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| 1 | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. | Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su | 2019 | National Science Review2019，6，3： | 12 |
| 2 | Effects of natural covers on soil evaporation of the shelterbelt along the Tarim Desert Highway显示文摘The control of soil evaporation is one of important approaches to save water. The artificially simulated evaporation experiments have been conducted in the hinterland of the Taklimakan Desert to reveal the effects of the natural covers on the soil evaporation of the Tarim Desert Highway shelterbelt as well as provide some insights in the efficient utilization of water resources and optimization of irrigation systems. The results showed that (1) All the covers, including the sand deposit, the salt crust, the litter, the sand-litter mixed layer and so on, can significantly inhibit the soil water evaporation. Specifically, the daily evaporation, the total evaporation, and the evaporation rate in covered sands were much smaller than that of sands without cover. The cover inhibition effects increased with the cover thickness. Particularly, the soil evaporation of the covered sands was less affected by external and internal factors than that of the bare sands. Moreover, the variation of daily evaporation of covered sands was smaller than that of bare sands. The cumulative evaporation varied linearly with time in the covered sands whereas it varied logarithmically in the bare sands. In addition, the soil evaporation in the bare sands showed significantly different characteristics in the early and late stages of the evaporation. (2) All the covers exhibited the significant inhibiting effect on the soil evaporation, and the inhibition efficiency increased logarithmically with the cover thickness. However, as the cover thickness was above a certain value, the increase in the inhibition efficiency was slow. Particularly, at a cover thickness of 2 cm, there was no obvious difference in the inhibition efficiency among all kinds of covers. The maximum inhibition efficiency as calculated from the daily evaporation on the first day of irrigation was: sand-litter mixed layer (79.92%) > litter layer (78.96%) > salt crust (75.58%) > sand bed (74.11%), whereas the average inhibiting efficiency as calculated from the cumulative soil evaporation at the end of an irrigation cycle (the fourth day) was: salt crust (67.78%) > sand-litter mixed layer (66.72%) > sand deposit (63.28%) > litter layer (61.74%). | ZHOU HongWei LI ShengYu SUN ShuGuo XU XinWen LEI JiaQiang LIU Shang DU WenYi YAN Zeng WANG YongChang | 2008 | Chinese Science Bulletin2008，53，S2： | 11 |
| 3 | Limited distribution and mechanism of the TetX4 tetracycline resistance enzyme显示文摘Tetracyclines,a group of antimicrobial agents targeting protein synthesis,have been extensively used in agricultural,veterinary,and clinic settings[1].The sporadic rise in tetracycline resistance is partially due to the occurrence of efflux pumps and/or ribosome protection[1,2].The growing body of tetracycline-inactivating enzymes(e.g.,TetX(X1 to X4)[3,4]and Tet(47 to 55)[5])represents an alternative mechanism for tetracycline resistance,and threatens the renewed interest of tigecycline as a last-resort defense against lethal infections with carbapenem-resistant Enterobacteriaceae and Acinetobacter species. | Yongchang Xu Lizhang Liu Jian Sun Youjun Feng | 2019 | Science Bulletin2019，64，20： | 4 |
| 4 | Discovery and its geological significance of the mantle- derived helium in the inclusions of the Ordovician oil-bearing reservoir rocks in the Huanghua depression,China显示文摘The values of the helium isotopes in the inclusions of the Ordovician reservoir rocks in the Kongxi buried hill belt in the Huanghua depression were first measured and the source of helium and its geological significance were investigated in comparison with those of the helium isotopes in the conclusions in the Ordovician rocks in the Ordos basin and the Tarim basin. The input of the mantle-derived helium into the inclusions in the carbonate reservoir rocks was found from the Konggu 3 well, the Konggu 4 well, and the Konggu 7 well in the Kongxi buried hill belt. The 3He/4He and R/Ra in the conclusions in the Ordovician oil-bearing reservoir rocks in the Konggu 7 well average 2.54×10-6(3) (sample quantity, the same below) and 1.82(3), respectively. The percent of the mantle-derived helium in the inclusions of the reservoir rocks