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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 3 | Conjugate Gradient Algorithm in the Four-Dimensional Variational Data Assimilation System in GRAPES显示文摘Minimization algorithms are singular components in four-dimensional variational data assimilation(4DVar).In this paper,the convergence and application of the conjugate gradient algorithm(CGA),which is based on the Lanczos iterative algorithm and the Hessian matrix derived from tangent linear and adjoint models using a non-hydrostatic framework,are investigated in the 4DVar minimization.First,the influence of the Gram-Schmidt orthogonalization of the Lanczos vector on the convergence of the Lanczos algorithm is studied.The results show that the Lanczos algorithm without orthogonalization fails to converge after the ninth iteration in the 4DVar minimization,while the orthogonalized Lanczos algorithm converges stably.Second,the convergence and computational efficiency of the CGA and quasi-Newton method in batch cycling assimilation experiments are compared on the 4DVar platform of the Global/Regional Assimilation and Prediction System(GRAPES).The CGA is 40%more computationally efficient than the quasi-Newton method,although the equivalent analysis results can be obtained by using either the CGA or the quasi-Newton method.Thus,the CGA based on Lanczos iterations is better for solving the optimization problems in the GRAPES 4DVar system. | Yongzhu LIU Lin ZHANG Zhihua LIAN | 2018 | Journal of Meteorological Research2018，32，6： | 9 |
| 4 | Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells显示文摘增加的证据被积累了在肿瘤开始显示 epigenetic 规定的重要角色。以前,我们观察到病毒核心(HCVc ) 蛋白质导致了的丙肝的 transfection 在正常胆汁的房间的恶意的转变,和那肿瘤 suppressor 基因 RASSF1A 是在由在倡导者区域的 hypermethylation 的许多 hilar cholangiocarcinoma 病人的 downregulated。在现在的学习,我们发现集合和 MYND 包含域的蛋白质 3 (SMYD3 ) ,新奇 histone methyltransferase,在有 HCV 感染的那些特别是在 cholangiocarcinoma 病人的 overexpressed。进 hilar cholangiocarcinoma 房间的 HCVc 的 Transfection 衬里 QBC939 和 FRH0201 能 upregulate SMYD3 的表示并且支持房间生长,它与我们的临床的研究的结果一致。这现象显示 SMYD3 与有 HCV 感染的 cholangiocarcinoma 开始的 epigenetic 规定有关。SMYD3 的 Overexpression 能禁止 RASSF1A 表示,而由 siRNA 的 SMYD3 的抑制改进了它的表示。Methylation 特定的聚合酶链反应(MS-PCR ) 结果证明 RASSF1A 倡导者的 methylation 地位被 SMYD3 调整。在结论, HCVc 能 upregulate 通过 SMYD3 的规定的 RASSF1A 倡导者的 methylation 地位,和 histone methylation 可以由未知机制影响下游的基因的 DNA methylation。 | Ning Guo Rufu Chen Zhihua Li Yonggang Liu Di Cheng Quanbo Zhou Jiajia Zhou Qing Lin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 8 |
| 5 | Leukocyte Membrane-Coated Liquid Metal Nanoswimmers for Actively Targeted Delivery and Synergistic Chemophotothermal Therapy显示文摘We report a leukocyte membrane-coated gallium nanoswimmer(LMGNS)capable of ultrasound-propelled motion,antibiofouling,and cancer cell recognition and targeting.The LMGNS consists of a needle-shaped gallium core encapsulating an anticancer drug and a natural leukocyte membrane shell.Under the propulsion of an ultrasound field,LMGNSs could autonomously move in biological media with a speed up to 108.7μms^(-1).The velocity and motion direction of the LMGNSs can be modulated by regulating the frequency and voltage of the applied ultrasound field.Owing to the leukocyte membrane coating,LMGNSs can not only avoid biofouling during the motion in blood but also possess cancer cell recognition capability.These LMGNSs could actively seek,penetrate,and internalize into the cancer cells and achieve enhanced anticancer efficiency by combined photothermal and chemical therapy.Such biofunctionalized liquid metal nanoswimmer presents a new type of multifunctional platform for biomedical applications. | Daolin Wang Changyong Gao Chang Zhou Zhihua Lin Qiang He | 2020 | Research2020，，1： | 8 |
| 6 | Experimental demonstration of transverse mode instability enhancement by a counter-pumped scheme in a 2 kW all-fiberized laser显示文摘Transverse mode instability(TMI)has become the major limitation for power scaling of fiber lasers with nearly diffraction-limited beam quality.Compared with a co-pumped fiber laser,a counter-pumped fiber laser reveals TMI threshold enhancement through a semi-analytical model calculation.We demonstrated a 2 kW high-power counter-pumped all-fiberized laser without observation of TMI.Compared with the co-pumped scheme,the TMI threshold is enhanced at least 50%in counter-pumped scheme,moreover,stimulated Raman scattering and four-wave mixing are suppressed simultaneously. | ZEBIAO LI ZHIHUA HUANG XIAOYU XIANG XIAOBAO LIANG HONGHUAN LIN SHANHUI XU ZHONGMIN YANG JIANJUN WANG FENG JING | 2017 | Photonics Research2017，5，2： | 6 |
