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| 1 | MicroRNA-21 targets tumor suppressor genes in invasion and metastasis显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 指向编码蛋白质的 mRNAs 的小非编码的 RNA 铺平的自然地发生的一个班。我们的以前的研究建议 mir-21 作为 oncogene 工作并且在 tumorigenesis 有一个角色,部分地通过肿瘤的规定压制或基因对流肌浆球蛋白 1 (TPM1 ) 。给那 TPM1 在房间移植被含有,在我们进一步调查了的这研究在房间侵略和肿瘤转移的 mir-21 的角色。我们发现在变形乳癌 MDA-MB-231 房间的 mir-21 的抑制显著地减少了侵略和肺转移。与这一致, TPM1 的宫外的表示显著地减少了房间侵略。而且,我们识别了二个另外的直接 mir-21 目标,规划房间死亡 4 (PDCD4 ) 并且妈大头针,哪个在侵略和转移被含有。象 TPM1 一样, PDCD4 和妈大头针也减少了 MDA-MB-231 房间的侵略海角。最后, PDCD4 的表示和妈大头针相反地在人的胸肿瘤标本与 mir-21 表示相关,显示由在这些肿瘤的 mir-21 的 PDCD4 和妈大头针的潜在的规定。总起来说,结果建议作为 oncogenic miRNA, mir-21 由指向多重肿瘤 / 转移不仅在肿瘤生长而且在侵略和肿瘤转移有一个角色压制或基因。因此, mir-21 的抑制可以为先进癌症的治疗提供一条新奇途径。 | Shuomin Zhu Hailong Wu Fangting Wu Daotai Nie Shijie Sheng Yin-Yuan Mo | 2008 | Cell Research2008，18，3： | 205 |
| 2 | Suppression of cell growth and invasion by miR-205 in breast cancer显示文摘MicroRNAs (miRNAs ) 内长的、小、非编码的 RNA,它能够在 post-transcriptional 的 silencing 基因表示铺平。在这研究,我们报导 miR-205 是显著地在与匹配的正常的胸织物相比的胸肿瘤的 underexpressed。同样,包括 MCF-7 和 MDA-MB-231,乳癌房间行比非恶意的 MCF-10A 房间表示低级 miR-205。兴趣, miR-205 的宫外的表示显著地禁止房间增长和抛锚独立人士生长,以及房间侵略。而且, miR-205 被显示在一个动物模型压制肺转移。最后,西方的污点与试金表明的酶记者结合了那 ErbB3 和脉管的 endothelial 生长因素 A ( VEGF --一)是为 miR-205 的直接目标,并且这 miR-205-mediated 抑制通过和在 ErbB3 和 VEGF 的 3 鈥? untranslated 区域( 3 鈥? UTR )的通常认为的 miR-205 绑定地点的直接相互作用是可能的--一。一起,这些结果建议 miR-205 是在乳癌的肿瘤 suppressor。 | Hailong Wu Shoumin Zhu Yin-Yuan Mo | 2009 | Cell Research2009，19，4： | 56 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 5 | Goal Programming for Stable Mode Transition in Tandem Turbo-ramjet Engines显示文摘为保证涡轮/冲压串联组合发动机能够实现平稳的模式转换,对能够实现平稳模式转换的多变量多目标规划算法展开了研究。首先论述了所研究的变循环涡轮/冲压组合发动机的结构特点、模式转换工作点的选取原则、涡扇设计参数和冲压模式设计参数的选取原则,并给出了涡扇和冲压模式的设计点性能。针对模式转换过程的各步骤及其控制目标,发展了部件级变循环组合发动机性能模型。在此模型的基础上,把Newton-Raphson算法运用于模式转换过程的多变量多目标优化研究中。研究结果表明,该算法具有很高的收敛性,满足规划目标的最大残差仅为0.06%。最后,利用上述算法设计了模式转换过程的过渡态控制规律,并完成了平稳模式转换过程的过渡态模拟。 | Chen Min Tang Hailong Zhu Zhili | 2009 | Chinese Journal of Aeronautics2009，22，5： | 12 |
| 6 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 7 | The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin显示文摘In this study,self-discriminating hybrid nanocrystals was utilized to explore the biological fate of quercetin hybrid nanocrystals(QT-HNCs)with diameter around 280 nm(QT-HNCs-280)and550 nm(QT-HNCs-550)following oral and intravenous administration and the contribution of integral nanocrystals to oral bioavailability enhancement of QT was estimated by comparing the absolute exposure of integral QT-HNCs and total QT in the liver.Results showed that QT-HNCs could reside in vivo as intact nanocrystals for as long as 48 h following oral and intravenous administration.A higher accumulation of integral QT-HNCs in liver and lung was observed for both oral and intravenous administration of QT-HNCs.The particle size affects the absorption and biodistribution of integral QT-HNCs and total QT.As compared to QT-HNCs-550,QT-HNCs-280 with smaller particle size is more easily absorbed,but dissolves faster in vivo,leading to higher distribution of QT(146.90 vs.117.91 h·mg/mL)but lower accumulation of integral nanocrystals(6.82 e10 vs.15.27 e10 h·[p/s]/[μW/cm2])in liver following oral administration.Due to its slower dissolution and enhanced recognition by RES,QT-HNCs-550 with larger diameter shows higher liver distribution for both of QT(1015.80 h·mg/mL)and integral nanocrystals(259.63 e10 h·[p/s]/[μW/cm2])than those of QT-HNCs-280(673.82&77.66 e10 h·[p/s]/[μW/cm2])following intravenous administration.The absolute exposure of integral QT-HNCs in liver following oral administration of QT-HNCs