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| 1 | Influence of soil type and genotype on Cd bioavailability and uptake by rice and implications for food safety显示文摘Cadmium(Cd) entering the human body via the food chain is of increasing concern.This study investigates the effects of soil type and genotype on variations in the Cd concentrations of different organs of nine rice plants grown on two types of soils with two Cd levels.Cd concentrations in nine rice cultivars varied significantly with genotype and soil type(P < 0.01).The Cd concentration was higher in red paddy soil(RP) than in yellow clayey paddy soil(YP).The average Cd concentrations of different organs in three rice types were indica > hybrid > japonica for the Cd treatments and controls.The polished grain concentration in YP and RP soils had a range of 0.055-0.23 mg/kg and 0.13-0.36 mg/kg in the Cd treatment,respectively.Two rice cultivars in YP soil and five rice cultivars in RP soil exceeded the concentration limits in the Chinese Food Hygiene Standard(0.2 mg/kg).The Cd concentrations in roots,stems,and leaves were all significantly and positively correlated to that in polished grain in a single test.The Cd concentrations in polished grain were positively and significantly(P < 0.01) correlated with the calculated transfer factors of stem to grain and leaf to grain Cd transfer.The results indicated that the variations of Cd concentration in grain were related to Cd uptake and the remobilization of Cd from stem and leaf to grain.Also,the cultivars with a strong tendency for Cd-accumulation should be avoided in paddy soil with low soil pH and low organic matter content to reduce the risks to human health from high Cd levels in rice. | Xinxin Ye Yibing Ma Bo Sun | 2012 | Journal of Environmental Sciences2012，24，9： | 34 |
| 2 | The technology of space plasma in-situ measurement on the China Seismo-Electromagnetic Satellite显示文摘The China Seismo-Electromagnetic satellite(CSES) was designed to study the ionospheric disturbances associated with earthquakes. Satellite payload includes nine instruments. Among them, we recall instruments for plasma analysis, electric,magnetic fields and high energy particle detectors. Langmuir probe(LP) and plasma analyzer package(PAP) are the in-situ payloads to measure space plasma. Its scientific objective is to research space plasma physics phenomena and the ionosphere changes caused by seismic. It is the first application of in-situ measurement technology in the field of space exploration in China.The Langmuir probe and Plasma Analyzer Package have been tested and calibrated to verify the performance in INAF-IAPS.Currently, on-orbit testing is being performed with satellites. | LIU Chao GUAN YiBing ZHENG XiangZhi ZHANG AiBing PIERO Diego SUN YueQiang | 2019 | Science China(Technological Sciences)2019，62，5： | 5 |
| 3 | Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer显示文摘Colorectal cancer is one of the leading causes of cancer death worldwide.According to global genomic status,colorectal cancer can be classified into two main types:microsatellite-stable and microsatellite-instable tumors.Moreover,the two subtypes also exhibit different responses to chemotherapeutic agents through distinctive molecular mechanisms.Recently,mitochondrial DNA depletion has been shown to induce apoptotic resistance in microsatellite-instable colorectal cancer.However,the effects of altered mitochondrial DNA copy number on the progression of microsatellite-stable colorectal cancer,which accounts for the majority of colorectal cancer,remain unclear.In this study,we systematically investigated the functional role of altered mitochondrial DNA copy number in the survival and metastasis of microsatellite-stable colorectal cancer cells.Moreover,the underlying molecular mechanisms were also explored.Our results demonstrated that increased mitochondrial DNA copy number by forced mitochondrial transcription factor A expression significantly facilitated cell proliferation and inhibited apoptosis of microsatellitestable colorectal cancer cells both in vitro and in vivo.Moreover,we demonstrated that increased