|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | High-Performance Li-ion Batteries and Super-capacitors Based on Prospective 1-D Nanomaterials显示文摘One-dimensional(1-D) nanomaterials with superior specific capacity, higher rate capability, better cycling peroperties have demonstrated significant advantages for high-performance Li-ion batteries and supercapacitors. This review describes some recent developments on the rechargeable electrodes by using 1-D nanomaterials(such as Li Mn2O4 nanowires, carbon nanofibers, Ni Mo O4 · n H2O nanorods, V2O5 nanoribbons,carbon nanotubes, etc.). New preparation methods and superior electrochemical properties of the 1-D nanomaterials including carbon nanotube(CNT), some oxides, transition metal compounds and polymers, and their composites are emphatically introduced. The VGCF/Li Fe PO4/C triaxial nanowire cathodes for Li-ion battery present a positive cycling performance without any degradation in almost theoretical capacity(160 m Ah/g).The Si nanowire anodes for Li-ion battery show the highest known theoretical charge capacity(4277 m Ah/g),that is about 11 times lager than that of the commercial graphite(372 m Ah/g). The SWCNT/Ni foam electrodes for supercapacitor display small equivalent series resistance(ESR, 52 m?) and impressive high power density(20 k W/kg). The advantages and challenges associated with the application of these materials for energy conversion and storage devices are highlighted. | Dandan Zhao Ying Wang Yafei Zhang | 2011 | Nano-Micro Letters2011，3，1： | 9 |
| 3 | High-efficiency second-order nonlinear processes in an optical microfibre assisted by few-layer GaSe显示文摘The centrosymmetric nature of silica fibre precludes the realisation of second-order nonlinear processes in optical fibre systems.Recently,the integration of 2D materials with optical fibres has opened up a great opportunity to develop allfibre active devices.Here,we demonstrate high-efficiency second-order nonlinear frequency conversions in an optical microfibre assisted with few-layer gallium selenide(GaSe)nanoflakes.Attributed to the strong evanescent field of the microfibre and ultrahigh second-order nonlinearity of the GaSe nanoflakes,second harmonic generation(SHG)and sum-frequency generation(SFG)are effectively achieved with only sub-milliwatt continuous-wave(CW)lasers in the wavelength range of 1500–1620 nm,covering the C and L telecom bands.The SHG intensity from the microfibre is enhanced by more than four orders of magnitude with the assistance of the GaSe nanoflakes on fibre nonlinear processes.Moreover,in the SFG process,the intensity transfer between different frequencies can be effectively manipulated by changing the wavelengths and powers of two pump lasers.The realised strong second-order nonlinearity in the GaSe-integrated microfibre might expand the applications of all-fibre devices in all-optical signal processing and new light source generation at awkward wavelengths. | Biqiang Jiang Zhen Hao Yafei Ji Yueguo Hou Ruixuan Yi Dong Mao Xuetao Gan Jianlin Zhao | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 4 | Critical roles of chemokine receptor CCR5 in regulating glioblastoma proliferation and invasion显示文摘Glioblastoma (GBM ) 是在成年人的最流行的恶意的主要大脑肿瘤并且展出异常地好攻击的显型的一个系列。肿瘤房间增长和侵略被 chemokines 和他们的受体极其调整。最近的研究证明了 chemokine CCL5 和它的受体 CCR5 在肿瘤侵略和转移起重要作用。尽管如此,在 GBM 的 CCR5 的角色仍然保持不清楚。现在的学习提供 chemokine 受体 CCR5 高度被表示并且在人的 GBM 把预后与穷人联系了的证据。机械学地, CCL5CCR5 调停 Akt 的激活,并且随后在 U87 和 U251 房间导致增长和侵略回答。而且, CCR5 的下面规定显著地在 U87 肿瘤禁止了 glioma 的生长异种皮移植老鼠模型。最后,在 GBM 的高 CCR5 表示在耐心的样品与增加的 p-Akt 表示被相关。一起,这些调查结果建议 CCR5 是与 gliomagenesis 联系的一个批评分子的事件。 | Lanfu Zhao Yuan Wang Yafei Xue Wenhai Lv Yufu Zhang Shiming He | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 4 |
