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| 1 | Effect of wheat bran insoluble dietary fiber with different particle size on the texture properties, protein secondary structure, and microstructure of noodles显示文摘This study was conducted to explore how the insoluble dietary fiber(IDF)of wheat bran with different particle size affects the texture properties,water distribution,protein secondary structure and microstructure of noodles.The results suggested that IDF addition increased the cooking loss and decreased the sensory evaluation because of the damage on dough structure,while as the IDF particle size decreased,the sensory score increased from 78.8 to 82.3 and cooking loss decreased from 8.65%to 7.65%,which could be attributed to that small particle-sized IDF limited the damage on protein network structure,decreased the T22 and t-structure,and increased the β1-structure.Moreover,IDF particle size had a significant correlation with protein secondary structures,texture properties and evaluation score of noodles.In conclusion,adding appropriate particle sizewould be an effectiveway of enhancing the nutritional and textural properties of noodles. | Jian Zhang Mengqin Li Chaoran Li Yanqi Liu | 2019 | Grain & Oil Science and Technology2019，2，4： | 20 |
| 2 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 3 | Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach显示文摘Lingguizhugan Decoction(LGZG)has been investigated in basic studies,with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease(NAFLD).This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting.A randomized,double-blinded,placebo-controlled trial was performed.A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG(two groups:standard dose and low dose)or placebo for 12 weeks on the basis of lifestyle modifications.The primary efficacy variable was homeostasis model assessment of insulin resistance(HOMA-IR).Analyses were performed in two populations in accordance with body mass index(BMI;overweight/obese,BMI 24 kg/m^(2);lean,BMI<24 kg/m^(2)).For overweight/obese participants,low-dose LGZG significantly decreased their HOMA-IR level compared with placebo(0.19(1.47)versus 0.08(1.99),P=0.038).For lean subjects,neither dose of LGZG showed a superior effect compared with placebo.Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A(PPP1R3A)and autophagy related 3(ATG3)significantly increased after LGZG intervention in overweight/obese population.Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3.Lean subjects may not be a targeted population for LGZG. | Liang Dai Jingjuan Xu Baocheng Liu Yanqi Dang Ruirui Wang Lijie Zhuang Dong Li Lulu Jiao Jianying Wang Lei Zhang Linda LDZhong Wenjun Zhou Guang Ji | 2022 | Frontiers of Medicine2022，16，5： | 7 |
| 4 | Graphene/phosphorene nano-heterojunction:facile synthesis, nonlinear optics, and ultrafast photonics applications with enhanced performance显示文摘Owing to its thickness-modulated direct energy band gap, relatively strong light–matter interaction, and unique nonlinear optical response at a long wavelength, few-layer black phosphorus, or phosphorene, becomes very attractive in ultrafast photonics applications. Herein, we synthesized a graphene/phosphorene nano-heterojunction using a liquid phase-stripping method. Tiny lattice distortions in graphene and phosphorene suggest the formation of a nano-heterojunction between graphene and phosphorene nanosheets. In addition, we systematically investigate their nonlinear optical responses at different wavelength regimes. Our experiments indicate that the combined advantages of ultrafast relaxation, broadband response in graphene, and the strong light–matter interaction in phosphorene can be combined together by nano-heterojunction. We have further fabricated two-dimensional(2D) nano-heterojunction based optical saturable absorbers and integrated them into an erbium-doped fiber laser to demonstrate the generation of a stable ultrashort pulse down to 148 fs. Our results indicate that a graphene/phosphorene nano-heterojunction can operate as a promising saturable absorber for ultrafast laser systems with ultrahigh pulse energy and ultranarrow pulse duration. We believe this work opens up a new approach to designing 2D heterointerfaces for applications in ultrafast photonics and other research.The fabrication of a 2D nano-heterojunction assembled from stacking different 2D materials, via this facile and scalable growth approach, paves the way for the formation and tuning of new 2D materials with desirable photonic properties and applications. | SHUNXIANG LIU ZHONGJUN LI YANQI GE HUIDE WANG RUI YUE XIANTAO JIANG JIANQING LI QIAO WEN HAN ZHANG | 2017 | Photonics Research2017，5，6： | 6 |