are 8.78%for QT-HNCs-280 and 5.88%for QT-HNCs-550,while the absolute exposure of total QT for QT-HNCs-280 and QT-HNCs-550 are 21.80%and 11.61%,respectively.Owing to imprecise quantifcation method,a surprisingly high contribution of integral QT-HNCs to oral bioavailability enhancement of QT(40.27%for QT-HNCs-280 and 50.65%for QT-HNCs-550)was obtained.These results revealed signifcant difference in absorption and biodistrbution between integral nanocrystals and overall drugs following oral and intravenous administration of QT-HNCs,and provided a meaningful reference for the contribution of integral nanocrystals to overall bioavailability enhancement. | Baode Shen Chengying Shen Weifeng Zhu Hailong Yuan | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 10 |
| 8 | First six months quality assessment of HY-2A SCAT wind products using in situ measurements显示文摘The first Chinese microwave ocean environment satellite HY-2A,carrying a Ku-band scatteromenter(SCAT),was successfully launched in August 2011.The first quality assessment of HY-2A SCAT wind products is presented through the comparison of the first 6 months operationally released SCAT products with in situ data.The in situ winds from the National Data Buoy Center(NDBC)buoys,R/V Polarstern,Aurora Australis,Roger Revelle and PY30-1 oil platform,were converted to the 10 m equivalent neutral winds.The temporal and spatial differences between the HY-2A SCAT and the in situ observations were limited to less than 5min and 12.5 km.For HY-2A SCAT wind speed products,the comparison and analysis using the NDBC buoys yield a bias of–0.49 m/s,a root mean square error(RMSE)of 1.3 m/s and an increase negative bias with increasing wind speed observation above 3 m/s.Although less accurate of HY-2A SCAT wind direction at low winds,the RMSE of 19.19 with a bias of 0.92 is found for wind speeds higher than 3 m/s.These results are found consistent with those from R/Vs and oil platform comparisons.Moreover,the NDBC buoy comparison results also suggest that the accuracy of HY-2A SCAT winds is consistent over the first half year of 2012.The encouraging assessment results over the first 6 months show that wind products from HY-2A SCAT will be useful for scientific community. | WANG He ZHU Jianhua LIN Mingsen HUANG Xiaoqi ZHAO Yili CHEN Chuntao ZHANG Youguang PENG Hailong | 2013 | Acta Oceanologica Sinica2013，32，11： | 10 |
| 9 | The validation of the significant wave height product of HY-2altimeter–primary results显示文摘The HY-2 satellite was successfully launched on 16 August 2011.The HY-2 significant wave height(SWH)is validated by the data from the South China Sea(SCS)field experiment,National Data Buoy Center(NDBC)buoys and Jason-1/2 altimeters,and is corrected using a linear regression with in-situ measurements.Compared with NDBC SWH,the HY-2 SWH show a RMS of 0.36 m,which is similar to Jason-1 and Jason-2 SWH with the RMS of 0.35 m and 0.37 m respectively;the RMS of corrected HY-2 SWH is 0.27 m,similar to 0.27 m and 0.23 m of corrected Jason-1 and Jason-2 SWH.Therefore the accuracy of HY-2 SWH products is close to that of Jason-1/2 SWH,and the linear regression function derived can improve the accuracy of HY-2 SWH products. | CHEN Chuntao ZHU Jianhua LIN Mingsen ZHAO Yili HUANG Xiaoqi WANG He ZHANG Youguang PENG Hailong | 2013 | Acta Oceanologica Sinica2013，32，11： | 7 |
