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| 1 | Xa7, a new executor R gene that confers durable and broad-spectrum resistance to bacterial blight disease in rice显示文摘Bacterial blight(BB)is a globally devastating rice disease caused by Xanthomonas oryzae pv.oryzae(Xoo).The use of disease resistance(R)genes in rice breeding is an effective and economical strategy for the control of this disease.Nevertheless,a majority of R genes lack durable resistance for long-term use under global warming conditions.Here,we report the isolation of a novel executor R gene,Xa7,that confers extremely durable,broad-spectrum,and heat-tolerant resistance to Xoo.The expression of Xa7 was induced by incompatible Xoo strains that secreted the transcription activator-like effector(TALE)AvrXa7 or PthXo3,which recognized effector binding elements(EBEs)in the Xa7 promoter.Furthermore,Xa7 induction was faster and stronger under high temperatures.Overexpression of Xa7 or co-transformation of Xa7 with avrXa7 triggered a hypersensitive response in plants.Constitutive expression of Xa7 activated a defense response in the absence of Xoo but inhibited the growth of transgenic rice plants.In addition,analysis of over 3000 rice varieties showed that the Xa7 locuswas found primarily in the indica and aus subgroups.A variation consisting of an 11-bp insertion and a base substitution(G to T)was found in EBEAvrXa7 in the tested varieties,resulting in a loss of Xa7 BB resistance.Through a decade of effort,we have identified an important BB resistance gene and characterized its distinctive interaction with Xoo strains;these findings will greatly facilitate research on the molecular mechanism of Xa7-mediated resistance and promote the use of this valuable gene in breeding. | Xifeng Chen Pengcheng Liu Le Mei Xiaoling He Long Chen Hui Liu Shurong Shen Zhandong Ji Xixi Zheng Yuchen Zhang Zhenyu Gao Dali Zeng Qian Qian Bojun Ma | 2021 | Plant Communications2021，2，3： | 9 |
| 2 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 3 | SPL5, a cell death and defense-related gene, encodes a putative splicing factor 3b subunit 3 (SF3b3) in rice显示文摘 | Xifeng Chen Liang Hao Jianwei Pan Xixi Zheng Guanghuai Jiang Yang Jin Zhimin Gu Qian Qian Wenxue Zhai Bojun Ma | 2012 | Molecular Breeding2012，，2： | 2 |
| 4 | A pH-responsive mesoporous silica nanoparticles-based drug delivery system with controlled release of andrographolide for OA treatment显示文摘Andrographolide(AG)has favorable anti-inflammatory and antioxidative capacity.However,it has low bioavailability due to high lipophilicity and can be easily cleared by the synovial fluid after intra-articular injection,leading to low therapeutic efficiency in osteoarthritis(OA).Herein,we designed a nano-sized pH-responsive drug delivery system(DDS)for OA treatment by using modified mesoporous silica nanoparticles(MSNs)with pH-responsive polyacrylic acid(PAA)for loading of AG to form AG@MSNs-PAA nanoplatform.The nanoparticles have uniform size(120 nm),high drug loading efficiency(22.3860.71%)and pH-responsive properties,beneficial to sustained release in OA environment.Compared with AG,AG@MSNs-PAA showed enhanced antiarthritic efficacy and chondro-protective capacity based on IL-1b-stimulated chondrocytes and anterior cruciate ligament transection-induced rat OA model,as demonstrated by lower expression of inflammatory factors and better prevention of proteoglycan loss.Therefore,the AG@MSNs-PAA nanoplatform may be developed as a promising OA-specific and on-demand DDS. | Mingwei He Zainen Qin Xiaonan Liang Xixi He Bikang Zhu Zhenhui Lu Qingjun Wei Li Zheng | 2021 | Regenerative Biomaterials2021，8，4： | 1 |
