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| 1 | On the tuning of electrical and thermal transport in thermoelectrics: an integrated theory–experiment perspective显示文摘During the last two decades,we have witnessed great progress in research on thermoelectrics.There are two primary focuses.One is the fundamental understanding of electrical and thermal transport,enabled by the interplay of theory and experiment;the other is the substantial enhancement of the performance of various thermoelectric materials,through synergistic optimisation of those intercorrelated transport parameters.Here we review some of the successful strategies for tuning electrical and thermal transport.For electrical transport,we start from the classical but still very active strategy of tuning band degeneracy(or band convergence),then discuss the engineering of carrier scattering,and finally address the concept of conduction channels and conductive networks that emerge in complex thermoelectric materials.For thermal transport,we summarise the approaches for studying thermal transport based on phonon–phonon interactions valid for conventional solids,as well as some quantitative efforts for nanostructures.We also discuss the thermal transport in complex materials with chemical-bond hierarchy,in which a portion of the atoms(or subunits)are weakly bonded to the rest of the structure,leading to an intrinsic manifestation of part-crystalline part-liquid state at elevated temperatures.In this review,we provide a summary of achievements made in recent studies of thermoelectric transport properties,and demonstrate how they have led to improvements in thermoelectric performance by the integration of modern theory and experiment,and point out some challenges and possible directions. | Jiong Yang Lili Xi Wujie Qiu Lihua Wu Xun Shi Lidong Chen Jihui Yang Wenqing Zhang Ctirad Uher David J Singh | 2016 | npj Computational Materials2016，，1： | 24 |
| 2 | Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma显示文摘Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via na?ve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid)(PEG-PLGA) nanoparticles. Neutrophil membranecoated nanoparticles(NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models,celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma. | Xi Cao Ying Hu Shi Luo Yuejing Wang Tao Gong Xun Sun Yao Fun Zhirong Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 9 |
| 3 | Implantable collamer lens for residual refractive error after corneal refractive surgery显示文摘AIM:To assess the safety,efficacy,predictability and stability of implantable collamer lens(ICL) for residual refractive error after corneal refractive surgery.METHODS: This study evaluated 19 eyes of 12 patients who underwent ICL implantation after corneal refractive surgeries.They were followed up for 1y to 5y of uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),manifest refractive error,flat and steep K value,axial length,intraocular pressure,corneal endothelial cell density,adverse events after ICL surgery.RESULTS: The mean follow-up period was 39.05 ±19.22 mo(range,1-5y).Spherical equivalent refractive error changed from-7.45±3.02 D preoperatively to-0.85±1.10 D 1wk to 1mo after ICL implantation,with the safety and efficacy indices being 1.12 and 1.15,respectively.A total of 52.63% of eyes were within ±0.5 D of the predicted spherical equivalents,73.68% were within ±1.0 D.A trend of mild regression towards myopia with axial elongation after 5y was observed.One eye with mild anterior capsule opacity and retinal detachment 1y after surgery were observed.CONCLUSION: ICL implantation is safe and effective for the correction of residual refractive error after corneal refractive surgeries,especially in moderate to high residual myopia. | Xun Chen Xiao-Ying Wang Xi Zhang Zhi Chen Xing-Tao Zhou | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 6 |
