits and delaying topdressing fertilization until G40 of winter wheat increased total grain yields and NRE and reduced N loss. This practice could be an environment-friendly N management strategy for wheat–peanut relay intercropping systems in China. | Zhaoxin Liu Fang Gao Yan Liu Jianqun Yang Xiaoyu Zhen Xinxin Li Ying Li Jihao Zhao Jinrong Li Bichang Qian Dongqing Yang Xiangdong Li | 2019 | The Crop Journal2019，7，1： | 12 |
| 6 | Spatial variability of soil organic carbon in the forestlands of northeast China显示文摘Soil organic carbon(SOC) is an effective indicator of soil fertility and productivity, and it varies spatially and temporally in relation to other soil properties. Spatial variability of SOC in the forestlands of northeast China was characterized using geostatistics. Soil samples at the depths of 0?20 cm, 20?40 cm and 40?60 cm were collected from sixty-three temporary plots to evaluate SOC concentration and density(SOCD) and other soil properties. We analyzed correlations between SOC and soil properties. Soil organic carbon concentrations were high. The total amount of C stored in soil(0?60 cm) was 16.23 kg·m-2 with the highest SOCD of 7.98 kg?m-2 in topsoil. Soil properties in most cases differed by horizon, suggesting different processes and effects in each horizon. Soil organic carbon had positive relationships with total N, P and K as well as readily available K, but did not show a significant positive correlation with available P. Spatial factors including elevation, slope and aspect affected SOC distribution. Soil organic carbon at 0?60 cm had strong spatial autocorrelation with nugget/sill ratio of 5.7%, and moderate structured dependence was found at 0?20 cm, which indicated the existence of a highly developed spatial structure. Spatial distributionsof SOC concentration and SOCD were estimated using regression-kriging, with higher prediction accuracy than ordinary kriging. The fractal dimension of SOC indicated the preferential pattern of SOC distribution, with the greatest spatial heterogeneity and strongest spatial dependence in the northeast-southwest direction. | Ling Liu Haiyan Wang Wei Dai Xiangdong Lei Xiaojuan Yang Xu Li | 2014 | Journal of Forestry Research2014，25，4： | 11 |
| 7 | Characteristics of an early Holocene climate and environment from lake sediments in Ebinur region, NW China显示文摘The characteristics of climatic environment in the early Holocene epoch were studied through analyzing environmental proxies from the sediments in the Ebinur Lake--a closed one in the arid region. The pollen assemblage and other geochemical indices showed that, the temperature was somewhat low in the period (8.0-11.5 cal kaBP) as a whole, but in the early period (11.5-10.6 cal kaBP) the temperature was higher, in company with more precipitation. In the conversion period from the early Holocene epoch to the middle Holocene epoch (8.9-8.0 cal kaBP) the climate fluctuated remarkably. Particularly the three layers of peat sediment revealed the strong instability of climate in the early Holocene epoch in the Ebinur region. All information on the development of peat and the experimental data of pollen and stable isotopes implied that, the climatic condition at 8.2, 8.6 and 10.5 cal kaBP was characterized by noticeable cold and humidness, and could be regarded as three cold and humid events in the early Holocene epoch. | WU Jinglu SHEN Ji WANG Sumin JIN Zhangdong YANG Xiangdong | 2005 | Science China Earth Sciences2005，48，2： | 10 |
| 8 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 9 | FLEXIBLE MAGNETIC WHEEL TYPE INTELLIGENT WELDING ROBOT FOR SPHERICAL TANK显示文摘An intelligent welding robot for spherical tank's all-position multi-layer welds is developed. Based on the dynamics analyzing and simulation testing, a flexible magnetic wheel mechanism is created as the robot's walking carriage. It makes the robot directly attracted to the surface of the spherical tank so as to realize the all-position walking and welding without rail. At the same time, a CCD real-time tracing system is developed for the robot to repeatedly trace the all-position and multi-layer seams. The welding tests show that the welding robot can make the all-position and multi-layer welds with high tracing accuracy, excellent quality and reliable behavior, and it can be applied for practical production. | Jiang Lipei Jiao Xiangdong Xue Long Ma Hongze Li Mingli Yang Zhaochun Department of Mechanical Engineering, Institute of Petro-chemical Technology,Beijing 102600, China | 2002 | Chinese Journal of Mechanical Engineering2002，15，2： | 9 |
| 10 | The IRE1α-XBP1 pathway regulates metabolic stressinduced compensatory proliferation of pancreatic β-cells显示文摘 | Tongfu Xu Liu Yang Cheng Yan Xiaoxia Wang Ping Huang Feng Zhao Liyun Zhao Mingliang Zhang Weiping Jia Xiangdong Wang Yong Liu | 2014 | Cell Research2014，24，9： | 8 |
