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| 1 | Therapeutic effect of acupuncture and massage for shoulder-hand syndrome in hemiplegia patients:a clinical two-center randomized controlled trial显示文摘OBJECTIVE:To evaluate the therapeutic effects of acupuncture and massage for shoulder-hand syndrome in hemiplegia patients.METHODS:One hundred and twenty hemiplegia patients with stage I shoulder-hand syndrome were randomly divided into a group treated with standardized electric acupuncture and massage,and a group treated with rehabilitation therapy for 6 weeks.The primary indices evaluated were pain on passive movement of the shoulder using the numeric pain rating scale(NPRS),and the number of patients with shoulder-hand syndrome at Steinbrocker stage II or III after treatment.The secondary indices were Fugl-Meyer evaluation of functional movement of the upper limb and hand using the modified rankin scale(MRS).RESULTS:At post-treatment evaluation and a 12-week follow-up visit,NPRS score,number of patients with stage II or III shoulder-hand syndrome,and MRS score were all improved in the acupuncture-massage group compared with the rehabilitation group(P<0.05).On Fugl-Meyer evaluation,functional movement of the upper limb was also improved in the acupuncture-massage group compared with the rehabilitation group(P<0.05).CONCLUSION:Standardized acupuncture-massage therapy may have curative effects on shoulder-hand syndrome in hemiplegia patients. | Ning Li Fengwei Tian Chengwei Wang Pengming Yu Xi Zhou Qian Wen Xiulan Qiao Lu Huang | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 25 |
| 2 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 3 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
| 4 | Foveated glasses-free 3D display with ultrawide field of view via a large-scale 2D-metagrating complex显示文摘Glasses-free three-dimensional(3D)displays are one of the game-changing technologies that will redefine the display industry in portable electronic devices.However,because of the limited resolution in state-of-the-art display panels,current 3D displays suffer from a critical trade-off among the spatial resolution,angular resolution,and viewing angle.Inspired by the so-called spatially variant resolution imaging found in vertebrate eyes,we propose 3D display with spatially variant information density.Stereoscopic experiences with smooth motion parallax are maintained at the central view,while the viewing angle is enlarged at the periphery view.It is enabled by a large-scale 2D-metagrating complex to manipulate dot/linear/rectangular hybrid shaped views.Furthermore,a video rate full-color 3D display with an unprecedented 160°horizontal viewing angle is demonstrated.With thin and light form factors,the proposed 3D system can be integrated with off-the-shelf purchased flat panels,making it promising for applications in portable electronics. | Jianyu Hua Erkai Hua Fengbin Zhou Jiacheng Shi Chinhua Wang Huigao Duan Yueqiang Hu Wen Qiao Linsen Chen | 2021 | Light(Science & Applications)2021，10，11： | 14 |
| 5 | Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease,2008-2013显示文摘Objective To investigate the serum total IgE(tlgE) and specific IgE(slgE) to common allergens among allergic patients in Guangzhou,China.Methods 7 085 patients were examined for tlgE and slgE to 15 allergens,based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.Results 3 758(53.04%) patients tested positive for tlgE,and 4 640(65.49%) for slgE.Der pteronyssinus,Der farinae,eggs,and cow's milk were the most common allergens leading to higher positive rates of slgE responses.Several peaks of sensitization were:Der