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| 1 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 2 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 3 | Tidal stress triggering effects of earthquakes based on various tectonic regions in China and related astronomical characteristics显示文摘Dividing the China's Mainland into different tectonic stress regions,we calculate tidal stress components along the seismic compressive and extensional principal stress axes at every earthquake's focus in different tectonic stress regions.Tidal stress triggering effect on every earthquake fault is analyzed.Based on this,the lunar-solar location parameters on the occurring times of earthquakes which suffered tidal triggering effects are calculated,and the distribution patterns of the lunar-solar location parameters in different tectonic stress regions are obtained.The results indicate that earthquake tidal triggering effects and related astronomical characteristics are dependent on the properties of regional tectonic stress and the geographic locations of earthquake faults. | WU XiaoPing MAO Wei HUANG Yong HU Hui HU YiLi | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，8： | 6 |
| 4 | Effects of redox potential on soil cadmium solubility:Insight into microbial community显示文摘Understanding the role of microbes in the solubility of cadmium(Cd) is of fundamental importance for remediation of Cd toxicity. The present study aimed to identify the microbes that involved in regulating Cd solubility and to reveal possible mechanisms. Therefore,microbial communities were investigated through high-throughput sequencing approach, the molecular ecological network was constructed and metagenomes were predicted. Our results indicated that redox conditions affected both the solubility of soil Cd and the microbial communities. Anaerobic microbes, such as Anaerolineaceae, did not only play important roles in shaping the microbial community in soils, but might also be involved in regulating the Cd solubility. Two possible mechanisms that how Anaerolineaceae involved in Cd solubility are(1) Anaerolineaceae are important organic matter degraders under anoxic conditions and(2) Anaerolineaceae can co-exist with methane metabolism microbes, while methane metabolism promotes the precipitation of soluble Cd. Thus, application of Anaerolineaceae in bioremediation of soil Cadmium contamination is a potential approach. The study provided a novel insight into the role of microbial community in the regulation of Cd solubility under different redox conditions, and suggested a potential approach for the remediation of soil Cd contamination. | Delong Meng Juan Li Tianbo Liu Yongjun Liu Mingli Yan Jin Hu Xiaoqi Li Xueduan Liu Yili Liang Hongwei Liu Huaqun Yin | 2019 | Journal of Environmental Sciences2019，31，1： | 6 |
| 5 | The diameter factor of aligned membranes facilitates wound healing by promoting epithelialization in an immune way显示文摘Topographical properties,such as pattern and diameter,of biomaterials play important roles in influencing cell activities and manipulating the related immune response during wound healing.We prepared aligned electrospinning membranes with different fiber diameters,including 319±100 nm(A300),588±132 nm(A600),and 1048±130 nm(A1000),by adjusting the distance from the tip to the collector,the injection rate,and the concentration of the solution.The A300 membranes significantly improved cell proliferation and spreading and facilitated wound healing(epithelization and vascularization)with the regeneration of immature hair follicles compared to the other membranes.Transcriptomics revealed the underlying molecular mechanism that A300 could promote immune-related processes towards a pro-healing direction,significantly promoting keratinocyte migration and skin wound healing.All the results indicated that wound healing requires the active participation of the immune process,and that A300 was a potential candidate for guided skin regeneration applications. | Chenbing Wang Chenyu Chu Xiwen Zhao Yang Yang Chen Hu Li Liu Jidong Li Yili Qu Yi Man | 2022 | Bioactive Materials2022，7，5： | 2 |
| 6 | Simultaneous biosorption of cadmium (II) and lead (II) ions by pretreated biomass of Phanerochaete chrysosporium显示文摘 | Qingbiao Li Songtao Wu Gang Liu Xinkai Liao Xu Deng Daohua Sun Yuelin Hu Yili Huang | 2003 | Separation and Purification Technology2003，，1： | 1 |