| 4 | Comparison of Two Molecular Assays For Detecting Smear Negative Pulmonary Tuberculosis显示文摘Objective To compare the performance of MTBDRplus V2 and Xpert MTB/RIF for detecting smear negative pulmonary tuberculosis(PTB). Methods Clinical PTB suspects were enrolled consecutively in Anhui Chest Hospital and Xi'an Chest Hospital from January to December in 2014. The sputum samples of smear negative PTB suspects were collected and decontaminated. The sediment was used to conduct MTBDRplus V2, Xpert MTB/RIF and drug susceptibility test(DST). All the samples with discrepant drug susceptibility result between molecular methods and phenotypic method were confirmed by DNA sequencing. Results A total of 1973 cases were enrolled in this study. The detection rates of Mycobacterium tuberculosis complex(MTBC) by MTBDRplus V2 and Xpert MTB/RIF were 27.67% and 27.98%, respectively. When setting MGIT culture result as a gold standard, the sensitivity and specificity of MTBDRplus V2 were 86.74% and 93.84%, and the sensitivity and specificity of Xpert MTB/RIF were 86.55% and 93.43%, respectively. For the detection of the resistance to rifampin, the sensitivity and specificity of MTBDRplus V2 were 94.34% and 96.62%, and the sensitivity and specificity of Xpert MTB/RIF were 88.68% and 95.96%, respectively. For the detection of the resistance to isoniazid, the sensitivity and specificity of MTBDRplus V2 were 77.38% and 98.02%, respectively. Conclusion MTBDRplus V2 and Xpert MTB/RIF can be used to detect MTBC in smear negative samples with satisfactory performance. | LI Qiang BAO Xun Di LIU Yun OU Xi Chao PANG Yu ZHAO Yan Lin | 2016 | Biomedical and Environmental Sciences2016，29，4： | 5 |
| 5 | Technology strategies to achieve carbon peak and carbon neutrality for China's metal mines显示文摘Greenhouse gas(GHG)emissions related to human activities have significantly caused climate change since the Industrial Revolution.China aims to achieve its carbon emission peak before 2030 and carbon neutrality before 2060.Accordingly,this paper reviews and discusses technical strategies to achieve the“dual carbon”targets in China’s metal mines.First,global carbon emissions and emission intensities from metal mining industries are analyzed.The metal mining status and carbon emissions in China are then examined.Furthermore,advanced technologies for carbon mitigation and carbon sequestration in metal mines are reviewed.Finally,a technical roadmap for achieving carbon neutrality in China’s metal mines is proposed.Findings show that some international mining giants have already achieved their carbon reduction targets and planned to achieve carbon neutrality by 2050.Moreover,improving mining efficiency by developing advanced technologies and replacing fossil fuel with renewable energy are two key approaches in reducing GHG emissions.Green mines can significantly benefit from the carbon neutrality process for metal mines through the carbon absorption of reclamation vegetations.Geothermal energy extraction from operating and abandoned metal mines is a promising technology for providing clean energy and contributing to the carbon neutrality target of China’s metal mines.Carbon sequestration in mine backfills and tailings through mineral carbonation has the potential to permanently and safely store carbon dioxide,which can eventually make the metal mining industry carbon neutral or even carbon negative. | Qifeng Guo Xun Xi Shangtong Yang Meifeng Cai | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，4： | 2 |
| 6 | Evaluation of the New Automatic Mycob.T Stainer andScanner for Detecting Acid-fast Bacilli in China显示文摘Objective To validate the performance of Mycob. T Stainer and Scanner(MTSS) for detecting acid-fast bacilli(AFB). Methods A total of 3,816 sputum samples from 1,515 tuberculosis(TB) suspects were tested at the Anhui Provincial Chest Hospital and the Linyi People's Hospital from April-August, 2016. Each specimen was placed on two smear slides. One slide was stained by the ziehl-neelsen(ZN) method to be read by conventional microscopy(CM). The other slide was stained and scanned by MTSS. All specimens were decontaminated with 4% NaO H, and then inoculated into solid culture. The performance of MTSS was assessed. Results MTSS produced higher average positivity rate(27.96%) as compared with the CM(26.83%). The overall sensitivity and specificity of MTSS were 78.9% and 93.9%, respectively. The sensitivity and specificity of CM was 77.4% and 95.0%, respectively. Conclusion MTSS exhibited a favorable performance in the detection of AFB. It may be an alternative to CM for screening TB. | LI Qiang ZHAO Yan Lin WANG Qing DENG Yun Feng BAO Xun Di YANG Hong Guo OU Xi Chao ZHAO Bing ZHANG Jing Bo | 2018 | Biomedical and Environmental Sciences2018，31，8： | 2 |
| 7 | MiR‐200c suppresses TGF‐β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer显示文摘 | Wen‐Dong Bai Xing‐Ming Ye Meng‐Yao Zhang Hua‐Yu Zhu Wen‐Jin Xi Xun Huang Jiao Zhao Bin Gu Guo‐Xu Zheng An‐Gang Yang Lin‐Tao Jia | 2014 | Int J Cancer2014，，6： | 1 |
