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| 1 | Chemical weathering intensity and element migration features of the Xiashu loess profile in Zhenjiang, Jiangsu Province显示文摘在 Zhenjiang 的 Xiashu 黄土侧面的化学捱过紧张和元素迁居特征在这篇论文被学习。(1 ) Xiashu 黄土侧面经历了中等化学捱过。看起来降水是更重要的 | CHEN Yingyong LI Xusheng HAN Zhiyong YANG Shouye WANG Yongbo YANG Dayuan | 2008 | Journal of Geographical Sciences2008，18，3： | 25 |
| 2 | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity显示文摘Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases. | Qin Chen Peiliang Shi Yufang Wang Dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 22 |
| 3 | Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation显示文摘Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the pyroptotic process. Here, we also found MMP collapse and ROS generation induced by Nlrp3 inflammasome activation as previous studies reported. The elimination of ROS alleviated the cleavage of Gsdmd, suggesting that Gsdmd cleavage occurs downstream of ROS release. Consistent with this result, hydrogen peroxide treatment augmented the cleavage of Gsdmd by caspase-1. Indeed, four amino acid residues of Gsdmd were oxidized under oxidative stress in macrophages. The efficiency of Gsdmd cleavage by inflammatory caspase-1 was dramatically reduced when oxidative modification was blocked by mutation of these amino acid residues. These results demonstrate that Gsdmd oxidation serves as a de novo mechanism by which mitochondrial ROS promote Nlrp3 inflammasome-dependent pyroptotic cell death. | Yufang Wang Peiliang Shi Qin Chen Zan Huang Dayuan Zou Jingzi Zhang Xiang Gao Zhaoyu Lin | 2019 | Journal of Molecular Cell Biology2019，11，12： | 23 |
| 4 | Optimal midcourse trajectory cluster generation and trajectory modification for hypersonic interceptions显示文摘The hypersonic interception in near space is a great challenge because of the target's unpredictable trajectory, which demands the interceptors of trajectory cluster coverage of the predicted area and optimal trajectory modification capability aiming at the consistently updating predicted impact point(PIP) in the midcourse phase. A novel midcourse optimal trajectory cluster generation and trajectory modification algorithm is proposed based on the neighboring optimal control theory. Firstly, the midcourse trajectory optimization problem is introduced; the necessary conditions for the optimal control and the transversality constraints are given.Secondly, with the description of the neighboring optimal trajectory existence theory(NOTET), the neighboring optimal control(NOC)algorithm is derived by taking the second order partial derivations with the necessary conditions and transversality conditions. The revised terminal constraints are reversely integrated to the initial time and the perturbations of the co-states are further expressed with the states deviations and terminal constraints modifications.Thirdly, the simulations of two different scenarios are carried out and the results prove the effectiveness and optimality of the proposed method. | Humin Lei Jin Zhou Dailiang Zhai Lei Shao Dayuan Zhang | 2017 | Journal of Systems Engineering and Electronics2017，28，6： | 10 |
| 5 | Optimal midcourse trajectory planning considering the capture region显示文摘An optimal midcourse trajectory planning approach that considers the capture region(CR) of the terminal guidance is proposed in this article based on the Gauss pseudospectral method(GPM). Firstly, the planar CR of the proportional navigation in terminal guidance is analyzed and innovatively introduced in the midcourse trajectory planning problems, with the collision triangle(CT) serving as the ideal terminal states parameters of the midcourse phase, and the CR area serving as the robustness against target maneuvers. Secondly, the midcourse trajectory planning problem that considers the path, terminal and control constraints is formulated and the well-developed GPM is used to generate the nominal trajectory that meets the CR demands. The interceptor will reshape the trajectory only when the former CR fails to cover the target, which has loosened the critical demand for frequent trajectory modification. Finally, the simulations of four different scenarios are carried out and the results prove the effectiveness and optimality of the proposed method. | ZHOU Jin SHAO Lei WANG Huaji ZHANG Dayuan LEI Humin | 2018 | Journal of Systems Engineering and Electronics2018，29，3： | 6 |
| 6 | Roles of MAP kinase signaling pathway in oocyte meiosis显示文摘Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases expressed widely in eu-karyotic cells. MAPK is activated by a cascade of protein kinase phosphorylation and plays pivotal roles in regulating meiosis process in oocytes. As an important physical substrate of MAPK, p90rsk mediates numerous MAPK functions. MAPK was activated at G2/M transition during meiosis. Its activity reached the peak at M I stage and maintained at this level until the time before the pronuclear formation after fertilization. There is complex interplay between MAPK and MPF in the meiosis regulation. Furthermore, other intracel-lular signal transducers, such as cAMP, protein kinase C and protein phosphotase, ect., also regulated the activity of MAPK at different stages during meiosis in oocytes. In the present article, the roles of MAPK signaling pathway in oo-cyte meiosis are reviewed and discussed. | Hengyu Fan Chao Tong Dayuan Chen Qingyuan Sun | 2002 | Chinese Science Bulletin2002，47，14： | 5 |