| 5 | Ultrafast nonlinear absorption and nonlinear refraction in few-layer oxidized black phosphorus显示文摘We experimentally investigated the nonlinear optical response in few-layer oxidized black phosphorus(OBP) by the femtosecond Z-scan measurement technique, and found that OBP not only possesses strong ultrafast saturable absorption but also a nonlinear self-defocusing effect that is absent in black phosphorus(BP). The saturable absorption property originates mainly from the direct band structure, which is still maintained in OBP. The emergence of self-defocusing might originate from the combined consequences of the oxygen-induced defects in BP. Our experimental findings might constitute the first experimental evidence on how to dynamically tune its nonlinear property, offering an inroad in tailoring its optical properties through chemical modification(oxidation, introducing defects, etc.). The versatile ultrafast nonlinear optical properties(saturable absorption and self-defocusing) imply a significant potential of the layered OBP in the development of unprecedented optoelectronic devices, such as mode lockers, optical switches, laser beam shapers, and wavelength converters. | Shunbin Lu Yanqi Ge Zhengbo Sun Zongyu Huang Rui Cao Chujun Zhao Shuangchun Wen Dianyuan Fan Jianqing Li Han Zhang | 2016 | Photonics Research2016，4，6： | 5 |
| 6 | Present advances and perspectives of broadband photo-detectors based on emerging 2D-Xenes beyond graphene显示文摘As an excellent optical device,photodetectors have many important applications,such as communication technology,display technology,scientific measurement,fire monitoring,aerospace and biomedical research,and ifs of great significance in the research of nanotechnology and optoelectronics.Graphene,as the first two-dimensional(2D)single-element nanomaterial,has the advantages of high carrier mobility,high strength,high light transmittance and excellent thermal conductivity,and ifs widely used in various nano-optical devices.The great success of graphene has led scientists to extensive research on other 2D single-element nanomaterials.Recently,a group of novel 2D single-element nanomaterials have attracted a lot of attention from scientists because of its excellent physical,chemical,electronic,mechanical and optical properties.Furthermore,it has opened a new door for the realization of new and efficient photodetectors.The group of 2D single-element nanomaterials are called 2D-Xenes and used to make high-performance photodetectors.Currently,there are few studies on photodetectors based on 2D-Xenes,but some 2D-Xenes have been applied to photodetectors and reported.Some of these have excellent photodetection performance,such as high photoresponsivity(R),broad spectral response range,fast photoresponse speed and high specific detectivity(D).Based on the novel 2D-Xenes,this review explores the types and preparation methods of 2D-Xenes,and the working mechanisms of 2D-Xenes photodetectors.Finally,the challenges and development trends of 2D-Xenes in the future are discussed.The research of 2D-Xenes is of great significance for the development of high-performance photodetectors in the future,and is expected to be widely used in other nanoelectronics and optical devices. | Bing Wang Shipeng Zhong Yanqi Ge Huide Wang Xiaoling Luo Han Zhang | 2020 | Nano Research2020，13，4： | 4 |
| 7 | Superior anti-corrosion and self-healing bi-functional polymer composite coatings with polydopamine modified mesoporous silica/graphene oxide显示文摘In this article,graphene oxide(GO)and benzotriazole-loaded mesoporous silica nanoparticles(BTA/MSNs)are combined on micro scale through the in situ polymerization of polydopamine(PDA),preparing a selfhealing bi-functional GO(fGO)used as nano-fillers for anti-corrosion enhancement of waterborne epoxy(WEP)coatings.Scanning electronic microscopy(SEM)images show that the BTA/MSNs are uniformly distributed on the surface of high aspect ratio GO nanosheets to endow GO nanocontainer characteristics.UV-vis profiles demonstrate that fGO has p H-controlled release function.Modulus at lowest frequency is generally used for comparing the corrosion resistance of organic coatings.Modulus at lowest frequency(1.42×10^(5)Ωcm^(2))after 30 days immersion in 3.5 wt.%Na Cl solution revealed 2 orders of magnitude higher that of blank WEP(1.17×10^(7)Ωcm^(2)).With artificial cracks on its coatings,fGO/WEP had no obvious rust compared with blank WEP after 240 h of immersion.We anticipate that self-healing and physical barrier bi-functional nanocontainers improve the traditional anticorrosion coating efficiency with better,longer-lasting performance for shipping,oil drilling or bridge maintenance. | Yanqi Ma Haowei Huang Hongda Zhou Michael Graham James Smith Xinxin Sheng Ying Chen Li Zhang Xinya Zhang Elena Shchukina Dmitry Shchukin | 2021 | Journal of Materials Science & Technology2021，，36： | 4 |