| 8 | Integrated strategies for chemotherapy cycles in nasopharyngeal carcinoma patients: Real-world data from two epidemic centers guiding decision-making显示文摘objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not evidence-confirmed.This study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and cost-effectiveness.Methods:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)analyses.The enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the groups.We developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk stratifications.Results:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,respectively.Five-year survivals were similar among the three groups after PSM and confirmed by IPTW.Grade 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other groups.Further exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by LRRFS.Conclusions:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC+3CCRT probably shortened LRRFS in high-and low-risk populations,respectively. | Zejiang Zhan Yingying Huang Jiayu Zhou Zhuochen Cai Haoyang Huang Ying Deng Wenze Qiu Xun Cao Xi Chen Chixiong Liang Lulu Zhang Xiang Guo Taize Yuan Xing Lyu | 2023 | Chinese Journal of Cancer Research2023，35，2： | 1 |
| 9 | Reinforcement of EPDM by in situ prepared Zinc dimethacrylate显示文摘 | Zong Lin PENG Xun HANG Yin Xi ZHANG | 2002 | Journal of Applied Polymer Science2002，84，： | 1 |
| 10 | Vibro-acoustic performance of steel–concrete composite and prestressed concrete box girders subjected to train excitations显示文摘Owning to good mechanical properties,steel–concrete composite(SCC)and prestressed concrete(PC)box girders are the types of elevated structures used most in urban rail transit.However,their vibro-acoustic differences are yet to be explored in depth,while structure-radiated noise is becoming a main concern in noise-sensitive environments.In this work,numerical simulation is used to investigate the vibration and noise characteristics of both types of box girders induced by running trains,and the numerical procedure is verified with data measured from a PC box girder.The mechanism of vibration transmission and vibro-acoustic comparisons between SCC and PC box girders are investigated in detail,revealing that more vibration and noise arise from SCC box girders.The vibration differences between them are around 7.7 dB(A)at the bottom plate,19.3 dB(A)at the web,and 6.7 dB(A)at the flange,while for structure-radiated noise,the difference is around 5.9 dB(A).Then,potential vibroacoustic control strategies for SCC box girders are discussed.As the vibro-acoustic responses of two types of girders are dominated by the force transmitted to the bridge deck,track isolation is better than structural enhancement.It is shown that using a floating track slab can make the vibration and noise of an SCC box girder lower than those of a PC box girder.However,structural enhancement for the SCC box girder is extremely limited in effects.The six proposed structural enhancement measures reduce vibration by only 1.1–3.6 dB(A) and noise by up to1.5 dB(A). | Xun Zhang Hao Luo Derui Kong Tao Chen Xi Li | 2021 | Railway Engineering Science2021，29，4： | 1 |
| 11 | Increased levels of IL-21 responses are associated with the severity of liver injury in patients with chronic active hepatitis B 显示文摘 | Pan Q Yu Y Tang Z Xi M Jiang H Xun Y Liu X Liu H Hu J Zang G | 2014 | J Viral Hepat2014，21，9： | 1 |
| 12 | Increased levels of IL ‐21 responses are associated with the severity of liver injury in patients with chronic active hepatitis B显示文摘 | Q. Pan Y. Yu Z. Tang M. Xi H. Jiang Y. Xun X. Liu H. Liu J. Hu G. Zang | 2014 | J Viral Hepat2014，，9： | 1 |
| 13 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 14 | Effects of ethanolic extract from Radix Scrophulariae on ventricular remodeling in rats显示文摘 | Xiao Yan Huang Chang Xun Chen Xue Mei Zhang Ying Liu Xi Min Wu Yi Ming Li | 2011 | Phytomedicine (-)2011，，3： | 1 |
| 15 | Effects of Nerve Growth Factor for Retinal Cell Survival in Experimental Retinal Detachment显示文摘 | Xiaodongx Sun Xun Xu Fenghua Wang Xi Zhang Zhang Yu Hongfen Lu P. C. Ho | 2007 | Current Eye Research2007，，9： | 1 |