in the Konggu 7 well reaches up to an average of 23.0%(3). The age of the contribution of the mantle-derived helium to the inclusions in the Kongxi buried hill belt is in the Late Triassic or the Early Tertiary. The finding of the mantle-derived helium shows that the interaction of the deep crust with mantle and the activity of deep faults occurred, the terrestrial heat flow value was high, and mantle-derived inorganic gas pools might be formed in the Kongxi buried hill belt. The finding of the mantle-derived helium in the inclusions of oil-bearing reservoir rocks also provides a new way for researching the activity of mantle-derived matter and its associated geological problems. | ZHANG Xiaobao XU Yongchang SUN Mingliang CHENG Keming LIU Wenhui LI Xiufen MA Liyuan | 2004 | Science China Earth Sciences2004，47，1： | 4 |
| 5 | Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair显示文摘Growth plate cartilage has limited self-repair ability,leading to poor bone bridge formation post-injury and ultimately limb growth defects in children.The current corrective surgeries are highly invasive,and outcomes can be unpredictable.Following growth plate injury,the direct loss of extracellular matrix(ECM)coupled with further ECM depletion due to the inhibitory effects of inflammation on the cartilage matrix protein greatly hinder chondrocyte regeneration.We designed an exosome(Exo)derived from bone marrow mesenchymal stem cells(BMSCs)loaded ECM-mimic hydrogel to promote cartilage repair by directly supplementing ECM and anti-inflammatory properties.Aldehyde-functionalized chondroitin sulfate(OCS)was introduced into gelatin methacryloyl(GM)to form GMOCS hydrogel.Our results uncovered that GMOCS hydrogel could significantly promote the synthesis of ECM due to the doping of OCS.In addition,the GMOCS-Exos hydrogel could further promote the anabolism of chondrocytes by inhibiting inflammation and ultimately promote growth plate injury repair through ECM remodeling. | Pengfei Guan Can Liu Denghui Xie Shichao Mao Yuelun Ji Yongchang Lin Zheng Chen Qiyou Wang Lei Fan Yongjian Sun | 2022 | Bioactive Materials2022，7，4： | 3 |
| 6 | Discrete Particle Simulation of Gas-Solid Flow in Air-Blowing Seed Metering Device显示文摘In this paper,the gas and seed flow characters in the air-blowing seed metering device are investigated by using the coupled computational fluid dynamics and discrete element method(CFD-DEM)in three dimensions(3D).The method of establishing boundary model based on the computer-aided design(CAD)drawing,has been used to build the boundary model of seed metering device.The 3D laser scanning technique and multi-element method are adopted to establish the particle model.Through a combined numerical and experimental effort,using 3D CFD-DEM software,which is based on the in-house codes,the mechanisms governing the gas and solid dynamic behaviors in the seed metering device have been studied.The gas velocity field and the effect of different rotational speeds and air pressures on the seeding performance and particle velocity have been studied,similar agreements between numerical and experimental results are gained.This reveals that the 3D CFD-DEM model established is able to predict the performance of the air-blowing seed metering device.It can be used to design and optimize the air-blowing seed metering device and other similar agriculture devices. | Zhengquan Li Pei Zhang Yongchang Sun Chenglin Zheng Liang Xu Dianyu E | 2021 | Computer Modeling in Engineering & Sciences2021，，6： | 2 |
| 7 | Imbalance between subpopulations of regulatory T cells in COPD显示文摘 | Jia Hou Yongchang Sun Yu Hao Jie Zhuo Xiaofang Liu Peng Bai Junyan Han Xiwei Zheng Hui Zeng | 2013 | Thorax2013，，12： | 2 |
| 8 | Polarization of plane wave propagating inside elastic hexagonal system solids显示文摘Based on the reported physical parameters for hexagonal system solids,we have calculated the effects of anisotropy on polarization of plane P-wave propagation.Herein we report the results of calculations and the newly observed physical phenomena.It is found that,for a given propagation,if the polarization is parallel to the wave vector,so also to the Poynting vector.In such a case,the phase velocity is identical to the energy velocity;the quasi P-wave degenerates to a pure P-wave along the propagation.It is also noted that if the polarization is parallel to the Poynting vector but not to the wave vector,the propagating wave cannot be a pure P-wave.Furthermore,the polarization in a quasi P-wave