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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Electroacupuncture attenuates neuropathic pain after brachial plexus injury显示文摘Electroacupuncture has traditionally been used to treat pain, but its effect on pain following brachial plexus injury is still unknown. In this study, rat models of an avulsion injury to the left brachial plexus root(associated with upper-limb chronic neuropathic pain) were given electroacupuncture stimulation at bilateral Quchi(LI11), Hegu(LI04), Zusanli(ST36) and Yanglingquan(GB34). After electroacupuncture therapy, chronic neuropathic pain in the rats' upper limbs was significantly attenuated. Immunofluorescence staining showed that the expression of β-endorphins in the arcuate nucleus was significantly increased after therapy. Thus, experimental findings indicate that electroacupuncture can attenuate neuropathic pain after brachial plexus injury through upregulating β-endorphin expression. | Shenyu Zhang Hailiang Tang Junming Zhou Yudong Gu | 2014 | Neural Regeneration Research2014，9，14： | 7 |
| 3 | Wettability and Bonding between Ni and Ti(C,N)with Multiple Carbide Additions显示文摘The wettability and bonding in Ni/Ti(C, N) systems with multiple carbide additions were studied by sessile drop technique and vacuum brazing technique, respectively. The phase characterizations of substrates and fracture surfaces were conducted by XRD. The microstructures at metal/ceramic interfaces and fracture surfaces were observed via SEM in back scattered mode and second electron mode, respectively. Furthermore, an X-ray energy-dispersive spectrometer (EDS) attached to SEM was used to study the elements diffusion in interfacial regions. The results reveal that diffusion and dissolution mechanism controlled reactive wetting takes place in the system in high temperature wetting. Results also show that the contact angles decrease with multiple carbide additions, and the effect of multiple carbide additions is stronger than that of single additions. The contact angle reaches the lowest value in the lowest TiC content case. The enhancement of the wettability is due to alloying procedure during high temperature wetting when metallic atoms diffuse into Ni phase, which decreases the interfacial energy of Ni/Ti(C, N) systems. The bonding results show that the interfacial bonding strength is higher than that of solid solutions, that makes most of the specimens fail in ceramics matrix. | Ning LIU, Minghai CHEN, Yudong XU, Jie ZHOU and Min SHIDepartment of Materials Science and Engineering, Hefei University of Technology, Hefei 230009, ChinaProf., Ph.D. | 2005 | Journal of Materials Science & Technology2005，21，1： | 6 |
| 4 | A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis显示文摘Both preclinical and established rheumatoid arthritis(RA)patients display alterations in the gut microbiome.Prevotella spp.are preferentially enriched in a subset of RA patients.Here,we isolated a Prevotella strain,P.copri RA,from the feces of RA patients and showed that colonization of P.copri RA exacerbated arthritis in a collagen-induced arthritis(CIA)model.With the presence of P.copri RA colonization,a high-fiber diet exacerbated arthritis via microbial alterations and intestinal inflammation.Colonization of P.copri together with a high-fiber diet enabled the digestion of complex fiber,which led to the overproduction of organic acids,including fumarate,succinate and short-chain fatty acids.Succinate promoted proinflammatory responses in macrophages,and supplementation with succinate exacerbated arthritis in the CIA model.Our findings highlight the importance of dysbiosis when evaluating the effects of dietary interventions on RA pathogenesis and provide new insight into dietary interventions or microbiome modifications to improve RA management. | Lingjuan Jiang Mengmeng Shang Shengnan Yu Yudong Liu Hui Zhang Yangzhong Zhou Min Wang Tingting Wang Hui Li Zhihua Liu Xuan Zhang | 2022 | Cellular & Molecular Immunology2022，19，12： | 6 |
| 5 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 6 | Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths,characterized by highly hypoxic tumor microenvironment.Hypoxia-inducible factor-1α(HIF-1α)is a major regulator involved in cellular response to changes of oxygen levels,supporting the adaptation of tumor cells to hypoxia.Bruceine D(BD)is an isolated natural quassinoid with multiple anti-cancer effects.Here,we identified BD could significantly inhibit the HIF-1α expression and its subsequently mediated HCC cell metabolism.Using biophysical proteomics approaches,we identified inhibitor of β-catenin and T-cell factor(ICAT)as the functional target of BD.By targeting ICAT,BD disrupted the interaction of bcatenin and ICAT,and promoted β-catenin degradation,which in turn induced the decrease of HIF-1α expression.Furthermore,BD could inhibit HCC cells proliferation and tumor growth in vivo,and knockdown of ICAT substantially increased resistance to BD treatment in vitro.Our data highlight the potential of BD as a modulator of β-catenin/HIF-1α