| 7 | STAP method based on atomic norm minimization with array amplitude-phase error calibration显示文摘In this paper,a space-time adaptive processing(STAP)method is proposed for the airborne radar with the array amplitude-phase error considered,which is based on atomic norm minimization(ANM).In the conventional ANM-based STAP method,the influence of the array amplitude-phase error is not considered and restrained,which inevitably causes performance deterioration.To solve this problem,the array amplitude-phase error is firstly estimated.Then,by pre-estimating the array amplitude-phase error information,a modified ANM model is built,in which the array amplitude-phase error factor is separated from the clutter response and the clutter covariance matrix(CCM)to improve the estimation accuracy of the CCM.To prove that the atomic norm theory is applicable in the presence of the array amplitude-phase error,the clutter sparsity is analyzed in this paper.Meanwhile,simulation results demonstrate that the proposed method is superior to the state-of-the-art STAP method.Moreover,the measured data is used to verify the effectiveness of the proposed method. | PANG Xiaojiao ZHAO Yongbo CAO Chenghu XU Baoqing HU Yili | 2021 | Journal of Systems Engineering and Electronics2021，32，1： | 1 |
| 8 | A new hydrodynamic approach by infusion of drag-reducing polymers to improve left ventricular function in rats with myocardial infarction显示文摘 | Xianghui Chen Daogang Zha Jiancheng Xiu Yulin Liao Kai Cui Huanbing Lin Zhengwei Jian Feng Hu Xuliang Huang Biying Zhou Qiaobing Huang Jianping Bin Yili Liu | 2010 | International Journal of Cardiology2010，，1： | 1 |
| 9 | A Novel Bionic Piezoelectric Actuator Based on the Walrus Motion显示文摘A novel bionic piezoelectric actuator based on the walrus motion to achieve high performance on large working stroke for micro/nano positioning systems is first proposed in this study.The structure of the proposed walrus type piezoelectric actuator is described,and its motion principle is presented in details.An experimental system is set up to verify its feasibility and explore its working performances.Experimental results indicate that the proposed walrus type piezoelectric actuator could realize large working stroke with only one driving unit and one coupled clamping unit;the maximum stepping displacement isΔL max=19.5μm in the case that the frequency f=1 Hz and the voltage U=120 V;the maximum speed V max=2275.2μm·s^(-1) when the frequency f=900 Hz and the voltage U=120 V;the maximum vertical load m max=350 g while the voltage U=120 V and the frequency f=1 Hz.This study shows the feasibility of mimicking the bionic motion of the real walrus animal to the design of piezoelectric actuators,which is hopeful for the real application of micro/nano positioning systems to achieve large working stroke and high performance. | Jianping Li Junjie Cai Nen Wan Yili Hu Jianming Wen Junwu Kan Song Chen Hongwei Zhao | 2021 | Journal of Bionic Engineering2021，18，5： | 1 |
| 10 | Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia显示文摘Although NPM1 mutations are frequently found in acute myeloid leukemia patients,therapeutic strategies are scarce and unsuitable for those who cannot tolerate intensive chemotherapy.Here we demonstrated that heliangin,a natural sesquiterpene lactone,exerts favorable therapeutic responses in NPM1 mutant acute myeloid leukemia cells,with no apparent toxicity to normal hematogenous cells,by inhibiting their proliferation,inducing apoptosis,causing cell cycle arrest,and promoting differentiation.In-depth studies on its mode of action using quantitative thiol reactivity platform screening and subsequent molecular biology validation showed that the ribosomal protein S2(RPS2)is the main target of heliangin in treating NPM1 mutant AML.Upon covalent binding to the C222 site of RPS2,the electrophilic moieties of heliangin disrupt pre-rRNA metabolic processes,leading to nucleolar stress,which in turn regulates the ribosomal proteins-MDM2-p53 pathway and stabilizes p53.Clinical data shows that the pre-rRNA metabolic pathway is dysregulated in acute myeloid leukemia patients with the NPM1 mutation,leading to a poor prognosis.We found that RPS2 plays a critical role in regulating this pathway and may be a novel treatment target.Our findings suggest a novel treatment strategy and lead compound for acute myeloid leukemia patients,especially those with NPM1 mutations. | Yin Feng Yefan Han Anni Hu Yi Qu Yili Hu Hao Wu Xinzhi Wang Li He | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 11 | Low-angle estimation using frequency-agile refined maximum likelihood algorithm based on optimal fusion显示文摘Low elevation estimation,which has attracted wide attention due to the presence of specular multipath,is essential for tracking radars.Frequency agility not only has the advantage of strong anti-interference ability,but also can enhance the performance of tracking radars.A frequency-agile refined maximum likelihood(RML)algorithm based on optimal fusion is proposed.The algorithm constructs an optimization problem,which minimizes the mean square error(MSE)of angle estimation.Thereby,the optimal weight at different frequency points is obtained for fusing the angle estimation.Through theoretical analysis and simulation,the frequency-agile RML algorithm based on optimal fusion can improve the accuracy of angle estimation effectively. | CHEN Sheng ZHAO Yongbo PANG Xiaojiao HU Yili CAO Chenghu | 2021 | Journal of Systems Engineering and Electronics2021，32，3： | 1 |
