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| 1 | Global change and climate-vegetation classification显示文摘Three phrases of the quantitative study of climate-vegetation classification and their characteristics are presented based on the review of advance in climate-vegetation interaction, a key issue of 'global change and terrestrial ecosystems (GCTE)' which is the core project of International Geosphere-Biosphere Programme (IGBP): (i) characterized by the correlation between natural vegetation types and climate; (? characterized by climatic indices which have obviously been restricted to plant ecophysiology; (iii) characterized by coupling both structure and function of vegetation. Thus, the prospective of climate-vegetation classification for global change study in China was proposed, especially the study coupling climate-vegetation classification models with atmospheric general circulation models (GCMs) was emphasized. | Guangsheng Zhou Yuhui Wang | 2000 | Chinese Science Bulletin2000，45，7： | 12 |
| 2 | Oil & Gas Drilling Technology in China:Past and Present显示文摘Drilling is a prerequisite for oil and gas exploration. As one of the core upstream business of oil and gas exploration and development, it mainly includes | Su Yinao Huang Hongchun Zhou Yuhui Gao Wenkai Zeng Qiang | 2009 | China Oil & Gas2009，16，4： | 9 |
| 3 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 4 | MiR-29a/b/c regulate human circadian gene hPER1 expression by targeting its 3/UTR显示文摘在哺乳动物的几必要生物进步被生理节奏的节奏调整。不过分子的机制 ofoscillating 这些生理节奏的节奏被揭开了,生理节奏的基因的特定的功能不是很, clear.It 被报导了那由 microRNA 将生理节奏的基因击倒是有用策略探索 circadianrhythms 的功能。在这研究,通过屏蔽途径的前面的生物信息学,我们作为有势力 inhibitorsfor 识别了 miR-29a/b/c 人的生理节奏的基因 hPER1。我们进一步发现 miR-29a/b/c 能直接在人的 A549 房间在 mRNA 和蛋白质表示层次指向 hPER1 3untranslated 区域(UTR ) 和下面调整 hPER1。因此,我们的调查结果建议 hPER1 的表示被 miR-29a/b/c 调整,它可以也为 hPER1 的功能提供新线索。 | Xiyan Zhao Xueqiang Zhu Shuting Cheng Yizhou Xie Zhengrong Wang Yanyou Liu Zhou Jiang Jing Xiao Huiling Guo Yuhui Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 7 |
| 5 | Magnetic yolk-shell structured anatase-based microspheres loaded with Au nanoparticles for heterogeneous catalysis显示文摘磁性的蛋黄壳组织了基于锐钛矿的 microspheres 在磁铁矿粒子上通过连续、灵巧的大音阶的第五音胶化涂层被制作,由退火列在后面处理。在与金 nanoparticles 装载之上,获得的功能的磁性的 microspheres 在向苯乙烯氧化物与非凡的高变换(89.5%) 和选择(90.8%) 催化苯乙烯的 epoxidation 作为异构的催化剂显示出优异性能。这些迷人的材料的构造过程为创造另外的功能的 nanocomposites 展示许多含意,这被相信。 | Chun Wang Junchen Chen Xinran Zhou Wei Li Yong Liu Qin Yue Zhaoteng Xue Yuhui Li Ahmed A. Elzatahry Yonghui Deng Dongyuan Zhao | 2015 | Nano Research2015，8，1： | 7 |
| 6 | PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus显示文摘地岬在许多细胞的活动起一个枢轴的作用,并且它的 subcellular 区分提供空间、时间的选择。这里,我们报导由二高度相应的蛋白质 PAQR10 和孕激素和 AdipoQ 受体家庭的 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个模式。PAQR10 和 PAQR11 在 Golgi 仪器是只局部性的。PAQR10/PAQR11 的 Overexpression 刺激基础、导致 EGF 的英皇家空军之阶级最低之兵 phosphorylation 并且以一种剂量依赖者方式增加英皇家空军之阶级最低之兵目标基因的表示。PAQR10/PAQR11 的 Overexpression 显著地提高 HRas, NRas 和 KRas4A 的 Golgi 本地化,然而并非 KRas4B。PAQR10 和 PAQR11 罐头也与 HRas, NRas 和 KRas4A 交往,然而并非 KRas4B。在由 PAQR10/PAQR11 的 overexpression 的 Golgi 仪器的增加的地岬蛋白质处于一个活跃状态。一致地, PAQR10 和 PAQR11 还原剂击倒在 Golgi 仪器的刺激 EGF 的英皇家空军之阶级最低之兵 phosphorylation 和地岬激活。有趣地, PAQR10 和 PAQR11 能与 RasGRP1,地岬的 guanine 核苷酸交换蛋白质,和 RasGRP1 的增加 Golgi 本地化交往。RasGRP1 的 C1 领域为和 PAQR10/PAQR11 的 RasGRP1 的相互作用必要、足够。由 overexpressed PAQR10/PAQR11 的英皇家空军之阶级最低之兵 phosphorylation 的模拟被 RasGRP1 的 downregulation 废除。而且, PC12 房间的区别被 PAQR10/PAQR11 的 overexpression 显著地提高。一起,这研究揭开由 PAQR10 和 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个新范例。 | Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen | 2012 | Cell Research2012，22，4： | 6 |
