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| 1 | Comparsion analysis of data mining models applied to clinical research in Traditional Chinese Medicine显示文摘OBJECTIVE: To help researchers selecting appropriate data mining models to provide better evidence for the clinical practice of Traditional Chinese Medicine(TCM) diagnosis and therapy.METHODS: Clinical issues based on data mining models were comprehensively summarized from four significant elements of the clinical studies:symptoms, symptom patterns, herbs, and efficacy.Existing problems were further generalized to determine the relevant factors of the performance of data mining models, e.g. data type, samples, parameters, variable labels. Combining these relevant factors, the TCM clinical data features were compared with regards to statistical characters and informatics properties. Data models were compared simultaneously from the view of applied conditions and suitable scopes.RESULTS: The main application problems were the inconsistent data type and the small samples for the used data mining models, which caused the inappropriate results, even the mistake results. These features, i.e. advantages, disadvantages, satisfied data types, tasks of data mining, and the TCM issues, were summarized and compared.CONCLUSION: By aiming at the special features of different data mining models, the clinical doctors could select the suitable data mining models to resolve the TCM problem. | Yufeng Zhao Qi Xie Liyun He Baoyan Liu Kun Li Xiang Zhang Wenjing Bai Lin Luo Xianghong Jing Ruili Huo | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 14 |
| 2 | Enhanced Carotenoid Production by a Mutant of the Marine Yeast Rhodotorula sp. hidai显示文摘After a serial of UV, EMS and NTG mutagenesis, a mutant named MM of the red marine yeast strain Rhodotorula sp. hidai was obtained. The mutant MM could produce 603.93 μg g-1 of carotenoid within 5 days in the medium containing 4.0 g sucrose, 1.5 g yeast extract, 0.1 g MgSO4, and 100 mL of sea water, with pH 6.0 and at 30 ℃, while only 213.18 μg g-1 of carotenoid was pro-duced by the wild type under the same conditions. | CONG Li, CHI Zhenming*, LI Jing, and WANG Xianghong UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Qingdao 266003, P. R. China | 2007 | Journal of Ocean University of China2007，6，1： | 6 |
| 3 | Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia显示文摘 | Juanjuan Xin Yangshuai Su Zhaokun Yang Wei He Hong Shi Xiaoyu Wang Ling Hu Xiaochun Yu Xianghong Jing Bing Zhu | 2016 | Frontiers of Medicine2016，10，4： | 5 |
| 4 | Identification of Differentially-expressed Genes in Intestinal Gastric Cancer by Microarray Analysis显示文摘Gastric cancer(GC) is one of the most frequent malignant tumors. In order to systematically characterize the cellular and molecular mechanisms of intestinal GC development,in this study, we used 22 K oligonucleotide microarrays and bioinformatics analysis to evaluate the gene expression profiles of GC in 45 tissue samples, including 20 intestinal GC tissue samples,20 normal appearing tissues(NATs) adjacent to tumors and 5 noncancerous gastric mucosa tissue samples. These profiles allowed us to explore the transcriptional characteristics of GC and determine the change patterns in gene expression that may be of clinical significance. 1519 and 1255 differentially-expressed genes(DEGs) were identified in intestinal GC tissues and NATs, respectively,as determined by Bayesian analysis(P < 0.001). These genes were associated with diverse functions such as mucosa secretion, metabolism, proliferation, signaling and development, which occur at different stages of GC development. | Shizhu Zang Ruifang Guo Rui Xing Liang Zhang Wenmei Li Min Zhao Jingyuan Fang Fulian Hu Bin Kang Yonghong Ren Yonglong Zhuang Siqi Liu Rong Wang Xianghong Li Yingyan Yu Jing Cheng Youyong Lu | 2014 | Genomics, Proteomics & Bioinformatics2014，12，6： | 4 |
