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| 1 | Detumbling strategy based on friction control of dual-arm space robot for capturing tumbling target显示文摘The rotational motion of a tumbling target brings great challenges to space robot on successfully capturing the tumbling target.Therefore,it is necessary to reduce the target's rotation to a rate at which capture can be accomplished by the space robot.In this paper,a detumbling strategy based on friction control of dual-arm space robot for capturing tumbling target is proposed.This strategy can reduce the target's rotational velocity while maintaining base attitude stability through the establishment of the rotation attenuation controller and base attitude adjustment controller.The rotation attenuation controller adopts the multi-space hybrid impedance control method to control the friction precisely.The base attitude adjustment controller applies the dual-arm extended Jacobian matrix to stabilize the base attitude.The main contributions of this paper are as follows:(1)The compliant control method is adopted to achieve a precise friction control,which can reduce the target angular velocity steadily;(2)The dual-arm extended Jacobian matrix is applied to stabilize the base attitude without affecting the target capture task;(3)The detumbling strategy of dualarm space robot is designed considering base attitude stabilization,realizing coordinated planning of the base attitude and the arms.The strategy is verified by a dual-arm space robot with two 7-DOF(degrees of freedom)arms.Simulation results show that,target with a rotation velocity of 20(°)/s can be effectively controlled to stop within 30 s,and the final deflection of the base attitude is less than 0.15°without affecting the target capture task,verifying the correctness and effectiveness of the strategy.Except to the tumbling target capture task,the control strategy can also be applied to other typical on-orbit operation tasks such as space debris removal and spacecraft maintenance. | Gang CHEN Yuqi WANG Yifan WANG Ji LIANG Long ZHANG Guangtang PAN | 2020 | Chinese Journal of Aeronautics2020，33，3： | 9 |
| 2 | The solar wind plasma upstream of Mars observed by Tianwen-1:Comparison with Mars Express and MAVEN显示文摘On the great journey to Mars,China’s first planetary exploration mission,the Tianwen-1 came within 26 million kilometers of Mars from 31 October 2020 to 25 January 2021 and was getting closer to its destination,the red planet,in search of answers to the cataclysmic climate change that occurred in Martian history.Both the escape of the Martian atmosphere and the loss of surface water were firmly influenced by solar activities.Tianwen-1 provided a unique chance to depict the solar wind streams between Earth and Mars during the minimum of Solar Cycle 25.During the three-month cruise phase of Tianwen-1,the solar wind flows were successively observed at Earth,Tianwen-1,and Mars.After the field of view correction and noise reduction,the solar wind velocity and density measured by Tianwen-1 show good agreement with those at Earth and Mars.The results indicate that the performance of the ion analyzer onboard the Tianwen-1 orbiter is reliable and stable.It is worth looking forward to the joint observations of ion escape with other Mars probes in the following Martian years. | Kai FAN Limei YAN Yong WEI Aibing ZHANG Linggao KONG Markus FRÄNZ Fei HE Lihui CHAI Chongjing YUAN Yuqi WANG Jun ZHONG Zhaojin RONG Zhonghua YAO Yongxin PAN Jun CUI Jiansen HE Wenya LI Binbin TANG Chi WANG | 2022 | Science China Earth Sciences2022，65，4： | 2 |
| 3 | Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor显示文摘Background:Overexpression of ATP-binding cassette(ABC)transporter is a major contributor to multidrug resistance(MDR),in which cancer cells acquire resistance to a wide spectrum of chemotherapeutic drugs.In this work,we evaluated the sensitizing effect of sitravatinib,a broad-spectrum tyrosine kinase inhibitor(TKI),on ATP-binding cassette subfamily B member 1(ABCB1)-and ATP-binding cassette subfamily C member 10(ABCC10)-mediated MDR.Methods:MTT assay was conducted to examine cytotoxicity and evaluate the sensitizing effect of sitravatinib at non-toxic concentrations.Tritium-labeled paclitaxel transportation,Western blotting,immunofluorescence analysis,and ATPase assay were carried out to elucidate the mechanism of sitravatinib-induced chemosensitization.The in vitro findings were translated into preclinical evaluation with the establishment of xenograft models.Results:Sitravatinib considerably reversed MDR mediated by ABCB1 and partially antagonized ABCC10-mediated MDR.Our in silico docking simulation analysis indicated that sitravatinib strongly