| 5 | Synthesis of Aminomethyl Arylsulfides via Novel Synthetic Auxiliary Benzotriazole Promoted by Samarium Diiodide显示文摘Aminomethyl arylsulfides are synthesized through nucleophilic substitution of abenzotriazolate anion by thiolates promoted by samarium diiodide. | Gen Liang LU Yun Fa ZHENG Yong Min ZHANG (1. Department of Chemistry. Zhejiang University (Campus Xixi ), Hangzhou 310028 Depatmentof Chemistry, Lishui Teachers College, Lishui 323000) | 1999 | Chinese Chemical Letters1999，10，9： | 1 |
| 6 | Experimental study on size effect of compressive strength and Deformation properties of large size fly ash concrete 显示文摘 | He xixi Lin sheyong Zheng xuecheng | 2011 | Ecological Environment and Technology of Concrete2011，477，： | 1 |
| 7 | ON THE INVARIANT FOR A FAMILY OF DEFORMED HALLEY METHODS显示文摘In this paper,an invariant determined by a function used to guarantee the convergence of all members with ι≤κ in the family of deformed Halley iterative methods for solving nonlinear equation in complex field is given.Results include some known ones as this special cases.We get not only the error estimates of the iterative sequences {zn,ι} but also those of f(zn,ι) for all ι≤κ. | HUANG Zhengda ZHENG Shiming (Department of Mathematics, Xixi Campus, Zhejiang University, Hangzhou 310028, China) | 2003 | Journal of Systems Science & Complexity2003，16，1： | 0 |
| 8 | Effect of Titanium on Methanol Synthesis from CO_2 Hydrogenation over Cu/γ-Al_2O_3显示文摘Titanium-modified (-alumina supported CuO catalyst has been prepared and used to methanol synthesis from CO2 hydrogenation. The addition of Ti to the CuO/(-Al2O3 catalyst made the copper in the catalyst exist in much smaller crystallites. The effect of the loading of Ti on the activity and selectivity to methanol from CO2 hydrogenation was investigated. The activity was found to increase with the increasing of surface area of metallic copper, but it is not a linear relationship. | Gong Xin QI, Jin Hua FEI*, Xiao Ming ZHENG, Zhao Yin HOU Institute of Catalysis, Zhejiang University (Xixi Campus) Hangzhou 310028 | 2001 | Chinese Chemical Letters2001，12，6： | 0 |
| 9 | In situ decorating the surface and interlayer of montmorillonite with Co_(0.5)Ni_(0.5)Fe_(2)O_(4) nanoparticles: A sustainable, biocompatible colorimetric platform for H_(2)O_(2) and acetylcholine显示文摘Originated from nature and used for nature is a way of sustainable development.In this work,montmorillonite(MMT),a natural two-dimensional(2D)layered mineral,the surface and interlayer of which were nano-decorated by chemical synthesis technique was applied in biological detection field.Magnetic ferrite(Co_(0.5)Ni_(0.5)Fe_(2)O_(4))was anchored on the surface and intercalated in the interlayer of montmorillonite,which served as a competitive candidate of enzyme mimics.Cytotoxicity test toward HUVEC and Hela cells verified the good biocompatibility of Co_(0.5)Ni_(0.5)Fe_(2)O_(4)-MMT,guaranteeing its safety in biological applications.Based on the peroxidase-like activity of Co_(0.5)Ni_(0.5)Fe_(2)O_(4)-MMT,a colorimetric sensing platform for H_(2)O_(2) was established by a facile mix-anddetect approach with the detection limit of 0.565μM(3σ/slope).It was implied that the peroxidase-like activity of Co_(0.5)Ni_(0.5)Fe_(2)O_(4)-MMT was originated from generation of·OH and·O_(2)–produced from catalytic decomposition process of H_(2)O_(2).Coupled with cascaded catalytic reactions of ACh,a facile and efficient sensing platform for ACh with satisfactory anti-interference ability was established.Thus,all these remarkable features highlighted the superiority of Co_(0.5)Ni_(0.5)Fe_(2)O_(4)-MMT,and endowed it with a powerful competitiveness in the fields of environmental assessing,biosensing,and disease monitoring. | Xixi Zhu Hongyu Li Tao Wu Hui Zhao Kaili Wu Wenjing Xu Fengjuan Qin Wenxing Chen Jinlong Zheng Qingyun Liu | 2022 | Nano Research2022，15，10： | 0 |