| 8 | Evaluation of human epidermal growth factor receptor 2 status of breast cancer using preoperative multidetector computed tomography with deep learning and handcrafted radiomics features显示文摘Objective:To evaluate the human epidermal growth factor receptor 2(HER2)status in patients with breast cancer using multidetector computed tomography(MDCT)-based handcrafted and deep radiomics features.Methods:This retrospective study enrolled 339 female patients(primary cohort,n=177;validation cohort,n=162)with pathologically confirmed invasive breast cancer.Handcrafted and deep radiomics features were extracted from the MDCT images during the arterial phase.After the feature selection procedures,handcrafted and deep radiomics signatures and the combined model were built using multivariate logistic regression analysis.Performance was assessed by measures of discrimination,calibration,and clinical usefulness in the primary cohort and validated in the validation cohort.Results:The handcrafted radiomics signature had a discriminative ability with a C-index of 0.739[95%confidence interval(95%CI):0.661-0.818]in the primary cohort and 0.695(95%CI:0.609-0.781)in the validation cohort.The deep radiomics signature also had a discriminative ability with a C-index of 0.760(95%CI:0.690-0.831)in the primary cohort and 0.777(95%CI:0.696-0.857)in the validation cohort.The combined model,which incorporated both the handcrafted and deep radiomics signatures,showed good discriminative ability with a C-index of 0.829(95%CI:0.767-0.890)in the primary cohort and 0.809(95%CI:0.740-0.879)in the validation cohort.Conclusions:Handcrafted and deep radiomics features from MDCT images were associated with HER2 status in patients with breast cancer.Thus,these features could provide complementary aid for the radiological evaluation of HER2 status in breast cancer. | Xiaojun Yang Lei Wu Ke Zhao Weitao Ye Weixiao Liu Yingyi Wang Jiao Li Hanxiao Li Xiaomei Huang Wen Zhang Yanqi Huang Xin Chen Su Yao Zaiyi Liu Changhong Liang | 2020 | Chinese Journal of Cancer Research2020，32，2： | 4 |
| 9 | Hepatic encephalopathy complicated with hyponatremia and acid-base disturbance and its prognosis显示文摘Objective:To improve the diagnosis and therapeutic effect of occurrence and development of hyponatremia and disorder of acid-base balance among patients with hepatic encephalopathy(HE) by elucidating the regularity and mechanism,as well as its influence on prognosis.Methods:327 HE patients admitted to our hospital from January 1990 to June 2010 were enrolled.Meanwhile 316 patients hospitalized in the medical department of the same hospital were chosen as the control group.Patients in both groups were given the same methods to measure arterial blood gas parameters(pH value,PaCO2,[HCO3-],TCO2,BE and SaO2),blood biochemistry([Na+],[K+],[Cl-]),liver function,kidney function and blood glucose,serum sodium,and thereupon tocalculate the anion gap(AG) and the potential [HCO3-],and acid-base balance disorder.Results:Among the 327 HE patients,hyponatremia was found in 188 cases(57.4%),of whom 132 patients died(70.2%).While among the 316 patients in control group,68 presented with hyponatremia(21.5%),and 19 died(27.9%).The incidence and mortality were significantly different between the two groups(P<0.001).All the 327 patients presented with different degrees of acid-base balance disorder and 178 died(54.4%),in whom 164(50.2%) belonged to simple acid-base balance disorder and 74(45.1%) died,136(41.6%) were dual acid-base balance disorder and 80(58.8%) died,27(8.2%) were triple acid-base disturbance and 24(88.9%) died.Whereas in the control group only 83 patients(26.2%) were recognized as simple and dual acid-base balance disorder,and 18(21.7%) died.There was higher incidence of acid-base balance disorder and mortality rate in HE group than control one(P<0.001).Conclusion:Hyponatremia is valuable to judge HE patients' prognosis.The key parameters in the judgment and evaluation on acid-base balance disorder among HE patients are the change of pH values and serum electrolyte values.When pH value ≤ 7.30 or > 7.55,it generally suggests a poor prognosis. | Ren Chengshan Wang Lei Zhao Xiaoyan Yang Shiming Zhang Yanqi Wang Xiwen Bo Jianying Zhang Pengbin Guo Hong Ling Xianlong Li Yihui Da Siping Xie Xia Ren Wei Li Chunhua Qian Guisheng | 2012 | Journal of Medical Colleges of PLA(China)2012，27，3： | 3 |