and stably bound to the transmembrane domain of ABCB1 human-mouse chimeric model.Furthermore,sitravatinib inhibited hydrolysis of ATP and synchronously decreased the efflux function of ABCB1.Thus,sitravatinib could considerably enhance the intracellular concentration of anticancer drugs.Interestingly,no significant alterations of both expression level and localization of ABCB1 were observed.More importantly,sitravatinib could remarkably restore the antitumor activity of vincristine in ABCB1-mediated xenograft model without observable toxic effect.Conclusions:The findings in this study suggest that the combination of sitrvatinib and substrate antineoplastic drugs of ABCB1 could attenuate the MDR mediated by the overexpression of ABCB1. | Yuqi Yang Ning Ji Chao-Yun Cai Jing-Quan Wang Zi-Ning Lei Qiu-Xu Teng Zhuo-Xun Wu Qingbin Cui Yihang Pan Zhe-Sheng Chen | 2020 | Cancer Communications2020，40，7： | 2 |
| 4 | Automated detection of parasitized Cadra cautella eggs by Trichogramma bourarachae using machine vision显示文摘Cadra(Ephestia)cautella(Walker)is a moth that attacks dates from ripening stages while on tree,throughout storage,and until consumption,causing enormous qualitative and quantitative damages,resulting in economic losses.Image-processing algorithms were developed for detecting and differentiating between three Cadra egg categories based on the success of Trichogramma bourarachae(Pintureau and Babaul)parasitization.These categories were parasitized(black and dark red),unparasitized fertile unhatched(yellow),and unparasitized hatched(white)eggs.Color,light intensity,and shape information was used to develop detection algorithms.Two image processing methods were developed based on three randomly selected images and were tested on a larger validation image set of 40 images:(i)segmentation and extractions of color and morphological features followed by Watershed delineation,and is referred to as Algorithm 1(ALGO1),(ii)finding circular objects by Hough Transformation followed by convolution filtering,and is referred to as Algorithm 2(ALGO2).ALGO1 and ALGO2 achieved correct classification rates(CCRs)for parasitized eggs of 92%and 96%,respectively.Their CCRs for unhatched eggs were 48%and 94%,and for hatched eggs were 42%and 73%,respectively.Regarding parasitized eggs,both methods performed satisfactorily,but,in general,ALGO2 outperformed ALGO1.These results ensure automatic evaluation of the efficiency of biological control of Cadra cautella by the egg parasitoid Trichogramma bourarachae by quantifying the rate of parasitization.The developed detection methods can be used by producers of biocontrol agents for online monitoring of Trichogramma and similar insect natural enemies during mass production and before release against crop pests.Moreover,with few adjustments these methods can be used in similar applications such as detecting plant diseases. | Mohammed S.El-Faki Yuqi Song Naiqian Zhang Hamadttu A.El-Shafie Pan Xin | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 2 |
| 5 | Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women显示文摘 | Rong Yang Xiaojing Ma Xiaoping Pan Feifei Wang Yuqi Luo Chengchen Gu Yuqian Bao Weiping Jia | 2013 | Menopause: The Journal of The North American Menopause Society2013，，5： | 1 |
| 6 | Molecular wakes for ultrashort laser pulses显示文摘The molecular wake-assisted interaction between two collinear femotosecond laser pulses is investigated in air,which leads to the generation of a controllable 1.8 mJ super-continuum pulse with an elongated self-guided channel due to the cross-phase modulation of the impulsively aligned diatomic molecules in air. For two parallel launched femtosecond laser pulses with a certain spatial separation,controllable attraction and repulsion of the pulses are observed due to the counter-balance among molecular wakes,Kerr and plasma effects,where the molecular wakes show a longer interaction distance than the others to control the propagation of the intense ultrashort laser pulses. | CAI Hua,WU Jian,LU PeiFen,TONG YuQi,YANG Xuan,BAI XueShi,LI Hao,PAN HaiFeng & ZENG HePing State Key Laboratory of Precision Spectroscopy,East China Normal University,Shanghai 200062,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 1 |