may deviate from the wave vector for more than 45°,but the deviation from the Poynting vector is always less than 45°.The energy velocity of a quasi SV-wave can be larger than that of the quasi P-wave in some propagation directions,even though the phase velocity of a quasi SV-wave may never be larger than either the phase velocity or energy velocity of the quasi P-wave.Finally,in case of parameters ε=0 and δ*≠0,the polarization of a quasi P-wave has an observed symmetry at a 45°phase angle.The anisotropy of a hexagonal system solid determines if a pure P-wave can be created and what the propagation direction is for a plane wave propagating inside such a hexagonal system solid. | FA Lin ZHAO MeiShan LIU YongChang WANG Lei WANG YanQiang SUN JiGang | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，2： | 2 |
| 9 | Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids显示文摘 | Meghan Cundall Yongchang Sun Christina Miranda John B. Trudeau Stephen Barnes Sally E. Wenzel | 2003 | The Journal of Allergy and Clinical Immunology2003，，6： | 1 |
| 10 | Oxidative Stress Upregulates PDCD4 Expression in Patients with Gastric Cancer via miR-21显示文摘 | Honglei Tu Haibing Sun Yan Lin Jie Ding Kejun Nan Zongfang Li Qiang Shen Yongchang Wei | 2014 | Current Pharmaceutical Design2014，，11： | 1 |
| 11 | RIGOROUS FULL-WAVE ANALYSIS OF THE BASE-STATION ANTENNAS显示文摘 | Chen Shengbing Zhang Fushun Jiao Yongchang Sun Baohua(institute of Antennas and EM Scattering Xidian University Xi’an 710071) | 2002 | Journal of Electronics(China)2002，，03： | 1 |
| 12 | Northeast power system simulator(NEPSS)显示文摘1.IntroductionThe Northeast Power System is one of the four bulk powersystems in China,which covers the provinces of Liaoning,Jilin,Heilongjiang and a small part of Inner Mongolia.The total installedcapacity in 1990 was 21,300 MW and the peak demand was 13,600MW.The Control Center is in Shenyang.The dispatching automationsystem which is mainly composed of a dual computer system(2XVAX785)was installed and put into operation in 1988.The plan | Gu Yongchang Wang Xinfeng Li Wenping Sun Guosheng Electrical Engineering Department of Tsinghua UniversityYang Songqi Xu Muliang Yang Kexuan Huang Yingju Electric Power Dispatching and Communication Bureau of Northeast Power Administration.P.R.China | 1992 | Electricity1992，，4： | 1 |
| 13 | De novo DNA methylation during monkey pre-implantation embryogenesis显示文摘首领 embryogenesis 的批评 epigenetic 规定必要 DNA methylome 变化。这里,我们在培植前恒河猴胚胎以及用定序方法的优化基于 tagmentation 的整个染色体的重亚硫酸盐学习的男、女的配偶子报导 DNA methylation 的染色体宽的作文, patterning,和阶段特定的动力学。我们证明在授精之上,父亲、母亲的染色体经历活跃 DNA demethylation,和染色体宽的 de novo DNA methylation 也在一样的时期被开始。由 8 房间阶段, remethylation 变得比 demethylation 更显著,导致全球 DNA methylation 的增加。基因的倡导者与氧化 phosphorylation 联系了,建议精力新陈代谢的这个模式不能被赞成是优先地在 8 房间阶段的 remethylated。在啮齿类动物不同, X 染色体 inactivation 没在猴子培植前开发期间被观察。我们的学习提供蜡的第一幅全面插图并且衰退 DNA methylation 动力学的阶段。最重要地,我们的 DNA methyltransferase loss-of-function 分析显示 DNA methylation 影响早猴子 embryogenesis。 | Fei Gao Yuyu Niu Yi Eve Sun Hanhn Lu Yongchang Chen Siguang Li Yu Kang Yuping Luo Chenyang Ni Juehua Yu Chang Li Nianqin Sun Wei Si Hong Wang Weizhi Ji Tao Tan | 2017 | Cell Research2017，27，4： | 1 |
| 14 | Homogeneous lauroylation of ball-milled bamboo in ionic liquid for bio-based composites production : Part I : Modifi- cation and characterization显示文摘 | WEN Jialong SUN Yongchang MENG Lingyan | 2011 | Ind Crops Prod2011，34，3： | 1 |
| 15 | Density functional theory study of Ir atom deposited on γ -Al 2 O 3 (001) surface显示文摘 | Yongchang Chen Chuying Ouyang Siqi Shi Zhaolin Sun Lijuan Song | 2008 | Physics Letters A2008，，2： | 1 |
| 16 | Imbalance between subpopulations of regulatory T cells in COPD显示文摘 | Jia Hou Yongchang Sun Yu Hao Jie Zhuo Xiaofang Liu Peng Bai Junyan Han Xiwei Zheng Hui Zeng | 2013 | Thorax2013，，12： | 1 |
| 17 | Ultra-thick,dense dual-encapsulated Sb anode architecture with conductively elastic networks promises potassium-ion batteries with high areal and volumetric capacities显示文摘Ultra-thick,dense alloy-type anodes are promising for achieving large areal and volumetric performance in potassium-ion batteries(PIBs),but severe volume expansion as well as sluggish ion and electron diffusion kinetics heavily impede their widespread application.Herein,we design highly dense(3.1 g cm^(-3))Ti_(3)C_(2)T_(x) MXene and graphene dual-encapsulated nano-Sb monolith architectures(HD-Sb@Ti_(3)C_(2)T_(x)-G)with high-conductivity elastic networks(1560 S m^(-1))and compact dually encapsulated structures,which