| 5 | Investigation of physicochemical properties and in-vitro in-vivo evaluation of agomelatine polymorphs显示文摘In the present study,Form I,Form II and Form III of agomelatine were prepared to investigate the variability of polymorphs,then the in-vitro in-vivo correlation were established.The presence of three polymorphs of agomelatine was corroborated through studies by XRPD,TGA and DSC.All the forms obtained were then subjected to the powder and intrinsic dissolution tests.The IDR ranked in the order of Form III>Form I>Form II.Form I and Form III both underwent solvent-mediated phase transformation(SMPT)to Form II during dissolution and the transition points were 62 and 45 min,respectively.Pharmacokinetic profiles were acquired after oral administration of tablets,showing that the ka and AUC0e12 h of Form I,Form II,Form III were 0.580.11,0.340.05,0.740.07 h1 and 296.2549.39,186.0545.93,331.1654.74 ng*h/ml,respectively.Good linearities between IDR and ka,IDR and AUC were established,suggesting that the agomelatine polymorphic forms with faster dissolution rates in-vitro would increase the rate and extent of oral absorption in-vivo.These results demonstrated that IDR was predictive in estimating the relative bioavailability of agomelatine polymorphic forms. | Wei Du Yuefang Zhou Yafei Gong Chunshun Zhao | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，3： | 4 |
| 6 | Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout显示文摘 | Dong, Zheng Li, Yuan Zhou, Jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia Pang, Yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun | 2017 | Protein & Cell2017，8，6： | 3 |
| 7 | Selective electrochemical production of hydrogen peroxide at zigzag edges of exfoliated molybdenum telluride nanoflakes显示文摘The two-electron reduction of molecular oxygen represents an effective strategy to enable the green,mild and on-demand synthesis of hydrogen peroxide.Its practical viability,however,hinges on the development of advanced electrocatalysts,preferably composed of non-precious elements,to selectively expedite this reaction,particularly in acidic medium.Our study here introduces 2H-MoTe2 for the first time as the efficient non-precious-metal-based electrocatalyst for the electrochemical production ofhydrogen peroxide in acids.We show that exfoliated 2H-MoTe2 nanoflakes have high activity(onset overpotential〜140 mV and large mass activity of 27 A g^-1 at 0.4 V versus reversible hydrogen electrode),great selectivity(H2O2 percentage up to 93%)and decent stability in 0.5 M H2SO4.Theoretical simulations evidence that the high activity and selectivity of 2H-MoTe2 arise from the proper binding energies of HOO*and O*at its zigzag edges that jointly favor the two-electron reduction instead of the four-electron reduction of molecular oxygen. | Xuan Zhao Yu Wang Yunli Da Xinxia Wang Tingting Wang Mingquan Xu Xiaoyun He Wu Zhou Yafei Li Jonathan NColeman Yanguang Li | 2020 | National Science Review2020，7，8： | 3 |
| 8 | Flower heads in Asteraceae—recruitment of conserved developmental regulators to control the flower-like inflorescence architecture显示文摘Inflorescences in the Asteraceae plant family,flower heads,or capitula,mimic single flowers but are highly compressed structures composed of multiple flowers.This transference of a flower-like appearance into an inflorescence level is considered as the key innovation for the rapid tribal radiation of Asteraceae.Recent molecular data indicate that Asteraceae flower heads resemble single flowers not only morphologically but also at molecular level.We summarize this data giving examples of how rewiring of conserved floral regulators have led to evolution of morphological innovations in Asteraceae.Functional diversification of the highly conserved flower meristem identity regulator LEAFY has shown a major role in the evolution of the capitulum architecture.Furthermore,gene duplication and subsequent sub-and neofunctionalization of SEPALLATA-and CYCLOIDEA-like genes in Asteraceae have been shown to contribute to meristem determinacy,as well as flower type differentiation—key traits that specify this large family.Future challenge is to integrate genomic,as well as evolutionary developmental studies in a wider selection of Asteraceae species to understand the detailed gene regulatory networks behind the elaborate inflorescence architecture,and to promote our understanding of how changes in regulatory mechanisms shape development. | Paula Elomaa Yafei Zhao Teng Zhang | 2018 | Horticulture Research2018，5，1： | 3 |