pteronyssinus,Der farinae,and Blomia tropicalis at age 10-12;cow's milk at age below 3;eggs at age 4-6.The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens.Sensitization to Der pteronyssinus(OR,1.6;P<0.05),Der farinae(OR,1.5;P<0.05),Blomia tropicalis(OR,1.4;P<0.05),Blattella germanica(OR,1.5;P<0.05),cow's milk(OR,1.3;P<0.05),and soy beans(OR,2.0;P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.Conclusion The major allergens in Guangzhou include Der pteronyssinus,Der farinae,cow's milk,and eggs.Sensitization to these allergens appears to be predictors of allergy-related disorder. | SUN Bao Qing CHEN De Hui ZHENG Pei Yan HUANG Hui Min LUO Wen Ting ZENG Guang Qiao ZHANG Xiao Wen | 2014 | Biomedical and Environmental Sciences2014，27，7： | 11 |
| 6 | Intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation for preservation of facial nerve function in patients with large acoustic neuroma显示文摘背景尽管各种各样的监视技术在颅骨底在损害的治疗习惯性地被使用了,因医生之治疗而引的面部局部麻痹或麻痹仍然是一个重要临床的问题。这研究的目的是调查面部马达唤起了潜力与 transcranial 监视的 intraoperative 的效果电的到2005年11月的从1月的面部神经 function.Method 的保藏上的刺激,有大声学的神经瘤的 19 个病人用 intraoperative 美容马达被对待为面部神经的保藏与 transcranial 监视电的刺激( TCEMEP )的唤起的潜力工作。在在肿瘤移动和面部神经的手术后的功能以后的 MEP 振幅的减少之间的关系是 analyzed.Results MEP 振幅减少了超过 75% 在 11 个病人, 6 介绍了重要美容麻痹(H-B 等级 3 ) ,和 5 有的温和美容麻痹(H-B 等级 2 ) 。在另外的 8 个病人,振幅其 MEP 减少了不到 75% , 1 富有经验的重要面部麻痹, 5 有温和面部麻痹,并且 2 是 normal.Conclusions Intraoperative TCEMEP 能被用来预言面部神经的手术后的功能。在 75 % 上面的减少的 MEP 振幅是为可能的严重面部麻痹的一个警报点。 | LIU Bai-yun TIAN Yong-ji LIU Wen LIU Shu-ling QIAO Hui ZHANG Jun-ting Jim Gui-jun | 2007 | Chinese Medical Journal2007，，4： | 10 |
| 7 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 8 | Measurement Uncertainty Evaluation of Conicity Error Inspected on CMM显示文摘The cone is widely used in mechanical design for rotation, centering and fixing. Whether the conicity error can be measured and evaluated accurately will directly influence its assembly accuracy and working performance. According to the new generation geometrical product specification(GPS), the error and its measurement uncertainty should be evaluated together. The mathematical model of the minimum zone conicity error is established and an improved immune evolutionary algorithm(IIEA) is proposed to search for the conicity error. In the IIEA, initial antibodies are firstly generated by using quasi-random sequences and two kinds of affinities are calculated. Then, each antibody clone is generated and they are self-adaptively mutated so as to maintain diversity. Similar antibody is suppressed and new random antibody is generated. Because the mathematical model of conicity error is strongly nonlinear and the input quantities are not independent, it is difficult to use Guide to the expression of uncertainty in the measurement(GUM) method to evaluate measurement uncertainty. Adaptive Monte Carlo method(AMCM) is proposed to estimate measurement uncertainty in which the number of Monte Carlo trials is selected adaptively and the quality of the numerical results is directly controlled. The cone parts was machined on lathe CK6140 and measured on Miracle NC 454 Coordinate Measuring Machine(CMM). The experiment results confirm that the proposed method not only can search for the approximate solution of the minimum zone conicity error(MZCE) rapidly and precisely, but also can evaluate measurement uncertainty and give control variables with an expected numerical tolerance. The conicity errors computed by the proposed method are 20%-40% less than those computed by NC454 CMM software and the evaluation accuracy improves significantly. | WANG Dongxia SONG Aiguo WEN Xiulan XU Youxiong QIAO Guifang | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 10 |
