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| 1 | International Association of Diabetes and Pregnancy Study Group criteria is suitable for gestational diabetes mellitus diagnosis: further evidence from China显示文摘 | Wei Yumei Yang Huixia Zhu Weiwei Yang Hongyun Li Haixia Yan Jie Zhang Cuilin | 2014 | Chinese Medical Journal2014，，20： | 129 |
| 2 | Microcalorimetric investigation of effect of berberine alkaloids from Coptis chinensis Franch on intestinal diagnostic flora growth显示文摘The inhibitory effect of three berberine alkaloids (BAs) from Coptis chinensis Franch, a traditional Chinese medicinal (TCM) herb, on Bifidobacterium adolescentis growth was investigated by micro- calorimetry. The power-time curves of B. adolescentis with and without BAs were acquired, meanwhile the extent and duration of inhibitory effect on the metabolism were evaluated by the growth rate con- stant (k), half inhibitory ratio (IC50), maximum heat-output power (Pmax), peak time of maximum heat-output power (tp) and total heat production (Qt). k, Pmax and Qt decreased, and tp was prolonged with the increase of BAs concentration. The IC50 of BAs is 806 μg/mL for berberine, 341 μg/mL for cop- tisine and 236 μg/mL for palmatine. The sequence of antimicrobial activity of BAs is berberine < cop- tisine < palmatine. Combined with previous studies, it could be shown that the sequences of antim- icrobial activity of BAs on both Bacillus shigae and Escherichia coli are berberine > coptisine > pal- matine. The structure-function relationship of BAs indicates that the functional group methylenedioxy or methoxyl at C2 and C3 might be the major group inducing the activities of BAs on E. coli and B. adolescentis. Meanwhile, the substituent groups at C2, C3, C9 and C10 almost have equal effect on B. shigae. | YAN Dan WEI Li XIAO XiaoHe ZHOU DanLei HAN YuMei | 2009 | Chinese Science Bulletin2009，54，3： | 12 |
| 3 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 4 | Risk of gestational diabetes recurrence and the development of type 2 diabetes among women with a history of gestational diabetes and risk factors: a study among 18 clinical centers in China显示文摘Background:Gestational diabetes mellitus(GDM)brings health issues for both mothers and offspring,and GDM prevention is as important as GDM management.It was shown that a history of GDM was significantly associated with a higher maternal risk for GDM recurrence.The incidence of GDM recurrence was unclear because of the incidence of second-child was low before 2016 in China.We aim to investigate the prevalence of GDM recurrence and its associated high-risk factors which may be useful for the prediction of GDM recurrence in China.Methods:A retrospective study was conducted which enrolled participants who underwent regular prenatal examination and delivered twice in the same hospital of 18 research centers.All participants were enrolled from January 2018 to October 2018,where they delivered the second baby during this period.A total of 6204 women were enrolled in this study,and 1002 women with a history of GDM were analyzed further.All participants enrolled in the study had an oral glucose tolerance test(OGTT)result at 24 to 28 weeks and were diagnosed as GDM in the first pregnancy according to the OGTT value(when any one of the following values is met or exceeded to the 75-g OGTT:0 h[fasting],≥5.10 mmol/L;1 h,≥10.00 mmol/L;and 2 h,≥8.50 mmol/L).The prevalence of GDM recurrence and development of type 2 diabetes mellitus were calculated,and its related risk factors were analyzed.Results:In 6204 participants,there are 1002 women(1002/6204,16.15%)with a history of GDM and 5202 women(5202/6204,83.85%)without a history of GDM.There are significant differences in age(32.43±4.03 years vs.33.00±3.34 years