| 10 | A FAMILY OF HIGH-ODER PARALLEL ROOTFINDERS FOR POLYNOMIALS显示文摘In this paper we present a family of parallel iterations of order m + 2 with parameter m = 0, 1… for simultaneous finding all zeros of a polynomial with- out evaluation of derivatives, which includes the well known Weierstrass-Durand- Dochev-Kerner and Borsch-Supan-Nourein iterations as the special cases for m = 0 and m = 1, respectively. Some numerical examples are given. | Shi-ming Zheng (Department of Mathematics, Xixi Campus,Zhejiang University, Hangzhou, 310028, China) | 2000 | Journal of Computational Mathematics2000，18，3： | 0 |
| 11 | Kinking-facilitated nano-crystallization in a shock compressed Mg-1Zn alloy显示文摘The local deformation behavior and dynamic recrystallization of a shock compressed Mg-1Zn alloy was investigated through EBSD and TEM.Since dislocation slipping and twinning were locally suppressed during high strain-rate deformation,a more flexible kinking deformation was activated to adjusted local orientation and facilitate slipping and twinning within the kinks.Meanwhile,due to the slow heat dissipation that resulted in a local temperature elevating,the kink bands were evolved into deformation bands with recrystallized nano-grains.Such a finding provides a new perspective for kinking-facilitated nanocrystallization in Mg alloys and other anisotropic metallic materials. | Yuxuan Liu Yangxin Li Qingchun Zhu Huan Zhang Xixi Qi Duofei Zheng Yunliang Li Dezhi Zhang Xiaoqin Zeng | 2023 | Journal of Magnesium and Alloys2023，11，4： | 0 |
| 12 | 人类心脏发育的单细胞转录组研究显示文摘文章简介本研究利用高精度的单细胞转录组测序等技术,全面、系统地解析了人类心脏发育过程中各种主要细胞类型的重要生物学特点,揭示了心脏发育过程中关键信号通路的时空特异性激活特征以及心肌细胞与非心肌细胞之间的复杂信号互作机制。同时通过与已发表的小鼠心脏发育单细胞转录组数据的系统比较。 | Yueli Cui Yuxuan Zheng Xixi Liu Liying Yan Xiaoying Fan Jun Yong Yuqiong Hu Ji Dong Qingqing Li Xinglong Wu Shuai Gao Jingyun Li Lu Wen 乔杰 汤富酬 | 2020 | 科学新闻2020，，2： | 0 |
| 13 | Biosensors for waterborne virus detection: Challenges and strategies显示文摘Waterborne viruses that can be harmful to human health pose significant challenges globally,affecting health care systems and the economy.Identifying these waterborne pathogens is essential for preventing diseases and protecting public health.However,handling complex samples such as human and wastewater can be challenging due to their dynamic and complex composition and the ultralow concentration of target analytes.This review presents a comprehensive overview of the latest breakthroughs in waterborne virus biosensors.It begins by highlighting several promising strategies that enhance the sensing performance of optical and electrochemical biosensors in human samples.These strategies include optimizing bioreceptor selection,transduction elements,signal amplification,and integrated sensing systems.Furthermore,the insights gained from biosensing waterborne viruses in human samples are applied to improve biosensing in wastewater,with a particular focus on sampling and sample pretreatment due to the dispersion characteristics of waterborne viruses in wastewater.This review suggests that implementing a comprehensive system that integrates the entire waterborne virus detection process with high-accuracy analysis could enhance virus monitoring.These findings provide valuable insights for improving the effectiveness of waterborne virus detection,which could have significant implications for public health and environmental management. | Xixi Song Zina Fredj Yuqiao Zheng Hongyong Zhang Guoguang Rong Sumin Bian Mohamad Sawan | 2023 | Journal of Pharmaceutical Analysis2023，13，11： | 0 |