| 7 | Application of a Step-by-Step Fingerprinting Identification Method on a Spilled Oil Accident in the Bohai Sea Area显示文摘In recent years,oil spill accidents occur frequently in the marine area of China.Finding out the spilled oil source is a key step in the relevant investigation.In this paper,a step-by-step fingerprinting identification method was used in a spilled oil accident in the Bohai Sea in 2002.Advanced chemical fingerprinting and data interpretation techniques were used to characterize the chemical composition and determine the possible sources of two spilled oil samples.The original gas chromatography -flame ionization detec-tion (GC-FID) chromatogram of saturated hydrocarbons was compared.The gas chromatography-mass spectrometry (GC/MS) chromatograms of aromatic hydrocarbons terpane and sterane,n-alkane and poly-aromatic hydrocarbons (PAHs) were analyzed.The correlation analysis on diagnostic ratios was performed with Student’s t-test.It is found that the oil fingerprinting of the spilled oil (designated as sz1) from the polluted sand beach was identical with the suspected oil (designated as ky1) from a nearby crude oil refinery factory.They both showed the fingerprinting character of mixed oil.The oil fingerprinting of the spilled oil (designated as ms1) collected from the port was significantly different from oil ky1 and oil sz1 and was with a lubricating oil fingerprint character.The identification result not only gave support for the spilled oil investigation,but also served as an example for studying spilled oil accidents. | SUN Peiyan GAO Zhenhui CAO Lixin WANG Xinping ZHOU Qing ZHAO Yuhui LI Guangmei | 2011 | Journal of Ocean University of China2011，10，1： | 4 |
| 8 | Bohai crude oil identification by gas chromatogram fingerprinting quantitative analysis coupled with cluster analysis显示文摘By gas chromatogram, six crude oils fingerprinting distributed in four oilfields and four oil platforms were analyzed and the corresponding normal paraffin hydrocarbon (including pristane and phytane) concentration was obtained by the internal standard method. The normal paraffin hydrocarbon distribution patterns of six crude oils were built and compared. The cluster analysis on the normal paraffin hydrocarbon concentration was conducted for classification and some ratios of oils were used for oils comparison. The results indicated: there was a clear difference within different crude oils in different oil fields and a small difference between the crude oils in the same oil platform. The normal paraffin hydrocarbon distribution pattern and ratios, as well as the cluster analysis on the normal paraffin hydrocarbon concentration can have a better differentiation result for the crude oils with small difference than the original gas chromatogram. | SUN Peiyan BAO Mutai GAO Zhenhui LI Mei ZHAO Yuhui WANG Xinping ZHOU Qing WANG Xiulin | 2006 | Acta Oceanologica Sinica2006，25，5： | 4 |
| 9 | Sensitive monitoring of RNA transcription levels using a graphene oxide fluorescence switch显示文摘Catalytic transfer of genetic information from DNA to RNA is very important in life activities. The unconventional RNA transcription level may be related to the source of genetic diseases. At present, conventional methods for detection of RNA transcripts usually involve cumbersome preparative steps, or require sophisticated laboratory equipments. In this study, we presented a rapid, sensitive nano-detection platform for monitoring of RNA transcript levels. T7 RNA polymerase transcription reaction is employed as the example to test the feasibility of this method. In this design, in vitro synthesized RNA products can be hybridized to the FAM labeled single strand DNA (ssDNA) probes which can be adsorbed onto the graphene oxide (GO) surface. Using GO as the fluorescence switch, excellent capacity of the signal-on fluorescence platform for detection of RNA transcripts level is demonstrated. Transcription levels sensing with this nano-platform achieved a sensitivity of 5 pmol/L transcription template. It is antici- pated that current developed RNA transcript nano-detection mode has the potential to be an alternative to the conventional RNA transcript detection methods. | ZHOU XiaoMing LIAO YuHui XING Da | 2013 | Chinese Science Bulletin2013，58，21： | 3 |
