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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Atomically dispersed Au_1 catalyst towards efficient electrochemical synthesis of ammonia显示文摘Tremendous efforts have been devoted to explore energy-efficient strategies of ammonia synthesis to replace Haber–Bosch process which accounts for 1.4% of the annual energy consumption. In this study,atomically dispersed Au_1 catalyst is synthesized and applied in electrochemical synthesis of ammonia under ambient conditions. A high NH_4^+ Faradaic efficiency of 11.1% achieved by our Au_1 catalyst surpasses most of reported catalysts under comparable conditions. Benefiting from efficient atom utilization, an NH_4^+ yield rate of 1,305 lg h^(-1) mg_(Au)^(-1) has been reached, which is roughly 22.5 times as high as that by supported Au nanoparticles. We also demonstrate that by employing our Au_1 catalyst, NH4+can be electrochemically produced directly from N_2 and H_2 with an energy utilization rate of 4.02 mmol kJ^(-1). Our study provides a possibility of replacing the Haber–Bosch process with environmentally benign and energy-efficient electrochemical strategies. | Xiaoqian Wang Wenyu Wang Man Qiao Geng Wu Wenxing Chen Tongwei Yuan Qian Xu Min Chen Yan Zhang Xin Wang Jing Wang Jingjie Ge Xun Hong Yafei Li Yuen Wu Yadong Li | 2018 | Science Bulletin2018，63，19： | 22 |
| 3 | Lung transplantation as therapeutic option in acute respiratory distress syndrome for coronavirus disease 2019-related pulmonary fibrosis显示文摘Background:Critical patients with the coronavirus disease 2019(COVID-19),even those whose nucleic acid test results had turned negative and those receiving maximal medical support,have been noted to progress to irreversible fatal respiratory failure.Lung transplantation(LT)as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients.Methods:From February 10 to March 10,2020,three male patients were urgently assessed and listed for transplantation.After conducting a full ethical review and after obtaining assent from the family of the patients,we performed three LT procedures for COVID-19 patients with illness durations of more than one month and extremely high sequential organ failure assessment scores.Results:Two of the three recipients survived post-LT and started participating in a rehabilitation program.Pearls of the LT team collaboration and perioperative logistics were summarized and continually improved.The pathological results of the explanted lungs were concordant with the critical clinical manifestation,and provided insight towards better understanding of the disease.Government health affair systems,virology detection tools,and modern communication technology all play key roles towards the survival of the patients and their rehabilitation.Conclusions:LT can be performed in end-stage patients with respiratory failure due to COVID-19-related pulmonary fibrosis.If confirmed positive-turned-negative virology status without organ dysfunction that could contraindicate LT,LT provided the final option for these patients to avoid certain death,with proper protection of transplant surgeons and medical staffs.By ensuring instant seamless care for both patients and medical teams,the goal of reducing the mortality rate and salvaging the lives of patients with COVID-19 can be attained. | Jing-Yu Chen Kun Qiao Feng Liu Bo Wu Xin Xu Guo-Qing Jiao Rong-Guo Lu Hui-Xing Li Jin Zhao Jian Huang Yi Yang Xiao-Jie Lu Jia-Shu Li Shu-Yun Jiang Da-Peng Wang Chun-Xiao Hu Gui-Long Wang Dong-Xiao Huang Guo-Hui Jiao Dong Wei Shu-Gao Ye Jian-An Huang Li Zhou Xiao-Qin Zhang Jian-Xing He | 2020 | Chinese Medical Journal2020，，12： | 19 |
