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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Antibody drug conjugate:the“biological missile”for targeted cancer therapy显示文摘Antibody–drug conjugate(ADC)is typically composed of a monoclonal antibody(mAbs)covalently attached to a cytotoxic drug via a chemical linker.It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells,which has become one of the hotspots for the research and development of anticancer drugs.Since the first ADC,Mylotarg®(gemtuzumab ozogamicin),was approved in 2000 by the US Food and Drug Administration(FDA),there have been 14 ADCs received market approval so far worldwide.Moreover,over 100 ADC candidates have been investigated in clinical stages at present.This kind of new anti-cancer drugs,known as“biological missiles”,is leading a new era of targeted cancer therapy.Herein,we conducted a review of the history and general mechanism of action of ADCs,and then briefly discussed the molecular aspects of key components of ADCs and the mechanisms by which these key factors influence the activities of ADCs.Moreover,we also reviewed the approved ADCs and other promising candidates in phase-3 clinical trials and discuss the current challenges and future perspectives for the development of next generations,which provide insights for the research and development of novel cancer therapeutics using ADCs. | Zhiwen Fu Shijun Li Sifei Han Chen Shi Yu Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 5 |
| 3 | Holocene sea level trend on the west coast of Bohai Bay,China: reanalysis and standardization显示文摘Using 110 newly revised Holocene sea level indicators categorized into three types,sediments(67),shelly cheniers(27)and oyster reefs(16),this paper firstly provides a Holocene relative sea level curve,based on multiple approaches of litho-and biostratigraphies and sedimentary faces analysis,for the west coast of Bohai Bay,China.Following considerations,including indicative meaning,the paleo tidal pattern and range and conversion from mean tidal level to mean sea level,an apparent relative mean sea level(RMSL)curve was further reconstructed.After systematical calibration using CALIB,those of the 48 reworked samples were further corrected for the residence-time effect.Similarly,the younger ages for another 35 samples were chosen at the subsample level.These result in a younger-oriented shift for about 0.5 ka.Three local spatial factors,including neotectonic subsidence(average rate about 0.1 mm/a),self-compaction of unconsolidated sediments(between a few decimeters to about 6 m)and subsidence due to groundwater withdrawal(between a few centimeters to about 2.5 m),were quantitatively corrected.Finally,the amended RMSL curve after eliminating all these local temporo-spatial factors is very likely to show non-existence of mid-Holocene highstand and imply potential influences of both ice-volume equivalent sea level and regional glacial isostatic adjustment.Although it is still unable to divide both global and regional factors,the slowdown of sea level rise,in 7.5–6.8 ka with a maximum height less than+1 m,may constrain the model effort in the near future. | Jianfen Li Zhiwen Shang Fu Wang Yongsheng Chen Lizhu Tian Xingyu Jiang Qian Yu Hong Wang | 2021 | Acta Oceanologica Sinica2021，40，7： | 5 |
| 4 | The Late Quaternary Coastal Geo-Environment Evolution and Modern Process of Bohai Bay,China显示文摘Paleoenvironmental reconstruction is fundamental to understand the modern environmental changes and to predict future environment,which is especially critical to understand the evolution of land and sea during geological periods.However,the basic geological research on China’s muddy coastal zone is not enough to | WANG Fu SHANG Zhiwen LI Jianfen CHEN Yongsheng WANG Hong | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 2 |
| 5 | Development of SCAR and CAPS markers for a partially dominant yellow seed coat gene in Brassica napus L 显示文摘 | Liu Zhiwen Fu Tingdong Wang Ying | 2006 | Euphytica2006，149，： | 1 |
| 6 | Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches显示文摘Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS. | Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang | 2020 | Asian Journal of Urology2020，7，3： | 1 |