mitochondrial DNA copy number enhanced the metastasis of microsatellite-stable colorectal cancer cells.Mechanistically,the survival advantage conferred by increased mitochondrial DNA copy number was caused in large part by elevated mitochondrial oxidative phosphorylation.Furthermore,treatment with oligomycin significantly suppressed the survival and metastasis of microsatellite-stable colorectal cancer cells with increased mitochondrial DNA copy number.Our study provides evidence supporting a possible tumor-promoting role for mitochondrial DNA and uncovers the underlying mechanism,which suggests a potential novel therapeutic target for microsatellite-stable colorectal cancer. | Xiacheng Sun Lei Zhan Yibing Chen Gang Wang Linjie He Qian Wang Feng Zhou Fang Yang Jin Wu Yousheng Wu Jinliang Xing Xianli He Qichao Huang | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 3 |
| 4 | A Satellite-borne Miniature Ion Mass Spectrometer for Space Plasma显示文摘The miniature design technology is an important trend in space exploration.Mass spectrometer is used extensively in the space environment detection.The miniature ion mass spectrometer utilizes a 127° cylindrical electrostatic analyzer accompanied with a Time of Flight(TOF)unit based on ultrathin carbon foil to measure the energy spectra and composition of space plasma.The Time of Flight technique has been used broadly in space plasma measurement.A new type of miniature method for the ion mass spectrometer is introduced.The total mass of the instrument is1.8 kg and the total power consumption is 2.0 W.The calibration results show that the energy measurement range is 8.71~43550eV,the energy resolution is 1.86%and the ion mass from 1 amu(1 amu= 1.67 × 10^(-27)kg) to 58 amu can be resolved by the miniature mass spectrometer.The miniature ion mass spectrometer also has a potential to be increased in the field of view by an electrostatic deflecting system to extend its application in space plasma detection.The miniature ion mass spectrometer has been selected for pre-study of Chinese Strategic Priority Research Program on Space Science. | KONG Linggao ZHANG Aibing ZHENG Xiangzhi AN Yaya WANG Wenjing TIAN Zhen GUAN Yibing LIU Chao DING Jianjing SUN Yueqiang | 2015 | 空间科学学报2015，35，6： | 2 |
| 5 | Performance Comparison of Distributed State Estimation Algorithms for Power Systems显示文摘A newly proposed distributed dynamic state estimation algorithm based on the maximum a posteriori(MAP) technique is generalised and studied for power systems. The system model involves linear time-varying load dynamics and nonlinear measurements. The main contribution of this paper is to compare the performance and feasibility of this distributed algorithm with several existing distributed state estimation algorithms in the literature. Simulations are tested on the IEEE 39-bus and 118-bus systems under various operating conditions. The results show that this distributed algorithm performs better than distributed quasi-steady state estimation algorithms which do not use the load dynamic model. The results also show that the performance of this distributed method is very close to that by the centralized state estimation method. The merits of this algorithm over the centralized method lie in its low computational complexity and low communication load. Hence, the analysis supports the efficiency and benefits of the distributed algorithm in applications to large-scale power systems. | SUN Yibing FU Minyue ZHANG Huanshui | 2017 | Journal of Systems Science & Complexity2017，30，3： | 1 |
| 6 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
| 7 | Fabrication and character- ization of electrospun SiO2 nanofibers absorbed with fatty acid eu- teeties for thermal energy storage/retrieval 显示文摘 | Zong Xue Cai Yibing Sun Guiyan | 2015 | Sol Energy Mater Sol Cells2015，132，： | 1 |
| 8 | Down-regulation of HLA-G boosted natural killer cell-mediated cytolysis in JEG-3 cells cultured in vitroJ 显示文摘 | Sun Lili Han Yibing Chen Jianhui | 2008 | Fertility and Sterility2008，90，6： | 1 |