| 4 | Glacier runoff variation and its influence on river runoff during 1961–2006 in the Tarim River Basin, China显示文摘Using monthly precipitation and temperature data from national meteorological stations, 90 m resolution DEM and a digital vector map of modern glaciers from the Chinese Glacier Inventory, the glacier mass balance and glacier runoff in the Tarim River Basin (TRB), China, were estimated based on a monthly degree-day model for 1961–2006. The results suggest that the modified monthly degree-day model can simulate the long-term changes in glacier mass balance and glacier runoff, which have been confirmed by short-term observation data and other results in literatures. The characteristics and trends of mass balance and glacier runoff variation were analyzed. It was found that the mean annual glacier mass balance during 1961–2006 was ?139.2 mm per year and the cumulative mass balance over the 46 year period was ?6.4 m in the TRB. The glacier mass balance displayed a clear decreasing trend over the entire TRB during 1961–2006. The average annual glacier runoff in the TRB was 144.16×108 m3 for 1961–2006. The results also show that glacier runoff has increased in the last 46 years, especially since the 1990s with 85.7% of the increased river flow being derived from the increased glacier runoff caused by loss of ice mass. Over the entire TRB, glacier runoff accounts for 41.5% of the total river flow during 1961–2006. The impact of glacier runoff on river flow has increased in the TRB as a result of glacier shrinkage. | Xin Gao BaiSheng Ye ShiQiang Zhang ChengJun Qiao XiaoWen Zhang | 2010 | Science China Earth Sciences2010，53，6： | 16 |
| 5 | Abnormal Failure Analysis of H13 Punches in Steel Squeeze Casting Process显示文摘In steel squeeze casting process, the working condition of a punch was very rigorous. The abnormal failure models of an H13 punch, such as plastic rubbed damnification, could not be avoided easily. Based on the analysis of the flow stress and the friction-shearing stress of an H13 punch in steel squeeze casting process, the following results were obtained: if the flow stress of an H13 punch was smaller than its friction-shearing stress, these abnormal failures could not be avoided; and if there were some protection measures that enable the flow stress to have a greater value than its friction-shearing one, the abnormal failures would not occur. In the production of 45# steel valves and catenary system components, the flow stress of a lateral H13 punch without any protection measure was about 29 MPa and its friction-shearing stress was about 51 MPa, then, the abnormal failures occurred; however, when the protection measures of the punch enabled its working temperature to have a value below 682 ℃, its flow stress was greater than its friction-shearing stress, and the abnormal failures were avoided. | ZHANG Mi-lan XING Shu-ming XIN Qiao XIAO Li-ming GOU Jun-nian WU Xia-ling | 2008 | Journal of Iron and Steel Research(International)2008，15，3： | 13 |
| 6 | Four new constituents from Taraxacum mongolicum显示文摘二新黄酮 glycosides ,isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- l-arabinopyranoside ( 1 )和isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- d-glucopyranoside ( 2 ),新 lignan , mongolicumin A ( 3 ),和新 guaianolide , mongolicumin B ( 4 )从薄公英属 mongolicum 的天线部分被孤立。他们的结构被主要阐明光谱分析。 | Shu Yun Shi Qi Zhou Hua Peng Chang Xin Zhou Ming Hui Hu Qiao Feng Tao Xiao Jiang Hao Joachim Stoeckigt Yu Zhao | 2007 | Chinese Chemical Letters2007，18，11： | 11 |