| 9 | Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle显示文摘Skeletal muscle disorders have posed great threats to health.Selective delivery of drugs and oligonucleotides to skeletal muscle is challenging.Aptamers can improve targeting efficacy.In this study,for the first time,the human skeletal muscle-specific ssDNA aptamers(HSM01,etc.)were selected and identified with Systematic Evolution of Ligands by Exponential Enrichment(SELEX).The HSM01 ssDNA aptamer preferentially interacted with human skeletal muscle cells in vitro.The in vivo study using tree shrews showed that the HSM01 ssDNA aptamer specifically targeted human skeletal muscle cells.Furthermore,the ability of HSM01 ssDNA aptamer to target skeletal muscle cells was not affected by the formation of a disulfide bond with nanoliposomes in vitro or in vivo,suggesting a potential new approach for targeted drug delivery to skeletal muscles via liposomes.Therefore,this newly identified ssDNA aptamer and nanoliposome modification could be used for the treatment of human skeletal muscle diseases. | Shuming Sun Han Liu Yan Hu Yanpeng Wang Mingri Zhao Yijun Yuan Yafei Han Yingying Jing Jin Cui Xiaoxiang Ren Xiao Chen Jiacan Su | 2023 | Bioactive Materials2023，，2： | 3 |
| 10 | A strategy for enhancing anaerobic digestion of waste activated sludge: Driving anodic oxidation by adding nitrate into microbial electrolysis cell显示文摘Cathodic reduction of CO_2 and anodic oxidation of organic matters are crucial to methaneproducing microbial electrolysis cell(MEC) applied in anaerobic digestion of waste activated sludge. However, cathodic CO_2 reduction is usually restrained by slow metabolism rates of H_2-utilizing methanogens and low electron-capturing capacity of CO_2, which consequently slows down the anodic oxidation that participates to sludge disintegration. Herein, a strategy with adding nitrate as electron acceptor to foster electronic transfer between the anode and cathode was proposed to improve anodic oxidation. Results showed that the average efficiency of anodic oxidation in the nitrate-added MEC increased by 55.9%. Accordingly,volatile suspended solid removal efficiency in the nitrate-added MEC was 21.9% higher than that of control MEC. Although the initial cumulative methane production in the nitrateadded MEC was lower than that of control MEC, the cumulative methane production in 24 days was 8.9% higher. Fourier transform infrared spectroscopy analysis indicated that anodic oxidation of MEC with nitrate accelerated the disintegration of sludge flocs and cell walls. Calculation on current signal further revealed that anodic oxidation driven by cathodic nitrate reduction was the main mechanism responsible for the improved sludge digestion. | Hong Peng Zhiqiang Zhao Hong Xiao Yafei Yang Huimin Zhao Yaobin Zhang | 2019 | Journal of Environmental Sciences2019，31，7： | 2 |
| 11 | Principles to tailor the saturable and reverse saturable absorption of epsilon-near-zero material显示文摘Indium tin oxide(ITO) films have recently emerged as a new class of functional materials for nonlinear optical(NLO) devices due to their exotic properties around epsilon-near-zero(ENZ) wavelength. Here, we experimentally investigated and tailored the NLO absorption properties of ITO films. The NLO absorption response of ITO films is investigated by using the femtosecond Z-scan measurement technique at two different wavelengths of 1030 nm(out of ENZ region) and 1440 nm(within ENZ region). Interestingly, we observed conversion behavior from saturable absorption(SA) to reverse saturable absorption(RSA) at 1030 nm with the increasing incident laser intensity, whereas only SA behavior was observed at 1440 nm. We demonstrate that SA behavior was ascribed to ground-state free electrons bleaching in the conduction band, and RSA was attributed to three-photon absorption. Moreover, results reveal that ITO film shows more excellent SA performance at 1440 nm with a nonlinear absorption coefficient of ~-23.2 cm∕GW and a figure of merit of ~1.22 × 10^(-16) esu · cm.Furthermore, we tailored the SA and RSA behaviors of ITO films at 1030 and 1440 nm wavelengths via post-annealing treatment. The modulatable NLO absorption was ascribed to the changing of free-carrier concentration in ITO films via annealing treatment. The experimental findings offered an inroad for researchers to tailor its NLO absorption properties by changing the free-carrier concentration through chemical modification such as annealing, oxidation, or defect implantation. The superior and tunable nonlinear optical response suggests that ITO film might be employed as a new class material with potential applications in novel optical switches or optical limiters to realize the all-optical information process. | HAO MA YUANAN ZHAO YUCHEN SHAO YAFEI LIAN WEILI ZHANG GUOHANG HU YUXIN LENG JIANDA SHAO | 2021 | Photonics Research2021，9，5： | 2 |