| 7 | Advertisement Call Variability in the Black-spined Toad Bufo melanostictus (Anura: Bufonidae) during the Breeding Season in Lishui, Zhejiang, China显示文摘Advertisement calls play an important role in influencing female mate choice and are regarded as one of the key characters responsible for reproductive isolation and speciation events in frogs and toads. The black-spined toad, Bufo melanostictus, is one of the most common amphibians in Southeast Asia and is frequently observed in human habitations throughout its distributional range. The advertisement calls of the toad have not been well described. Here, we report the advertisement calls of this species from Lishui, Zhejiang, China during its breeding season. The advertisement calls of B. melanostictus are composed of single notes with a single harmonic frequency emitted sporadically. The call parameters recorded in this study were highly variable across recording times and with different body sizes. Dominant frequency was negatively correlated with body size. Comparing the calls of the B. melanostictus population from Lishui with the populations from five other localities(Bangkok, Thailand; Coorg, India; Burma, Myanmar; Bali, Indonesia; Halimun-Salak National Park, Indonesia), we found that call structure was similar among five different populations with no harmonics, while the Halimun-Salak National Park population contained two clear harmonics. Dominant frequency was similar between Bali(1.56 kHz) and Coorg(1.6 kHz) populations, while it was highly variable among other populations. Besides call duration, call interval and pulse/call rate may also be significantly different among the comparing populations. Pooling the available data, we observed some similarities and differences in call parameters among the six populations. | Li WEI Lihua ZHAO Xiaohao MA Xiaoli FAN Xiaomei MA Zhihua LIN | 2012 | Asian Herpetological Research2012，3，2： | 6 |
| 8 | Seamlet carving for shape-aware image resizing显示文摘In this paper we propose an optimized seam-carving approach for anti-shearing image resizing.Current image/video seam-carving strategy only focuses on deleting the pixels along 8-connected seams,which may lead to the obvious information loss during resizing.Unlike the traditional seam-carving methods,our approach can construct a seamlet to handle the discontinuous pixels and further achieve an optimized image resizing results with shape-preservation.In particular,to suppress zigzag artifacts,we introduce the anti-shearing energy into the seamlet generation,which includes two steps:1) the energy map is formalized by using Gabor filtering and the saliency map;2) The energy computation is optimized in Gabor feature space to obtain the resizing results without the connectivity restriction.The experimental results and comparisons show the effectiveness of our method. | LIN Xiao SHENG Bin MA LiZhuang SHEN Yang CHEN ZhiHua | 2012 | Science China(Information Sciences)2012，55，5： | 6 |
| 9 | Tail loss affects fecundity but not offspring traits in the Chinese skink Eumeces chinensis显示文摘 | Hongliang LU Jianfang GAO Xiaohao MA Zhihua LIN Xiang JI | 2012 | Current Zoology2012，58，2： | 5 |
| 10 | Ca^(2+)-supplying black phosphorus-based scaffolds fabricated with microfluidic technology for osteogenesis显示文摘Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus(P),calcium(Ca),and silicon(Si).We developed black phosphorus(BP)-based,three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential ions for bone defect treatment.The fibrous scaffolds were fabricated from 3D poly(L-lactic acid)(PLLA)nanofibers(3D NFs),BP nanosheets,and hydroxyapatite(HA)-porous SiO2 nanoparticles.The 3D BP@HA NFs possess three advantages:i)stably connected pores allow the easy entrance of bone marrow-derived mesenchymal stem cells(BMSCs)into the interior of the 3D fibrous scaffolds for bone repair and osteogenesis;ii)plentiful nutrients in the NFs strongly improve osteogenic differentiation in the bone repair area;iii)the photothermal effect of fibrous scaffolds promotes the release of elements necessary for bone formation,thus achieving accelerated osteogenesis.Both in vitro and in vivo results demonstrated that the 3D BP@HA NFs,with the assistance of NIR laser,exhibited good performance in promoting bone regeneration.Furthermore,microfluidic technology makes it possible to obtain high-quality 3D BP@HA NFs with low costs,rapid processing,high throughput and mass production,greatly improving the prospects for clinical application.This is also the first BP-based bone scaffold platform that can self-supply Ca^(2+),which may be the blessedness for older patients with bone defects or patients with damaged bones as a result of calcium loss. | Zhanrong Li Xingcai Zhang Jiang Ouyang Dandan Chu Fengqi Han Liuqi Shi Ruixing Liu Zhihua Guo Grace X.Gu Wei Tao Lin Jin Jingguo Li | 2021 | Bioactive Materials2021，6，11： | 4 |