| 9 | Comparative analysis of robotic vs laparoscopic radical hysterectomy for cervical cancer显示文摘BACKGROUND Cervical cancer is the most common gynecological malignancy,ranking first in female reproductive malignancies with more than 500000 new cases and 275000 deaths each year.Traditionally,open radical hysterectomy is considered the standard surgical procedure for the treatment of resectable cervical cancer.The latest guidelines from the National Comprehensive Cancer Network and the European Society of Gynecological Oncology suggest that open surgery and laparoscopic surgery(using traditional laparoscopic or robotic techniques)are the main surgical approaches for radical hysterectomy for patients with stage IA2-IIA cervical cancer.Robotic surgery has been increasingly used in abdominal surgery and has shown more beneficial effects.AIM To analyse the perioperative conditions,complications,and short-term and longterm effects in patients undergoing robotic radical hysterectomy(RRH)and laparoscopic radical hysterectomy(LRH)to compare their clinical efficacy,safety,and feasibility.METHODS The perioperative data of patients undergoing RRH and LRH were extracted and collected from the database of surgical treatments for cervical cancer for statistical analysis.RESULTS Of the patients,342 underwent LRH for cervical cancer,and 216 underwent RRH.The total complication rate was 9.65%(20 patients)in the RRH group and 17.59%(60 patients)in the LRH group.The complication rate was significantly lower in the RRH group than in the LRH group.There was no significant difference in the follow-up period(P=0.658).The total recurrence rates were 15.7%and 12%in the RRH and LRH groups,respectively.The progression-free survival time was 28.91±15.68 mo and 28.34±15.13 mo in the RRH and LRH groups,respectively(P=0.669).The overall survival(OS)rates were 92.13%and 94.45%in the RRH and LRH groups,respectively(P=0.292).The OS time was 29.87±15.92 mo and 29.41±15.14 mo in the RRH and LRH groups,respectively(P=0.732).The survival curves and the progression-free survival curves were not statistically significantly different between the two groups(P=0.407 and 0.28,respectively).CONCLUSION RRH is associated with significantly less operative time and blood loss than LRH.The two procedures have similar complication rates,OS,and progression-free survival time. | Li Chen Li-Ping Liu Na Wen Xiao Qiao Yuan-Guang Meng | 2019 | World Journal of Clinical Cases2019，7，20： | 9 |
| 10 | Soil Organic Matter Fractions under Different Vegetation Types in Permafrost Regions along the Qinghai-Tibet Highway, North of Kunlun Mountains, China显示文摘As a key attribute of soil quality, soil organic matter(SOM) and its different fractions play an important role in regulating soil nutrient cycling and soil properties.This study evaluated the soil carbon(C) and nitrogen(N) concentrations in different SOM fractions(light– and heavy fractions,microbial biomass) under different vegetation types and analyzed their influencing factors in continuous permafrost regions along the Qinghai-Tibet Highway in the North of Kunlun Mountains, China.Soil samples were collected in pits under four vegetation types — Alpine swamp meadow(ASM), Alpine meadow(AM), Alpine steppe(AS) and Alpine desert(AD) — at the depth of 0-50 cm.The vegetation coverage was the highest at ASM and AM, followed byAS and AD.The results indicated that the concentrations of light fraction carbon(LFC) and nitrogen(LFN), and microbial biomass carbon(MBC)and nitrogen(MBN) decreased as follows: ASM > AM >AS > AD, with the relatively stronger decrease of LFC,whereas the heavy fraction