| 7 | Ecological Restoration and Traditional Knowledge Preservation through Eco-cultural Tourism Development:Case Study from Baimaxueshan Nature Reserve Area显示文摘1 Introduction This paper relates the experience of simultaneously implementing a community-based grassland recovery project and developing eco-cultural tourism nearby a high alpine nature reserve in Southwestern China.It illustrates a development model where ecosystem restoration and preservation of traditional knowledge are merged in a tourism development project intended to address already existing ecological degradation,deterioration and loss of cultural heritage and traditional knowledge,as well as to alleviate poverty. | LIU Chunhui YIN Lun Karlis ROKPELNIS XUE Dayuan | 2012 | Journal of Resources and Ecology2012，3，3： | 3 |
| 8 | Genomic footprints of Kam Sweet Rice domestication indicate possible migration routes of theDongpeople inChina andprovide resources for future rice breeding显示文摘The Dong people are one of China’s 55 recognized ethnic minorities,but there has been a long-standing debate about their origins.In this study,we performed whole-genome resequencing of Kam Sweet Rice(KSR),a valuable,rare,and ancient rice landrace unique to the Dong people.Through comparative genomic analyses of KSR and other rice landraces from south of the Yangtze River Basin in China,we provide evidence that the ancestors of the Dong people likely originated from the southeast coast of China at least 1000 years ago.Alien introgression and admixture in KSR demonstrated multiple migration events in the history of the Dong people.Genomic footprints of domestication demonstrated characteristics of KSR that arose from artificial selection and geographical adaptation by the Dong people.The key genes GS3,Hd1,and DPS1(related to agronomic traits)and LTG1 and MYBS3(related to cold tolerance)were identified as domestication targets,reflecting crop improvement and changes in the geographical environment of the Dong people during migration.A genome-wide association study revealed a candidate yield-associated gene,Os01g0923300,a specific haplotype in KSR that is important for regulating grain number per panicle.RNA-sequencing and quantitative reverse transcription-PCR results showed that this gene was more highly expressed in KSR than in ancestral populations,indicating that it may have great value in increasing yield potential in other rice accessions.In summary,our work develops a novel approach for studying human civilization and migration patterns and provides valuable genomic datasets and resources for future breeding of high-yield and climate-resilient rice varieties. | Chunhui Liu Tianyi Wang Huicha Chen Xiaoding Ma Chengzhi Jiao Di Cui Bing Han Xiaobing Li Aixia Jiao Renchao Ruan Dayuan Xue Yanjie Wang Longzhi Han | 2023 | Molecular Plant2023，16，2： | 3 |
| 9 | Microsatellite DNA analysis proves nucleus of interspecies reconstructed blastocyst coming from that of donor giant panda显示文摘A method for DNA isolation from early development of blastocyst and further analysis of nuclear and mitochondrial DNA was developed in present study. Total DNA was prepared from interspecies reconstructed blastocyst and a giant panda specific microsatellite locus g010 was successfully amplified. DNA sequencing of the PCR product showed that two sequences of reconstructed blastocysts are the same as that of positive control giant panda. Our results prove that the nucleus of interspecies reconstructed blastocyst comes from somatic nucleus of donor giant panda. | DING Bo SHI Peng XIANGYU Jinggong ZHANG Yaping CHEN Dayuan SUN Qingyuan LI Guangpeng WANG Minkang LIU Yilong KANG Li HAN Zhiming SONG Xiangfen LI Jingsong CHEN Yuchun | 2000 | Chinese Science Bulletin2000，45，20： | 3 |
| 10 | Hypertrophic cardiomyopathy: Can the noninvasive diagnostic testing identify high risk patients?显示文摘Hypertrophic cardiomyopathy(HCM) is the most common cause of sudden cardiac death(SCD) in the young, particularly among athletes. Identifying high risk individuals is very important for SCD prevention. The purpose of this review is to stress that noninvasive diagnostic testing is important for risk assessment. Extreme left ventricular hypertrophy and documented ventricular tachycardia and fibrillation increase the risk of SCD. Fragmented QRS and T wave inversion in multiple leads are more common in high risk patients. Cardiac magnetic resonance imaging provides complete visualization of the left ventricular chamber, allowing precise localization of the distribution of hypertrophy and measurement of wall thickness and cardiac mass. Moreover, with late gadolinium enhancement, patchy myocardial fibrosis within the area of hypertrophy can be detected, which is also helpful in risk stratification. Genetic testing is encouraged in all cases, especially in those with a family history of HCM and SCD. | Li Zhang Obinna Mmagu Liwen Liu Dayuan Li Yuxin Fan Adrian Baranchuk Peter R Kowey | 2014 | World Journal of Cardiology2014，6，8： | 3 |