| 10 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 11 | Breathable,antifreezing,mechanically skin-like hydrogel textile wound dressings with dual antibacterial mechanisms显示文摘Hydrogels are emerging as the most promising dressings due to their excellent biocompatibility,extracellular matrix mimicking structure,and drug loading ability.However,existing hydrogel dressings exhibit limited breathability,poor environmental adaptability,potential drug resistance,and limited drug options,which extremely restrict their therapeutic effect and working scenarios.Here,the current research introduces the first paradigm of hydrogel textile dressings based on novel gelatin glycerin hydrogel(glyhydrogel)fibers fabricated by the Hofmeister effect based wet spinning.Benefiting from the unique knitted structure,the textile dressing features excellent breathability(1800 times that of the commercially available 3 M dressing)and stretchability(535.51±38.66%).Furthermore,the glyhydrogel textile dressing can also withstand the extreme temperature of-80℃,showing the potential for application in subzero environments.Moreover,the introduction of glycerin endows the textile dressing with remarkable antibacterial property and expands the selection of loaded drugs(e.g.,clindamycin).The prepared glyhydrogel textile dressing shows an excellent infected wound healing effect with a complete rat skin closure within 14 days.All these functions have not been achievable by traditional hydrogel dressings and provide a new approach for the development of hydrogel dressings. | Sihan Jiang Jiajia Deng Yuhui Jin Bo Qian Wanqi Lv Qiangqiang Zhou Enhua Mei Rasoul Esmaeely Neisiany Yuehua Liu Zhengwei You Jie Pan | 2023 | Bioactive Materials2023，，3： | 3 |
| 12 | Partitioning root and microbial contributions to soil respiration in Leymus chinensis populations显示文摘 | Bingrui Jia Guangsheng Zhou Fengyu Wang Yuhui Wang Wenping Yuan Li Zhou | 2005 | Soil Biology and Biochemistry2005，，4： | 3 |
| 13 | High order moments of first hitting times for single death processes显示文摘We present an explicit and recursive representation for high order moments of the first hitting times of single death processes.Based on that,some necessary or sufficient conditions of exponential ergodicity as well as a criterion on■-ergodicity are obtained for single death processes,respectively. | Yuhui ZHANG Xiaofeng ZHOU | 2019 | Frontiers of Mathematics in China2019，14，5： | 3 |
| 14 | Pullulan Acetate Coated Magnetite Nanoparticles for Hyper-Thermia:Preparation,Characterization and In Vitro Experiments显示文摘Amphipathic polymer pullulan acetate (PA)-coated magnetic nanoparticles were prepared and characterized by various physicochemical means. The cytotoxicity and cellular uptake of the magnetic nanoparticles were examined. The hyperthermic effect of the magnetic nanoparticles on tumor cells was evaluated. Transmission electron microscopy (TEM) showed that the PA coated magnetic nanoparticles (PAMNs) had spherical morphology. Dynamic light scattering (DLS) showed that the size distribution of PAMNs was unimodal,with an average diameter of 25.8 nm ± 6.1 nm. The presence of the adsorbed layer of PA on the magnetite surface was confirmed by Fourier transform infrared (FTIR) spectroscopy. Magnetic measurements revealed that the saturation magnetization of the PAMNs reached 51.9 emu/g and the nanoparticles were superparamagnetic. Thermogravimetric analysis (TGA) showed that the Fe_(3)O_(4) particles constituted 75 wt% of the PAMNs. The PAMNs had good heating properties in an alternating magnetic field. Cytotoxicity assay showed that PAMNs exhibited no significant cytotoxicity against L929 cells. TEM results showed that a large number of PAMNs were internalized into KB cells. PAMNs have good hyperthermia effect on KB cells in vitro by magnetic field induced hyperthermia. These novel magnetic nanoparticles have great potential as magnetic hyperthermia mediators. | Fuping Gao Yuanyuan Cai Jing Zhou Xiaoxue Xie Weiwei Ouyang Yuhui Zhang Xufei Wang Xiaodong Zhang Xiaowen Wang Lingyun Zhao Jintian Tang | 2010 | Nano Research2010，3，1： | 2 |