vs.32.19±3.37 years,P<0.001),pregnancy interval(4.06±1.44 years vs.3.52±1.43 years vs.3.38±1.35 years,P=0.004),prepregnancy body mass index(BMI)(27.40±4.62 kg/m^(2)vs.23.50±3.52 kg/m^(2)vs.22.55±3.47 kg/m^(2),P<0.001),history of delivered macrosomia(22.7%vs.11.0%vs.6.2%,P<0.001)among the development of diabetes mellitus(DM),recurrence of GDM,and normal women.Moreover,it seems so important in the degree of abnormal glucose metabolism in the first pregnancy to the recurrence of GDM and the development of DM.There are significant differences in OGTT levels of the first pregnancy such as area under the curve of OGTT value(18.31±1.90 mmol/L vs.16.27±1.93 mmol/L vs.15.55±1.92 mmol/L,P<0.001),OGTT fasting value(5.43±0.48 mmol/L vs.5.16±0.49 mmol/L vs.5.02±0.47 mmol/L,P<0.001),OGTT 1-hour value(10.93±1.34 mmol/L vs.9.69±1.53 mmol/L vs.9.15±1.58 mmol/L,P<0.001),OGTT 2-hour value(9.30±1.66 mmol/L vs.8.01±1.32 mmol/L vs.7.79±1.38 mmol/L,P<0.001),incidence of impaired fasting glucose(IFG)(fasting plasma glucose≥5.6 mmol/L)(31.3%vs.14.6%vs.8.8%,P<0.001),and incidence of two or more abnormal OGTT values(68.8%vs.39.7%vs.23.9%,P<0.001)among the three groups.Using multivariate analysis,the factors,such as age(1.07[1.02-1.12],P=0.006),prepregnancy BMI(1.07[1.02,1.12],P=0.003),and area under the curve of OGTT in the first pregnancy(1.14[1.02,1.26],P=0.02),have an effect on maternal GDM recurrence;the factors,such as age(1.28[1.01-1.61],P=0.04),pre-pregnancy BMI(1.26[1.04,1.53],P=0.02),and area under the curve of OGTT in the first pregnancy(1.65[1.04,2.62],P=0.03),have an effect on maternal DM developed further.Conclusions:The history of GDM was significantly associated with a higher maternal risk for GDM recurrence during follow-up after the first pregnancy.The associated risk factors for GDM recurrence or development of DM include age,high pre-pregnancy BMI,history of delivered macrosomia,the OGTT level in the first pregnancy,such as the high area under the curve of OGTT,IFG,and two or more abnormal OGTT values.To prevent GDM recurrence,women with a history of GDM should do the preconception counseling before preparing next pregnancy. | Yumei Wei Juan Juan Rina Su Geng Song Xu Chen Ruiqin Shan Ying Li Shihong Cui Shangrong Fan Ling Feng Zishan You Haixia Meng Yan Cai Cuilin Zhang Huixia Yang | 2022 | Chinese Medical Journal2022，，6： | 7 |
| 5 | The action of medicinal animal horns on Escherichia coli growth investigated by microcalorimetry and chemometric analysis显示文摘The action of Cornu Cervi Pantotrichum (CCP), Cornu Cervi (CC) and Cornu Saigae Tataricae (CST) on Escherichia coli growth were investigated using microcalorimetry to find the heat change regularity of microbial growth. The similarity of thermogenic curves and thermodynamics parameters were investigated as evaluation index, such as the growth rate constant in the first expo- nential phase (k1), maximum power in the first exponential phase (P1), maximum power in the secondary exponential phase (P2), peak time in the first exponential phase (T1), peak time in the stationary phase (T2) and the total heat production in stage 1 (Q1), and the total heat production in stage 2 (Q2). Chemometric analysis was used as a reference for the bioactivity evaluation of medicinal animal horns. The results indicated that the similarity between CST and the control was smaller than that between CCP, CC and the control. Both CCP and CC could increase the heat in the microbial growth, whereas CST decreased it. The biotic thermal activity of different medicinal animal horns was objectively, qualitatively, and quantitatively evaluated by the similarity of thermogenic curves and thermodynamics parameters analysis. | YAN Dan HAN YuMei LUO JiaoYang ZHANG Ping TANG HuiYing PENG Cheng XIAO XiaoHe | 2010 | Chinese Science Bulletin2010，55，26： | 6 |
