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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China显示文摘 | Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 3 | Linearization Learning Method of BP Neural Networks显示文摘LinearizationLearningMethodofBPNeuralNetworksZhouShaoqian,DingLixin,ZhangJianStateKeyLaboratoryofSoftwareEngineering,WuhanUn... | Zhou Shaoqian Ding Lixin Zhang Jian Tang Xinhua | 1997 | Wuhan University Journal of Natural Sciences1997，2，1： | 4 |
| 4 | miR-200b and miR-200c as Prognostic Factors and Mediators of Gastric Cancer Cell Progression显示文摘 | Hailin Tang Min Deng Yunyun Tang Xinhua Xie Jiaoli Guo Yanan Kong Feng Ye Qi Su Xiaoming Xie | 2013 | Clinical Cancer Research2013，，20： | 4 |
| 5 | Four residues of propeptide are essential for precursor folding of nattokinase显示文摘Subtilisin propeptide 作为指导先锋合拢的 intramolecular 女伴工作。Nattokinase, subtilisin 家庭的一个成员,当由信号肽, propeptide,和一个 subtilisin 领域组成的一位先锋,和它的合拢的机制尚待被理解,被综合。在这研究,贡献先锋合拢的 nattokinase propeptide 的必要残余是坚定的。删除分析证明在 propeptide 的保存区域为先锋合拢是重要的。单个地点并且多地点 mutagenesis 研究证实了 Tyr10, Gly13, Gly34,和 Gly35 的角色。在期间上演(i) 并且(ii ) 将先锋合拢, Tyr10 和 Gly13 形成 subtilisin 的接口的部分域。当 Gly34 和 Gly35 与将稳定 propeptide 的结构的一个螺旋连接了时。四倍的翼变化, Y10A/G13A/G34A/G35A,为 propeptide 导致了女伴功能的损失。这个工作为先锋经由第二等的结构和运动参数分析合拢显示出 propeptide 的必要残余。 | Yan Jia Xinhua Cao Yu Deng Wei Bao Changyan Tang Hanjing Ding Zhongliang Zheng Guolin Zou | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 6 | Large electrocaloric effect in BaTiO_3 based multilayer ceramic capacitors显示文摘The electrocaloric effect(ECE) of multilayer ceramic capacitor(MLCC) of Y5 V type was directly measured via a differential scanning calorimetry(DSC) method and a reference resistor was used to calibrate the heat flow due to the heat dissipation. The results are compared with those calculated from Maxwell relations by using the polarization data obtained from the polarization–electric field hysteresis loops. The direct method shows a larger ECE temperature change, which is accounted for the situation approaches an ideal condition. For the indirect method using Maxwell relations, only the polarization projection along the electric field was taken into account, which will be less than the randomly distributed real polarizations that contribute to the ECE. The MLCCs exhibit a broad peak of ECE around 80 C, which will be favorite for the practical ECE cooling devices. | LU Biao WEN XinHua TANG ZhenHua LIANG Bo TAO Tao XIE ZhiWei ZHANG TianFu TANG XinGui XIANG Yong LIAO Jie LU ShengGuo | 2016 | Science China(Technological Sciences)2016，59，7： | 3 |
| 7 | Enhanced U(Ⅵ) bioreduction by alginate-immobilized uranium-reducing bacteria in the presence of carbon nanotubes and anthraquinone-2,6-disulfonate显示文摘Uranium-reducing bacteria were immobilized with sodium alginate, anthraquinone-2,6-disulfonate(AQDS), and carbon nanotubes(CNTs). The effects of different AQDS-CNTs contents, U(Ⅳ) concentrations, and metal ions on U(Ⅳ) reduction by immobilized beads were examined. Over 97.5% U(Ⅵ)(20 mg/L) was removed in 8 hr when the beads were added to 0.7% AQDS-CNTs, which was higher than that without AQDS-CNTs. This result may be attributed to the enhanced electron transfer by AQDS and CNTs. The reduction of U(Ⅵ) occurred at initial U(Ⅵ) concentrations of 10 to 100 mg/L and increased with increasing AQDS-CNT content from 0.1% to 1%. The presence of Fe(Ⅲ), Cu(Ⅱ) and Mn(Ⅱ)slightly increased U(Ⅵ) reduction, whereas Cr(Ⅵ), Ni(Ⅱ), Pb(Ⅱ), and Zn(Ⅱ) significantly inhibited U(Ⅵ) reduction. After eight successive incubation-washing cycles or 8 hr of retention time(HRT) for 48 hr of continuous operation, the removal efficiency of uranium was above 90% and 92%, respectively. The results indicate that the AQDS-CNT/AL/cell beads are suitable for the treatment of uranium-containing wastewaters. | Weida Wang Yali Feng Xinhua Tang Haoran Li Zhuwei Du Aifei Yi Xu Zhang | 2015 | Journal of Environmental Sciences2015，27，5： | 3 |