| 5 | Optimum Production and Characterization of an Acid Protease from Marine Yeast Metschnikowia reukaufii W6b显示文摘The marine yeast strain W6b isolated from sediment of the South China Sea was found to produce a cell-bound acid protease.The crude acid protease produced by this marine yeast showed the highest activity at pH 3.5 and 40 ℃.The optimal pH and temperature for the crude acid protease were in agreement with those for acid protease produced by the terrestrial yeasts.The optimal medium of the acid protease production was seawater containing 1.0% glucose, 1.5% casein, and 0.5% yeast extract, and the optimal cultivation conditions of the acid protease production were pH 4.0, a temperature of 25 ℃ and a shaking speed of 140 rmin-1.Under the optimal conditions, 72.5 UmL-1 of acid protease activity could be obtained in cell suspension within 48 h of fermentation at shake flask level.The acid protease production was induced by high-molecular-weight nitrogen sources and repressed by low-molecu-lar-weight nitrogen sources.Skimmed-milk-clotting test showed that the crude acid protease from the cell suspension of the yeast W6b had high skimmed milk coagulability.The acid protease produced by M.reukaufii W6b may have highly potential applications in cheese, food and fermentation industries. | LI Jing PENG Ying WANG Xianghong CHI Zhenming | 2010 | Journal of Ocean University of China2010，9，4： | 3 |
| 6 | Assessment of the determination of asodicarbonamide and its decomposition produet semiearbazide:investigation of variation in flour and flour products 显示文摘 | YE Jing WANG Xianghong SANG Yaxin | 2011 | Food and Feed Chemistry2011，59，17： | 1 |
| 7 | Photocatalytic ozonation of dimethyl phthalate with TiO 2 prepared by a hydrothermal method显示文摘 | Yuan Jing Laisheng Li Qiuyun Zhang Ping Lu Peihong Liu Xianghong Lü | 2011 | Journal of Hazardous Materials2011，，1： | 1 |
| 8 | Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission显示文摘 | Jeremy S. Rossman Xianghong Jing George P. Leser Robert A. Lamb | 2010 | Cell2010，，6： | 1 |
| 9 | A marine killer yeast against the pathogenic yeast strain in crab ( Portunus trituberculatus ) and an optimization of the toxin production显示文摘 | Xianghong Wang Zhenming Chi Lixi Yue Jing Li Meiju Li Longfei Wu | 2006 | Microbiological Research2006，，1： | 1 |
| 10 | Formation of ethyl carbamate and changes during fermentation and storage of yellow rice wine显示文摘 | Pinggu Wu Chenggang Cai Xianghong Shen Liyuan Wang Jing Zhang Ying Tan Wei Jiang Xiaodong Pan | 2014 | Food Chemistry2014，，： | 1 |
| 11 | Isolation and identification of a marine killer yeast strain YF07b and cloning of the gene encoding killer toxin from the yeast显示文摘It was found that the marine yeast strain YF07b could secrete a large amount of killer toxin against a pathogenic yeast strain WCY which could cause milky disease in Portunus trituberculatus.The marine yeast strain YF07b was identified to be Pichia anomala according to the results of routine yeast identification and 18S rDNA and ITS sequences.The gene encoding killer toxin in the marine yeast strain YF07b was amplified by PCR technology.After sequencing,the results show that an open reading frame,consisting of 1 281 bp,encoded a presumed protein of 427 amino acids.The sequence of the cloned gene was found to have 99% match with that of the gene encoding killer toxin in Pichia anomalas strain K.A signal peptide including 17 amino acids appeared in the N-terminal domain of the killer toxin.Therefore,the mature protein consisted of 410 amino acids,its molecular mass was estimated to be 47.4 ku and its isoelctronic point was 4.5. | WANG Xianghong CHI Zhenming LI Jing | 2007 | Acta Oceanologica Sinica2007，26，6： | 1 |
| 12 | Vapor-Liquid Equilibrium of Ethylene + Mesitylene System and Process Simulation for Ethylene Recovery显示文摘The amount of ethylene in refinery off-gas is high with a mass fraction of 20%,but the refinery off-gas is usually used as fuel gas in most refineries.The separation and recovery of ethylene is of remarkable significance for saving energy and reducing carbon dioxide emission.The aim of this paper is to use a novel absorbent mesitylene for the ethylene absorption process and assess its application feasibility through the ethylene + mesitylene vapor-liquid equilibrium data measurement and its binary interaction parameter correlation,as well as the simulation for ethylene separation process. | GUO Jing WU Xianghong JING Shuhong ZHANG Qian ZHENG Danxing | 2011 | Chinese Journal of Chemical Engineering2011，19，4： | 0 |