| 6 | Neuroprotective effects of combined lead and cadmium,as well as N-acetylcysteine,on cerebral cortical neurons following lipid peroxidation injury显示文摘BACKGROUND:Studies have reported the antioxidant effects of lead and cadmium in the central nervous system,but very few have addressed the combined toxicity of lead and cadmium.The mechanisms by which these combined heavy metals are toxic,as well as how to protect cells from these agents,remains poorly understood. OBJECTIVE:Primary cultured rat cortical neurons were used to determine the effects of combined lead and cadmium on levels of glutathione peroxidase(GSH-Px),superoxide dismutase(SOD), catalase(CAT),and acetylcholinesterase(AChE),as well as malondialdehyde(MDA),and to evaluate the neuroprotective effects of N-acetylcysteine(NAC). DESIGN,TIME AND SETTING:An in vitro toxicological observation was performed at the Comparative Medicine Center of Yangzhou University from August 2007 to April 2008. MATERIALS:Lead acetate,cadmium acetate,and NAC were purchased from Sigma-Aldrich(St. Louis,USA).Commercial kits of GSH-Px,SOD,CAT,AChE,and MDA were purchased from Nanjing Jiancheng Bioengineering Institute,Nanjing,China. METHODS:The cerebral cortical neurons were isolated from newborn Sprague dawley rats at 24 hours after birth and primary cultured for 6 days.Thereafter,the cells were treated with a range of cadmium doses(0,5.0,and 10.0μmol/L),lead doses(0,1.0,and 2.0μmol/L),or a combination of the two for 12 hours at 37℃in a 5%CO_2 incubator,respectively.In addition,the cells were incubated with different doses of cadmium and/or lead and(0 and 50μmol/L) NAC for 12 hours to assess the protective effects on cell survival. MAIN OUTCOME MEASURES:The activity of SOD,GSH-Px,CAT,and AChE,as well as MDA content,in the cell lysates was detected using commercial kits. RESULTS:At 12 hours after treatment,compared to the control group,activity of GSH-Px,SOD, and AChE in the lead,cadmium,or combined treated cells was significantly decreased with increasing doses of cadmium/or lead(P<0.05),but CAT activity and MDA levels were significantly increased(P<0.05).The combination of cadmium and lead led to higher levels of toxicity than individual exposure. CONCLUSION:The degree of oxidative damage increased when the two heavy metals were combined.NAC protected neonatal cortical neurons by increasing activity of anti-oxidative enzymes, and reducing lipid peroxidation,but the reduction was not statistically significant. | Yumei Zhang Hao Lu Yan Yuan Xuezhong Liu Zongping Liu | 2009 | Neural Regeneration Research2009，4，11： | 4 |
| 7 | Heat transfer enhancement in a tube fitted with helical blade rotors with grooves显示文摘 | Zhen Zhang Weimin Yang Changfeng Guan Yumei Ding Hua Yan | 2013 | Experimental Thermal and Fluid Science2013，，： | 4 |
| 8 | Heat transfer enhancement in the tube fitted with Left–Right helical blade rotors显示文摘 | Zhen Zhang Hua Yan Weimin Yang Yinpeng Zhou Yumei Ding Changfeng Guan | 2013 | Applied Thermal Engineering (-)2013，，1： | 4 |
| 9 | Heat transfer enhancement in double-pipe heat exchanger by means of rotor-assembled strands显示文摘 | Zhen Zhang Yumei Ding Changfeng Guan Hua Yan Weimin Yang | 2012 | Chemical Engineering & Processing: Process Intensification2012，，： | 4 |