| 11 | Relationship between Chief Executive Officer characteristics and corporate environmental information disclosure in Thailand显示文摘This study focuses on the influence of Chief Executive Officer(CEO)characteristics on environmental information disclosure(EID)in the annual reports of companies listed on the Stock Exchange of Thailand.A regression analysis method is used to explore the relationship between CEO characteristics and corporate environmental disclosure.Pollution-intensive companies are taken as the samples in this study.Results show that financial expertise,educational level,and tenure of CEOs are positively correlated with corporate EID.By contrast,age or gender of CEOs is insignificantly related to EID. | Dayuan LI Aiqi LIN Lu ZHANG | 2019 | Frontiers of Engineering Management2019，6，4： | 3 |
| 12 | Effects of ubiquitin-protea-some pathway on mouse sperm capacitation, acrosome reaction and in vitro fertilization显示文摘Chlortetracycline (CTC) fluorescence patterns were used to study changes in the patterns B and AR of mouse sperm after incubation with reagents that would block the UPP. They were the monoclonal antibody againstubiquitinated proteins——UCPi; the polyclonal antibodyagainst ubiquitin-anti-Ub, and a special inhibitor againstproteasome——ALLN. Furthermore, we treated the capaci-tated sperm or the eggs with these reagents separately and tested whether the normal in vitro fertilization was blocked or not. Results illustrate that UCP1, anti-Ub, and ALLN have little effects on sperm capacitation and acrosome reaction, but they do inhibit fusion of mouse sperm with eggs, which suggests that UPP play an important role in mouse in vitro fertilization. | WANG Hongmei SONG Changcheng DUAN Chongwen SHI Weixian LI Cunxi CHEN Dayuan WANG Yongchao | 2002 | Chinese Science Bulletin2002，47，2： | 2 |
| 13 | Serial nuclear transfer improves the development of interspecies reconstructed giant panda (Aluropoda melanoleucd) embryos显示文摘Interspecies somatic nuclear transfer (NT) may provide a new approach for preservation of the endangered rare species. Previous interspecies cloning studies have shown that a nucleus from a quiescent somatic cell supports early development of reconstructed embryos in the ooplasm from another species. In this study, we transferred nonqui-escent somatic cells from a giant panda into the perivitelline space of the enucleated rabbit oocytes. After electrofusion (at the rate of 71.6%) and electrical activation, 4.2% of the panda-rabbit reconstructed embryos developed to blastocyst in vitro. For improving the development rate of reconstructed embryos, we used serial NT in this study, i.e. blas-tomeres from reconstructed morulae were transferred into the perivitelline space of the enucleated rabbit oocytes. The fusion rates in the groups of serial I, serial Ⅱ and serial Ⅲ were 79.5%, 84.1% and 78.0%, respectively, having no difference with that of somatic group. And the blastocyst rates in serial NT groups | LI Jinsong CHEN Dayuan HAN Zhiming ZHU Ziyu WEN Duancheng SUN Qingyuan LIU Zhonghua WANG Minkang LIAN Li DU Jun WANG Pengyan ZHANG Hemin | 2002 | Chinese Science Bulletin2002，47，6： | 2 |
| 14 | Modulation of constitutive nitric oxide synthase, Bcl - 2 and Fas expression in cultured human voronary endothelial cells exposed to anoxia - reoxygenation and angiotensin II : role of AT1 receptor activation显示文摘 | Dayuan Li Kathleen Tomson | 1999 | Cardiovascular Research1999，41，： | 1 |
| 15 | Advances in interspecific pregnancy显示文摘Interspecific pregnancy in which the conceptus and female carrying the pregnancy are of different species is a key step to interspecific cloning. Cloning endangered animals by interspecific pregnancy is such a highlight catching people’s eyes nowadays. In this article, the history of interspecific pregnancy, the methods for establishment of interspecific pregnancy, the corresponding theories, barriers and applied prospects are reviewed. | Xichao Wang Bojie Dai Enkui Duan Dayuan Chen | 2001 | Chinese Science Bulletin2001，46，21： | 1 |
| 16 | Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming显示文摘Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative diseases.However,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains unavailable.Here,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded proteins.Nanoformulation ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model mice.These findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases. | Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu Minjun Xu Qingxiang Song Huahua Song Gan Jiang Zaiming Tang Xiaoling Gao Hongzhuan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 17 | LOX-1,an oxidized LDL endothelial receptor,induces CD40/CD40L signaling in human coronary artery endothelial cells显示文摘 | Dayuan Li Ling Liu Hongjiang Chen Tatsuya Sawamura Mehta JL | 2003 | Arterioscler Thromb Vasc Biol2003，23，： | 1 |
| 18 | Role of Caspases in Ox-LDL–Induced Apoptotic Cascade in Human Coronary Artery Endothelial Cells显示文摘 | Jiawei Chen Jawahar L. Mehta Nezam Haider Xingjian Zhang Jagat Narula Dayuan Li | 2004 | Circulation Research: Journal of the American Heart Association2004，，3： | 1 |
| 19 | Sedimentary records of large Holocene flo-ods from the middle reaches of the Yellow River, China显示文摘 | | 2000 | Geomorphology2000，33，： | 1 |
| 20 | Sedimentary records of large Holocene floods from the middle reaches of the Yellow River, China显示文摘 | Yang Dayuan Yu Ge Xie Yuebo | 2000 | Geomorphology2000，33，12： | 1 |
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