| 13 | Occurrence and Diversity of Pichia spp. in Marine Environments显示文摘A total of 328 yeast strains from seawater,sediments,mud of salterns,the guts of marine fish and marine algae were obtained. The results of routine identification and molecular methods show that five yeast strains obtained in this study belonged to Pichia spp.,including Pichia guilliermondii 1uv-small,Pichia ohmeri YF04d,Pichia fermentans YF12b,Pichia burtonii YF11A and Pichia anomala YF07b. Further studies revealed that Pichia anomala YF07b could produce killer toxin against pathogenic yeasts in crabs while Pichia guilliermondii 1uv-small could produce high activity of extracellular inulinase. It is advisable to test if Pichia ohmeri YF04d obtained in this study is related to central-venous-catheter-associated infection. | LI Jing CHI Zhenming WANG Xianghong WANG Lin SHENG Jun GONG Fang | 2008 | Journal of Ocean University of China2008，7，3： | 0 |
| 14 | MomL inhibits bacterial antibiotic resistance through the starvation stringent response pathway显示文摘Antibiotic resistance in gram-negative pathogens has become one of the most serious global public health threats.The role of the N-acyl homoserine lactone(AHL)-mediated signaling pathway,which is widespread in gram-negative bacteria,in the bacterial resistance process should be studied in depth.Here,we report a degrading enzyme of AHLs,MomL,that inhibits the antibiotic resistance of Pseudomonas aeruginosa through a novel mechanism.The MomL-mediated reactivation of kanamycin is highly associated with the relA-mediated starvation stringent response.The degradation of AHLs by MomL results in the inability of LasR to activate relA,which,in turn,stops the activation of downstream rpoS.Further results show that rpoS directly regulates the type VI secretion system H2-T6SS.Under MomL treatment,inactivated RpoS fails to regulate H2-T6SS;therefore,the expression of effector phospholipase A is reduced,and the adaptability of bacteria to antibiotics is weakened.MomL in combination with kanamycin is effective against a wide range of gram-negative pathogenic bacteria.Therefore,this study reports a MomL-antibiotic treatment strategy on antibiotic-resistant bacteria and reveals its mechanism of action. | Qin Dou Jin Yuan Rilei Yu Jiahui Yang Jiayi Wang Yuxiang Zhu Jing Zhong Hongan Long Zhiqing Liu Xianghong Wang Yuying Li Yichen Xiao Jiazhen Liang Xiao-Hua Zhang Yan Wang | 2022 | mLife2022，1，4： | 0 |
| 15 | Clinical pathology of nodal micrometasteses in non-small cell lung cancer显示文摘Objective:To explore whether the conventional pathologic stages of some non-small cell lung cancer (NSCLC) patients were underestimated.Methods:195 lymph node samples were taken from 25 NSCLC patients during the operations.Firstly,each resulting tissue block was processed for routine paraffin embedding.Then the 6~10 serial sections were chosen,each 5 μm thick,from every paraffin block of the lymph node.Finally,the first and the second last sections of each lymph node were stained by hematoxylin eosin (HE),and the other serial sections were used for the immunohistochemical (IHC) staining examination with the monoclonal antibody against cyokeratin 19.Results:With HE staining,30 of the 195 regional lymph nodes revealed dominant nodal metastases,and none showed micrometastases.IHC staining was performed on 135 lymph nodes that were identified as free of metastases by HE staining,31 showed micrometastases;none showed gross nodal metastases.There was a significant difference between HE staining staging and IHC staining staging (P<0.05).Conclusion:Conventional HE staining can accurately detect gross nodal metastases in the lymph nodes of NSCLC patients,but is unfit for detecting lymph nodal micrometastases.IHC staining analysis can significantly facilitate the detection of occult micrometastatic tumor cells in lymph nodes,and its assessment of nodal micrometastases can provide a refinement of TNM stage for NSCLC patients.Our results provide a rationale for extensive lymph nodes sampling. | Wang Yunxi Zhang Jing Chu Xiangyang Sun Yu'e Wang Zhanbo Li Xianghong Tong Xinyuan | 2012 | Journal of Medical Colleges of PLA(China)2012，27，2： | 0 |