| 10 | Real-time Dispatchable Region of Renewable Generation Constrained by Reactive Power and Voltage Profiles in AC Power Networks显示文摘A large amount of renewable energy generation(REG)has been integrated into power systems,challenging the operational security of power networks.In a real-time dispatch,system operators need to estimate the ability of the power network to accommodate REG with a limited reserve capacity.The real-time dispatchable region(RTDR)is defined as the largest range of a power injection that the power network can accommodate in a certain dispatch interval for a given dispatch base point.State-of-the-art research on the RTDR adopts a DC power flow model regardless of the voltage profiles and reactive power,which can overlook potentially insecure operational states of the system.To address this issue,this paper proposes an AC power flow based RTDR model simultaneously considering the reactive power and voltage profiles constraints.The nonlinear constraints in our model are approximated using a linear power flow model together with a polytope approximation technique for quadratic constraints.An adaptive constraint generation algorithm is used to calculate the RTDR.Simulation results using the IEEE 5-bus and 30-bus systems illustrate the advantages of the proposed model. | Yanqi Liu Zhigang Li Q.H.Wu Haibo Zhang | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 3 |
| 11 | Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior显示文摘Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carrier.However,how to control the drug release from silica nanorattle is still a challenge.In this study,we designed two methods,in-situ polymerization method and water in oil in water(W/O/W) double emulsion method,to coat a nanosized poly(lactic-co-glycolic acid)(PLGA) layer onto the surface of silica nanorattle for controlling the drug release behavior.Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle(PLGA@SN).The drug release profile,cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery. | LI LinLin ZHANG YanQi HAO NanJing CHEN Dong TANG FangQiong | 2012 | Chinese Science Bulletin2012，57，27： | 2 |
| 12 | Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy显示文摘The capping agents for liquid metal (LM) nanodroplets in aqueous solutions are restricted to thiol-containing and positively-charged molecules or macromolecules.However,both thiolate-metal complex and electrostatic interaction are liable to detachment upon strong mechanical forces such as sonication,leading to limited stability and applications.To address this,we utilized ultrasmall water soluble melanin nanoparticles (MNPs) as the capping agent,which exhibited strong metal binding capability with the oxide layer of gallium based LMs and resulted in enhanced stability.Interestingly,shape-controlled synthesis of LM nanodroplets can be achieved by the incorporation of MNPs.Various EGaln nanostructures including nanorice,nanosphere and nanorod were obtained by simply tuning the feed ratio,sonication time,and suspension temperature.Among these shapes,EGaln nanorice has the best photothermal conversion efficiency,which could be leveraged for photothermal therapy. | Junjie Yan Xudong Zhang Yang Liu Yanqi Ye Jicheng Yu Qian Chen Jinqiang Wang Yuqi Zhang Quanyin Hu Yang Kang Min Yang Zhen Gu | 2019 | Nano Research2019，12，6： | 2 |
| 13 | OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING显示文摘Stimulator of interferon genes(STING)is an adaptor protein that is critical for effective innate antiviral and antitumor immunity.The activity of STING is heavily regulated by protein ubiquitination,which is fine-tuned by both E3 ubiquitin ligases and deubiquitinases.Here,we report that the deubiquitinase OTUD5 interacts with STING,cleaves its K48-linked polyubiquitin chains,and promotes its stability.Consistently,knockout of OTUD5 resulted in faster turnover of STING and subsequently impaired type I IFN signaling following cytosolic DNA stimulation.More importantly,Lyz2-Cre Otud5^(fl/Y) mice and CD11-Cre Otud5^(fl/Y) mice showed more susceptibility to herpes simplex virus type 1(HSV-1)infection and faster development of melanomas than their corresponding control littermates,indicating that OTUD5 is indispensable for STING-mediated antiviral and antitumor immunity.Our data suggest that OTUD5 is a novel checkpoint in the cGAS-STING cytosolic DNA sensing pathway. | Yunyun Guo Fei Jiang Lingli Kong Haifeng Wu Honghai Zhang