axis mediated HCC metabolism. | Rui Huang Lijun Zhang Jinmei Jin Yudong Zhou Hongwei Zhang Chao Lv Dong Lu Ye Wu Hong Zhang Sanhong Liu Hongzhuan Chen Xin Luan Weidong Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 7 | Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling显示文摘Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in vitro.The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing.One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating Stat3.Accordantly,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer cells.The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells.Furthermore,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells.Together,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF. | Li Liu Yudong Wu Cheng Zhang Chong Zhou Yining Li Yi Zeng Chunbo Zhang Rong Li Daya Luo Lieliang Wang Long Zhang Shuo Tu Huan Deng Shiwen Luo Ye-Guang Chen Xiangyang Xiong Xiaohua Yan | 2020 | Journal of Molecular Cell Biology2020，12，9： | 4 |
| 8 | Experimental studies on electrical breakdown field strength of electrode with water mist containing MC additives显示文摘Water mist is one of the effective candidates for halon replacement used in electrical environment fire protec-tion. Water mist additives may greatly enhance fire suppres-sion effectiveness. In electrical environment, electrical breakdown field strength (E) is one of the important factors that control the performance of electrical equipment. In this study the variation principles of electrical breakdown field strength and the electrical characteristics of MC additives were investigated by electrode discharging experiments. Ex-perimental results showed that electrical breakdown field strength was impacted obviously by the conductive metal ions and insulated fluorocarbon surfactants in MC additives. The attenuation percentages of E in different experimental cases were described, thus providing scientific guidance for the use of water mist and MC additives in electrical fire sup-pression. | FANG Yudong LIU Jianghong LIAO Guangxuan XU Qiang ZHOU Xiaomeng | 2005 | Chinese Science Bulletin2005，50，23： | 3 |
| 9 | Effect of Ni Addition on Microstructure of Matrix in Casting Tungsten Carbide Particle Reinforced Composite显示文摘Microstructure of the matrix directly influences the performance and the application of metal matrix composites. By using vacuum casting-infiltration method to manufacture casting tungsten carbide particle reinforced composite,the addition of Ni can alter the microstructure of the matrix of composite.High carbon chromium steel was chosen as the substrate.The casting process was achieved at 1580℃with vacuum degree of 0.072—0.078 MPa.Padding of the molten steel in each part of the preform was different,and the solidification of each part of the composite was different,too.Microstructure of the matrix was various in different parts of the composite.The Ni addition had enlarged the austenite zone in matrix,which would improve the corrosion resistance of the composite.The phase identification of the composite was performed by X-ray diffraction technique.The result showed that Fe3W3C was the primary precipitated carbide and its composition had a direct link with the decomposition of the casting tungsten carbide particles.The hardness of the matrix mainly depended on the reinforced carbide,i.e.Fe3W3C. | Quan Shan Zulai Li Yehua Jiang Rong Zhou Yudong Sui | 2013 | Journal of Materials Science & Technology2013，29，8： | 3 |
| 10 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 11 | The downregulation of miR-200c/141 promotes ZEB1/2 expression and gastric cancer progression显示文摘 | Xinliang Zhou Yudong Wang Baoen Shan Jing Han Haifeng Zhu Yalei Lv Xiaojie Fan Meixiang Sang Xian-De Liu Wei Liu | 2015 | Medical Oncology2015，，1： | 2 |
| 12 | An atlas of CNV maps in cattle, goat and sheep显示文摘Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and plants.However,the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain unknown.Here,we generated CNV region(CNVR)datasets which were diverged or shared among cattle,goat,and sheep,including 886 individuals from 171 diverse populations.Using 9 environmental factors for genome-wide association study(GWAS),we identified a series of candidate CNVRs,including genes relating to immunity,tick resistance,multi-drug resistance,and muscle development.The number of CNVRs shared between species is significantly higher than expected(P<0.00001),and these CNVRs may be more persist than the single nucleotide polymorphisms(SNPs)shared between species.We also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional genes.This study provides the evidence that balancing selection might be more common in mammals than previously considered,and might play an important role in the daily activities of these ruminant species. | Yongzhen Huang Yunjia Li Xihong Wang Jiantao Yu Yudong Cai Zhuqing Zheng Ran Li Shunjin Zhang Ningbo Chen Hojjat Asadollahpour Nanaei Quratulain Hanif Qiuming Chen Weiwei Fu Chao Li Xiukai Cao Guangxian Zhou Shudong Liu Sangang He Wenrong Li Yulin Chen Hong Chen Chuzhao Lei Mingjun Liu Yu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 13 | The Pellet Enhanced Performance on the HL-2A Tokamak显示文摘 | DING Xuantong YANG Qingwei YAN Longwen ZHU Genliang CAO Zeng XIAO Zhenggui GAO Qingdi LONG Yongxing LIU Dequan LIU Yi ZHOU Yan PAN Yudong CUI Zhengying HUANG Yuan LIU Zetian SHI Zhongbing JI Xiaoquan XIAO Weiwen LIU Yong | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 1 |