| 7 | Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Envt cells in vivo显示文摘HIV-specific chimeric antigen receptor(CAR)T-cells have been developed to target HIV-1 infected CD4t T-cells that express HIV Env proteins.However,T cell exhaustion and the patient-specific autologous paradigm of CAR-T cell hurdled clinical applications.Here,we created HIV-specific CAR-T cells using human peripheral blood mononuclear cells and a 3BNC117-E27(3BE)CAR construct that enabled the expression of programmed cell death protein(PD-1)-blocking scFv E27 and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117 to target native HIV Env.Compared with T cells expressing 3BNC117-CAR alone,3BE CAR-T cells showed greater cytotoxic activity against HIV Envt cells with stronger proliferation capability,higher killing efficiency,and enhanced cytokine secretion in the presence of HIV Env-expressing cells.Furthermore,we manufactured TCR-deficient 3BE CAR-T cells through gene editing and demonstrated that these CAR-T cells could effectively kill HIV Env^(+) cells in vivo without the occurrence of severe graft-versus-host disease(GvHD)in NSG mice.These data suggest that we have provided a feasible approach to the generation of“off-theshelf”anti-HIV CAR-T cells in combination with PD-1 checkpoint blockade immunotherapy,which can be a powerful therapeutic candidate for the functional cure of HIV. | Hanyu Pan Xinyi Yang Jing Wang Huitong Liang Zhengtao Jiang Lin Zhao Yanan Wang Zhiming Liang Xiaoting Shen Qinru Lin Yue Liang Jinglong Yang Panpan Lu Yuqi Zhu Min Li Pengfei Wang Jianqing Xu Hongzhou Lu Huanzhang Zhu | 2023 | Virologica Sinica2023，38，2： | 0 |
| 8 | A specific and selective chemiluminescent probe for Pd^(2+) detection显示文摘As an important transition metal catalyst, palladium is extensively used in many areas including electronics industry, petroleum industry, automobile industry and fine chemicals engineering. However,it brings harm to the environment as well as people's health. Herein, we managed to introduce a butynyl group to 1,2-dioxetane developing a reaction-based chemiluminescent probe as well as an imaging approach for monitoring palladium(II). Exhibiting enhanced total flux in Pd2+enriched areas, palladium chemiluminescent probe(PCL) may afford potential utility for detecting Pd2+in vitro, in cellulo and in vivo. | Yuqi Gao Yuxing Lin Tingting Liu Xiaomeng Zhang Feng Xu Pan Liu Lupei Du Minyong Li | 2019 | Chinese Chemical Letters2019，30，1： | 0 |
| 9 | Numerical study of a trapezoidal bypass dual throat nozzle显示文摘Bypass Dual Throat Nozzle(BDTN)is a novel type of fluidic thrust vectoring nozzle.To improve the infrared stealth performance of BDTN,a nozzle based on BDTN is proposed and numerically simulated.Each cross-section along the x-axis of the novel nozzle becomes a trapezoid,which is named“BDTN-TRA.”The main numerical simulation results show that BDTN-TRA can produce a thrust vectoring angle when the upper or lower bypass valve is open.The angle difference between the two conditions mentioned above is usually approximately 1°-2°.Even if the two bypasses are closed,BDTN-TRA can produce a small thrust vectoring angle at around 3°-5°.When the sidewall angle increases from 60°to 90°,the thrust coefficient and thrust vectoring angle under each work condition usually decrease.A larger aspect ratio indicates better performance.As the aspect ratio increases over 7.2,the performance of BDTN-TRA is quite close to that of BDTN with rectangular cross-sections at the same aspect ratio.These features will benefit the control and trimming for future aircraft design,especially for the flying wing layout aircraft.Last but not least,BDTN-TRA has a more extraordinary mixing performance compared with BDTN.The distributions of static temperature and axial velocity along the x-axis of BDTN-TRA with sidewall angle of 60°decrease faster than those of BDTN.When the total temperature of the inlet equals 1600 K,the static temperature difference between BDTN-TRA with sidewall angles of 60°and 90°is over 360 K at twice the length of the nozzle downstream of the nozzle exit,which is the reflection for excellent infrared stealth for the fighter. | Shuai HUANG Jinglei XU Kaikai YU Yangsheng WANG Ruifeng PAN Kuangshi CHEN Yuqi ZHANG | 2023 | Chinese Journal of Aeronautics2023，36，3： | 0 |
| 10 | Investigation of operative skills and cranioplasty complications using biomimetic bone(nano-hap/collagen composites)显示文摘The aim of the current study was to investigate the operation skills and complications associated with skull defect repair using biomimetic bone(nano-hap/collagen composites). Clinical data from 45 patients with skull defects who underwent cranioplasty with biomimetic bone from January 2014 to January 2017 were retrospectively analyzed.All patients participated in follow-up visits from 8 months to 3 years postoperatively. Cranioplasties were successful in all 45 patients,but 17 patients(20 cases) presented various complications, including subcutaneous hydrops(14 cases), biomimetic bone fixation loosening(4 cases), wound indolence(1 case), and biomimetic bone fragmentation(1 case). Cranioplasty complications in surgeries using biomimetic bone are more common in children than in adults.Understanding the physicochemical properties of biomimetic bone and the normal developmental process in children, as well as mastering the appropriate surgical skills and implementing the effective preventive measures are all ways to reduce and control the incidence of complications associated with biomimetic bone cranioplasty. | Tuoyu Chen Lin Chen Xin Pan Chaoqiang Xue Qinglin Zhang Yuqi Zhang | 2018 | Translational Neuroscience and Clinics2018，4，2： | 0 |