| 10 | Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation,drug delivery and bioactivity显示文摘Mesoporous silica thin film has been widely used in various fields,particularly the medical implant coating for drug delivery.However,some drawbacks remain with the films produced by traditional method(evaporation-induced self-assembly,EISA),such as the poor permeability caused by their horizontal aligned mesochannels.In this study,the vertical aligned mesoporous silica thin film(VMSTF)is uniformly grown alongside the walls of titania nanotubes array via a biphase stratification growth method,resulting in a hierarchical two-layered nanotubular structure.Due to the exposure of opened mesopores,VMSTF exhibits more appealing performances,including rapid degradation,efficient small-molecular drug(dexamethasone)loading and release,enhanced early adhesion and osteogenic differentiation of MC3T3-E1 cells.This is the first time successfully depositing VMSTF on nanoporous substrate and our findings suggest that the VMSTF may be a promising candidate for bone implant surface coating to obtain bioactive performances. | Zhe Li Yide He Lasse Hyldgaard Klausen Ning Yan Jing Liu Fanghao Chen Wen Song Mingdong Dong Yumei Zhang | 2021 | Bioactive Materials2021，6，5： | 4 |
| 11 | Numerical study on thermo-hydraulic characteristics of turbulent flow in a circular tube fitted with helical blade rotors显示文摘 | Zhen Zhang Weimin Yang Changfeng Guan Yumei Ding Hua Yan | 2013 | International Journal of Heat and Mass Transfer2013，，： | 3 |
| 12 | Effect of acupuncture plus conventional treatment on brain activity in ischemic stroke patients: a regional homogeneity analysis显示文摘OBJECTIVE: To determine differences in cerebral activity evoked by acupuncture and conventional stroke treatment, and identify the treatment targets.METHODS: In total, 21 patients were randomly divided into two groups. Group A(11 patients) received both acupuncture and conventional treatment, while group B(10 patients) received conventional treatment only. Resting-state functional magnetic resonance imaging(f MRI) was performed on each participant before and after treatment. Regional homogeneity analysis was performed to investigate the potential mechanism of acupuncture treatment by comparing differences in cerebral activity between treatments.RESULTS: Group A showed higher Re Ho in the frontal lobe(BA6, BA46), supra-marginal gyrus(BA40),middle temporal gyrus(BA21), cerebellum, and insula. Group B showed higher Re Ho in the frontal lobe(BA6) and parietal lobe(BA3, BA7).CONCLUSION: Acupuncture and conventional treatment triggered relatively different clinical efficacy and brain responses. Acupuncture treatment more significantly improved the symptoms of stroke patients. More marked changes in sensory,emotional, and motor areas(including the frontal lobe, middle temporal gyrus, cerebellum, and insula) might reflect the specific acupuncture mechanism. | Wu Ping Zeng Fang Li Yongxin Li Ji Qiu Lihua Qin Wei Luo Lu Yin Canxin Xiong Yan Bai Yu Wang Dan Zhou Yumei Liang Fanrong | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 13 | Heat transfer and friction characteristics of turbulent flow through plain tube inserted with rotor-assembled strands显示文摘 | Zhen Zhang Weimin Yang Changfeng Guan Yumei Ding Fengxiang Li Hua Yan | 2011 | Experimental Thermal and Fluid Science2011，，： | 3 |
| 14 | Interference of CsGPA1,theα-submit of G protein,reduces drought tolerance in cucumber seedlings显示文摘The G proteinα-subunit,GPA1,is an integral component of several signaling pathways in plants,including response to abiotic stress.However,the molecular mechanism behind these processes remains largely unknown in the cucumber plant(Cucumis sativus L.).In order to further understand the role of CsGPA1 in cucumber under drought stress,changes in plant growth,physiological parameters,and gene expression of CsAQPs were all measured under water stress induced by polyethylene glycol(PEG)using wild type(WT)and CsGPA1-interference(RNAi)cucumber seedlings.Our results demonstrated that the RNAi plants had lower drought tolerance,displaying seriously withered leaves,lower relative growth rate,lower root-shoot ratio,and lower root activity under drought stress