| 14 | dbSCI:A manually curated database of SARS-CoV-2 inhibitors for COVID-19显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the pathogen of the ongoing coronavirus disease 2019(COVID-19)global pandemic.Here,by centralizing published cell-based experiments,clinical trials,and virtual drug screening data from the NCBI PubMed database,we developed a database of SARS-CoV-2 inhibitors for COVID-19,dbSCI,which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments,81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses.dbSCI provides four major functions:(1)search the drug target or its inhibitor for SARS-CoV-2,(2)browse target/inhibitor information collected from cell experiments,clinical trials,and virtual drug screenings,(3)download,and(4)submit data.Each entry in dbSCI contains 18 types of information,including inhibitor/drug name,targeting protein,mechanism of inhibition,experimental technique,experimental sample type,and reference information.In summary,dbSCI provides a relatively comprehensive,credible repository for inhibitors/drugs against SARS-CoV-2 and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19. | QIANG WANG GUO ZHAO LONGXIANG XIE XUAN LI XIXI YU QIONGSHAN LI BAOPING ZHENG ZULIPINUER WUSIMAN XIANGQIAN GUO | 2023 | BIOCELL2023，47，2： | 0 |
| 15 | Predictive Control Model Based on the MPC Algorithm on Three Different Road Sections显示文摘Predictive control is an advanced control algorithm,which is widely used in industrial process control.Among them,model predictive control(MPC)is an important branch of predictive control.Its basic principle is to use the system model to predict future behavior and determine the current control action by optimizing the objective function.This paper discusses the application of MPC in the prediction and control of the speed of vehicles to optimize traffic flow.It is a valuable reference for alleviating traffic congestion and improving travel efficiency and smoothness and provides scientific basis and technical support for future highway traffic management. | Xiaoxi Liu Xixi Zheng Shuming Zhang Zhidong Wang | 2024 | Journal of Electronic Research and Application2024，8，2： | 0 |
| 16 | APPLICATION OF NEWTON'S AND CHEBYSHEV'S METHODS TO PARALLEL FACTORJZATION OF POLYNOMIALS显示文摘In this paper it is shown m two different ways that one of the family of parallel iterations to determine all real quadratic factors of polynomials presented in [12] is Newton’s method applied to the special equation (1.7) below. Furthermore, we apply Chebyshev’s method to (1.7) and obtain a new parallel iteration for factorization of polynomials. Finally, some properties of the parallel iterations are discussed. | Shi-ming Zheng (Department of Mathematics, Xixi Campus, Zhejiang University, Hangzhou 310028, China) | 2001 | Journal of Computational Mathematics2001，19，4： | 0 |
| 17 | A real-world study of immune checkpoint inhibitors in advanced triple-negative breast cancer显示文摘Background:Triple-negative breast cancer(TNBC)is the most aggressive type of breast cancer.Immune checkpoint inhibitors(ICIs)have been widely used to treat various tumors and have changed the landscape of tumor management,but the data from real-world studies of ICIs for TNBC treatment remain limited.The aim of this study was to evaluate the efficacy of ICIs in the treatment of patients with advanced TNBC in a real-world setting and to explore possible correlates.Methods:The clinical data of advanced TNBC patients who received ICI treatment in the Chinese People's Liberation Army(PLA)General Hospital were collected.Treatment responses,outcomes and adverse events(AEs)were assessed.Results:Eighty-one patients were included in the study.The confirmed objective response rate(ORR)was 32.1%,and the disease control rate(DCR)was 64.2%.The median progression-free survival(PFS)was 4.2 months,and the median overall survival(OS)was 11.0 months.PFS and OS were longer in patients who achieved clinical benefit from ICIs and shorter in patients who received later-line ICIs and higher levels of inflammation;specifically,patients with higher TILs had longer PFS.Overall AEs were tolerable.Conclusions:ICIs are effective in the treatment of advanced TNBC,and the adverse reactions are tolerable.A panel of biomarkers including LDH,ALP,and bNLR were identified to predict the efficacies of ICIs in TNBC treatment. | Zheng Zhang Yadi Zhang Chuanling Liu Jiakang Shao Yimeng Chen Yimin Zhu Li Zhang Boyu Qin Ziqing Kong Xixi Wang Yutong Wang Deqin Huang Liqun Liu Yuxin Zhou Ran Tao Zengjie Yang Mei Liu Weihong Zhao | 2023 | Cancer Innovation2023，2，3： | 0 |