| 8 | Designer uniform Li plating/stripping through lithium–cobalt alloying hierarchical scaffolds for scalable high-performance lithium-metal anodes显示文摘Lithium metal anodes are of great interest for advanced high-energy density batteries such as lithiumair, lithium-sulfur and solid-state batteries, due to their low electrode potential and ultra-high theoretical capacity. There are, however, several challenges limiting their practical applications, which include low coulombic efficiency, the uncontrollable growth of dendrites and poor rate capability. Here, a rational design of 3D structured lithium metal anodes comprising of in-situ growth of cobalt-decorated nitrogen-doped carbon nanotubes on continuous carbon nanofibers is demonstrated via electrospinning.The porous and free-standing scaffold can enhance the tolerance to stresses resulting from the intrinsic volume change during Li plating/stripping, delivering a significant boost in both charge/discharge rates and stable cycling performance. A binary Co-Li alloying phase was generated at the initial discharge process, creating more active sites for the Li nucleation and uniform deposition. Characterization and density functional theory calculations show that the conductive and uniformly distributed cobalt-decorated carbon nanotubes with hierarchical structure can effectively reduce the local current density and more easily absorb Li atoms, leading to more uniform Li nucleation during plating. The current work presents an advance on scalable and cost-effective strategies for novel electrode materials with 3D hierarchical microstructures and mechanical flexibility for lithium metal anodes. | Xinhua Liu Xiaojuan Qian Weiqiang Tang Hui Luo Yan Zhao Rui Tan Mo Qiao Xinlei Gao Yang Hua Huizhi Wang Shuangliang Zhao Chao Lai Magda Titirici Nigel PBrandon Shichun Yang Billy Wub | 2021 | Journal of Energy Chemistry2021，30，1： | 2 |
| 9 | A novel secretagogin/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet β-cell apoptosis显示文摘Excessive accumulation of cholesterol inβcells initiates endoplasmic reticulum(ER)stress and associated apoptosis.We have reported that excessive uptake of cholesterol by MIN6 cells decreases the expression of secretagogin(SCGN)and then attenuates insulin secretion.Here,we aimed to determine whether cholesterol-induced SCGN decrease is involved in the modulation of ER stress and apoptosis in pancreaticβcells.In this study,MIN6 cells were treated with oxidized low-density lipoprotein(ox-LDL)for 24 h,and then intracellular lipid droplets and cell apoptosis were quantified,and SCGN and ER stress markers were identified by western blot analysis.Furthermore,small interfer RNA(siRNA)-mediated SCGN knockdown and recombinant plasmid-mediated SCGN restoration experiments were performed to confirm the role of SCGN in ER stress and associated cell apoptosis.Finally,the interaction of SCGN with ATF4 was computationally predicted and then validated by a co-immunoprecipitation assay.We found that ox-LDL treatment increased the levels of ER stress markers,such as phosphorylated protein kinase-like endoplasmic reticulum kinase,phosphorylated eukaryotic initiation factor 2 alpha,activating transcription factor 4(ATF4),and transcription factor CCAAT-enhancer-binding protein homologous protein,and promoted MIN6 