| 11 | EXPERIMENTAL AND NUMERICAL STUDIES OF THE ANTI-PENETRATION PERFORMANCE OF SANDWICH PANELS WITH ALUMINUM FOAM CORES显示文摘Effects of face-sheet thickness and core thickness of sandwich panels, and shape of projectiles on the penetration resistance of sandwich panels were discussed, while typical penetration failure modes were presented. It was shown that the anti-penetration performance of sandwich panels was enhanced with the increase of face-sheet or core thickness; The penetration resistance of sandwich panels was shown to be strongest to blunt-shaped projectile impacts,weaker to hemispherical-nose-shaped projectile impacts, and weakest to conical-shaped projectile impacts. The corresponding numerical simulation was carried out using the finite element code LS-DYNA V970. Numerical results showed that the penetration time decreased with the increase of projectile impact velocity. | Fei Yang Weijing Niu Lin Jing Zhihua Wang Longmao Zhao Hongwei Ma | 2015 | Acta Mechanica Solida Sinica2015，28，6： | 3 |
| 12 | Toxic Effects of Three Heavy Metallic Ions on Rana zhenhaiensis Tadpoles显示文摘Heavy metal pollution is widespread in some areas of China and results in contamination of land, water, and air with which all living organisms interact. In this study, we used three heavy metallic ions(Cu2+, Pb2+ and Zn2+) to assess their toxicity effects on mortality, blood biomarker and growth traits(body length and body mass) of Rana zhenhaiensis tadpoles. The results showed that the toxicity levels of the three metallic ions were different when conducted with different experiment designs. For acute toxicity tests, Cu2+ was the most toxic with the highest tadpole mortality. The mortalities of tadpoles showed significant differences among the treatments at the same exposure time endpoints(24, 48, 72 and 96h). Results from repeated measures ANOVA indicated that metallic ion concentration, exposure time and their interactions significantly affected the mortalities of R. zhenhaiensis tadpoles. Also, the toxicity effects of all binary combinations of the three metallic ion treatments showed synergism. The half lethal concentrations(LC50) decreased with increasing exposure time during the experimental period, and the safe concentration(SC) values of Cu2+, Pb2+ and Zn2+ were different from each other. Combined and compared LC50 values with previous data reported, it is suggestes that the toxicity levels of metal pollution to anuran tadpoles should be species-and age-related. For blood biomarker tests, Zn2+ was the most toxic with the highest total frequencies of abnormal erythrocytic nucleus. All three metallic ions caused higher abnormal erythrocytic nucleus compared with control groups. In a chronic toxicity test, Pb2+ was the most toxic with lowest growth traits. Survival rate(except for 18 days), total body length and body mass showed significant differences among the treatments. These findings indicated that tadpoles of R. zhenhaiensis should be as a bioindicator of heavy metals pollution. | Li WEI Guohua DING Sainan GUO Meiling TONG Wenjun CHEN Jon FLANDERS Weiwei SHAO Zhihua LIN | 2015 | Asian Herpetological Research2015，6，2： | 3 |
| 13 | Effects of Predation by Invasive Western Mosquitofish(Gambusia affinis) on Survival of Eggs,Embryos and Tadpoles of Pelophylax nigromaculatus and Duttaphrynus melanostictus in South China显示文摘Alien species are one of the most serious threats to the decline and extinction of native amphibian populations. In this study, we examined the predation of invasive Western Mosquitofish Gambusia affinis on the eggs, embryos, and tadpoles of Duttaphrynus melanostictus and Pelophylax nigromaculatus in south China. Our results suggested that the survival of eggs and embryos remaining in the egg capsules of P. nigromaculatus and D. melanostictus was significantly higher than those removed from the egg capsule at 12-h intervals within 72 h in the presence of G. affinis. The survival of P. nigromaculatus eggs and embryos without egg capsules was significantly lower than those of D. melanostictus without egg capsules. The survival of P. nigromaculatus