carbon(HFC) and nitrogen(HFN) concentrations were lower in AS soils than in the AD soils.The relatively higher proportions of LFC/SOC and MBC/SOC in the 0-10 cm depth under the ASM soils are mainly resulted from its higher substrate input and soil moisture content.Correlation analysis demonstrated that aboveground biomass, soil moisture content, soil organic carbon(SOC) and total nitrogen(TN) positively correlated to LFC, LFN, HFC, HFN, MBC and MBN, while p H negatively correlated to LFC, LFN, HFC, HFN, MBC and MBN.There was no relationship between active layer thickness and SOM fractions, except for the LFC.Results suggested that vegetation cover, soil moisture content, and SOC and TN concentrations were significantly correlated with the amount and availability of SOM fractions, while permafrost had less impact on SOM fractions in permafrost regions of the central Qinghai–Tibet Plateau. | SHANG Wen ZHAO Lin WU Xiao-dong LI Yu-qiang YUE Guang-yang ZHAO Yong-hua QIAO Yong-ping | 2015 | Journal of Mountain Science2015，12，4： | 9 |
| 11 | DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells显示文摘染色质改变为人的初发的细菌房间的 epigenetic reprogramming 是重要的。然而,全面染色质状态还没为人的胎儿的细菌房间(FGC ) 被分析了。这里,我们使用 nucleosome 占有和 methylation 定序方法在人和老鼠在胎儿的细菌房间开发期间在一系列关键时间点分析染色体宽的染色质可接近性和 DNA methylome。我们在人和老鼠 FGC 发现 116 887 和 137 557 个弄空 nucleosome 的区域(NDR ) ,盖住 germline 特定、高度有活力的规章的 genomic 元素的一个大集合,例如 enhancers。而且,我们发现远侧的 NDR 在人的 FGC 为象 NANOG , SOX17 , AP2 和 OCT4 那样的 pluripotency 和细菌房间主人管理者的有约束力的主题明确地被充实,显示在pluripotency相关的基因和细菌之间的精细的规章的平衡的存在在人的 FGC 的房间特定的基因,并且为在 vivo 的细菌房间开发的这些基因的功能的意义。我们的工作为把提供一张全面、高分辨率的路线图染色质状态转变动力学在人和老鼠 FGC 的 epigenomic reprogramming 期间。 | Hongshan Guo Boqiang Hu Liying Yan Jun Yong Yan Wu Yun Gao Fan Guo Yu Hou Xiaoying Fan Ji Dong Xiaoye Wang Xiaohui Zhu Jie Yan Yuan Wei Hongyan Jin Wenxin Zhang Lu Wen FuchouTang Jie Qiao | 2017 | Cell Research2017，27，2： | 9 |
| 12 | Clinical features and outcomes of 210 patients with idiopathic pulmonary fibrosis显示文摘 | Cai Miaotian Zhu Min Ban Chengjun Su Jin Ye Qiao Liu Yan Zhao Wen Wang Chen Dai Huaping | 2014 | Chinese Medical Journal2014，，10： | 8 |
| 13 | Response of root morphology, physiology and endogenous hormones in maize(Zea mays L.) to potassium deficiency显示文摘Potassium(K)deficiency is one of the major abiotic stresses which has drastically influenced maize growth and yield around the world.However,the physiological mechanism of K deficiency tolerance is not yet fully understood.To identify the differences of root morphology,physiology and endogenous hormones at different growing stages,two maize inbred lines 90-21-3(tolerance to K deficiency)and D937(sensitive to K deficiency)were cultivated in the long-term K fertilizer experimental pool under high potassium(+K)and low potassium(-K)treatments.The results indicated that the root length,volume and surface area of 90-21-3 were significantly higher than those of D937 under-K treatment at different growing stages.It was noteworthy that the lateral roots of 90-21-3 were dramatically higher than those of D937 at tasselling and flowering stage under-K treatment.Meanwhile,the values of superoxide dismutase(SOD)and oxidizing force of 90-21-3were apparently higher than those of D937,whereas malondialdehyde(MDA)content of D937 was obviously increased.Compared with+K treatment,the indole-3-acetic acid(IAA)content of 90-21-3 was largely increased under-K treatment,whereas it was sharply decreased in D937.On the contrary,abscisic acid(ABA)content of 90-21-3 was slightly increased,but that of D937 was significantly increased.The zeatin riboside(ZR)content of 90-21-3 was significantly decreased,while that of D937 was relatively increased.These results indicated that the endogenous hormones were stimulated in 90-21-3to adjust lateral root development and to maintain the physiology function thereby alleviating K deficiency. | ZHAO Xin-hua YU Hai-qiu WEN Jing WANG Xiao-guang DU Qi WANG Jing WANG Qiao | 2016 | Journal of Integrative Agriculture2016，15，4： | 8 |