| 12 | Research on the Ideological and Political Construction of Mathematics Foundations of Information Security显示文摘Mathematics foundations of information security is a core course in the subject of information security.In view of the current national ideological and political conference in universities,finding a way to integrate this course with ideological and political education attracts a lot of attention from the education community.This paper makes an assay of the significance of the combination of mathematics foundations of information security course and ideological and political education,and introduces the teaching practice of mathematics foundations of information security course combined with ideological and political education.Through the combination of ideological and political education and curriculum content,cultivating all-round development of talents who study information security. | Hu Xiong Hang Yan Yili Li | 2022 | 计算机教育2022，，12： | 0 |
| 13 | Short-range clutter suppression method combining oblique projection and interpolation in airborne CFA radar显示文摘The airborne conformal array(CFA)radar's clutter ridges are range-modulated,which result in a bias in the estimation of the clutter covariance matrix(CCM)of the cell under test(CUT),further,reducing the clutter suppression performance of the airborne CFA radar.The clutter ridges can be effectively compensated by the space-time separation interpolation(STSINT)method,which costs less computation than the space-time interpolation(STINT)method,but the performance of interpolation algorithms is seriously affected by the short-range clutter,especially near the platform height.Location distributions of CFA are free,which yields serious impact that range spaces of steering vector matrices are non-orthogonal complement and even no longer disjoint.Further,a new method is proposed that the shortrange clutter is pre-processed by oblique projection with the intersected range spaces(OPIRS),and then clutter data after being pre-processed are compensated to the desired range bin through the STSINT method.The OPIRS also has good compatibility and can be used in combination with many existing methods.At the same time,oblique projectors of OPIRS can be obtained in advance,so the proposed method has almost the same computational load as the traditional compensation method.In addition,the proposed method can perform well when the channel error exists.Computer simulation results verify the effectiveness of the proposed method. | HU Yili ZHAO Yongbo PANG Xiaojiao CHEN Sheng | 2021 | Journal of Systems Engineering and Electronics2021，32，1： | 0 |
| 14 | Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring显示文摘Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and wearability.However,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial application.Herein,aflexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is pro-posed.The porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and NaHCO3.Due to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aflat pressure sensor without a porous MNA structure.Finite-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the sen-sor.In addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode structure.Most importantly,it was found that the sensor could accurately monitor the motion of afinger,wrist joint,arm,face,abdomen,eye,and Adam’s apple.Furthermore,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s apple.Finally,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×tion.Compared to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer. | Jiahui Xu Minghao Wang Minyi Jin Siyan Shang Chuner Ni Yili Hu Xun Sun Jun Xu Bowen Ji Le Li Yuhua Cheng Gaofeng Wang | 2024 | Nanotechnology and Precision Engineering2024，7，1： | 0 |
| 15 | Features and mechanism of neotectonic deformation of the Xishan fault system west of Urumqi显示文摘We have made careful field investigation and trench exploration to the Xishan fault system in west of Urumqi,and an integrated analysis in conjunction with data of deep seismic sounding.Our result suggests that under the SN-oriented compressive stress,the Xishan block moves steadily toward the Tianshan Mountains in south,resulting in southward thrust-slip and crustal shortening,particularly the southward thrust of the Xishan fault which serves as the main boundary in south.North of the Xishan fault are the Wangjiagou fault and Jiujiawan fault which are the secondary faults associated with the Xishan fault in generation.Both faults have slippage along horizons during the uplift of the Xishan block,and the Jiujia-wan fault has also a component of normal faulting due to the influence of the Bogeda nappe structure.These two faults accommodate the fold deformation of the hanging wall of the Xishan fault,thus the Xishan fault-bounded swell is character-ized by monocline.All secondary faults of the Xishan fault system constitute a common seismogenic structural system,so that their seismic hazards should be considered in an equal manner. | Chuanyong Wu Jun Shen Jun Li Zhiyong Xiang Jun Hu Yili Ya'er | 2009 | Earthquake Science2009，22，1： | 0 |