| 7 | A cooperative detection game:UAV swarm vs.one fast intruder显示文摘This paper studies a special defense game using unmanned aerial vehicle(UAV)swarm against a fast intruder.The fast intruder applies an offensive strategy based on the artificial potential field method and Apollonius circle to scout a certain destination.As defenders,the UAVs are arranged into three layers:the forward layer,the midfield layer and the back layer.The co-defense mechanism,including the role derivation method of UAV swarm and a guidance law based on the co-defense front point,is introduced for UAV swarm to co-detect the intruder.Besides,five formations are designed for comparative analysis when ten UAVs are applied.Through Monte Carlo experiments and ablation experiment,the effectiveness of the proposed co-defense method has been verified. | XIAO Zhiwen FU Xiaowei | 2023 | Journal of Systems Engineering and Electronics2023，34，6： | 0 |
| 8 | Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations显示文摘Uncommon epidermal growth factor receptor(EGFR) mutations account for 10% 20% of all EGFR mutations in non-small-cell lung cancer(NSCLC). The uncommon EGFR-mutated NSCLC is associated with poor clinical outcomes and generally achieved unsatisfactory effects to the current therapies using standard EGFR-tyrosine kinase inhibitors(TKIs), including afatinib and osimertinib. Therefore, it is necessary to develop more novel EGFR-TKIs to treat uncommon EGFR-mutated NSCLC.Aumolertinib is a third-generation EGFR-TKI approved in China for treating advanced NSCLC with common EGFR mutations. However, it remains unclear whether aumolertinib is effective in uncommon EGFR-mutated NSCLC. In this work, the in vitro anticancer activity of aumolertinib was investigated in engineered Ba/F3 cells and patient-derived cells bearing diverse uncommon EGFR mutations. Aumolertinib was shown to be more potent in inhibiting the viability of various uncommon EGFR-mutated cell lines than those with wild-type EGFR. And in vivo, aumolertinib could also significantly inhibit tumor growth in two mouse allograft models(V769-D770insASV and L861Q mutations) and a patientderived xenografts model(H773-V774insNPH mutation). Importantly, aumolertinib exerts responses against tumors in advanced NSCLC patients with uncommon EGFR mutations. These results suggest that aumolertinib has the potential as a promising therapeutic candidate for the treatment of uncommon EGFR-mutated NSCLC. | Chen Shi Cong Zhang Zhiwen Fu Jinmei Liu Yuanfeng Zhou Bao Cheng Cong Wang Shijun Li Yu Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 9 | Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs显示文摘A series of new monobactam sulfonates is continuously synthesized and evaluated for their antimicrobial efficacies against Gram-negative bacteria.Compound 33a(IMBZ18G)is highly effective in vitro and in vivo against clinically intractable multi-drug-resistant(MDR)Gram-negative strains,with a highly druglike nature.The checkerboard assay reveals its significant synergistic effect withβ-lactamase inhibitor avibactam,and the MIC values against MDR enterobacteria were reduced up to 4—512folds.X-ray co-crystal and chemoproteomic assays indicate that the anti-MDR bacteria effect of 33a results from the dual inhibition of the common PBP3 and some class A and Cβ-lactamases.Accordingly,preclinical studies of 33a alone and 33a-avibactam combination as potential innovative candidates are actively going on,in the treatment ofβ-lactamase-producing MDR Gram-negative bacterial infections. | Zhiwen Li Zhihao Guo Xi Lu Xican Ma Xiukun Wang Rui Zhang Xinxin Hu Yanxiang Wang Jing Pang Tianyun Fan Yonghua Liu Sheng Tang Haigen Fu Jingpu Zhang Yinghong Li Xuefu You Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 10 | Copper‑based metal halides for X‑ray and photodetection显示文摘Copper-based metal halides have become important materials in the feld of X-ray and photodetection due to their excellent optical properties,good environmental stability and low toxicity.This review presents the progress of research on crystal structure/morphology,photophysics/optical properties and applications of copper-based metal halides.We also discuss the challenges of copper-based metal halides with a perspective of their future research directions. | Fu Qiu Yutian Lei Zhiwen Jin | 2022 | Frontiers of Optoelectronics2022，15，4： | 0 |