| 10 | Homeostasis of Brassinosteroids Regulated by DRL1, a Putative Acyltransferase in Arabidopsis显示文摘在调整工厂生长和开发并且在对多样的环境暗示作出回应的各种各样的方面的 Brassinosteroids (BR ) 戏必需品角色,和他们的新陈代谢是在工厂调整他们的动态平衡的一个重要方法。这里,我们识别了主导的异种,矮子和圆 leaf-1 (drl1-D ) ,它展出弱 BR 缺乏或 BR 感觉迟钝的变异的显型,包括短、圆的叶子,延长老朽,相形见绌的形状,和 BR 应答的基因的改变的表示层次。胚轴长度和根抑制试金建议 drl1-D 异种通常对 BR 作出回应,但是减少了 BR 发信号产量。几 BR,包括的 typhasterol (TY ) , 6-deoxotyphasterol (6-deoxoTY ) ,和 6-deoxocastasterone (6-deoxoCS ) 的内长的层次,比在在 drl1-D 异种是显著地更低的野类型。DRL1 基因编码 acyltransferase 并且是广泛地在叶子,根,花,和 siliques 表示了。没有 DRL1 和它的相当或相同的事物的植物是更大的,提高的 BR 发信号。DRL1 的表示被 eBL 导致并且由骆驼毛的织物禁止了。DRL1 被通过酯化作用催化 BR 变化形式多半涉及 BR 新陈代谢,它在调整 BR 动态平衡并且在 Arabidopsis 对不能生活的压力作出回应起重要作用。 | Wenjiao Zhu Haijiao Wang Shozo Fujioka Tao Zhou Hailong Tian Weisheng Tian Xuelu Wang | 2013 | Molecular Plant2013，6，2： | 7 |
| 11 | A Quantitative Evaluation of Shale Gas Content in Different Occurrence States of the Longmaxi Formation: A New Insight from Well JY-A in the Fuling Shale Gas Field,Sichuan Basin显示文摘Comprehensive quantitative evaluation of shale gas content and the controlling factors in different occurrence states is of great significance for accurately assessing gas-bearing capacity and providing effective well-production strategies. A total of 122 core samples from well JY-A in the Fuling shale gas field were studied to reveal the characteristics of S_1 l shale,15 of which were selected to further predict the shale gas content in different occurrence states, which are dependent on geological factors in the thermal evolution process. Geological parameters were researched by a number of laboratory programs, and the factors influential in controlling shale gas content were extracted by both PCA and GRA methods and prediction models were confirmed by the BE method using SPSS software. Results reveal that the adsorbed gas content is mainly controlled by TOC, Ro, SSA, PD and pyrite content, and the free gas content is mainly controlled by S_2, quartz content, gas saturation and formation pressure for S_1 l in well JY-A. Three methods, including the on-site gas desorption method, the empirical formula method, and the multiple regression analysis method were used in combination to evaluate the shale gas capacity of well JY-A, all of which show that the overall shale gas content of well JY-A is in the range of 2.0–5.0 m^3/t and that the free gas ratio is about 50%, lower than that of well JY-1. Cause analysis further confirms the tectonics and preservation conditions of S_1 l in the geological processes, especially the influence of eastern boundary faults on well JY-A, as the fundamental reasons for the differences in shale gas enrichment in the Jiaoshiba area. | TANG Ling SONG Yan LI Qianwen PANG Xiongqi JIANG Zhenxue LI Zhuo TANG Xianglu YU Hailong SUN Yue FAN Shichao ZHU Lin | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 7 |
| 12 | Bifurcation method for solving multiple positive solutions to Henon equation显示文摘Three algorithms based on the bifurcation method are applied to solving the D4 symmetric positive solutions to the boundary value problem of Henon equation. Taking r in Henon equation as a bi- furcation parameter, the D4-Σd(D4-Σ1, D4-Σ2) symmetry-breaking bifurcation points on the branch of the D4 symmetric positive solutions are found via the extended systems. Finally, Σd(Σ1, Σ2) sym- metric positive solutions are computed by the branch switching method based on the Liapunov-Schmidt reduction. | YANG ZhongHua LI ZhaoXiang ZHU HaiLong | 2008 | Science China Mathematics2008，51，12： | 6 |