| 16 | Rational design of smart adsorbent equipped with a sensitive indicator via ligand exchange:A hierarchical porous mixed-ligand MOF for simultaneous removal and detection of Hg^(2+)显示文摘The increasing accumulation of toxic mercury species in water environment has posed a serious health threat worldwide, making it inevitable to develop the versatile materials to achieve efficient prevention and remediation of mercury pollution. Guided by the solvent-assisted ligand exchange (SALE) approach, this work rationally constructed a mixed-ligand NH2-UiO-66-SH (NSU66) with hierarchical-pore structure by incorporating the thiol-rich ligands (H2DMBD) into the water-stable NH2-UiO-66 (NU66) precursor to act as a smart adsorbent equipped with sensitive detector for simultaneous sensing and removal of Hg2+. Unlike the traditional adsorbents, the as-prepared NSU66 not only exhibits a remarkable removal ability with fast capture rate (within 60.0 min), large uptake capacity (265.29 mg/g), and qualified selectivity, but also possesses satisfactory sensing capability, accompanied by low detection limit (3.50 × 10−2 µM), wide linear range (1.00–99.7 µM), high specificity, and strong anti-interference capability. The detection function plays a vital role in indicating the removal behavior and the pre-enrichment effect of adsorption process correspondingly improves the sensitivity of indicator. Notably, the sensing and trapping capabilities of NSU66 are significantly improved compared to the NU66, which stems from the delicate design of the mixed-ligand and hierarchical-pore structure. Furthermore, proven excellent stability and recyclability emphasize the feasibility of NSU66 in practical applications. These results suggest that the smart NSU66 adsorbent can serve as a favorable platform for early warning and guided removal of toxic Hg2+ in water. | Liang Zhang Jing Wang Huiting Wang Wentao Zhang Wenxin Zhu Ting Du Yongsheng Ni Xianghong Xie Jing Sun Jianlong Wang | 2021 | Nano Research2021，14，5： | 0 |
| 17 | Selection of Yarrowia lipolytica Strains with High Protein Content from Yeasts Isolated from Different Marine Environments显示文摘A total of 78 Yarrowia lipolytica yeast strains from seawater, sediments, mud of salterns, the guts of marine fish, and marine algae were obtained. After the crude protein of the yeasts was estimated by the method of Kjehldahl, we found that seven strains of the marine yeasts grown in soy bean cake hydrolysate with 20 g L-1 of glucose for 48 h at 28℃ contained more than 41.0 g protein per 100 g of cell dry weight and the cell dry weight was more than 4.4 g per L of the culture. Among them, strain SWJ-1b contained the highest crude protein. The results of Biolog identification and molecular methods further confirmed that they indeed belonged to Y. lipolytica. | CHI Zhenming WANG Fang WANG Lin LI Jing WANG Xianghong | 2007 | Journal of Ocean University of China2007，6，4： | 0 |
| 18 | Removal of Arsenic from Chlamys farreri with Different Methods显示文摘Arsenic is commonly found in seafood,and the toxicity of different speciation varies widely.Therefore,there is an urgent need to reduce the content and analyze the speciation of arsenic to improve the safety of seafood.In this study,arsenic was removed from Chlamys farreri by adding ferric ions and sodium citrate or reducing the salinity of seawater.Then,the speciation of arsenic was analyzed.The results showed that the removal rates of arsenic were 20%,23%,24%and 18%when C.farreri individuals were treated with 0.1 g L^(−1)Fe^(3+),0.4 g L^(−1),0.6 g L^(−1)sodium citrate or decreasing seawater salinity to 17 within 48 h,respectively.Furthermore,it was detected that the arsenic speciation in the C.farreri was mainly polar arsenic,and among the polar arsenic was mainly arsenic betaine.These results indicated that the removal of arsenic can be achieved by adding the removal agent or changing the seawater salinity under the experimental conditions.The speciation of arsenic did not change during the removal process and it was mainly excreted in the speciation of arsenic betaine. | HE Jing LIU Qingkang MENG Xianghong LIU Bingjie | 2022 | Journal of Ocean University of China2022，21，6： | 0 |
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