| 14 | Widespread infection and diverse infection patterns of Wolbachia in Chinese aphids显示文摘Wolbachia 是感染大量节肢动物和丝虫的线虫的细胞内部的共生者。蚜虫从事与他们的 endosymbionts 的多样、复杂的关系。Wolbachia 的四超群(A, B, M 和 N ) 以前在蚜虫和超群 M 被检测, N 仅仅在蚜虫被发现。在这研究,我们在中国在蚜虫的自然人口检测了并且描述 Wolbachia 感染。三超群(A, B 和 M ) 在检验蚜虫种类被发现。超群 M 是优势的,而超群 A 和 B 仅仅在某些种类被检测。超群 N 没在这研究被发现。也就是,有在蚜虫的 Wolbachia 的四个感染模式有超群 M 的感染独自一个,有超群 A 和 M,有超群 B 和 M 的合作感染,和有超群 A, B 和 M 的合作感染的合作感染。仅仅有超群 M 的感染的模式是通用的并且在所有评估亚科被发现。仅仅二个亚科, Aphidinae 和 Lachninae,表明了介绍所有四个感染模式。三个模式在 Calaphidinae 被观察(M, A&M, B&M ) 并且 Eriosomatinae (M, B&M, A&B&M ) 。二个模式在 Anoeciinae 被观察(M, A&M ) 并且 Greenideinae (M, B&M ) ,并且一仅仅模式(M) 在 Aphidoidea 的留下的家庭或亚科被观察。这些结果显示在中国蚜虫的 Wolbachia 感染是普遍的。种系发生的分析建议超群 M 在中国在蚜虫的所有主人种类之中很快并且最近散布了的那 Wolbachia。为这传播和它的机制的原因在他们的蚜虫主人上与 Wolbachia 的可能的效果一起被讨论。 | Zhe Wang Xiao-Min Su Juan Wen Li-Yun Jiang Ge-Xia Qiao | 2014 | Insect Science2014，21，3： | 8 |
| 15 | Alcohol Drinking, Dyslipidemia, and Diabetes: A Population-based Prospective Cohort Study among Inner Mongolians in China显示文摘Objective No previous studies have evaluated the association between dyslipidemia,alcohol drinking,and diabetes in an Inner Mongolian population.We aimed to evaluate the co-effects of drinking and dyslipidemia on diabetes incidence in this population.Methods The present study was based on 1880 participants from a population-based prospective cohort study among Inner Mongolians living in China.Participants were classified into four subgroups according to their drinking status and dyslipidemia.Multivariate logistic regression analysis and receiver operating characteristic(ROC) curves were used to evaluate the association between alcohol drinking,dyslipidemia,and diabetes.Results During the follow-up period,203 participants were found to have developed diabetes.The multivariable-adjusted odds ratios(95% confidence interval) for the incidence of non-dyslipidemia/drinkers,dyslipidemia/non-drinkers,and dyslipidemia/drinkers in diabetic patients were 1.40(0.82-2.37),1.73(1.17-2.55),and 2.31(1.38-3.87),respectively,when compared with non-dyslipidemia/non-drinkers.The area under the ROC curve for a model containing dyslipidemia and drinking status along with conventional factors(AUC=0.746) was significantly(P=0.003) larger than the one containing only conventional factors(AUC=0.711).Conclusion The present study showed that dyslipidemia was an independent risk factor for diabetes,and that drinkers with dyslipidemia had the highest risk of diabetes in the Mongolian population.These findings suggest that dyslipidemia and drinking status may be valuable in predicting diabetes incidence. | LIANG Zhu QIU Qiao Yan WU Jia Hui ZHOU Jing Wen XU Tian ZHANG Ming Zhi ZHANG Yong Hong ZHANG Shao Yan | 2016 | Biomedical and Environmental Sciences2016，29，8： | 7 |
| 16 | Comparison of Efficacy and Safety between First and Second Generation Drug-eluting Stents in Patients with Stable Coronary Artery Disease: A Single-center Retrospective Study显示文摘 | Ru Liu Fei Xiong Yuan Wen Yuan-Liang Ma Yi Yao Zhan Gao Bo Xu Yue-Jin Yang Shu-Bin Qiao Run-Lin Gao Jin-Qing Yuan | 2017 | Chinese Medical Journal2017，，14： | 7 |