| 13 | The genome of Medicago polymorpha provides insights into its edibility and nutritional value as a vegetable and forage legume显示文摘Medicago polymorpha is a nutritious and palatable forage and vegetable plant that also fixes nitrogen.Here,we reveal the chromosome-scale genome sequence of M.polymorpha using an integrated approach including Illumina,PacBio and Hi-C technologies.We combined PacBio full-length RNA-seq,metabolomic analysis,structural anatomy analysis and related physiological indexes to elucidate the important agronomic traits of M.polymorpha for forage and vegetable usage.The assembled M.polymorpha genome consisted of 457.53Mb with a long scaffold N50 of 57.72Mb,and 92.92%(441.83Mb)of the assembly was assigned to seven pseudochromosomes.Comparative genomic analysis revealed that expansion and contraction of the photosynthesis and lignin biosynthetic gene families,respectively,led to enhancement of nutritious compounds and reduced lignin biosynthesis in M.polymorpha.In addition,we found that several positively selected nitrogen metabolism-related genes were responsible for crude protein biosynthesis.Notably,the metabolomic results revealed that a large number of flavonoids,vitamins,alkaloids,and terpenoids were enriched in M.polymorpha.These results imply that the decreased lignin content but relatively high nutrient content of M.polymorpha enhance its edibility and nutritional value as a forage and vegetable.Our genomic data provide a genetic basis that will accelerate functional genomic and breeding research on M.polymorpha as well as other Medicago and legume plants. | Jiawen Cui Zhaogeng Lu Tianyi Wang Gang Chen Salma Mostafa Hailong Ren Sian Liu Chunxiang Fu Li Wang Yingfang Zhu Jinkai Lu Xiang Chen Zhenwu Wei Biao Jin | 2021 | Horticulture Research2021，8，1： | 6 |
| 14 | Assessment of the initial sea surface temperature product of the scanning microwave radiometer aboard on HY-2 satellite显示文摘HY-2 satellite is the first satellite for dynamic environmental parameters measurement of China,which was launched on 16th August 2011.A scanning microwave radiometer(RM)is carried for sea surface temperature(SST),sea surface wind speed,columnar water vapor and columnar cloud liquid water detection.In this paper,the initial SST product of RM was validated with in-situ data of National Data of Buoy Center(NDBC)mooring and Argo buoy.The validation results indicate the accuracy of RM SST is better than 1.7 C.The comparison of RM SST and WindSat SST shows the former is warmer than the latter at high sea surface wind speed and the difference between these SSTs is depend on the sea surface wind speed.Then,the relationship between the errors of RM SST and sea surface wind speed was analyzed using NDBC mooring measurements.Based on the results of assessment and errors analysis,the suggestions of taking account of the affection of sea surface wind speed and using sea surface wind speed and direction derived from the microwave scatteromter aboard on HY-2 for SST product calibration were given for retrieval algorithm improvement. | ZHAO Yili ZHU Jianhua LIN Mingsen CHEN Chuntao HUANG Xiaoqi WANG He ZHANG Youguang PENG Hailong | 2014 | Acta Oceanologica Sinica2014，33，1： | 5 |
| 15 | Multifunctional SiC@SiO_(2) Nanofiber Aerogel with Ultrabroadband Electromagnetic Wave Absorption显示文摘Traditional ceramic materials are generally brittle and not flexible with high production costs,which seriously hinders their practical applications.Multifunctional nanofiber ceramic aerogels are highly desirable for applications in extreme environments,however,the integration of multiple functions in their preparation is extremely challenging.To tackle these challenges,we fabricated a multifunctional SiC@SiO_(2) nanofiber aerogel(SiC@SiO_(2) NFA)with a threedimensional(3D)porous cross-linked structure through a simple chemical vapor deposition method and subsequent heat-treatment process.The as-prepared SiC@SiO_(2) NFA exhibits an ultralow density(~11 mg cm^(-3)),ultra-elastic,fatigue-resistant and refractory