Xiaorong Chen Jian Zhao Baoshan Cai Yanqi Li Chunhong Ma Fan Yi Lei Zhang Bingyu Liu Yi Zheng Lingqiang Zhang Chengjiang Gao | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 14 | The 1 PW/0.1 Hz laser beamline in SULF facility显示文摘In this paper,we report the recent progress on the 1 PW/0.1 Hz laser beamline of Shanghai Superintense Ultrafast Laser Facility(SULF).The SULF-1 PW laser beamline is based on the double chirped pulse amplification(CPA)scheme,which can generate laser pulses of 50.8 J at 0.1 Hz after the final amplifier;the shot-to-shot energy fluctuation of the amplified pulse is as low as 1.2%(std).After compression,the pulse duration of 29.6 fs is achieved,which can support a maximal peak power of 1 PW.The contrast ratio at-80 ps before main pulse is measured to be 2.5×10^-11.The focused peak intensity is improved by optimizing the angular dispersion in the grating compressor.The maximal focused peak intensity can reach 2.7×10^19W/cm2 even with an f/26.5 off-axis parabolic mirror.The horizontal and vertical angular pointing fluctuations in 1 h are measured to be 1.89 and 2.45μrad,respectively.The moderate repetition rate and the good stability are desirable characteristics for lasermatter interactions.The SULF-1 PW laser beamline is now in the phase of commissioning,and preliminary experiments of particle acceleration and secondary radiation under 300–400 TW/0.1 Hz laser condition have been implemented.The progress on the experiments and the daily stable operation of the laser demonstrate the availability of the SULF-1 PW beamline. | Zongxin Zhang Fenxiang Wu Jiabing Hu Xiaojun Yang Jiayan Gui Penghua Ji Xingyan Liu Cheng Wang Yanqi Liu Xiaoming Lu Yi Xu Yuxin Leng Ruxin Li Zhizhan Xu | 2020 | High Power Laser Science and Engineering2020，8，1： | 2 |
| 15 | A Promising Anti-Cytokine-Storm Targeted Therapy for COVID-19:The Artificial-Liver Blood-Purification System显示文摘The coronavirus disease 2019(COVID-19)pan-epidemic,resulting from infection with the 2019 novel coronavirus(2019-nCoV),also known as severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),is currently the source of public health concern worldwide;however,treatment of this infection has been clinically challenging in many patients[1].Importantly,2019-nCoV is the third fatal coronavirus that has emerged in the past two decades,following SARS-CoV and the Middle East respiratory syndrome(MERS)-CoV[2].The numbers of confirmed cases of COVID-19 infection and related deaths are still rising.As of 9 March 2020. | Yimin Zhang Liang Yu LingLing Tang Mengfei Zhu Yanqi Jin Zhouhan Wang Lanjuan Li | 2021 | Engineering2021，7，1： | 2 |
| 16 | Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma显示文摘 | Shiren Sun Xiaoxuan Ning Jie Liu Lili Liu Yu Chen Shuang Han Yanqi Zhang Jie Liang Kaichun Wu Daiming Fan | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 2 |
| 17 | Broadband Cr^(3+)-sensitized upconversion luminescence of LiScSi_(2)O_(6):Cr^(3+)/Er^(3+)显示文摘Broadband sensitization is an effective strategy to enhance the upconversion luminescence(UCL) of lanthanide ions.Herein,novel UC materials LiScSi_(2)O_(6):Cr^(3+)/Er^(3+)(LSS:Cr^(3+)/Er^(3+)) were synthesized by high-temperature solid state reaction and their luminescent properties were investigated.LSS:Cr^(3+)/Er^(3+)has the broadband absorption in the spectral range of 600-800 nm,and meanwhile shows green UC emissions of Er^(3+)upon pumping Cr^(3+) by the 690 nm laser.The UCL of LSS:Cr^(3+)/Er^(3+)belongs to the twophoton process and is attributed to the energy transfer upconversion mechanism.The effects of the Cr^(3+)and Er^(3+)concentration as well as the Yb^(3+)introduction were also studied.LSS:Cr^(3+)/Yb^(3+)/Er^(3+) exhibits the interesting dual-mode UCL,capable of generating the UCL of Cr^(3+) upon pumping Yb^(3+)ions and the UCL of upon pumping Cr^(3+) ions.This research might promote the development of novel broadband Cr^(3+)-sensitized UC materials. | Yu Duan Yanqi Liu Guangjun Zhang Leqi Yao Qiyue Shao | 2021 | Journal of Rare Earths2021，39，10： | 2 |
| 18 | Tyrosine phosphatase Shp2 regulates pi 15RhoGEF/Rhodependent dendritic cell migration显示文摘The orchestrated migration of dendritic cells(DCs)to secondary lymphoid organs relies on C-C chemokine receptor type 7(CCR7)and its ligand C-C motif chemokine ligand 19(CCL19),and DC migration to lymph nodes is crucial for the initiation and progression of adaptive immune responses. | Yun Xu Yun Zhang Yanyan Yang Yanqi Liu Qiaoying Tian Pan Liu Zhifan Ding Hongqiang Cheng Xue Zhang Yuehai Ke | 2021 | Cellular & Molecular Immunology2021，18，3： | 2 |