| 14 | Laser-induced inverted patterning of nanocrystals embedded glass for micro-light-emitting diodes显示文摘High resolution and full-color light-emitting diodes require precise and efficient patterning of light-emitting structures containing quantum dots or nanocrystals.We report light-induced inverted patterning of nanocrystals in glasses for micro-light-emitting diodes.Ultrafast laser pulse induces structural destruction and amorphization of nanocrystals in glasses,forming inverted luminescent patterns.High-throughput patterning of micrometer-scale,thermally stable,and highly photoluminescent structures in nanocrystals embedded glass is realized.This patterning method provides a novel way to fabricate high-performance and ultrahigh-resolution color conversion layers for micrometer-scale light-emitting diodes. | Yuzhou Hu Ying Ye Wenchao Zhang Kai Li Yao Zhou Yudong Zhang Zhao Deng Jianjun Han Xiujian Zhao Chao Liu | 2023 | Journal of Materials Science & Technology2023，，19： | 1 |
| 15 | Clinical research of postoperative comprehensive rehabilitation in treating brachial plexus injuries显示文摘Brachial plexus injury is regarded as one of the most difficult international medical problem.Microsurgery is an advanced technology and has progressed further on the operation,especially on the nerve repair.1,2 In recent years,rehabilitation on the brachial plexus injury has been reported home and abroad,3 but there is no clear report on the rehabilitation treatment of brachial plexus injury after nerve bridging or nerve transfer.Hence,we designed the research to ensure that comprehensive rehabilitation has obvious effect on the nerve recovery after operation.Comprehensive rehabilitation is the using of health care measures to treat the dysfunction left by hurt or diseases that always lead to the loss of life or work ability temporarily or permanently.And then it can restore the functionality to the maximum possible and help the patients to recover physically,psychologically,and vocationally. | Xu Xiaojun Zhou Junming Gu Yudong | 2014 | Chinese Medical Journal2014，，9： | 1 |
| 16 | Infuence of Composition on Self-toughening and Oxidation Properties of Y-a-Sialons显示文摘Y-a-sialon ceramics with different compositions were hot-press sintered.Varying the m or n value in the a-Sialon general formula,both the a-sialon grain morphology and phase assemblages present diversification,therefore,affecting the toughness and hardness.Meanwhile,varying the compositional parameters also influenced the composition and structure of the intergranular glass phase,as well as its oxidation behavior at 1100e1200℃.The oxidation of the intergranular phase M0in the Y-a-sialon ceramics was significantly enhanced with further rising the oxidation temperature to 1300℃. | Chunfeng Liu Feng Ye Rongsen Xia Lei Zhang Yu Zhou Yudong Huang | 2013 | Journal of Materials Science & Technology2013，29，10： | 1 |
| 17 | Gigantic enhancement in response and reset time of ZnO UV nanosensor by utilizing Schottky contact and Surface functionalization 显示文摘 | Zhou Jun Gu Yudong Hu Youfan | 2009 | Appl Phys Left2009，94，19： | 1 |
| 18 | A TDMA-based MAC protocol with cooperative diversity显示文摘 | Yang Zhou Yao Yudong Li Xiaochen | 2010 | IEEE Comm Letters2010，14，6： | 1 |
| 19 | Ultra-stable and color-tunable manganese ions doped lead-free cesium zinc halides nanocrystals in glasses for light-emitting applications显示文摘All inorganic CsPbX_(3)(X=Cl,Br,and I)perovskite nanocrystals have made unprecedented radical progresses for opto-electronic applications,but their instability and toxicity of lead impede their wide applications.Herein,we report the first precipitation of leadfree Mn:Cs_(2)ZnX_(4) nanocrystals in glasses.Efficient green and red photoluminescence are realized from these Mn:Cs_(2)ZnX_(4 )nanocrystals in glasses.By adjusting the size and halide component in these nanocrystals,coordination environment of Mn^(2+)ions can be tuned,leading to tunable photoluminescence with improved quantum efficiency.It is illustrated that in-situ precipitation of these Mn:Cs_(2)ZnX_(4) nanocrystals in glasses significantly improves their thermal-,chemical-,and photo-stabilities,making them promising for light-emitting diodes with stable chromaticity coordinates. | Kai Li Ying Ye Wenchao Zhang Yao Zhou Yudong Zhang Shisheng Lin Hang Lin Jian Ruan Chao Liu | 2022 | Nano Research2022，15，10： | 1 |
| 20 | Association of Lumican Gene with Susceptibility to Pathological Myopia in the Northern Han Ethnic Chinese显示文摘 | Fengju Zhang Tingzhun Zhu Zhongjun Zhou Yudong Wu Yang Li Edward Manche | 2009 | Journal of Ophthalmology2009，，： | 1 |
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