| 18 | A Spectrophotometric Study on the Host-Guest Complexation of β-Cyclodextrin with 3-Indolyl Acetate in Dilute Aqueous Solution by Determining Solubility of Guest Substance显示文摘3-Indolyl acetate can be soluhilized in dilute aqueous solution of beta cy clodextrin. dueto the formation of host-guest complex through hydrophobic interaction between the indolyl groupand the inside cave of the cyclodextrin molecule. The thermodynamic pararneters of thecomplexing process can be estimated utilizing the spectrophotometric data. | De Zhi SUN Jian CHENI Wei Min LU and Xiao Ming ZHENG(Institute of Catalysis. Xixi Xiaoqu. Zhejiang University. Hangzho 310028Department of Chemistry, Liaocheng Teachers College. Liaocheng, 252000 Shandong.Department of Chemistry, Zhejiang Normal Univers | 1999 | Chinese Chemical Letters1999，10，5： | 0 |
| 19 | Spatial Differences and Influencing Factors of Dissolved Gaseous Mercury in the Yellow Sea and Bohai Sea in Spring显示文摘From 28 March to 17 April, 2018, different forms of mercury(Hg) in the Yellow Sea and Bohai Sea were measured to study the influencing factors on the distribution and transformation of Hg in spring using a shared cruise. The mean concentration of dissolved gaseous mercury(DGM) in the surface water of the Yellow and Bohai Seas was(44.3 ± 43.9) pg/L, which was close to that in mid-latitude oceans and deep seas. The ratio of DGM to THg(total mercury) was lower than in the oceans and in the Yellow and Bohai Seas in summer or fall. DGM concentrations in surface water were highest in the central part of the South Yellow Sea and were higher than those in the Bohai Sea, and their spatial distributions were consistent with RHg(reactive mercury). DGM and RHg correlated positively with water temperature in surface seawater(r = 0.506, P < 0.01;r = 0.278, P < 0.05). The concentrations of both DGM and RHg in surface water were controlled by solar radiation and water temperature. Foggy weather did not benefit the production of DGM and RHg. DGM in the bottom seawater was mainly affected by Dissolved Oxygen and water temperature(r =-0.366, P < 0.01;r = 0.331, P < 0.01), produced mainly by anaerobic reactions of the bottom seawater and sediment microorganisms. The bottom DGM concentrations in the Yellow and Bohai Seas were the highest, and DGM produced in bottom seawater and sediment plays a more important role than the surface water in spring. The concentrations of DGM and RHg in the surface and bottom water in the South Yellow Sea were all higher than those in the middle layer. Vertical variations in the North Yellow Sea and the Bohai Sea were small. The production and distribution of DGM and RHg were influenced by differences of latitude and by the Yellow Sea warm current in spring. | LIU Ruhai ZHENG Wen CHONG Xixi WANG Yan YI Dan | 2021 | Chinese Geographical Science2021，31，1： | 0 |
| 20 | A New Catalyst System V-Cs-Cu-Tl for Selective Oxidation of p-tert Butyl Toluene to p-tert Benzaldehyde显示文摘In this paper, a new catalyst system V-Cs-Cu-Tl was studied in the gas phase selective oxidation for p-tert butyl toluene to p-tert benzaldehyde. The catalyst system was prepared by impregnation method. The results obtained are optimum value and have good advantages in environmental protection. | Min CHEN*, Ren Xian ZHOU, Xiao Ming ZHENG Institute of Catalysis, Zhejiang University, Xixi Campus, Hangzhou 310028 | 2001 | Chinese Chemical Letters2001，12，2： | 0 |
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