cell apoptosis;in addition,the expression of SCGN was downregulated.siRNA-mediated SCGN knockdown exacerbatedβ-cell ER stress by increasing ATF4 expression.Pretreatment of MIN6 cells with the recombinant SCGN partly antagonized ox-LDL-induced ER stress and apoptosis.Furthermore,a co-immunoprecipitation assay revealed an interaction between SCGN and ATF4 in MIN6 cells.Taken together,these results demonstrated that pancreaticβ-cell apoptosis induced by ox-LDL treatment can be attributed,in part,to an SCGN/ATF4-dependent ER stress response. | Li Wu Yuncheng Lv Ying Lv Sunmin Xiang Zhibo Zhao Ziqing Tang Linling Ou Bin Yan Xinhua Xiao Gebo Wen Renxian Cao Jing Yang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 2 |
| 10 | Effects of Active Gases on Droplet Transfer and Weld Morphology in Pulsed-Current NG-GMAW of Mild Steel显示文摘The current research of narrow-gap gas metal arc welding(NG-GMAW)primarily focuses on improving the sidewall fusion and avoiding the lack-of-fusion defect.However,the high cost and operation difficulty of the methods limit the industrial application.In this study,small amount of active gases CO_(2) and O_(2) were added into pure argon inert shielding gas to improve the weld formation of pulsed-current narrow-gap gas metal arc welding(NG-GMAW)of mild steel.Their effects on droplet transfer and arc behavior were investigated.A high-speed visual sensing system was utilized to observe the metal transfer process and arc morphology.When the proportion of CO_(2),being added into the pure argon shielding gas,changes from 5%to 25%,the metal transfer mode changes from pulsed spray streaming transfer to pulsed projected spray transfer,while it remains the pulsed spray streaming transfer when 2%to 10%O_(2) is added.Both CO2 and O_(2) are favorable to stabilizing arc and welding process.O_(2) is even more effective than CO_(2).However,O_(2) is more likely to cause slags on the weld surface,while CO_(2) can improve the weld appearance in some sense.The weld surface concavity in NG-GMAW is greatly influenced by the addition of active gas,but the weld width and weld penetration almost keep constant.This study proposes a new method which is beneficial to improving the weld bead formation and welding process stability. | Guoqiang Liu Xinhua Tang Qi Xu Fenggui Lu Haichao Cui | 2021 | Chinese Journal of Mechanical Engineering2021，34，4： | 2 |
| 11 | Determination of trace Pb(Ⅱ), Cd(Ⅱ) and Zn(Ⅱ) using differential pulse stripping voltammetry without Hg modification显示文摘In this work,we reported a simultaneous determination approach for Pb(II),Cd(II)and Zn(II)atμg L 1concentration levels using differential pulse stripping voltammetry on a bismuth film electrode(BiFE).The BiFE could be prepared in situ when the sample solution contained a suitable amount of Bi(NO)3,and its analytical performance was evaluated for the simultaneous determination of Pb(II),Cd(II)and Zn(II)in solutions.The determination limits were found to be 0.19μg L 1for Zn(II),and0.28μg L 1for Pb(II)and Cd(II),with a preconcentration time of 300 s.The BiFE approach was successfully applied to determine Pb(II),Cd(II)and Zn(II)in tea leaf and infusion samples,and the results were in agreement with those obtained using an atomic absorption spectrometry approach.Without Hg usage,the in situ preparation for BiFE supplied a green and acceptability sensitive method for the determination of the heavy metal ions. | LIN Qi LIN HongMei ZHANG YuanHui RONG MingCong KE HuiXian TANG XinHua CHEN Xi | 2013 | Science China Chemistry2013，56，12： | 2 |