| 7 | Epidemiology of hospitalized pediatric glaucoma patients in Beijing Tongren Hospital显示文摘对在中国的小儿科的绿内障的流行和发生的背景不基于人口的评价是可得到的。这里,我们在我们考察了的 China.Methods 在北京 Tongren 医院里描述就医的小儿科的绿内障病人的光谱小儿科的病人的图表,从出生到 18 岁与北京 Tongren 医院里的绿内障的分泌物诊断,从 2002 ~ 2008。所有孩子为反绿内障外科被招收,对待绿内障的 sequelae,或管理手术后的复杂并发症。我们评估了人口统计的特征和不同绿内障 subtypes.Results 的比例小儿科的病人(n=1452 ) 从 2002 ~ 2008 说明了 12.91% 全部的绿内障住院病人,并且最后,小儿科的绿内障的数据为在中国来自 28 个省,自治市和自治区域的 1055 个孩子被介绍。男孩们所有年龄在所有子类型和 et 是更普通的,与到 2.32:1 的女孩的男孩的全部的比率。先天的绿内障是最普通的子类型,在所有病人的为 46.07% 的财务和在不到 3 岁的孩子的为 69.95% 的财务。先天的绿内障病人的中部的介绍年龄是有创伤的绿内障的 2 years.Patients 是第二个很普通的组(n=128, 12.13%) ,并且在老年介绍了(中部的介绍年龄是 11 年) 。创伤的绿内障的多数发生在在 10 和 15 岁之间的孩子(n=72, 56.25%) 。Aphakic 绿内障是第三个大多数普通(9.19%) 先天的绿内障是的 subtype.Conclusions 在在北京 Tongren 的就医的小儿科的病人的最流行的绿内障子类型医院。创伤的绿内障的预防和治疗能在开发国家减少视觉损坏的发生。为绿内障的靠近的后续在小儿科的奔流外科以后是重要的。 | QIAO Chun-yan WANG Liang-hai TANG Xin WANG Tao YANG Di-ya WANG Ning-li | 2009 | Chinese Medical Journal2009，，10： | 11 |
| 8 | Anycast service model and its QoS routing algorithm显示文摘In the Internet, a group of replicated servers is commonly used in order to improve the scalability of network service. Anycast service is a new network service that can improve network load distribution and simplify certain applications. In this paper, the authors described a simple anycast service model in the Internet without significant affecting the routing and protocol processing infrastructure that was already in place, and proposed an anycast QoS routing algorithm for this model. The algorithm used randomized method to balance network load and improve its performance. Several new techniques are proposed in the algorithm, first, theminimum hops for each node are used in the algorithm, which are used as metric for computing the probability of possible out links. The metric is pre computed for each node in the network, which can simplify the network complexity and provide the routing process with useful information. Second, randomness is used at the link level and depends dynamically on the routing configuration. This provides great flexibility for the routing process, prevents the routing process from overusing certain fixed routing paths, and adequately balances the delay of the routing path. the authors assess the quality of QoS algorithm in terms of the acceptance ratio on anycast QoS requests, and the simulation results on a variety of network topologies and on various parameters show that the algorithm has good performances and can balance network load effectively. | WANG Jian xin, CHEN Song qiao, CHEN Jian er (College of Information Science and Engineering, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001，8，2： | 11 |
| 9 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 10 | Synthesis of CNT film on the surface of micro-pyramid array and its intense pulsed emission characteristics显示文摘We developed a new scheme to suppress the electric-field-screening effect in high growth density of a carbon nanotube(CNT) film during its intense pulsed emission.We synthesize the CNT film on a tridimensional surface(t-CNT film).The tridimensional surface includes wet etched silicon pyramids,and the Ni layer is electroless plated thereon.The intense pulsed emission characteristics of the t-CNT and planar-grown CNT(p-CNT) films were measured using a diode structure in single-pulse mode.The even turn-on field decreased from 5.5 V/μm for p-CNTs to 2.8 V/m for t-CNTs,and the peak emission current increased from 232 A for p-CNTs to 324 A for t-CNTs at a peak field intensity ~12.2 V/m.The peak current of the t-CNT film increased by ~39.7% over the p-CNT film.It is clear that the micro-pyramid array can effectively suppress the field screening effect to improve the electron-emission of CNT films. | ZENG FanGuang LI Xin LIU WeiHua QIAO ShuZhen MA HuaLi ZHANG Rui XIA LianSheng CHEN Yi LIU XingGuang ZHANG Huang | 2012 | Chinese Science Bulletin2012，57，14： | 10 |