| 19 | Coupling radiomics analysis of CT image with diversification of tumor ecosystem: A new insight to overall survival in stage Ⅰ-Ⅲ colorectal cancer显示文摘Objective: This study aimed to establish a method to predict the overall survival(OS) of patients with stage Ⅰ-Ⅲ colorectal cancer(CRC) through coupling radiomics analysis of CT images with the measurement of tumor ecosystem diversification.Methods: We retrospectively identified 161 consecutive patients with stage Ⅰ-Ⅲ CRC who had underwent radical resection as a training cohort. A total of 248 patients were recruited for temporary independent validation as external validation cohort 1, with 103 patients from an external institute as the external validation cohort 2. CT image features to describe tumor spatial heterogeneity leveraging the measurement of diversification of tumor ecosystem, were extracted to build a marker, termed the EcoRad signature. Multivariate Cox regression was used to assess the EcoRad signature, with a prediction model constructed to demonstrate its incremental value to the traditional staging system for OS prediction.Results: The EcoRad signature was significantly associated with OS in the training cohort [hazard ratio(HR)=6.670;95% confidence interval(95% CI): 3.433-12.956;P<0.001), external validation cohort 1(HR=2.866;95% CI: 1.646-4.990;P<0.001) and external validation cohort 2(HR=3.342;95% CI: 1.289-8.663;P=0.002).Incorporating the EcoRad signature into the prediction model presented a higher prediction ability(P<0.001) with respect to the C-index(0.813, 95% CI: 0.804-0.822 in the training cohort;0.758, 95% CI: 0.751-0.765 in the external validation cohort 1;and 0.746, 95% CI: 0.722-0.770 in external validation cohort 2), compared with the reference model that only incorporated tumor, node, metastasis(TNM) system, as well as a better calibration,improved reclassification and superior clinical usefulness.Conclusions: This study establishes a method to measure the spatial heterogeneity of CRC through coupling radiomics analysis with measurement of diversification of the tumor ecosystem, and suggests that this approach could effectively predict OS and could be used as a supplement for risk stratification among stage Ⅰ-Ⅲ CRC patients. | Yanqi Huang Lan He Zhenhui Li Xin Chen Chu Han Ke Zhao Yuan Zhang Jinrong Qu Yun Mao Changhong Liang Zaiyi Liu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 20 | Insights into the Formation Mechanism of Low Water Saturation in Longmaxi Shale in the Jiaoshiba Area, Eastern Sichuan Basin显示文摘Investigating the variation of water content in shale reservoir is important to understand shale gas enrichment and evaluate shale gas resource potential.Low water saturation is widely spread in Longmaxi marine organic-rich shale.To illustrate the formation mechanism of low water saturation,this paper analyzed water saturation of Longmaxi shale reservoir,restored the history of natural gas carrying water capacity combining homogenization temperature and trapping pressure of fluid inclusion with simulated thermal history,and established a model to explain pore water displaced by natural gas during the thermal evolution.Results show that the gas-rich Longmaxi shale reservoir is characterized by low water saturation with measured values ranging from 9.81%to 48.21%and an average value of 28.22%.TOC in high-mature to over-high-mature Longmaxi organic-rich shale is negatively correlated with water saturation,indicating that well-connected organic pores are not available for water.However,quartz and clay mineral content are positively correlated with water saturation,which suggests that inorganic-matter-hosted pores are the main storage space for water formation.The water carrying capacity of natural gas varies as a function of gas generation and expulsion history,which displaces bound and movable water in organic pores that are part of bound and movable water from inorganic pores.The process can be divided into two phases.The first phase occurred due to the kerogen degradation into gas at Ro of 1.2%–1.6%with a water carrying capacity of natural gas ranging from 5632.57–7838.73 g/km3.The second phase occurred during the crude oil cracking into gas at Ro>1.6%with a water carrying capacity of natural gas ranging from 10620.04 and 19480.18 g/km3.The water displacement associated with natural gas generation and migration resulted in gas filling organic pores and gas-water coexisting in the brittle-mineral-hosted pores and clay-mineral-hosted pores. | Yanqi Zhang Li Liu | 2021 | Journal of Earth Science2021，32，4： | 2 |
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