| 12 | Urban Expansion of China from the 1970s to 2020 Based on Remote Sensing Technology显示文摘Based on Remote Sensing (RS) and Geographical Information System (GIS) technology,urban expansion of 75 cities in China from the 1970s to 2020 was reconstructed by visual-interpretation method,which described the growing process of urban lands and its influences on local land use structures synchronously.By employing annual expansion area per city and urban expansion density,spatial-temporal characteristics and macro patterns of urban expansion were analyzed from the aspects of regional-distributions,administrative-levels and population-sizes comprehensively.Results indicate that:1) urban expansion in China was universal,distinct,persistent,periodic and fluctuating.In the past five decades,urban lands of 75 monitored cities in China expanded dramatically from 3606.26 km2 to 30 521.13 km2.2) Though urban expansion presented significant differences from the aspects of regional distribution,administrative levels,and population sizes,it exhibited a deceleration trend in the 13th Five-Year Plan among all kinds of cities.3) Cultivated lands were the first land resource for urban expansion,and 55.17% of newly-expanded urban lands appeared by encroaching this land use type.China’s urban expansion has caused sustained pressure on cultivated land protection,especially in super megacities,and the contradiction between urban expansion and cultivated land protection will always exist.4) The compactness of urban lands in China increased before 1987 and reduced in the next three decades,which was consistent with the implementation of major policies and the deployment of national strategies,and is expected to become compact with a stopping declining or even rebounding after the 13th Five-Year Plan. | LIU Fang ZHANG Zengxiang ZHAO Xiaoli LIU Bin WANG Xiao YI Ling ZUO Lijun XU Jinyong HU Shunguang SUN Feifei WANG Yafei | 2021 | Chinese Geographical Science2021，31，5： | 2 |
| 13 | 3-Oxodapagliflozin as a Potent and Highly Selective SGLT2 Inhibitor for the Treatment of Type 2 Diabetes显示文摘 | ZHANG Shuo WANG Yuli LIU Wei XIE Yafei LIU Yuqiang XU Weiren TANG Lida WANG Jianwua ZHAO Guilong | 2014 | Chemical Research in Chinese Universities2014，30，5： | 2 |
| 14 | The Controllability, Observability, and Stability Analysis of a Class of Composite Systems with Fractional Degree Generalized Frequency Variables显示文摘This paper is concerned with fundamental properties of a class of composite systems with fractional degree generalized frequency variables, including controllability, observability and stability. Firstly, some necessary and sufficient conditions are given to guarantee controllability and observability of such composite systems. Then we prove that the stability problem of such composite systems can be reduced to judging whether a fractional degree polynomial is stable. Finally, the stability analysis result is applied in the supervisory control of fractional-order multi-agent systems, and an example is provided to illustrate the effectiveness of the proposed methods. | Cuihong Wang Yafei Zhao YangQuan Chen | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，3： | 2 |
| 15 | Design, Synthesis and Biological Activity of Tetrazole-bearing Uric Acid Transporter 1 Inhibitors显示文摘 | CAI Wenqing LIU Wei XIE Yafei WU Jingwei LIU Yuqiang LIU Changying XU Weiren TANG Lida WANG Jianwu ZHAO Guilong | 2017 | Chemical Research in Chinese Universities2017，33，1： | 2 |