| 16 | Role of pigment epithelium-derived factor on proliferation and migration of choroidal capillary endothelium induced by vascular endothelial growth factor in vitro显示文摘背景颜料导出上皮的因素(PEDF ) 在几个正常机关被表示并且作为 neovascularization 的一个禁止者识别了。在现在的学习,我们调查了 PEDF 的效果在一在里面眼睛的 choroidal neovascularization.Methods Microdissection 的 vitro 模型被用来孤立人的 choroidal endothelial 房间( CEC ),由 superparamagnetic 祷告( Dynabeads )的使用列在后面与 CD31 抗体涂,它有选择地绑在 endothelial 房间表面。有教养的 choroidal 上的脉管的 endothelial 生长因素( VEGF )的 mitogenic 和 motogenic 效果毛状的 endothelial 房间当面被检验或 PEDF 的缺席( 1 , 10 , 100 ,并且 1000 ng/ml )用房间计数和迁居 assays.Results 房间,到祷告的界限用一个磁性的粒子选矿厂被孤立,他们成功地有教养、描绘是拥有的 endothelial 房间比到 von Willebrand 的95% immunoreactivity 大因素。PEDF 压制了导致 VEGF 的 choroidal 的增长和迁居毛状的 endothelial 房间。然而,我们使用了的 PEDF 的集中在 CECs.Conclusions PEDF 玩了的正常上有小效果刺激 VEGF 的 choroidal endothelial cell.These 调查结果的生长和迁居上的一个重要角色建议 PEDF 可以是 choroidal neovascular 混乱的处理的一条有效途径。 | WANG Feng-hua SUN Xiao-dong ZHANG Xi XU Xun ZHU Qi HUANG Jian-nan FAN Ying GU Qing LIU Hai-yang | 2007 | Chinese Medical Journal2007，，17： | 1 |
| 17 | Passive tracking and size estimation of volume target based on acoustic vector intensity显示文摘The special sections of volume target are observed with acoustic vector intensity according to the difference among their radiated-noise characteristics, then three sections are tracked with Kalman filtering, and target size is estimated. Simulation results indicate that in ideal condition three sections of a ship can be tracked and ship’s size can be estimated even though one of three sections can not be observed. | LIU Xun ,XIANG Jinglin, ZHOU Yue (Northwestern Polytechnic University Xi’an 710072) | 2001 | Chinese Journal of Acoustics2001，20，3： | 1 |
| 18 | Therapeutic effects of recombinant human endostatin adenovirus in a mouse model of malignant pleural effusion显示文摘 | Fang Fang Ping Chen Xin Wu Li Yang Xun Yang Zhen-Xiang Xi Bin-Wen Zhou Xi-Kun Zhou Zhi-Yong Qian Bo Xiao Yu-Quan Wei | 2009 | Journal of Cancer Research and Clinical Oncology2009，，9： | 1 |
| 19 | Multiblock poly(ether-b-amide)copolymers comprised of PA1212 and PPO-PEO-PPO with specific moisture-responsive and antistatic properties显示文摘Functional multiblock poly(ether-b-amide)(PEBA)copolymers,comprised of PA1212(polyamide 1212)as hard segments and Jeffamine ED-2003 as soft segments,were successfully prepared via two-step melt polycondensation without any amidation catalyst.Here,using diamino-terminated poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide)(PPO-PEO-PPO),Jeffamine ED-2003,enhances the compatibility between polyamide oligomer and polyether,which is better than the traditional route using hydroxyl-terminated polyether.The chemical structure of multiblock PEBAs,as well as the microphase separated structure with crystalline phase of polyamide and polyether,were confirmed by heteronuclear multiple-bond correlation spectrum,heteronuclear multiple quantum correlation spectrum,Fourier transform infrared spectroscopy(FT-IR),differential scanning calorimetry and dynamic mechanical analysis.The hydrophilic PEBA copolymers showed water adsorption ranging from 87.3%to 17.1%depending on the polyether content,and specially showed moisture responsive behavior within seconds when exposed to moisture.The corresponding mechanism was studied using time-resolved attenuated total reflectance FT-IR spectroscopy in the molecular level and the water diffusion coefficient was estimated to be 1.07×10^(–8)cm^(2)∙s^(-1).Two-dimensional correlation FT-IR spectra analysis was performed to confirm that the interaction between water and polyether phase was in preference to that between water and polyamide matrix,and water molecule only forms hydrogen bond with the polyether segment.Due to the incorporation of PEO segments,the PEBAs have the surface resistivity varying from 5.6×10^(9)to 6.5×10^(10)Ω,which makes PEBA potential candidate as permanent antistatic agent. | Jie Jiang Wei Cheng Qiuyu Tang Xun Pan Jinjin Li Ling Zhao Zhenhao Xi Weikang Yuan | 2023 | Chinese Journal of Chemical Engineering2023，53，1： | 1 |
| 20 | Gynecologic infections seen in ThinPrep cytological test in Wuhan, China显示文摘这研究试图分析流行细菌,在 ThinPrep cytological 测试(TCT ) 的 Candida, Trichomonas,和人的乳头状瘤病毒(HPV ) 感染表现在中国武汉的女人上。ThinPrep 油迹被二个独立富有经验的病理学家屏蔽并且从 2008 ~ 2010 报导了。46 866 ThinPrep 油迹的一个总数被学习,并且有发炎的油迹被分析。44 162 个注册病人,发炎变化被观察在 21 935 (49.7%) 并且在 6884 的特定的感染(31.4%) 。检测的感染如下:细菌, 5663 (82.3%) ;Candida, 825 (12.0%) ;Trichomonas, 273 (4.0%) ;并且 HPV, 148 (2.1%) 。重要变化在在 2010 前后经历了 TCT 的女人之中在细菌和 Candida 的流行被发现。< 啜 class= “ a-plus-plus ” > 2 揭示了在 2010 以后在油迹发现的特定的感染的一个增加的比例(P = 0.000 ) 。在结论,细菌的感染在 ThinPrep 油迹是最可检测的,由 Candida 和 Trichomonas 列在后面。TCT 识别的感染的流行被发现在在中国的以前的文学类似。 | Hang Zhou Yao Jia Jian Shen Shaoshuai Wang Xiong Li Ru Yang Kecheng Huang Ting Hu Fangxu Tang Jin Zhou Jingping Yuan Lei Huang Xun Tian Zhilan Chen Qinghua Zhang Changyu Wang Ling Xi Dongrui Deng Hui Wang Ding Ma Shuang Li | 2014 | Frontiers of Medicine2014，8，2： | 1 |
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