| 17 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 18 | Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study显示文摘Objective Prior pulmonary tuberculosis(PTB) on chest X-ray(CXR) was commonly found in infertile patients receiving examinations before in vitro fertilization and embryo transfer(IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after IVF-ET.Method We conducted a retrospective cohort study of 14,254 infertile patients who had received IVFET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth,clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB groups.Results The untreated PTB group had significantly lower clinical pregnancy(31.7% vs. 38.1%) and live birth(23.8% vs. 30.6%) rates than the non-PTB group(both P < 0.001). Multivariate analysis revealed that untreated PTB was a risk factor for decreased live birth rate [odds ratio(OR), 0.80;95% confidence interval(CI), 0.66–0.98;P = 0.028] in all patients and for increased miscarriage(OR, 4.19;95% CI,1.69–10.39;P = 0.002) and decreased live birth(OR, 0.45;95% CI, 0.24–0.83;P = 0.011) rates in patients with unexplained infertility.Conclusions Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population. | GAI Xiao Yan CHI Hong Bin ZENG Lin CAO Wen Li CHEN Li Xue ZHANG Chen LU Ming NING Lan Ding CHANG Chun ZHANG Wei Xia LIU Ping LI Rong SUN Yong Chang QIAO Jie | 2021 | Biomedical and Environmental Sciences2021，34，2： | 6 |
| 19 | Graphene/phosphorene nano-heterojunction:facile synthesis, nonlinear optics, and ultrafast photonics applications with enhanced performance显示文摘Owing to its thickness-modulated direct energy band gap, relatively strong light–matter interaction, and unique nonlinear optical response at a long wavelength, few-layer black phosphorus, or phosphorene, becomes very attractive in ultrafast photonics applications. Herein, we synthesized a graphene/phosphorene nano-heterojunction using a liquid phase-stripping method. Tiny lattice distortions in graphene and phosphorene suggest the formation of a nano-heterojunction between graphene and phosphorene nanosheets. In addition, we systematically investigate their nonlinear optical responses at different wavelength regimes. Our experiments indicate that the combined advantages of ultrafast relaxation, broadband response in graphene, and the strong light–matter interaction in phosphorene can be combined together by nano-heterojunction. We have further fabricated two-dimensional(2D) nano-heterojunction based optical saturable absorbers and integrated them into an erbium-doped fiber laser to demonstrate the generation of a stable ultrashort pulse down to 148 fs. Our results indicate that a graphene/phosphorene nano-heterojunction can operate as a promising saturable absorber for ultrafast laser systems with ultrahigh pulse energy and ultranarrow pulse duration. We believe this work opens up a new approach to designing 2D heterointerfaces for applications in ultrafast photonics and other research.The fabrication of a 2D nano-heterojunction assembled from stacking different 2D materials, via this facile and scalable growth approach, paves the way for the formation and tuning of new 2D materials with desirable photonic properties and applications. | SHUNXIANG LIU ZHONGJUN LI YANQI GE HUIDE WANG RUI YUE XIANTAO JIANG JIANQING LI QIAO WEN HAN ZHANG | 2017 | Photonics Research2017，5，6： | 6 |
| 20 | Morphology of liquid drops and thin films on a solid surface with sinusoidal microstructures显示文摘稳固的材料的表面微观结构在各种各样的弄湿和露水 etting 现象起一个重要作用。在现在的纸,微观结构的效果和液体微滴和薄电影的形态学和进化上的底层表面的 nano 结构被检验。微滴和电影在正弦曲线表面上满足的管理方程被考虑瓦得瓦力,表面紧张,严肃和静水力学的压力导出。液体微滴和薄电影的形态学数字地在粗糙的各种各样的典型尺寸下面被模仿。微滴形状在底层微观结构的典型尺寸之上显示出重要依赖,这被发现。吸水的底层上的薄液膜可以有水平表面或复制底层形态学,取决于粗糙的波长。 | Jian Lin Liu Xi Qiao Feng Shou Wen Yu | 2006 | Acta Mechanica Sinica2006，22，4： | 6 |
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