| 11 | Establishing a human pancreatic stem cell line and transplanting induced pancreatic islets to reverse experimental diabetes in rats显示文摘The major obstacle in using pancreatic islet transplantation to cure type I and some type II diabetes is the shortage of the donors. One of ways to overcome such obstacle is to isolate and clone pancreatic stem cells as 'seed cells' and induce their differentiation into functional islets as an abundant trans-plantation source. In this study, a monoclonal human pancreatic stem cell (mhPSC) line was obtained from abortive fetal pancreatic tissues. Pancreatic tissues were taken from abortive fetus by sterile procedures, and digested into single cells and cell clusters with 0.1% type IV collagenase. Cultured in modified glucose-low DMEM with 10% fetal bovine serum (FBS), these single cells and cell clusters adhered to culture dishes, and then primary epidermal-like pancreatic stem cells started to clone. After digesting with 0.25% trypsin and 0.04% EDTA, fibroblasts and other cells were gradually eliminated and epithelioid pancreatic stem cells were gradually purified during generations. Using clone-ring selection, the mhPSCs were obtained. After addition of 10 ng/mL epidermal growth factor (EGF) in cell culture medium, the mhPSCs quickly grew and formed a gravelstone-like monolayer. Continuously proliferated, a mhPSC line, which was derived from a male abortive fetus of 4 months old, has been passed through 50 generations. More than 1×109 mhPSCs were cryo-preserved in liquid nitrogen. Karyotype analysis showed that the chromosome set of the mhPSC line was normal diploid. Immunocytochemistry results demonstrated that the mhPSC line was positive for the pdx1, glucagon, nestin and CK19, and negative for the insulin, CD34, CD44 and CD45 protein expression. RT-PCR revealed further that the mhPSCs expressed transcription factors of the pdx1, glucagon, nestin and CK19. Also, in vitro induced with β-mercaptoethanol, the mhPSCs differentiated into nerve cells that expressed the NF protein. Induced with nicotinamide, the mhPSCs differentiated into functional islet-like clusters, as identified by di-thizone staining, which expressed the transcription factor of the insulin and secreted the insulin and C-peptide. Furthermore, the transplantation of mhPSCs-induced pancreatic islets into the subcapsular region of the kidney in streptozotocin-induced diabetic rats could reduce blood glucose levels and prolong the life time. | XIAO Mei AN LiLong YANG XueYi GE Xin QIAO Hai ZHAO Ting MA XiaoFei FAN JingZhuang ZHU MengYang DOU ZhongYing | 2008 | Science China(Life Sciences)2008，51，9： | 9 |
| 12 | Role of C6ORF120, an N-glycosylated protein, is implicated in apoptosis of CD4+ T lymphocytes显示文摘背景尽管CD4+ T 房间 apoptosis 和CD8+ T 房间回答广泛地在 HIV 感染期间被学习了, apoptosis 怎么发信号,在房间仍然需要是在场的 elucidated.The 的CD4+ T 被开始学习被设计描绘功能未知的基因, C6orf120 ,并且阐明它在 导致tunicamycin 的CD4+ T apoptosis.Methods 的主要角色编码顺序的 C6orf120 从外部血 mononuclear 房间( PBMC )被放大爱滋病 patients.The DNA 碎片的全部的 RNA | LI Xin QIAO Yong CHANG Lu-si XIAO Fan LU Lian-he HAO Xiao-hua ZHANG Ren-wen WU Hao WEI Hong-shan | 2011 | Chinese Medical Journal2011，，21： | 8 |
| 13 | A new biflavonoid from Selaginella labordei Hieron.ex Christ显示文摘新 biflavonoid, 2,3-dihydro-5,5 ′ ′, 7,7 ′ ′, 4 ′ -pentahydroxy-6,6′′-dimethyl-[3′-O-4′′′]-biflavone 1 和二已知的 biflavonoids 2,3 ′ ′ -dihydroochnaflavone 2 和 2 ′ ′, 3 ′ ′ -dihydro-3′,3′′′-biapigenin 3 从 Selaginella labordei 神庙的植物被孤立。前基督。他们的结构被分光镜的方法阐明。 | Jia Cheng Xu Xin Qiao Liu Ke Li Chen | 2009 | Chinese Chemical Letters2009，20，8： | 7 |