eggs and embryos with egg capsules was significantly higher than those of D. melanostictus with egg capsules from 24 h to 72 h except for 12 h. The survival of D. melanostictus tadpoles was significantly higher than that of P. nigromaculatus tadpoles in the presence of G. affinis. The survival of Gosner stage 26 tadpoles of P. nigromaculatus was significantly higher than that of Gosner stage 30 tadpoles from 12 h to 60 h, but there were no significant differences at 72 h. In contrast, the survival of Gosner stage 26 tadpoles of D. melanostictus was significantly lower than that of Gosner stage 30 tadpoles within 72 h, recording every 12 h. The increasing temperature caused a significant increase in predation by G. affinis on P. nigromaculatus eggs and embryos. The outer jelly capsule surrounding anurans eggs might serve as a mechanical defense against predation by G. affinis due to its large diameter, relatively stationary state and unpalatability. The differences in the vulnerability of P. nigromaculatus and D. melanostictus embryos and tadpoles to G. affinis probably due to differences in the unpalatability, black skin and activity. Based on the magnitude of predation by G. affinis on the eggs, embryos and tadpoles of these two species and the combined impact of temperature, we might speculate that invasive G. affinis and global warming would have more detrimental impacts on population viability of P. nigromaculatus than D. melanostictus in China. | Xiaoli FAN Zhihua LIN Xiang LI Li WEI Guohua DING | 2016 | Asian Herpetological Research2016，7，1： | 3 |
| 14 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 15 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 16 | IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma显示文摘 | Jiankun Liu Yuzhong Duan Xiaoming Cheng Xi Chen Wei Xie Haixia Long Zhihua Lin Bo Zhu | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 2 |
| 17 | Boosting of reversible capacity delivered at a low voltage below 0.5 V in mildly expanded graphitized needle coke anode for a high-energy lithium ion battery显示文摘The rate performance and cycle stability of graphitized needle coke(GNC)as anode are still limited by the sluggish kinetics and volume expansion during the Li ions intercalation and de-intercalation process.Especially,the output of energy density for lithium ion batteries(LIBs)is directly affected by the delithiation capacity below 0.5 V.Here,the mildly expanded graphitized needle coke(MEGNC)with the enlarged interlayer spacing from 0.346 to 0.352 nm is obtained by the two-step mild oxidation intercalation modification.The voltage plateau of MEGNC anode below 0.5 V is obviously broadened as compared to the initial GNC anode,contributing to the enhancement of Li storage below the low voltage plateau.Moreover,the coin full cell and pouch full cell configured with MEGNC anode exhibit much enhanced Li storage ability,energy density and better cycling stability than those full cells configured with GNC and commercial graphite anodes,demonstrating the practical application value of MEGNC.The superior anode behaviors of MEGNC including the increased effective capacity at low voltage and superior cyclic stability are mainly benefited from the enlarged interlayer spacing,which not only accelerates the Li ions diffusion rate,but also effectively alleviates the volume expansion and fragmentation during the Li ions intercalation process.In addition,the above result is further confirmed by the density functional theory simulation.This work provides an effective modification strategy for the NC-based graphite to enhance the delithiation capacity at a low voltage plateau,dedicated to improving the energy density and durability of LIBs. | Dong Sun Lu Zhao Zhihua Xiao Kai Zhao Rundan Lin Hongmei Song Xilu Zhang Xinlong Ma Chong Peng Xiaoqiao Huang Xingxun Li Jinsen Gao Chunming Xu | 2022 | Journal of Energy Chemistry2022，31，11： | 2 |