| 9 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 10 | Remarks on the paper [Appl. Math. Comput. 207 (2009) 388–396]显示文摘 | Zhenlai Han Tongxing Li Shurong Sun Yibing Sun | 2009 | Applied Mathematics and Computation2009，，11： | 1 |
| 11 | A Selection Strategy of Test Node in Analogy Circuit with Sensitivity显示文摘 | Longfu Zhou Yonghe Hu Ming Zhao Yibing Shi Yi Sun Hong Tang Shuo Li | 2011 | 通讯和计算机(中英文版)2011，8，10： | 1 |
| 12 | 腔镜下外阴癌腹股沟淋巴切除术的临床研究(英文)显示文摘Objective:The aim of this study was to explore the new method of inguinal lymphadenectomy in order to reduce side effects of conventional method for patients with vulvar carcinoma.Methods:Lipolysis and liposuction were performed to subcutaneous fat on inguinal region.We inserted endoscope and filled with CO 2 gases to this field and then resected inguinal lymph nodes with ultrasonic scalpel.The operative field was placed with the vacuum sealing drainage and pressured with soft saline bag after the operation.Results:Many lymphatic vessel,small blood vessels and hanging lymph nodes in the subcutaneous tissues of inguinal region were revealed after lipolysis and liposuction and lymph nodes can be easily removed.The follow-up so far showed that healing of the incision was good and there was no lymphedema of patient's lower limb and inguinal region.Conclusion:Endoscopic inguinal lymphadenectomy can resect the lymph nodes and keep most of the lymphatic vessels.So this technique has less influence on the lymph backflow of lower limb and inguinal region and can avoid the huge incision of conventional method.This method is worthy of further study. | Qiang Wu Yuzhong Wu Zhihua Sun Yibing Zhao Henghua Shao Junwei Qu | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，6： | 0 |
| 13 | Confinement of Fe atoms between MoS_(2) interlayers drives phase transition for improved reactivity in Fenton-like reactions显示文摘Phase manipulation of MoS_(2) from thermodynamically stable 2H phase to the unstable but more reactive 1T phase represents a crucial strategy for improving the reactivity in many reactions.The widely adopted wet chemistry approach uses intercalating entities especially alkali metal ions to achieve the phase transition;however,these entities are normally inert for the target reaction.Here,we describe the first use of iron atoms for the intercalation of 2H-MoS_(2) layers,driving the partial transition from 2H to 1T phase.Interestingly,in the peroxymonosulfate(PMS)-based Fenton-like reactions,the interlayered confinement of Fe atoms not only activates the inert basal plane,but also adds more reactive Fe sites for the formation of metal-PMS complex as primary reactive species for pollutant removal.In the degradation of a model pollutant carbamazepine(CBZ),the Fe-intercalated MoS_(2) exhibits a first order rate constant 13.3 times higher than 2H-MoS_(2).This strategy is a new direction for manipulating the phase composition and boosting the catalytic reactivity of MoS_(2)-based catalysts in various scenarios,including environmental remediation and energy applications. | Yibing Sun Yu Zhou Hongchao Li Chuan Wang Xuan Zhang Qian Ma Yingchun Cheng Jieshu Qian Bingcai Pan | 2024 | Nano Research2024，17，3： | 0 |
| 14 | Studies on the in vitro fertilizaion in cattle显示文摘Studies on the in vitro fertilizaion in cattleStudiesontheinvitrofertilizaionincattle￥YangQinzhang;XuXiaoJi;LiuGuoyi;SunQingy... | Yang Qinzhang Xu Xiao Ji Liu Guoyi Sun Qingyuan Han Yibing Xu Libin Xia Ping Qian Richeng Song Xuexiong and Qin Pengchun.(Department of Biotechnology,Northeast Agrict.ltural University,Harbin 150030,P.R.China)Ye Xinghua(Dcpartment of Animal Medicine,North | 1994 | Journal of Northeast Agricultural University(English Edition)1994，1，1： | 0 |
