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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | A family study of obsessive-compulsive disorder 显示文摘 | Paul DL Alsobrook JP Goodman W | 1995 | Am J Psychiatry1995，152，1： | 1 |
| 3 | Radiotherapy for Liver Metastases: A Review of Evidence显示文摘 | Morten H?yer Anand Swaminath Sean Bydder Michael Lock Alejandra Méndez Romero Brian Kavanagh Karyn A. Goodman Paul Okunieff Laura A. Dawson | 2012 | International Journal of Radiation Oncology Biology Physics2012，，3： | 1 |
| 4 | Geographies of food: ’Afters’显示文摘 | Cook Ian Hobson Kersty Hallett Lucius Guthman Julie Murphy Andrew Hulme Alison Sheller Mimi Crewe Louise Nally David Roe Emma Mather Charles Kingsbury Paul Slocum Rachel Imai Shoko Duruz Jean Philo Chris Buller Henry Goodman Mike Hayes-C | 2011 | Progress in Human Geography2011，，1： | 1 |
| 5 | The 'Core' of the Workout Should Be on the Ball 显示文摘 | Goodman Paul | 2003 | NACA''s Performance training Journal2003，2，5： | 1 |
| 6 | Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls显示文摘 | Darren R. Brenner Paul Brennan Paolo Boffetta Christopher I. Amos Margaret R. Spitz Chu Chen Gary Goodman Joachim Heinrich Heike Bickeb?ller Albert Rosenberger Angela Risch Thomas Muley John R. McLaughlin Simone Benhamou Christine Bouchardy Juan Pablo Lew | 2013 | Human Genetics2013，，： | 1 |
| 7 | The determinants of commitment in the distributor-manufacturer relationship显示文摘 | Leaster E1 Goodman Paul A1 Dion | 2001 | Industrial Marketing Management2001，30，： | 1 |
| 8 | A family study of Obsessive-Compulsive Disorder显示文摘 | Pauls DL Alsobrook JP Goodman W | 1995 | Am J Psychiatry1995，152，： | 1 |
| 9 | Diagnosis of Pulmonary Embolism in the Coronary Care Unit显示文摘 | Paul D. Stein H. Dirk Sostman Russell D. Hull Lawrence R. Goodman Kenneth V. Leeper Alexander Gottschalk Victor F. Tapson Pamela K. Woodard | 2009 | The American Journal of Cardiology2009，，6： | 1 |
| 10 | Connecting the corc显示文摘 | Paul J Goodman | 2004 | NSCA''S Performance Training Journal2004，，6： | 1 |
| 11 | Clinical Characteristics of Patients with Acute Pulmonary Embolism: Data from PIOPED II显示文摘 | Paul D. Stein Afzal Beemath Fadi Matta John G. Weg Roger D. Yusen Charles A. Hales Russell D. Hull Kenneth V. Leeper H. Dirk Sostman Victor F. Tapson John D. Buckley Alexander Gottschalk Lawrence R. Goodman Thomas W. Wakefied Pamela K. Woodard | 2007 | The American Journal of Medicine2007，，10： | 1 |
| 12 | Entecavir for Treatment of Lamivudine-Refractory, HBeAg-Positive Chronic Hepatitis B显示文摘 | Morris Sherman Cihan Yurdaydin Jose Sollano Marcelo Silva Yun–Fan Liaw Janusz Cianciara Anna Boron–Kaczmarska Paul Martin Zachary Goodman Richard Colonno Anne Cross Gail Denisky Bruce Kreter Robert Hindes | 2006 | Gastroenterology2006，，7： | 1 |
| 13 | Has the ClOpidogrel and Metoprolol in Myocardial Infarction Trial (COMMIT) of early β-blocker use in acute coronary syndromes impacted on clinical practice in Canada? Insights from the Global Registry of Acute Coronary Events (GRACE)显示文摘 | Jeremy Edwards Shaun G. Goodman Raymond T. Yan Robert C. Welsh Jan M. Kornder J. Paul DeYoung Denis Chauret Jean-Pierre Picard Kim A. Eagle Andrew T. Yan | 2011 | American Heart Journal2011，，： | 1 |
| 14 | Connecting the Core显示文摘 | Paul J Goodman | 2004 | NACA''s Perfor- mance Training Journal2004，3，6： | 1 |
| 15 | Predictive Value of Callous-Unemotional Traits in a Large Community Sample显示文摘 | Paul Moran Richard Rowe Clare Flach Jacqueline Briskman Tamsin Ford Barbara Maughan Stephen Scott Robert Goodman | 2009 | Journal of the American Academy of Child & Adolescent Psychiatry2009，，11： | 1 |
| 16 | Connecting the Core 显示文摘 | Paul J Goodman | 2004 | NACA''s Pefor- mance Training Journal2004，3，6： | 1 |
| 17 | Creating effective University-industry alliances: An organizational learning perspective显示文摘 | Richard M. Cyert Paul S. Goodman | 1996 | Organizational Dynamics1996，，4： | 1 |
| 18 | The ' Core' Of The Workout Should Be On The Ball 显示文摘 | Paul J Goodman M S | 2003 | NACA'' s Performance Training Journal2003，2，5： | 1 |
| 19 | Monitoring systemic donor lymphocyte macrochimerism to aid the diagnosis of graftversus-host disease after liver transplantation显示文摘 | Anna L. Taylor Paul Gibbs Surendran Sudhindran Tim Key Reyna S. Goodman C. Helen Morgan Christopher J. E. Watson Luc Delriviere Graeme J. Alexander Neville V. Jamieson J. Andrew Bradley Craig J. Taylor | 2004 | Transplantation2004，，3： | 1 |
| 20 | Connecting the Core显示文摘 | Paul J Goodman | | 0，，06： | 1 |
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