| 18 | Maternal Thermal Effects on Female Reproduction and Hatchling Phenotype in the Chinese Skink(Plestiodon chinensis)显示文摘We maintained gravid Chinese skinks(Plestiodon chinensis) at three constant temperatures(25, 28 and 31 °C) during gestation, and randomly assigned eggs from each female to one of the same three temperatures for incubation to determine maternal thermal effects on female reproduction and hatchling phenotype. Maternal temperature affected egg-laying date, hatching success and hatchling linear size(snout-vent length, SVL) but not clutch size, egg size, egg component, and embryonic stage at laying. More specifically, females at higher temperatures laid eggs earlier than did those at low temperatures, eggs laid at 31 °C were less likely to hatch than those laid at 25 °C or 28 °C, and hatchlings from eggs laid at 31 °C were smaller in SVL. Our finding that maternal temperature(pre-ovipositional thermal condition) rather than incubation temperature(post-ovipositional thermal condition) affected hatching success indicated that embryos at early stages were more vulnerable to temperature than those at late stages. Our data provide an inference that moderate maternal temperatures enhance reproductive fitness in P. chinensis. | Li MA Zhihua LIN Jianfang GAO Hong LI Xiang JI Hongliang LU | 2018 | Asian Herpetological Research2018，9，4： | 2 |
| 19 | Satellite-based RAR performance simulation for measuring directional ocean wave spectrum based on SAR inversion spectrum显示文摘Some missions have been carried out to measure wave directional spectrum by synthetic aperture radar (SAR) and airborne real aperture radar (RAR) at a low incidence.Both them have their own advantages and limitations.Scientists hope that SAR and satellite-based RAR can complement each other for the research on wave properties in the future.For this study,the authors aim to simulate the satellite-based RAR system to validate performance for measuring the directional wave spectrum.The principal measurements are introduced and the simulation methods based on the one developed by Hauser are adopted and slightly modified.To enhance the authenticity of input spectrum and the wave spectrum measuring consistency for SAR and satellite-based RAR,the wave height spectrum inversed from Envisat ASAR data by cross spectrum technology is used as the input spectrum of the simulation system.In the process of simulation,the sea surface,backscattering signal,modulation spectrum and the estimated wave height spectrum are simulated in each look direction.Directional wave spectrum are measured based on the simulated observations from 0 ? to 360 ? .From the estimated wave spectrum,it has an 180 ? ambiguity like SAR,but it has no special high wave number cut off in all the direction.Finally,the estimated spectrum is compared with the input one in terms of the dominant wave wavelength,direction and SWH and the results are promising.The simulation shows that satellite-based RAR should be capable of measuring the directional wave properties.Moreover,it indicates satellite-based RAR basically can measure waves that SAR can measure. | REN Lin MAO Zhihua HUANG Haiqing GONG Fang | 2010 | Acta Oceanologica Sinica2010，29，4： | 2 |
| 20 | Measurements of ocean wave spectrum from airborne radar at small incidence angles显示文摘This paper proposes the retrieval method of ocean wave spectrum for airborne radar observations at small incidence angles,which is slightly modified from the method developed by Hauser.Firstly,it makes use of integration method to estimate total mean square slope instead of fitting method,which aims to reduce the affects of fluctuations superposed on normalized radar cross-section by integration.Secondly,for eliminating the noise spectrum contained in signal spectrum,the method considers the signal spectrum in certain look direction without any long wave components as the assumed noise spectrum,which would be subtracted from signal spectrum in any look direction for linear wave spectrum retrieval.Estimated ν from the integration method are lower than the one from fitting method and have a standard deviation of 0.004 between them approximately.The assumed noise spectrum energy almost has no big variations along with the wave number and is slightly lower to the high wave number part of signal spectrum in any look direction,which follows that the assumption makes sense.The retrieved directional spectra are compared with the buoy records in terms of peak wavelength,peak direction and the significant wave height.Comparisons show that the retrieved peak wavelength and significant wave height are slightly higher than the buoy records but don't differs significantly (error less than 10%).For peak direction,the swell waves in first case basically propagate in the wind direction 6 hours ago and the wind-generated waves in second case also propagate in the wind direction,but the 180° ambiguity remains.Results show that the modified method can carry out the retrieval of directional wave spectrum. | REN Lin PAN Delu MAO Zhihua | 2011 | Acta Oceanologica Sinica2011，30，1： | 2 |
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