| 15 | Mucin-Producing Urothelial-Type Adenocarcinoma of the Prostate (a Case Report and Review of the Literature)显示文摘OBJECTIVE To report clinical and pathologic findings of one case of mucin-producing urothelial-type adenocarcinoma of the prostate, and to discuss the diagnosis and prognosis of this disease. METHODS The patient was a 60-year-old man who had an 8-month history of urinary frequency and dysuria culminating in an aggravating condition for 10-days. Laboratory results were tPSA 3.0 and fPSA 0.4. An ultrasound and digital rectal exam showed no abnormal findings, so he was diagnosed as having benign prostatic hyperplasia, and underwent a transurethral prostate resection. RESULTS The findings during the operation resembled benign prostatic hyperplasia (BPH), whereas the pathological exam showed that the pro-static construction was deranged in the tumor infiltrating region, with many mucin lakes and signet ring cell in the cancer tissue. Immunohisto-chemical staining revealed that the cancer tissue was negative for prostate-specific antigen (PSA) and postive for carcinoembryonic antigen (CEA). Final diagnosis: mucin-producing urothelial-type adenocarcinoma of the prostate. After 50 Gy radiotherapy, the patient was free of recurrent signs and metastasis up to 8 months after operation. CONCLUSION Mucin-producing urothelial-type adenocarcinoma of the prostate is extremely rare. Its differential diagnosis mainly includes conventional prostatic adenocarcinoma with mucin production and secondary adenocarcinoma. The diagnosis and treatment of this disease should be further investigated. | Haitao Niu Guang Sun Jiwu Chang Yibing Zhang | 2006 | Chinese Journal of Clinical Oncology2006，3，5： | 0 |
| 16 | The effect of subbranch for the quantification of local hemodynamic environment in the coronary artery:a computed tomography angiography–based computational fluid dynamic analysis显示文摘Background:Hemodynamic parameters derived from computed tomography angiography–based computational fluid dynamics(CFD)analysis have been widely used for clinical decision-making and researches to assess the vulnerability of atherosclerotic plaques and explain the initialization and development of atherosclerosis.Subbranches in the CFD model might affect the accuracy of hemodynamic parameters,but the effectiveness has been least quantified.Methods:A coronary artery baseline model was generated with focal stenosis at the proximal left anterior descending artery.Nineteen comparing models were created by systematically removing various subbranches to examine the changes in hemodynamic parameters,including time-averaged pressure(TAP),time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI),and particle relative residence time(RRT).Changes in these parameters were assessed quantitatively around the stenosis and near the region where subbranches were removed.Results:The removal of subbranches caused a significant change in outflow rate,and there was generally a decrease in all CFD parameters in the regions of interest with a decrease in outflow rate.The subbranch removal had a significant impact on the calculation of TAWSS,OSI,and RRT,whereas TAP was insensitive to the removal with approximately 0.25%variation in all 19 models.The local effect from removing branch segments generally became negligible after 5 diameters away from the cutting-off position,but the decrease could be affected by other factors,such as a large curvature.Conclusion:The outflow rate is a dominant factor for the calculation of TAP,TAWSS,OSI,and RRT.Removal of subbranches has a minor effect on the TAP calculation,but its effect is considerable on the TAWSS,OSI,and RRT.The effect of subbranch removal is limited in a region with 5 local diameters. | Yibing Shi Jin Zheng Ning Yang Yang Chen Jingxi Sun Ying Zhang Xuanxuan Zhou Yongguang Gao Suqing Li Haijing Zhu Julio Acosta-Cabronero Ping Xia Zhongzhao Teng | 2022 | Emergency and Critical Care Medicine2022，2，4： | 0 |
| 17 | mRNA expression of CYP4 in marine polychaete Marphysa sanguinea in response to benzo[a]pyrene显示文摘Rapid amplification of cDNA ends (RACE) and real-time polymerase chain reaction (RT-PCR) were carried out to analyze the CYP4 gene expression in polychaete Marphysa sanguinea exposed to benzo[a]pyrene (BaP) in this study. The full length of MsCYP4 cDNA was 2 470 bp, and it encoded 512 amino acids. The deduced amino acid sequence showed 47% identity with CYP4F from frog Xenopus tropicalis and shared high homology with other known CYP4 sequences. To analyse the role of CYP4 in protecting M. sanguinea from BaP exposure, three BaP groups were established: 0.5, 5 and 50 μg/L. Polychaetes were sampled after 3, 7 and 12 d. At 0.5 μg/L, the effect of BaP on MsCYP4 gene expression increased with time prolonged. MsCYP4 gene expression curve showed Ushaped trend with time in 5 and 50 μg/L BaP groups. Therefore, MsCYP4 gene may play an important role in maintaining the balance of cellular metabolism and protecting M. sanguinea from BaP toxicity. | Wanjuan Li Huan Zhao Fuyang Ba Shaojuan Li Xiupeng Sun Dazuo Yang Yibing Zhou | 2019 | Acta Oceanologica Sinica2019，38，6： | 0 |