| 11 | Historical trophic evolutions and their ecological responses from shallow lakes in the middle and lower reaches of the Yangtze River: Case studies on Longgan Lake and Taibai Lake显示文摘The evolutions of diatom floras and the total phosphorous (TP) concentrations in the historical period were reconstructed for two lakes, Longgan and Taibai in the middle Yangtze River,based on high resolutional fossil diatom study from two sediment cores and an established regional diatom-TP transfer function. The TP concentration in Longgan Lake changed slightly in the range of 36-62 μg/L and kept its middle trophic level in the past 200 years. The changes of diatom assemblages reflect a macrophyte-dominated history of the lake. During the nineteenth century, the lake TP concentration increased comparatively, corresponding to the increase in abundance of benthic diatoms. The progressive increase of epiphytic diatoms since the onset of the twentieth century indicates the development of aquatic plants, coinciding with the twice drops of water TP level. The TP concentration in Taibai Lake kept a stable status about 50 μg/L before 1953 AD, while diatoms dominated by facultative planktonic Aulacoseira granulata shifted quickly to epiphytic diatom species, indicating a rapid expansion of aquatic vegetation. During 1953-1970 AD, the coverage of aquatic plants decreased greatly inferred by the low abundance of epiphytic diatoms as well as declined planktonic types, and the reconstructed TP concentration shows an obvious rising trend firstly, suggesting the beginning of the lake eutrophication. The lake was in the eutrophic condition after 1970, coinciding with the successive increase of planktonic diatoms. The comparison of the two lakes suggests the internal adjustment and purification function of aquatic plants for nutrients in water. The discrepancy of TP trends in the two lakes after 1960 reflects two different patterns of lake environmental response to human disturbance. Sediments in Taibai Lake clearly recorded the process of lake ecological transformation from the macrophyte-dominated stage to the algae-dominated stage. The limits of TP concentration (68-118 μg/L) in the transitional state can be considered as the critical value between the two stable ecosystems. Further work will be necessary to provide more evidence from the sediments in more eutrophic lakes for the primary inference. The reconstructive TP level and the inference of aquatic plants from fossil diatoms in different lakes, as well as their comparison provide a scientific basis for ecological restoration of eutrophic lakes in research regions. | YANG Xiangdong SHEN Ji DONG Xuhui LIU Enfeng WANG Sumin | 2006 | Science China Earth Sciences2006，49，z1： | 8 |
| 12 | Recent progress in flexible and wearable bio-electronics based on nanomaterials显示文摘能监视并且确定的灵活、可拉长的生物传感器特定的微型环境产生的电或化学的信号吸引了很多注意。能亲密地被纳入皮或组织的便携生物传感器为医药诊断和治疗提供一个新机会。在最近的年里,为灵活、可拉长的系统在设备集成和材料和生产过程的设计有庞大的进步。这里,我们在在灵活、可拉长的生物传感器采用的 nanomaterials 描述最近的开发。我们考察为象免除有机体的气体那样的重要生理、生物的标记的察觉使用的如此的生物传感器的成功的例子。而且,我们关于包括多功能的 nanomaterials 的综合平台提供最近的成就的详细概述。与在生物电子的多功能的 nanomaterials 的有效集成有关的问题和挑战也被讨论。 | Yanbing Yang Xiangdong Yang Yaning Tan Quan Yuan | 2017 | Nano Research2017，10，5： | 8 |
| 13 | The directional migration and differentiation of mesenchymal stem cells toward vascular endothelial cells stimulated by biphasic calcium phosphate ceramic显示文摘Osteoinductivity of porous calcium phosphate(CaP)ceramics has been widely investigated and confirmed,and it might be attributed to the rapid formation of the vascular networks after in vivo implantation of the ceramics.In this study,to explore the vascularization mechanism within the CaP ceramics,the migration and differentiation of bone marrow-derived mesenchymal stem cells(BMSCs)under the stimulation of porous biphasic calcium phosphate(BCP)ceramic with excellent osteoinductivity were systematically investigated.The results indicated that the directional migration of BMSCs toward BCP ceramic occurred when evaluated by using a transwell model,and the BMSCs migration was enhanced by the seeded macrophages on the ceramic in advance.Besides,by directly culturing BMSCs on BCP ceramic discs under both in vitro and in vivo physiological environment,it was found that the differentiation of BMSCs toward vascular endothelial cells(VECs)happened under the stimulation of BCP ceramic,as was confirmed by the up-regulated gene expressions and protein secretions of VECs-related characteristic factors,including kinase insert domain receptor,von willebrand factor,vascular cell adhesion molecule-1 and cadherin 5 in the BMSCs.This study offered a possibility for explaining the origin of VECs during the rapid vascularization process after in vivo implantation of porous CaP ceramics and could give some useful guidance to reveal the vascularization mechanism of the ceramics. | Ying Chen Jing Wang Xiangdong Zhu Xuening Chen Xiao Yang Kai Zhang Yujiang Fan Xingdong Zhang | 2018 | Regenerative Biomaterials2018，5，3： | 8 |