| 11 | Responsive Trimodal Probes for In Vivo Imaging of Liver Inflammation by Coassembly and GSH-Driven Disassembly显示文摘Noninvasive in vivo imaging of hepatic glutathione(GSH)levels is essential to early diagnosis and prognosis of acute hepatitis.Although GSH-responsive fluorescence imaging probes have been reported for evaluation of hepatitis conditions,the low penetration depth of light in liver tissue has impeded reliable GSH visualization in the human liver.We present a liver-targeted and GSH-responsive trimodal probe(GdNPs-Gal)for rapid evaluation of lipopolysaccharide-(LPS-)induced acute liver inflammation via noninvasive,real-time in vivo imaging of hepatic GSH depletion.GdNPs-Gal are formed by molecular coassembly of a GSH-responsive Gd(III)-based MRI probe(1-Gd)and a liver-targeted probe(1-Gal)at a mole ratio of 5/1(1-Gd/1-Gal),which shows high r_(1) relaxivity with low fluorescence and fluorine magnetic resonance spectroscopic(^(19)F-MRS)signals.Upon interaction with GSH,1-Gd and 1-Gal are cleaved and GdNPs-Gal rapidly disassemble into small molecules 2-Gd,2-Gal,and 3,producing a substantial decline in r_(1) relaxivity with compensatory enhancements in fluorescence and ^(19)F-MRS.By combining in vivo magnetic resonance imaging(^(1)H-MRI)with ex vivo fluorescence imaging and ^(19)F-MRS analysis,GdNPs-Gal efficiently detect hepatic GSH using three independent modalities.We noninvasively visualized LPS-induced liver inflammation and longitudinally monitored its remediation in mice after treatment with an anti-inflammatory drug,dexamethasone(DEX).Findings highlight the potential of GdNPs-Gal for in vivo imaging of liver inflammation by integrating molecular coassembly with GSH-driven disassembly,which can be applied to other responsive molecular probes for improved in vivo imaging. | Yuxuan Hu Yuqi Wang Xidan Wen Yifan Pan Xiaoyang Cheng Ruibing An Guandao Gao Hong-Yuan Chen Deju Ye | 2020 | Research2020，，1： | 0 |
| 12 | Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells显示文摘Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for PCa.Herein,we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients,including gene mutations,mRNA/protein/surface protein distributions,and pharmaceutical responses.The multi-omics analyses identify Anterior Gradient 2(AGR2)as a pre-operative prognostic biomarker in PCa.Through the drug library screening,we describe crizotinib as a selective compound for malignant PCa primary cells.We further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug correlations.Surprisingly,the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft model.Our integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses,allowing for more precise diagnosis and therapies. | Ziruoyu Wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang Jiaqi Wang Jiying Zhu Jianbo Pan Wei Jiang Zengxia Li Mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 13 | Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease显示文摘Parvalbumin interneurons belong to the major types of GABAergic interneurons.Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied,the distribution and vulnerability of the neurites and fibers extending from parvalbumin interneurons have not been detailly interrogated.Through the Cre recombinase-reporter system,we visualized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain.We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions,among which the cortex and thalamus exhibited the most intense parvalbumin signals.In regions such as the striatum and optic tract,even long-range thick parvalbumin projections were detected.Furthermore,in mouse models of temporal lobe epilepsy and Parkinson’s disease,parvalbumin fibers suffered both massive and subtle morphological alterations.Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations. | Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao | 2023 | Neuroscience Bulletin2023，39，11： | 0 |
| 14 | Correction:Spatial Distribution of Parvalbumin‑Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease显示文摘In this article the wrong figure appeared as Fig.3,the figure should have appeared as shown below. | Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao | 2023 | Neuroscience Bulletin2023，39，11： | 0 |