| 11 | Self-frequency-conversion nanowire lasers显示文摘Semiconductor nanowires(NWs)could simultaneously provide gain medium and optical cavity for performing nanoscale lasers with easy integration,ultracompact footprint,and low energy consumption.Here,we report Ⅲ-Ⅴsemiconductor NW lasers can also be used for self-frequency conversion to extend their output wavelengths,as a result of their non-centrosymmetric crystal structure and strongly localized optical field in the NWs.From a GaAs/In0.16Ga0.84As core/shell NW lasing at 1016 nm,an extra visible laser output at 508 nm is obtained via the process of second-harmonic generation,as confirmed by the far-field polarization dependence measurements and numerical modeling.From another NW laser with a larger diameter which supports multiple fundamental lasing wavelengths,multiple self-frequency-conversion lasing modes are observed due to second-harmonic generation and sum-frequency generation.The demonstrated self-frequency conversion of NW lasers opens an avenue for extending the working wavelengths of nanoscale lasers,even to the deep ultraviolet and THz range. | Ruixuan Yi Xutao Zhang Chen Li Bijun Zhao Jing Wang Zhiwen Li Xuetao Gan Li Li Ziyuan Li Fanlu Zhang Liang Fang Naiyin Wang Pingping Chen Wei Lu Lan Fu Jianlin Zhao Hark Hoe Tan Chennupati Jagadish | 2022 | Light(Science & Applications)2022，11，6： | 0 |
| 12 | 全基因组关联研究发现中国人群前列腺癌两个新易感位点9q31.2和19q13.4显示文摘0前言在全球范围内,前列腺癌的发病率和病死率存在着巨大差异。该病在西方发达国家发病率最高,在非裔美国人群病死率最高,而在亚洲人群中发病率及病死率均为全球最低,提示不同人种在前列腺癌的遗传方面存在异质性。在欧美和日本人群中,全基因组关联研究(GWAS)技术已经被用于检测前列腺癌的遗传易感性位点,但至今尚无关于GWAS检测中国人群前列腺癌易感位点的报道。 | Jianfeng Xu Zengnan Mo Dingwei Ye Meilin Wang Fang Liu Guangfu Jin Chuanliang Xu Xiang Wang Qiang Shao Zhiwen Chen Zhihua Tao Jun Qi Fangjian Zhou Zhong Wang Yaowen Fu Dalin He Qiang Wei Jianming Guo Denglong Wu Xin Gao Jianlin Yuan Gongxian Wang Yong Xu Guozeng Wang Haijun Yao Pei Dong Yang Jiao Mo Shen Jin Yang Jun Ou-Yang Haowen Jiang Yao Zhu Shancheng Ren Zhengdong Zhang Changjun Yin Xu Gao Bo Dai Zhibin Hu Yajun Yang Qijun Wu Hongyan Chen Peng Peng Ying Zheng Xiaodong Zheng Yongbing Xiang Jirong Long Jian Gong Rong Na Xiaoling Lin Hongjie Yu Sha Tao Junjie Feng Jishan Sun Wennuan Liu Ann Hsing Jianyu Rao Qiang Ding Fredirik Wiklund Henrik Gronberg Xiao-Ou Shu Wei Zheng Hongbing Shen Li Jin Rong Shi Daru Lu Xuejun Zhang Jielin Sun S Lilly Zheng Yinghao Sun | 2013 | 第二军医大学学报2013，34，4： | 0 |
| 13 | Efficient acetoin production from pyruvate by engineered Halomonas bluephagenesis whole-cell biocatalysis显示文摘Acetoin is an important platform chemical,which has a wide range of applications in many industries.Halomonas bluephagenesis,a chassis for next generation of industrial biotechnology,has advantages of fast growth and high tolerance to organic acid salts and alkaline environment.Here,α-acetolactate synthase andα-acetolactate decarboxylase from Bacillus subtilis 168 were co-expressed in H.bluephagenesis to produce acetoin from pyruvate.After reaction condition optimization and further increase ofα-acetolactate decarboxylase expression,acetoin production and yield were significantly enhanced to 223.4 mmol·L^(-1) and 0.491 mol·mol^(-1) from 125.4 mmol·L^(-1) and 0.333 mol·mol^(-1),respectively.Finally,the highest titer of 974.3 mmol·L^(-1)(85.84 g·L^(-1))of acetoin was accumulated from 2143.4 mmol·L^(-1)(188.6 g·L^(-1))of pyruvic acid within 8 h in fed-batch bioconversion under optimal reaction conditions.Moreover,the reusability of the cell catalysis was also tested,and the result illustrated that the whole-cell catalysis obtained 433.3,440.2,379.0,442.8 and 339.4 mmol·L^(-1)(38.2,38.8,33.4,39.0 and 29.9 g·L^(-1))acetoin in five repeated cycles under the same conditions.This work therefore provided an efficient H.bluephagenesis whole-cell catalysis with a broad development prospect in biosynthesis of acetoin. | Meiyu Zheng Zhenzhen Cui Jing Zhang Jing Fu Zhiwen Wang Tao Chen | 2023 | Frontiers of Chemical Science and Engineering2023，17，4： | 0 |
| 14 | Structures of magnetic null points in reconnection diffusion region:Cluster observations显示文摘Magnetic reconnection is a very important and fundamental plasma process in transferring energy from magnetic field into plasma. Previous theory, numerical simulations and observations mostly concen-trate on 2-dimensional (2D) model; however, magnetic reconnection is a 3-dimensional (3D) nonlinear process in nature. The properties of reconnection in 3D and its associated singular structure have not been resolved completely. Here we investigate the structures and characteristics of null points inside the reconnection diffusion region by introducing the discretized Poincaré index through Gauss integral and using magnetic field data with high resolution from the four satellites of Cluster mission. We esti-mate the velocity and trajectory of null points by calculating its position in different times, and compare and discuss the observations with different reconnection models with null points based on character-istics of electric current around null points. | HU YunHui DENG XiaoHua ZHOU Meng TANG RongXin ZHAO Hui FU Song SU ZhiWen WANG JingFang YUAN ZhiGang R. NAKAMURA W. BAUMJOHANN H. REME C. M. CARR | 2008 | Chinese Science Bulletin2008，53，12： | 0 |
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