| 14 | Improvement in the intense pulsed emission stability of grown CNT films via an electroless plated Ni layer显示文摘Carbon nanotube(CNT)films were grown on silicon wafers with and without a nickel layer(Si-CNT and Ni-CNT)via the pyrolysis of iron phthalocyanine.The nickel layer was prepared using the electroless plating method.To study the emission stability of Si-CNT and Ni-CNT cathodes during intense pulsed emission,emission characteristics were measured repeatedly with a diode structure using a Marx generator as a voltage source.For the peak values of the pulsed voltage,which were in the range between 1.62-1.66 MV(corresponding to electric field intensities between 11.57-11.85 V/μm),the first cycle emission current was 109.4 A for Si-CNT and 180.5 A for Ni-CNT.By comparing the normalized emission currents of the Si-CNT and Ni-CNT cathodes,the improvement in the emission stability can be easily quantified.The number of emission cycles necessary for the peak current to decay from 100%to 50%increased from^3 for Si-CNT to^11 for a Ni-CNT film. | ZENG FanGuang LI Xin LIU WeiHua QIAO ShuZhen MA HuaLi ZHANG Rui XIA LianSheng CHEN Yi LIU XingGuang ZHANG Huang | 2011 | Chinese Science Bulletin2011，56，22： | 7 |
| 15 | Millennial climate changes since MIS 3 revealed by element records in deep-sea sediments from northern South China Sea显示文摘High resolution elemental records in core MD05-2903 from the northern South China Sea were obtained from XRF scanning and grain size and mineral component analyses.The K/Ti curve reveals climate changes since MIS 3 on a millennial scale,representing one of the best such records so far from deep-sea sediments of the South China Sea.When compared our K/Ti record with other climate records from high latitude ice cores and from East Asia stalagmites,variations in the K/Ti record show some typical saw-shaped features of rapid climate changes in the Northern Hemisphere.Grain size analysis reveals a close relationship between variations in K/Ti and in the fine end-member grain size.XRD analysis confirms that high K/Ti layers were dominated by K-rich weathering minerals,especially illite,while low K/Ti layers contain low illite but high abundance of Ti-rich heavy minerals.Therefore,the K/Ti record reflects changes in the input and deposition of fine weathering minerals and heavy minerals in the northern South China Sea region during stadials and interstadials.These elemental changes were largely controlled by variations in rainfall,erosion,and fluvial transportation induced by East Asia Monsoon. | Xin Xie Hong-Bo Zheng Pei-Jun Qiao | 2014 | Chinese Science Bulletin2014，59，8： | 7 |
| 16 | Gender difference of clinical characteristics in Chinese patients with spontaneous variant angina显示文摘变体咽峡炎(VA ) 的背景自发的攻击是冠的动脉疾病(CAD ) 的一个唯一的部件,并且与严重心脏的事件联系。然而,没有数据关于在有 VA 的自发的攻击的中国病人的性差别是可得到的。因此,现在的回顾的学习被开始从 2003 年 1 月随 VA.Methods 的自发的攻击评估中国女病人的临床的特征到 2008 年 1 月, 209 个病人的一个总数被诊断在 Fu Wai 让了 VA 的自发的攻击医院。他们, 27 是女性,并且他们的临床的调查结果是镇定的并且与为风险因素,临床的特征和 angiographical findings.Results 的方面的男病人相比 VA 的自发的攻击与男病人相比在女性(12.9%) 是相对不平常的。女病人多半是更少有吸烟的历史(14.8%对79.7%, P < 0.001 ),更可能有 CAD 的家庭历史(33.3%对11.0%, P < 0.01 ),并且在攻击期间让了室的纤维性颤动的更大的发生(11.1%对2.2%, P < 0.05 )。在在经历了有的 VA 的自发的攻击的二个 groups.Conclusion 汉语女性病人之间的另外的特征没有重要差别更少的吸烟历史, CAD 的更多的家庭历史和比男病人的室的纤维性颤动的更高的出现的特征。 | ZHU Cheng-gang LI Jian-jun XU Yan-lu YUAN Jin-qing QIN Xue-wen YANG Yue-jin QIAO Shu-bin CHEN Ji-lin CHEN Zai-jia GUO Yuan-lin GAO Zhan ZHENG Xin | 2010 | Chinese Medical Journal2010，，11： | 6 |