| 15 | Synergistic precipitant powered self-assembly of papain for cross-linked enzyme crystals preparation显示文摘In this study,we prepared cross-linked enzyme crystals(CLECs)of papain to further broaden the application of the enzyme with high activity in extreme environments.Initially,papain crystals were successfully obtained based on the micro-batch,batch,and expanded batch crystallization experiments.Specifically,ammonium sulfate and polyethylene glycol 6000(PEG6000)were synergistically used as the precipitants,while L-cysteine was applied to enhance the activity of papain.Furthermore,the interaction between L-cysteine and papain was modeled by molecular docking technique.It was found that L-cysteine could form a hydrogen bond with aspartic acid residue(Asp)at site 158,and the electrostatic attraction with lysine residue(Lys)at site 156 was also quite obvious.Then the enzyme crystals were cross-linked by glutaraldehyde at optimized conditions.The papain CLECs were identified by various methods,and it was found that the thermal stability and enzymatic activity both increased compared to the raw enzyme.More importantly,it could be applied at more rigorous conditions,for example,pH of 4. | Qi Hao Pan Guo Honghai Wang Min Su Chunli Li Yuqi Hu Weiyi Su | 2024 | Particuology2024，85，2： | 0 |
| 16 | Neutrophil ferroptotic death promotes autoimmune pathogenesis显示文摘Ferroptosis is an iron-dependent, non-apoptotic cell death program marked by aberrant accumulation of membranea-ssociated lipid radicals and hydroperoxides (Zou and Schreiber, 2020). Normal cells deploy multiple mechanisms. | Zijian Pan Nathchar Naowarojna Yuqi Wang Mangze Hu Yilong Zou | 2022 | Science China(Life Sciences)2022，65，4： | 0 |
| 17 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy显示文摘Microphthalmia transcription factor(MITF)regulates melanocyte development and is the“lineage-specific survival”oncogene of melanoma.MITF is essential for melanoma initiation,progression,and relapse and has been considered an important therapeutic target;however,direct inhibition of MITF through small molecules is considered impossible,due to the absence of a ligand-binding pocket for drug design.Here,our structural analyses show that the structure of MITF is hyperdynamic because of its out-of-register leucine zipper with a 3-residue insertion.The dynamic MITF is highly vulnerable to dimer-disrupting mutations,as we observed that MITF loss-of-function mutations in human Waardenburg syndrome type 2 A are frequently located on the dimer interface and disrupt the dimer forming ability accordingly.These observations suggest a unique opportunity to inhibit MITF with small molecules capable of disrupting the MITF dimer.From a high throughput screening against 654,650 compounds,we discovered compound TT-012,which specifically binds to dynamic MITF and destroys the latter’s dimer formation and DNA-binding ability.Using chromatin immunoprecipitation assay and RNA sequencing,we showed that TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells.In addition,TT-012 inhibits the growth of high-MITF melanoma cells,and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models.Together,this study demonstrates a unique hyperdynamic dimer interface in melanoma oncoprotein MITF,and reveals a novel approach to therapeutically suppress MITF activity. | Zaizhou Liu Kaige Chen Jun Dai Peng Xu Wei Sun Wanlin Liu Zhixin Zhao Steven P.Bennett Peifeng Li Tiancheng Ma Yuqi Lin Akinori Kawakami Jing Yu Fei Wang Chunxi Wang Miao Li Peter Chase Peter Hodder Timothy P.Spicer Louis Scampavia Chunyang Cao Lifeng Pan Jiajia Dong Yong Chen Biao Yu Min Guo Pengfei Fang David E.Fisher Jing Wang | 2023 | Cell Research2023，33，1： | 0 |
| 18 | Surgical method of lateral ventriculo-superior sagittal sinus shunt surgery for hydrocephalus显示文摘From August 2016 to June 2018, a total of 7 patients underwent lateral ventriculo-superior sagittal shunt surgeries in our hospital. All cases were followed up for 3 months to 2 years after the surgeries. The results of their head CT scans or MRI scans indicated that the conition of hydrocephalus generally improved, and the symptoms of intracranial hypertension significantly improved or disappeared. The superior sagittal sinus shunt surgery for hydrocephalus is simple to operate and also safe and effective, and it's an important method of treatment for hydrocephalus. This article described the specific surgical procedure for lateral ventriculo-superior sagittal shunt surgery in detail so that this surgical procedure can be better promoted. | Xin Pan Yuqi Zhang | 2018 | Translational Neuroscience and Clinics2018，4，1： | 0 |
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