| 14 | The biological effect of recombinant humanized collagen on damaged skin induced by UV-photoaging:An in vivo study显示文摘The application of medical devices to repair skin damage is clinically accepted and natural polymer enjoys an important role in this field,such as collagen or hyaluronic acid,etc.However,the biosafety and efficacy of these implants are still challenged.In this study,a skin damage animal model was prepared by UV-photoaging and recombinant humanized type Ⅲ collagen(rhCol Ⅲ)was applied as a bioactive material to implant in vivo to study its biological effect,comparing with saline and uncrosslinked hyaluronic acid(HA).Animal skin conditions were non-invasively and dynamically monitored during the 8 weeks experiment.Histological observation,specific gene expression and other molecular biological methods were applied by the end of the animal experiment.The results indicated that rhCol Ⅲ could alleviate the skin photoaging caused by UV radiation,including reduce the thickening of epidermis and dermis,increase the secretion of Collagen Ⅰ(Col Ⅰ)and Collagen Ⅲ(Col Ⅲ)and remodel of extracellular matrix(ECM).Although the cell-material interaction and mechanism need more investigation,the effect of rhCol Ⅲ on damaged skin was discussed from influence on cells,reconstruction of ECM,and stimulus of small biological molecules based on current results.In conclusion,our findings provided rigorous biosafety information of rhCol Ⅲ and approved its potential in skin repair and regeneration.Although enormous efforts still need to be made to achieve successful translation from bench to clinic,the recombinant humanized collagen showed superiorities from both safety and efficacy aspects. | Jing Wang He Qiu Yang Xu Yongli Gao Peijie Tan Rui Zhao Zhanhong Liu Yajun Tang Xiangdong Zhu Chongyun Bao Hang Wang Hai Lin Xingdong Zhang | 2022 | Bioactive Materials2022，7，5： | 7 |
| 15 | Laparoscopic-assisted radical gastrectomy for distal gastric cancer显示文摘A 48-year-old female patient was diagnosed with a superficial depressed type early gastric cancer (type IIc) of 1.0 cm at the gastric angle as indicated by gastroscopy. Laparoscopic-assisted greater omentumpreserving D2 radical gastrectomy was performed in combination with Billroth I reconstruction under general anesthesia for the distal gastric cancer on April 5, 2013. The postoperative recovery was satisfying without complications. The patient was discharged seven days after surgery. | Yian Du Xiangdong Cheng Zhiyuan Xu Litao Yang Ling Huang Bing Wang Pengfei Yu Ruizeng Dong | 2013 | Chinese Journal of Cancer Research2013，25，4： | 6 |
| 16 | Determination of Elastoplastic Mechanical Properties of the Weld and Heat Affected Zone Metals in Tailor-Welded Blanks by Nanoindentation Test显示文摘The elastoplastic mechanical properties of the weld and heat affected zone metals have comparatively major impact on the forming process of tailor-welded blanks. A few scholars investigated the elastoplastic mechanical properties of the weld and heat affected zone, but they only simply assumed that it was a uniform distribution elastoplastic material different from the base materials. Four types of tailor-welded blanks which consist of ST12 and 304 stainless steel plates are selected as the research objects, the elastoplastic mechanical properties of the tailor-welded blanks weld and heat affected zone metals are obtained based on the nanoindentation tests, and the Erichsen cupping tests are conducted by combining numerical simulation with physical experiment. The nanoindentation tests results demonstrate that the elastoplastic mechanical properties of the weld and heat affected zone metals are not only different from the base materials, but also varying between the weld metals and the heat affected zone metals. Comparing the Erichsen cupping test resulted from numerical with that from experimental method, it is found that the numerical value of Erichsen cupping test which consider the elastoplastic mechanical properties of the weld and heat affected zone metals have a good agreement with the experimental result, and the relative error is only 4.8%. The proposed research provides good solutions for the inhomogeneous elastoplastic mechanical properties of the tailor-welded blanks weld and heat affected zone metals, and improves the control performance of tailor-welded blanks forming accuracy. | MA Xiangdong GUAN Yingping YANG Liu | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 6 |