compared to WT plants.Physiological studies indicated that the suppression of CsGPA1 weakened drought stress tolerance due to higherwater loss rate in the leaves,higher levels of hydrogen peroxide(H2O2),increased malondialdehyde(MDA)content,lower free proline content,lower soluble sugar content,lower soluble protein content,and decreased antioxidant enzyme activities.qRT-PCR analysis demonstrated that the interference of CsGPA1 up-regulated the expression of most AQP genes(except for CsPIP2;3 in leaves)and down-regulated the expression of CsPIP1;2,CsPIP1;4,CsPIP2;1,and CsPIP2;4 in roots under drought stress when compared to WT plants.Our results demonstrated that CsGPA1 could function as a positive regulator in drought stress response by decreasing the accumulation of reactive oxygen species(ROS),improving permeable potentials,and reducing water loss in cucumber plants. | Yumei Liu Qinghua Du Longqiang Bai Mintao Sun Yansu Li Chaoxing He Jun Wang Xianchang Yu Yan Yan | 2021 | Horticultural Plant Journal2021，7，3： | 3 |
| 15 | The development road of ammonium phosphate fertilizer in China显示文摘Ammonium phosphate fertilizer is the compounds containing nitrogen and phosphorus that are usually produced through the neutralization reaction of phosphoric acid and ammonia.At present,there are a variety of products,such as slurry monoammonium phosphate(MAP),diammonium phosphate(DAP),industrial grade MAP,water soluble MAP,water soluble ammonium polyphosphate(APP)and so on.After more than 60 years of development,China’s ammonium phosphate fertilizer industry has experienced the road of from scratch and from weak to strong.The successful development of the slurry MAP technology ended the history that the high concentration phosphate fertilizer cannot be produced by using the medium and low grade phosphate ore.The continuous,stable and large-scale production of DAP plant provides sufficient guarantee for DAP products in China.The development of new ammonium phosphate fertilizer products,such as industrial grade MAP,water soluble MAP,water soluble APP,provides technical support for the transformation and upgrading of phosphorus chemical enterprises.In this paper,the production methods,the development history and the latest research progress of ammonium phosphate fertilizers were reviewed. | Dehua Xu Benhe Zhong Xinlong Wang Xue Li Yanjun Zhong Zhengjuan Yan Jingxu Yang Xiaobin Li Yumei Wang Xiaohou Zhou | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 3 |
| 16 | Nitrogen-doped Co_(3)O_(4) nanowires enable high-efficiency electrochemical oxidation of 5-hydroxymethylfurfural显示文摘Developing highly efficient and cost-effective catalysts for electrochemically oxidizing biomass-derived 5-hydroxymethylfurfural(HMF)into value-added 2,5-furandicarboxylic acid(FDCA)is of great importance.Herein,we report a controllable nitrogen doping strategy to significantly improve the catalytic activity of Co_(3)O_(4)nanowires for highly selective electro-oxidation of HMF into FDCA.The nitrogen doping leads to the generation of defects including nitrogen dopants and oxygen vacancies in Co_(3)O_(4)nanowires,which is conducive to the formation of catalytically active sites.As a result,the electro-oxidation potential for HMF is only 1.38 V(vs.RHE)when the current density reaches 50 mA/cm^(2).More importantly,the conversion rate of HMF is as high as 99.5%,and the yield of FDCA is up to 96.4%. | Mengxiao Sun Yue Wang Chunsen Sun Yan Qi Jia Cheng Yumei Song Lixue Zhang | 2022 | Chinese Chemical Letters2022，33，1： | 2 |