| 18 | The influence of silica on reaction rates and molecular hydrogen(H_(2))generation during olivine hydrothermal alteration显示文摘Hydrothermal alteration of olivine greatly influences geodynamics and the recycling of volatiles(such as water and carbon)in subduction zones.Silica is an important component of geological fluids,and its influence on the hydrothermal alteration of olivine remains poorly constrained.In this study,we performed experiments at 300–515℃ and 3.0 kbar(1 bar=10^(5)Pa)by reacting well homogenized mixtures of olivine and silica powders with saline solutions(0.5 mol L^(−1)NaCl).Silica greatly influences the reaction pathways,reaction rates,and molecular hydrogen(H_(2))formation during olivine hydrothermal alteration.In experiments at 300℃ and 3.0 kbar with mixtures of olivine and 10 wt%silica,olivine was replaced by serpentine and talc.The proportions of serpentine and talc were determined according to standard curves based on infrared spectroscopy analyses.Around 6.5%serpentine and 12%talc were produced after an experimental duration of 7 days,which had no change after a longer period(14 days).Compared to the kinetics in silica-free systems,the rates of olivine hydrothermal alteration in experiments with 10 wt%silica are much lower.The overall reaction is:4.5Forsterite+5.5SiO_(2),aq+4H_(2)O=Serpentine+2Talc.With the addition of more silica(20 wt%and 40 wt%),olivine was transformed into talc.The rates of reaction were much faster,e.g.,for experiments with olivine and 20 wt%silica,43%of talc was produced after 14 days,which increased to 77%for experiments with 40 wt%silica over the same period.The overall reaction is:3Forsterite+5SiO_(2),aq+2H_(2)O=2Talc.In experiments at 400–505℃ and 3.0 kbar,the promoting effect of silica on olivine hydrothermal alteration was also observed,which is closely associated with a decrease in Gibbs free energies of olivine hydrothermal alteration.At 300℃ and 3.0 kbar,silica decreased H_(2)formed during olivine hydrothermal alteration by around an order of magnitude,resulting in an increase in oxygen fugacity.Based on measured H_(2),we calibrated oxygen fugacities,ranging from 0.96 to 3.41 log units below FMQ(fayalite-magnetitequartz buffer assemblage).This study suggests that the infiltration of SiO_(2)-bearing fluids into peridotites greatly influences redox conditions and the rates of olivine hydrothermal alteration. | Ruifang HUANG Weidong SUN Xing DING Yusheng ZHAO Yibing LI Xiuqi SHANG | 2024 | Science China Earth Sciences2024，67，1： | 0 |
| 19 | Intelligent Road Safety System Based on Multi-Function Warning Device显示文摘A warming device for car driving is proposed in this paper,which includes support rods and warning plates.In this device,several display screens are insalled on one side of the warning panel.Indicator lights are set on the display screen.A waning board is mounted on the top box.Several radar detectors are mounted on one side of the top box,and the radar detectors orrespond to the display screens.Several waming lights are installed on the top box,and the waning lights orespond to sevenl radar detectors.The sliding side of the support rod cleans the unit.The change of positions of the indicator lights based on the radar detectors will be rellected on the display screens,which allows drivers to understand the situation of the road.Therefore,they can prepare for changing lanes and overtaking,and understand the position and speed of all vehicles in this road section in advance. | Xueqing Wang Jingyi Zhang Yibing Qu Zipeng Wei Tong Li Boyu Sun | 2023 | Journal of Electronic Research and Application2023，7，4： | 0 |
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