| 17 | The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice显示文摘G-protein signaling and ubiquitin-dependent degradation are both involved in grain development in rice,but how these pathways are coordinated in regulating this process is unknown.Here,we show that Chang Li Geng 1(CLG1),which encodes an E3 ligase,regulates grain size by targeting the Gγprotein GS3,a negative regulator of grain length,for degradation.Overexpression of CLG1 led to increased grain length,while overexpression of mutated CLG1 with changes in three conserved amino acids decreased grain length.We found that CLG1 physically interacts with and ubiquitinats GS3which is subsequently degraded through the endosome degradation pathway,leading to increased grain size.Furthermore,we identified a critical SNP in the exon 3 of CLG1 that is significantly associated with grain size variation in a core collection of cultivated rice.This SNP results in an amino acid substitution from Arg to Ser at position 163 of CLG1 that enhances the E3 ligase activity of CLG1 and thus increases rice grain size.Both the expression level of CLG1 and the SNP CLG1163S may be useful variations for manipulating grain size in rice. | Wensi Yang Kun Wu Bo Wang Huanhuan Liu Siyi Guo Xiaoyu Guo Wei Luo Shengyuan Sun Yidan Ouyang Xiangdong Fu Kang Chong Qifa Zhang Yunyuan Xu | 2021 | Molecular Plant2021，14，10： | 6 |
| 18 | Characterization of miRNomes in Acute and Chronic Myeloid Leukemia Cell Lines显示文摘Myeloid leukemias are highly diverse diseases and have been shown to be associated with microRNA(miRNA) expression aberrations. The present study involved an in-depth miRNome analysis of two human acute myeloid leukemia(AML) cell lines, HL-60 and THP-1, and one human chronic myeloid leukemia(CML) cell line, K562, via massively parallel signature sequencing. mRNA expression profiles of these cell lines that were established previously in our lab facilitated an integrative analysis of miRNA and mRNA expression patterns. miRNA expression profiling followed by differential expression analysis and target prediction suggested numerous miRNA signatures in AML and CML cell lines. Some miRNAs may act as either tumor suppressors or oncomiRs in AML and CML by targeting key genes in AML and CML pathways. Expression patterns of cell type-specific miRNAs could partially reflect the characteristics of K562, HL-60 and THP-1 cell lines, such as actin filament-based processes, responsiveness to stimulus and phagocytic activity. miRNAs may also regulate myeloid differentiation, since they usually suppress differentiation regulators. Our study provides a resource to further investigate the employment of miRNAs in human leukemia subtyping, leukemogenesis and myeloid development. In addition, the distinctive miRNA signatures may be potential candidates for the clinical diagnosis, prognosis and treatment of myeloid leukemias. | Qian Xiong Yadong Yang Hai Wang Jie Li Shaobin Wang Yanming Li Yaran Yang Kan Cai Xiuyan Ruan Jiangwei Yan Songnian Hu Xiangdong Fang | 2014 | Genomics, Proteomics & Bioinformatics2014，12，2： | 6 |
| 19 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 20 | Human movement monitoring and behavior recognition for intelligent sports using customizable and flexible triboelectric nanogenerator显示文摘Effective collection,recognition,and analysis of sports information is the key to intelligent sports,which can help athletes to improve their skills and formulate scientific training plans and competition strategies.At present,wearable electronic devices used for movement monitoring still have some limitations,such as high cost and energy consumption,incompatibility of suitable flexibility and personalized spatial structure,dissatisfactory data analysis methods,etc.In this work,a novel three-dimensionalprinted thermoplastic polyurethane is introduced as the elastic shell and friction layer,and it endows the proposed customizable and flexible triboelectric nanogenerator(CF-TENG)with personalized spatial structure and robust correlation to external pressure.In practical application,it exhibits highly sensitive responses to the joint-bending motion of the finger,wrist,or elbow.Furthermore,a pressure-sensing insole and smart ski pole based on CF-TENG are manufactured to build a comprehensive sports monitoring system to transmit the athletes’motion information from feet and hands through the plantar pressure distribution and ski pole action.To recognize the movement status,the self-developed automatic peak recognition algorithm(P-Find)and machine learning algorithm(subspace K-Nearest Neighbors)were introduced to accurately distinguish the four typical motion behaviors and three primary sub-techniques of cross-country skiing,with accuracy rates of 98.2%and 100%.This work provides a novel strategy to promote the personalized applications of TENGs in intelligent sports. | YANG Yun HOU XiaoJuan GENG WenPing MU JiLiang ZHANG Le WANG XiangDong HE Jian XIONG Ji Jun CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，4： | 6 |
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