| 17 | LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice显示文摘The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion.Here,we report that deleting Pinch1 in limb mesenchymal stem cells(MSCs)and Pinch2 globally(double knockout;dKO)in mice causes severe chondrodysplasia,while single mutant mice do not display marked defects.Pinch deletion decreases chondrocyte proliferation,accelerates cell differentiation and disrupts column formation.Pinch loss drastically reduces Smad2/3 protein expression in proliferative zone(PZ)chondrocytes and increases Runx2 and Col10a1 expression in both PZ and hypertrophic zone(HZ)chondrocytes.Pinch loss increases sclerostin and Rankl expression in HZ chondrocytes,reduces bone formation,and increases bone resorption,leading to low bone mass.In vitro studies revealed that Pinch1 and Smad2/3 colocalize in the nuclei of chondrocytes.Through its C-terminal region,Pinch1 interacts with Smad2/3 proteins.Pinch loss increases Smad2/3 ubiquitination and degradation in primary bone marrow stromal cells(BMSCs).Pinch loss reduces TGF-β-induced Smad2/3 phosphorylation and nuclear localization in primary BMSCs.Interestingly,compared to those from single mutant mice,BMSCs from dKO mice express dramatically lower protein levels ofβ-catenin and Yap1/Taz and display reduced osteogenic but increased adipogenic differentiation capacity.Finally,ablating Pinch1 in chondrocytes and Pinch2 globally causes severe osteopenia with subtle limb shortening.Collectively,our findings demonstrate critical roles for Pinch1/2 and a functional redundancy of both factors in the control of chondrogenesis and bone mass through distinct mechanisms. | Yiming Lei Xuekun Fu Pengyu Li Sixiong Lin Qinnan Yan Yumei Lai Xin Liu Yishu Wang Xiaochun Bai Chuanju Liu Di Chen Xuenong Zou Xu Cao Huiling Cao Guozhi Xiao | 2020 | Bone Research2020，8，4： | 2 |
| 18 | Facile synthesis of MoS_2/graphite intercalated composite with enhanced electrochemical performance for sodium ion battery显示文摘MoS_2 is a promising anode material for sodium ion batteries owing to its two-dimensional layered structure and high specific capacity. But it still exhibits a poor cycle stability and limited rate capability for Na+storage because of its poor electrical conductivity and structural instability. In this work,MoS_2/graphite composite is fabricated by mechanically delaminated and restacked MoS_2 and graphite to form two-dimensional composite layers. The graphite sheets will improve electrical conductivity and prevent the aggregation as well as structure collapse of the MoS_2 layers during charge–discharge process.The MoS_2/graphite composite exhibits excellent Na+storage properties. It delivers a high discharge specific capacity of 358.2 m Ah/g at a current density of 100 m A/g in the first discharge process and with capacity retention of 68.1% after 800 cycles(retains 244 m Ah/g). The average discharge specific capacities retain 250.9 and 225.4 m Ah/g corresponding to the current densities of 100 and 1000 m A/g, showing excellent rate capability. The improved electrochemical performance is attributed to the improved electrical conductivity and structural stability after composition of graphite sheets. The study demonstrates a new research strategy for improving sodium ion storage properties of MoS_2. | Qingqing Yang Maocheng Liu Yumei Hu Yan Xu Lingbin Kong Long Kang | 2018 | Journal of Energy Chemistry2018，27，4： | 2 |
| 19 | Moisture Absorption and Mechanical Properties of Chemically Modified Linen/Polypropylene Composites显示文摘 | HU Qiuxue LI Li YAN Wenling ZHAO Qi ZHANG Niaona ZHANG Yumei DONG Jinbiao LIU Baijun HU Wei | 2017 | Chemical Research in Chinese Universities2017，33，6： | 1 |
| 20 | Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum显示文摘 | Liang Guo Jianhui Xie Yuanyuan Ruan Lei Zhou Haiyan Zhu Xiaojing Yun Yan Jiang Long Lü Kangli Chen Zhihui Min Yumei Wen Jianxin Gu | 2009 | International Immunopharmacology2009，，10： | 1 |
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