exhibit a large volumetric capacity of 1780.2 mAh cm^(-3)(gravimetric capacity:565.0 mAh g^(-1)),a long-term stable lifespan of 500 cycles with 82%retention,and a large areal capacity of 8.6 mAh cm^(-2)(loading:31 mg cm^(-2))in PIBs.Using ex-situ SEM,in-situ TEM,kinetic investigations,and theoretical calculations,we reveal that the excellent areal and volumetric performance mechanism stems from the three dimensional(3D)high-conductivity elastic networks and the dualencapsulated Sb architecture of Ti_(3)C_(2)T_(x) and graphene;these effectively mitigate against volume expansion and the pulverization of Sb,offering good electrolyte penetration and rapid ionic/electronic transmission.Ti_(3)C_(2)T_(x) also decreases the Kþdiffusion energy barrier,and the ultra-thick compact electrode ensures volumetric and areal performance.These findings provide a feasible strategy for fabricating ultra-thick,dense alloy-type electrodes to achieve high areal and volumetric capacity energy storage via highly-dense,dual-encapsulated architectures with conductive elastic networks. | Zhonggang Liu Xi Liu Bingchun Wang Xinying Wang Dongzhen Lu Dijun Shen Zhefei Sun Yongchang Liu Wenli Zhang Qiaobao Zhang Yunyong Li | 2023 | eScience2023，3，6： | 0 |
| 18 | Clinical treatment and prognostic observation for different pathological infiltrations in 537 patients with unilateral retinoblastoma显示文摘 | Wang Yizhuo Huang Dongsheng Shi Jitong Ma Jianmin Zhao Junyang Li Bin Xu Xiaolin Hu Huimin Zhou Yan Sun Yongchang | 2014 | Chinese Medical Journal2014，，20： | 0 |
| 19 | Profiling of immune features to predict immunotherapy efficacy显示文摘Immune checkpoint blockade(ICB)therapies exhibit substantial clinical benefit in different cancers,but relatively low response rates in the majority of patients highlight the need to understand mutual relationships among immune features.Here,we reveal overall positive correlations among immune checkpoints and immune cell populations.Clinically,patients benefiting from ICB exhibited increases for both immune stimulatory and inhibitory features after initiation of therapy,suggesting that the activation of the immune microenvironment might serve as the biomarker to predict immune response.As proof-of-concept,we demonstrated that the immune activation score(ISD)based on dynamic alteration of interleukins in patient plasma as early as two cycles(4-6 weeks)after starting immunotherapy can accurately predict immunotherapy efficacy.Our results reveal a systematic landscape of associations among immune features and provide a noninvasive,cost-effective,and time-efficient approach based on dynamic profiling of pre-and on-treatment plasma to predict immunotherapy efficacy. | Youqiong Ye Yongchang Zhang Nong Yang Qian Gao Xinyu Ding Xinwei Kuang Rujuan Bao Zhao Zhang Chaoyang Sun Bingying Zhou Li Wang Qingsong Hu Chunru Lin Jianjun Gao Yanyan Lou Steven HLin Lixia Diao Hong Liu Xiang Chen Gordon B.Mills Leng Han | 2022 | The Innovation2022，3，1： | 0 |
| 20 | Modification Mechanism and Uniaxial Fatigue Performances of A356.2 Alloy Treated by Al-Sr-La Composite Refinement-Modification Agent显示文摘Modification mechanism and uniaxial fatigue properties of A356.2 alloy treated by Al-6Sr-7La and traditional Al-5Ti-1B/Al-10Sr(hereinafter refers to traditional treated alloy) were investigated by constant stress amplitude method. Microstructure, dislocation and Si twinning of the alloys were studied by thermal analysis, scanning electron microscopy(SEM) and transmission electron microscopy(TEM). The results showed that Al-6Sr-7La possesses better refining and modification effect than Al-5Ti-1B/Al-10Sr. Meanwhile, fatigue properties of the alloy treated by Al-6Sr-7La are higher than traditional treated alloy, and this is mainly owing to that Al-6Sr-7La treated alloy has more twins in eutectic Si and lower twin spacing. In addition, higher density of nanophases formed on twin faces and La-rich clusters appear at multiple twin intersections. Stacking faults and entrapped nanophases appeared on growing Si twin faces. Impurity induced twinning(IIT) mechanism and twin plane re-entrant edge(TPRE) mechanism are valid for eutectic Si which are important for mechanical optimization of A356.2 alloy. | Liang Chang Qingfeng Zhao Xingchuan Xia Yuming Ding Binxu Guo Jian Ding Ying Tang Zan Zhang Chong Li Xiaomian Sun Junjie Guo Kaihong Song Yongchang Liu | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，6： | 0 |
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