| 16 | Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T-cell acute lymphoblastic leukemia显示文摘Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased.We proposed that targeting LDHA may be a potential strategy to improve T-ALL outcomes.The current study was conducted to investigate the antileukemic effect of LDHA gene-targeting treatment on T-ALL and the underlying molecular mechanism.Methods:Primary T-ALL cell lines Jurkat and DU528 were treated with the LDH inhibitor oxamate.MTT,colony formation,apoptosis,and cell cycle assays were performed to investigate the effects of oxamate on T-ALL cells.Quantitative real-time PCR(qPCR)and Western blotting analyses were applied to determine the related signaling pathways.A mitochondrial reactive oxygen species(ROS)assay was performed to evaluate ROS production after T-ALL cells were treated with oxamate.A T-ALL transgenic zebrafish model with LDHA gene knockdown was established using CRISPR/Cas9 gene-editing technology,and then TUNEL,Western blotting,and T-ALL tumor progression analyses were conducted to investigate the effects of LDHA gene knockdown on T-ALL transgenic zebrafish.Results:Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells.It also arrested Jurkat and DU528 cells in G0/G1 phase and stimulated ROS production(all P<0.001).Blocking LDHA significantly decreased the gene and protein expression of c-Myc,as well as the levels of phosphorylated serine/threonine kinase(AKT)and glycogen synthase kinase 3 beta(GSK-3β)in the phosphatidylinositol 3′-kinase(PI3K)signaling pathway.LDHA gene knockdown delayed disease progression and down-regulated c-Myc mRNA and protein expression in T-ALL transgenic zebrafish.Conclusion:Targeting LDHA exerted an antileukemic effect on T-ALL,representing a potential strategy for T-ALL treatment. | Haizhi Yu Yafei Yin Yifang Yi Zhao Cheng Wenyong Kuang Ruijuan Li Haiying Zhong Yajuan Cui Lingli Yuan Fanjie Gong Zhihua Wang Heng Li Hongling Peng Guangsen Zhang | 2020 | Cancer Communications2020，40，10： | 2 |
| 17 | ABNORMAL SHOOT 6 interacts with KATANIN 1 and SHADE AVOIDANCE 4 to promote cortical microtubule severing and ordering in Arabidopsis显示文摘Plant interphase cortical microtubules(cMTs)mediate anisotropic cell expansion in response to environmental and developmental cues.In Arabidopsis thaliana,KATANIN 1(KTN1),the p60 catalytic subunit of the conserved MT-severing enzyme katanin,is essential for cMT ordering and anisotropic cell expansion.However,the regulation of KTN1-mediated cMT severing and ordering remains unclear.In this work,we report that the Arabidopsis IQ67 DOMAIN(IQD)family gene ABNORMAL SHOOT 6(ABS6)encodes a MT-associated protein.Overexpression of ABS6 leads to elongated cotyledons,directional pavement cell expansion,and highly ordered transverse cMT arrays.Genetic suppressor analysis revealed that ABS6-mediated cMT ordering is dependent on KTN1 and SHADE AVOIDANCE 4(SAV4).Live imaging of cMT dynamics showed that both ABS6 and SAV4 function as positive regulators of cMT severing.Furthermore,ABS6 directly interacts with KTN1 and SAV4 and promotes their recruitment to the cMTs.Finally,analysis of loss-of-function mutant combinations showed that ABS6,SAV4,and KTN1 work together to ensure the robust ethylene response in the apical hook of dark-grown seedlings.Together,our findings establish ABS6 and SAV4 as positive regulators of cMT severing and ordering,and highlight the role of cMT dynamics in fine-tuning differential growth in plants. | Yuanfeng Li Meng Deng Haofeng Liu Yan Li Yu Chen Min Jia Hui Xue Jingxia Shao Jun Zhao Yafei Qi Lijun An Fei Yu Xiayan Liu | 2021 | Journal of Integrative Plant Biology2021，63，4： | 2 |
| 18 | Image annotation techniques based on feature selection for class-pairs显示文摘 | Jianjiang Lu Ran Li Yafei Zhang Tianzhong Zhao Zining Lu | 2010 | Knowledge and Information Systems2010，，2： | 1 |
| 19 | Removal of methylene blue from aqueous solutions by adsorption onto chemically activated halloysite nanotubes 显示文摘 | Luo Peng Zhang Bing Zhao Yafei | 2011 | korean Journal of Chemical Engineering2011，28，3： | 1 |
| 20 | Removal of methylene blue from aqueous solutions by adsorption onto chemically activated halloysite nanotubes 显示文摘 | Luo Peng Zlumg Bing Zhao Yafei | 2011 | Korean Journal of Chemical Engineering2011，28，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员