| 15 | A noise and artifact suppression using resampling(NASR)method to facilitate de novo protein structure determination显示文摘Background The search of heavy atoms is crucial to the de novo determination of protein structures.Typically,the difference Patterson map is calculated as a first step to solve substructure.However,the pseudo-peaks and noises inherent in such maps arising from the high symmetry and large size of protein structures accompanied with the data collection errors inevitably pose a challenge in accurate real space-based substructure determination.Purpose In order to mitigate such pseudo-peaks and noises and further improve signal-to-noise ratio(SNR)of the difference Patterson map,the noise and artifact suppression using resampling(NASR)method originally proposed in nuclear magnetic resonance is introduced into protein crystallography in this work to optimize the difference Patterson map.Methods The NASR method makes use of the statistical learning theory,which in this work repeatedly samples a fixed portion of diffraction data(sub-dataset)randomly followed by a statistical analysis of the multiple calculated difference Patterson maps to discard pseudo-peaks and noises.Its feasibility is based on the fact that the true vector peaks of the heavy atoms keep static in the multiple random sub-datasets,whereas the pseudo-peaks and noises fluctuate remarkably.And the key of this method lies in the design of a weighting function to distinguish true vector peaks from pseudo-peaks and noises,as well as a proper selection of the parameters associated with the function.Results The introduced NASR method is both numerically and experimentally demonstrated to be feasible in suppressing spurious peaks and non-correlative noises intrinsic to the difference Patterson maps.As a result,the SNR of the difference Patterson maps can be enhanced to some extent to facilitate real space-based substructure determination.Conclusion It is therefore anticipated that the proposed method may provide a meaningful insight into how to denoise the difference Patterson maps,which in turn assists in locating heavy atoms and further facilitates de novo protein structure determination. | Menglu Hu Zengqiang Gao Qiang Zhou Zhi Geng Yuhui Dong | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 16 | A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet(Setaria italica)显示文摘 | Guanqing Jia Xuehui Huang Hui Zhi Yan Zhao QiangZhao Wenjun Li Yang Chai Lifang Yang Kunyan Liu Hengyun Lu Chuanrang Zhu Yiqi Lu Congcong Zhou Danlin Fan Qijun Weng Yunli Guo Tao Huang LeiZhang Tingting Lu Qi Feng Hangfei Hao HongkuanLiu Ping Lu Ning Zhang Yuhui Li Erhu Guo ShujunWang Suying Wang Jinrong Liu Wenfei Zhang GuoqiuChen Baojin Zhang Wei Li Yongfang Wang HaiquanLi Baohua Zhao Jiayang Li Xianmin Diao Bin HanJia | 2013 | Nature Genetics2013，45，8： | 1 |
| 17 | Simulating phonological characteristics of two dominant grass species in a semi-arid steppe ecosystem显示文摘 | Yuan Wenping Zhou Guangsheng Wang Yuhui | 2007 | Ecological Research2007，22，5： | 1 |
| 18 | CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasisof pancreatic adenocarcinoma: A clinical study显示文摘 | Weixia Zhong Weiwei Chen Dexian Zhang Jujie Sun Yuhui Li Jianbo Zhang Yongsheng Gao Wuyuan Zhou Sheng Li | 2012 | Experimental and Therapeutic Medicine2012，，3： | 1 |
| 19 | Estimating biomass and net primary production from forest inventory data: A case study of China’s Larix forests显示文摘 | Zhou Guangsheng Wang Yuhui Jiang Yanling | 2002 | Ecology Manage2002，169，12： | 1 |
| 20 | Multispectroscopic studies for the identification of archaeological frankincense excavated in the underground palace of Bao’en Temple, Nanjing: near infrared, midinfrared, and Raman spectroscopies显示文摘 | Lei Zhou Dawa Shen Junquan He Yuhui Wei Qinglin Ma Zhide Hu | 2012 | J Raman Spectrosc2012，，10： | 1 |
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