performance,high temperature thermal stability,thermal insulation properties,and significant strain-dependent piezoresistive sensing behavior.Furthermore,the SiC@SiO_(2) NFA shows a superior electromagnetic wave absorption performance with a minimum refection loss(RL_(min))value of-50.36 d B and a maximum effective absorption bandwidth(EAB_(max))of 8.6 GHz.The successful preparation of this multifunctional aerogel material provides a promising prospect for the design and fabrication of the cutting-edge ceramic materials. | Limeng Song Fan Zhang Yongqiang Chen Li Guan Yanqiu Zhu Mao Chen Hailong Wang Budi Riza Putra Rui Zhang Bingbing Fan | 2022 | Nano-Micro Letters2022，14，9： | 4 |
| 16 | A preliminary assessment of the sea surface wind speed production of HY-2 scanning microwave radiometer显示文摘A scanning microwave radiometer(RM)was launched on August 16,2011,on board HY-2 satellite.The six-month long global sea surface wind speeds observed by the HY-2 scanning microwave radiometer are preliminarily validated using in-situ measurements and WindSat observations,respectively,from January to June 2012.The wind speed root-mean-square(RMS)difference of the comparisons with in-situ data is1.89 m/s for the measurements of NDBC and 1.72 m/s for the recent four-month data measured by PY30-1oil platform,respectively.On a global scale,the wind speeds of HY-2 RM are compared with the sea surface wind speeds derived from WindSat,the RMS difference of 1.85 m/s for HY-2 RM collocated observations data set is calculated in the same period as above.With analyzing the global map of a mean difference between HY-2 RM and WindSat,it appears that the bias of the sea surface wind speed is obviously higher in the inshore regions.In the open sea,there is a relatively higher positive bias in the mid-latitude regions due to the overestimation of wind speed observations,while the wind speeds are underestimated in the Southern Ocean by HY-2 RM relative to WindSat observations. | HUANG Xiaoqi ZHU Jianhua LIN Mingsen ZHAO Yili WANG He CHEN Chuntao PENG Hailong ZHANG Youguang | 2014 | Acta Oceanologica Sinica2014，33，1： | 4 |
| 17 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 18 | A review of progress in coupled ocean-atmosphere model developments for ENSO studies in China显示文摘El Nino-Southern Oscillation(ENSO) is the strongest interannual signal that is producedby basinscale processes in the tropical Pacific,with significant effects on weather and climate worldwide.In the past,extensive and intensive international efforts have been devoted to coupled model developments for ENSO studies.A hierarchy of coupled ocean-atmo sphere models has been formulated;in terms of their complexity,they can be categorized into intermediate coupled models(ICMs),hybrid coupled models(HCMs),and fully coupled general circulation models(CGCMs).ENSO modeling has made significant progress over the past decades,reaching a stage where coupled models can now be used to successfully predict ENSO events 6 months to one year in advance.Meanwhile,ENSO exhibits great diversity and complexity as observed in nature,which still cannot be adequately captured by current state-of-the-art coupled models,presenting a challenge to ENSO modeling.We primarily reviewed the long-term efforts in ENSO modeling continually and steadily made at different institutions in China;some selected representative examples are presented here to review the current status of ENSO model developments and applications,which have been actively pursued with noticeable progress being made recently.As ENSO simulations are very sensitive to model formulations and process representations