| 17 | A new bibenzyl derivative from Pleione bulbocodioides显示文摘A new bibenzyl derivative 1,named 2-(4'-hydroxybenzyl)-3-(3'-hydroxyphenethyl)-5-methoxy-cyclohexa-2,5-diene-1,4- dione,and two known stilbenoids(2,3)were isolated from the tubers of Pleione bulbocodioides(Franch.)Rolfe.Their structures were elucidated by spectroscopic methods. | Xin Qiao Liu Qiao Yu Yuan Yuan Qiang Guo | 2008 | Chinese Chemical Letters2008，19，5： | 6 |
| 18 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 19 | Effect of experimental warming on soil respiration under conventional tillage and no-tillage farmland in the North China Plain显示文摘Understanding the response of soil respiration to global warming in agro-ecosystem is crucial for simulating terrestrial carbon(C) cycle.We conducted an infrared warming experiment under conventional tillage(CT) and no-tillage(NT) farmland for winter wheat and summer maize rotation system in North China Plain(NCP).Treatments include CT with and without warming(CTW and CTN),NT with and without warming(NTW and NTN).The results indicated that warming had no significant effect on soil moisture in irrigated farmland of NCP(P>0.05).The elevated average soil temperature of 1.1-1.6°C in crop growing periods could increase annual soil CO_2 emission by 10.3%in CT filed(P>0.05),but significantly increase it by 12.7%in NT field(P<0.05),respectively.The disturbances such as plowing,irrigation and precipitation resulted in the obvious soil CO_2 emission peaks,which contributed 36.6-40.8%of annual soil cumulative CO_2 emission.Warming would enhance these soil CO_2 emission peaks;it might be associated with the warming-induced increase of autotrophic respiration and heterotrophic respiration.Compared with un-warming treatments,dissolved organic carbon(DOC) and soil microbial biomass carbon(MBC) in warming treatments were significantly increased by 11.6-23.4 and 12.9-23.6%,respectively,indicating that the positive responses of DOC and MBC to warming in both of two tillage systems.Our study highlights that climate warming may have positive effects on soil C release in NCP in association with response of labile C substrate to warming. | TU Chun LI Fa-dong QIAO Yun-feng ZHU Nong GU Cong-ke ZHAO Xin | 2017 | Journal of Integrative Agriculture2017，16，4： | 6 |
| 20 | Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology显示文摘Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development.Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.Our data reveal that the global methylation levels of high-quality blastocysts are similar(0.30 ± 0.02,mean ± SD).while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts.The proportion of blastocysts with a methylation level falling within the range of 0.30 ± 0.02 in different grades correlates with the live birth rate for that grade.Moreover,abnormal methylated regions are associated with the failure of embryonic development.Furthermore,we can use the methylation data of cells biopsied from trophectoderm to predict the blastocyst methylation level as well as to detect the aneuploidy of the blastocysts.Our data indicate that global abnormal methylome reprogramming often occurs in human embryos,and suggest that DNA methylome is a potential biomarker in blastocyst selection in ART. | Guoqiang Li Yang Yu Yong Fan Congru Li Xiaocui Xu Jialei Duan Rong Li Xiangjin Kang Xin Ma Xuepeng Chen Yuwen Ke Jie Yan Ying Lian Ping Liu Yue Zhao Hongcui Zhao Yaoyong Chen Xiaofang Sun Jianqiao Liu Jie Qiao Jiang Liu | 2017 | Journal of Genetics and Genomics2017，44，10： | 5 |
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