| 12 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 13 | Application of circular la- ser vision sensor (CLVS) on welded seam tracking显示文摘 | Xu Peiquan Tang Xinhua Yao Shun | 2008 | Journal of Materials Processing Technology2008，24，7： | 1 |
| 14 | Effect of heavy metals on the stabilization of mercury(II) by DTCR in desulfurization solutions显示文摘 | Jiaai Hou Rongjie Lu Mingyang Sun Shams Ali Baig Tingmei Tang Lihua Cheng Xinhua Xu | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 15 | Stabilization of mercury in flue gas desulfurization gypsum from coal-fired electric power plants with additives显示文摘 | Mingyang Sun Jiaai Hou Tingmei Tang Rongjie Lu Lihua Cheng Xinhua Xu | 2012 | Fuel Processing Technology2012，，： | 1 |
| 16 | A Preliminary Urinary Metabolomics Study of Sprague-Dawley Rats after Short‑term Ketamine Administration by Proton Nuclear Magnetic Resonance Spectroscopy显示文摘Drug abuse has become a global problem.The mass spectrometry‑based metabolic consequences of ketamine administration in anesthesia and therapy have been well studied,but to the best of our knowledge,metabolomic studies of ketamine abuse based on nuclear magnetic resonance(NMR)spectroscopy are still lacking.In this study,twenty Sprague–Dawley rats were randomly assigned into two groups:a control group(n=10)and a ketamine group(n=10).The animals in the ketamine group received intraperitoneal injections of ketamine twice daily at 12‑h intervals at progressively increasing doses over a period of 9 days,while the control group received an equal volume of saline.The urine samples were collected for 24 h at days 0,1,3,5,7,and 9 for the metabolomics study.The metabolic changes in urine after short‑term ketamine administration were analyzed by proton NMR coupled with multivariate statistical analysis.The results indicated that short‑term ketamine exposure led to significant alterations of the metabolites in the urine of the rats.Specifically,1,3,7‑trimethyluric acid,1,3‑dimethyluric acid,acetoacetic acid,acetylglycine,creatine,sarcosine,dimethylglycine,glycine,and theobromine were significantly increased in the urine.Significant changes were also found in metabolites related to antioxidant and energy metabolism,including acetoacetic acid,succinate,1,3,7‑trimethyluric acid,1,3‑dimethyluric acid,creatine,and taurine.Our findings indicated that short‑term ketamine administration leads to disorder of energy metabolism and oxidative stress.In addition,the modified metabolites identified could serve as the new biological markers and potential biological indices reflecting the underlying mechanism of ketamine abuse. | Xiang Lu Qunxing Tang Yi Ye Run Guo Fan Chen Xinhua Dai Youyi Yan Linchuan Liao | 2016 | Journal of Forensic Science and Medicine2016，2，2： | 1 |
| 17 | Electrochemical characterization of poly(eriochrome black T) modified glassy carbon electrode and its application to simultaneous determination of dopamine, ascorbic acid and uric acid显示文摘 | Hong Yao Yuanyuan Sun Xinhua Lin Yuhai Tang Liying Huang | 2007 | Electrochimica Acta2007，，20： | 1 |
| 18 | Hg 0 oxidative absorption by K 2 S 2 O 8 solution catalyzed by Ag + and Cu 2+显示文摘 | Xinhua Xu Qunfeng Ye Tingmei Tang Dahui Wang | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 19 | Enhanced Hg 2+ removal and Hg 0 re-emission control from wet fuel gas desulfurization liquors with additives显示文摘 | Tingmei Tang Jiang Xu Rongjie Lu Jingjing Wo Xinhua Xu | 2010 | Fuel2010，，12： | 1 |
| 20 | Application of circular la-ser vision sensor ( CLVS) on welded seam tracking 显示文摘 | Xu Peiquan Tang Xinhua Yao Shun | 2008 | Journalof Materials Processing Technology2008，205，13： | 1 |
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