etc.,dedicated efforts have been devoted to ENSO model developments and improvements.Now,different ocean-atmosphere coupled models have been available in China,which exhibit good model performances and have already had a variety of applications to climate modeling,including the Coupled Model Intercomparison Project Phase 6(CMIP6).Nevertheless,large biases and uncertainties still exist in ENSO simulations and predictions,and there are clear rooms for their improvements,which are still an active area of researches and applications.Here,model performances of ENSO simulations are assessed in terms of advantages and disadvantages with these differently formulated coupled models,pinpointing to the areas where they need to be further improved for ENSO studies.These analyses provide valuable guidance for future improvements in ENSO simulations and predictions. | ZHANG Rong-Hua YU Yongqiang SONG Zhenya REN Hong-Li TANG Youmin QIAO Fangli WU Tongwen GAO Chuan HU Junya TIAN Feng ZHU Yuchao CHEN Lin LIU Hailong LIN Pengfei WU Fanghua WANG Lin | 2020 | Journal of Oceanology and Limnology2020，38，4： | 4 |
| 19 | (Ca,Sr,Ba)ZrO_(3):A promising entropy-stabilized ceramic for titanium alloys smelting显示文摘A novel entropy-stabilized(ES)(Ca,Sr,Ba)ZrO_(3) ceramic has been designed and synthesized by pressureless sintering of CaZr03,SrZr03 and BaZr03 powders mixtures at 1450℃,1500℃and 1550℃for 3 h.X-ray diffraction,scanning electron microscopy and transmission electron microscopy analyses collectively indicate that a single solid solution is formed with a homogeneous distribution of metal elements after sintering at 1550℃.The relative density and hardness of the ES(Ca,Sr,Ba)ZrO_(3) ceramic sintered at 1550℃are 97.79%and 10.840.33 GPa,re s pectively.This ES(Ca,Sr,Ba)ZrO_(3) exhibits lower thermal conductivity from 373 K to 1073 K than their constituting zirconates,CaZrO_(3),SrZrO_(3) and BaZrO_(3).Most importantly,the ES(Ca,Sr,Ba)ZrO_(3) ceramic possesses good corrosion resistance to TiNi alloy melt and no distinct reaction layer exists between TiNi alloy and ES(Ca,Sr,Ba)ZrO_(3) ceramic in the contact region.The combination of these properties indicates that ES(Ca,Sr,Ba)ZrO_(3) ceramic is promising for use as a novel crucible material for the melting of titanium alloys. | Shuaihang Qiu Mingliang Li Gang Shao Hailong Wang Jinpeng Zhu Wen Liu Bingbing Fan Hongliang Xu Hongxia Lu Yanchun Zhou Rui Zhang | 2021 | Journal of Materials Science & Technology2021，，6： | 3 |
| 20 | OmpA-like protein Loa22 from Leptospira interrogans serovar Lai is cytotoxic to cultured rat renal cells and promotes inflammatory responses显示文摘细螺旋体病肾的疾病是细螺旋体病的普通临床的表明之一,包括尖锐肾的失败和 tubulointerstitial 肾炎。外部膜蛋白质相似蛋白质 Loa22 是从螺旋体 interrogans 的脂蛋白并且被建议了是一个相应毒力因素。然而,在 leptospiral nephropathy 的 Loa22 的角色还没被理解。在现在的学习,我们构造了向量并且人工地在 Escherichia coli BL21 (DE ) pLysS 房间表示了 Loa22。在广泛的纯化以后,与 GST 标签蛋白质控制一起, Loa22 蛋白质被用来在有教养的老鼠测试 cytotoxicity 近似小管房间(NRK52E ) 并且在煽动性的回答的正式就职上检验它的效果。用词法检查,2,3二度( 2-methoxy-4-nitro-5-sulfophenyl ) -5-[(phenylamino)carbonyl]-2H-tetrazoium hydrixide 吸收度,喂奶脱氢酶试金和经由流动 cytometry 的 apoptosis 的分析, Loa22 蛋白质调停,这被发现以一种剂量依赖者方式的 NRK52E 房间上的直接细胞毒素的效果。用即时 PCR,西方的弄污和 immunofluorescence,它被发现那 Loa22 蛋白质 upregulates 像使用费的受体的表示 2 (TLR2 ) ,导致氮的氧化物 synthase 并且支持氮的氧化物的生产(没有) 并且由 NRK52E 房间的单核白血球 chemoattractant protein-1 (MCP-1 ) 。用堵住抗体的 TLR2,在 Loa22 刺激要求 TLR2 的激活以后,另外,它被 NRK52E 房间发现那和 MCP-1 生产。一起,我们的数据建议 Loa22 是 L 的一个批评毒力因素。interrogans 并且通过直接调停涉及 leptospiral nephropathy cytotoxicity 和提高的煽动性的回答。 | Ying Zhang Lang Bao Hailong Zhu Bi Huang Huidong Zhang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 3 |
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