| 16 | M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator显示文摘Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture healing.Macrophages play a key role in the process of fracture healing by undergoing polarization into either M1 or M2 subtypes,which respectively exhibit pro-inflammatory or anti-inflammatory functions.Therefore,modulation of macrophage polarization to the M2 subtype is beneficial for fracture healing.Exosomes perform an important role in improving the osteoimmune microenvironment due to their extremely low immunogenicity and high bioactivity.In this study,we extracted the M2-exosomes and used them to intervene the bone repair in diabetic fractures.The results showed that M2-exosomes significantly modulate the osteoimmune microenvironment by decreasing the proportion of M1 macrophages,thereby accelerating diabetic fracture healing.We further confirmed that M2-exosomes induced the conversion of M1 macrophages into M2 macrophages by stimulating the PI3K/AKT pathway.Our study offers a fresh perspective and a potential therapeutic approach for M2-exosomes to improve diabetic fracture healing. | Yili Wang Qiushui Lin Hao Zhang Sicheng Wang Jin Cui Yan Hu Jinlong Liu Mengmeng Li Kun Zhang Fengjin Zhou Yingying Jing Zhen Geng Jiacan Su | 2023 | Bioactive Materials2023，，10： | 0 |
| 17 | Target height and multipath attenuation joint estimation with complex scenarios for very high frequency radar显示文摘Low-angle estimation for very high frequency(VHF)radar is a difficult problem due to the multipath effect in the radar field,especially in complex scenarios where the reflection condition is unknown.To deal with this problem,we propose an algorithm of target height and multipath attenuation joint estimation.The amplitude of the surface reflection coefficient is estimated by the characteristic of the data itself,and it is assumed that there is no reflected signal when the amplitude is very small.The phase of the surface reflection coefficient and the phase difference between the direct and reflected signals are searched as the same part,and this represents the multipath phase attenuation.The Cramer-Rao bound of the proposed algorithm is also derived.Finally,computer simulations and real data processing results show that the proposed algorithm has good estimation performance under complex scenarios and works well with only one snapshot. | Sheng CHEN Yongbo ZHAO Yili HU Chenghu CAO Xiaojiao PANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，6： | 0 |
| 18 | Reversibility of the structure and dewaterability of anaerobic digested sludge显示文摘The reversibility of the structure and dewaterability of broken anaerobic digested sludge(ADS)is important to ensure the efficiency of sludge treatment or management processes.This study investigated the effect of continuous strong shear(CSS)and multipulse shear(MPS)on the zeta potential,size(median size,d_(50)),mass fractal dimension(D_F),and capillary suction time(CST)of ADS aggregates.Moreover,the self-regrowth(SR)of broken ADS aggregates during slow mixing was also analyzed.The results show that raw ADS with d_(50) of 56.5μm was insensitive to CSS–SR or MPS–SR,though the size slightly decreased after the breakage phase.For conditioned ADS with d_(50) larger than 600μm,the breakage in small-scale surface erosion changed to large-scale fragmentation as the CSS strength increased.In most cases,after CSS or MPS,the broken ADS had a relatively more compact structure than before and d_(50) is at least 200μm.The CST of the broken fragments from optimally dosed ADS increased,whereas that corresponding to overdosed ADS decreased.MPS treatment resulted in larger and more compact broken ADS fragments with a lower CST value than CSS.During the subsequent slow mixing,the broken ADS aggregates did not recover their charge,size,and dewaterability to the initial values before breakage.In addition,less than 15%self-regrowth in terms of percentage of the regrowth factor was observed in broken ADS after CSS at average velocity gradient no less than 1905.6 sec^(-1). | Yiqi Sheng Yili Wang Wei Hu Xu Qian Huaili Zheng Xiaoxiu Lun | 2016 | Journal of Environmental Sciences2016，28，4： | 0 |
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