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16篇 您的检索式:作者名="Guangyi Wei"
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1Application of ultra-sonication, acid precipitation and membrane filtration for co-recovery of protein and humic acid from sewage sludge显示文摘一个新奇方法被用于共同恢复从为液体化肥和动物的除去的污水污泥的蛋白质和腐殖的酸喂。在污水污泥的蛋白质首先用 ultrasonication 和酸降水的过程被提取,然后腐殖的酸经由膜过滤被恢复。抽取效率是 125.9 mg 腐殖的酸 ???????????????????????? 卓吗?Liangliang WEI Kun WANG Xiangjuan KONG Guangyi LIU Shuang CUI Qingliang ZHAO Fuyi CUI 2016Frontiers of Environmental Science & Engineering2016,10,2:9
2Super-resolution fluorescence-assisted diffraction computational tomography reveals the threedimensional landscape of the cellular organelle interactome显示文摘The emergence of super-resolution(SR)fluorescence microscopy has rejuvenated the search for new cellular substructures.However,SR fluorescence microscopy achieves high contrast at the expense of a holistic view of the interacting partners and surrounding environment.Thus,we developed SR fluorescence-assisted diffraction computational tomography(SR-FACT),which combines label-free three-dimensional optical diffraction tomography(ODT)with two-dimensional fluorescence Hessian structured illumination microscopy.The ODT module is capable of resolving the mitochondria,lipid droplets,the nuclear membrane,chromosomes,the tubular endoplasmic reticulum,and lysosomes.Using dual-mode correlated live-cell imaging for a prolonged period of time,we observed novel subcellular structures named dark-vacuole bodies,the majority of which originate from densely populated perinuclear regions,and intensively interact with organelles such as the mitochondria and the nuclear membrane before ultimately collapsing into the plasma membrane.This work demonstrates the unique capabilities of SR-FACT,which suggests its wide applicability in cell biology in general.Dashan Dong Xiaoshuai Huang Liuju Li Heng Mao Yanquan Mo Guangyi Zhang Zhe Zhang Jiayu Shen Wei Liu Zeming Wu Guanghui Liu Yanmei Liu Hong Yang Qihuang Gong Kebin Shi Liangyi Chen 2020Light(Science & Applications)2020,9,1:7
3Processes of coastal ecosystem carbon sequestration and approaches for increasing carbon sink显示文摘The oceans are the largest carbon pools on Earth, and play the role of a 'buffer' in climate change. Blue carbon, the carbon(mainly organic carbon) captured by marine ecosystems, is one of the important mechanisms of marine carbon storage.Blue carbon was initially recognized only in the form of visible coastal plant carbon sequestration. In fact, microorganisms(phytoplankton, bacteria, archaea, viruses, and protozoa), which did not receive much attention in the past, account for more than 90% of the total marine biomass and are the main contributors to blue carbon. Chinese coastal seas, equivalent to 1/3 of China's total land area, have a huge carbon sink potential needing urgently research and development. In this paper, we focus on the processes and mechanisms of coastal ocean's carbon sequestration and the approaches for increasing that sequestration. We discuss the structures of coastal ecosystems, the processes of carbon cycle, and the mechanisms of carbon sequestration. Using the evolution of coastal ocean's carbon sinks in sedimentary records over geologic times, we also discuss the possible effects of natural processes and anthropogenic activities on marine carbon sinks. Finally, we discuss the prospect of using carbon sequestration engineering for increasing coastal ocean's carbon storage capacity.ZHANG Yao ZHAO MeiXun CUI Qiu FAN Wei QI JiaGuo CHEN Ying ZHANG YongYu GAO KunShan FAN JingFeng WANG GuangYi YAN ChongLing LU HaoLiang LUO YaWei ZHANG ZiLian ZHENG Qiang XIAO Wei JIAO NianZhi 2017Science China Earth Sciences2017,60,5:6
4Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies.Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li 2020Cell Research2020,30,5:4
5Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis显示文摘Dear Editor,The axolotl,Ambystoma mexicanum,has extraordinary capability to fully recover multiple tissues after lost,whereas such capability has disappeared in mammals.Thus,deci-phering detailed mechanisms underlying axolotl regenera-tion could provide valuable lessons for regenerative medicine.However,many questions,such as the origin of essential progenitor cells and key responses of individual types of cells for regeneration remain elusive(Haas and Whited,2017).Newly developed single-cell RNA sequenc-ing(scRNA-seq)method enables researchers to observe cellular and molecular dynamics in axolotl regeneration at the single-cell resolution(Gerber et al.,2018;Leigh et al.,2018),but the reported transcriptome landscapes are only for certain cell types or in certain regenerative stages.A complete overview of the regeneration process for all cell types is still lacking.Hanbo Li Xiaoyu Wei Li Zhou Weiqi Zhang Chen Wang Yang Guo Denghui Li Jjianyang Chen Tianbin Liu Yingying Zhang Shuai Ma Congyan Wang Fujian Tan Jiangshan Xu Yang Liu Yue Yuan Liang Chen Qiaoran Wang Jing Qu Yue Shen Shanshan Liu Guangyi Fan Longqi Liu Xin Liu Yong Hou Guang-Hui Liu Ying Gu Xun Xu 2021Protein & Cell2021,12,1:3
6The Marine Redox Change and Nitrogen Cycle in the Early Cryogenian Interglacial Time: Evidence from Nitrogen Isotopes and Mo Contents of the Basal Datangpo Formation, Northeastern Guizhou, South China显示文摘Cryogenian Datangpo Formation was deposited during the interglacial time between the Sturtian and Marinoan ice ages. We studied nitrogen isotope compositions and contents of Mo of the black shales from the basal Datangpo Formation in northeastern Guizhou, South China, for an attempt to reconstruct the marine redox change and nitrogen cycle during the interglacial time. Based on lithostratigraphy as well as geochemical profiles, the basal black shales can be divided into four intervals: Interval 1 has the lowest δ^(15)N value(+5.0‰); in interval 2, δ^(15)N values vary between +6.4‰ and +7.4‰(the first peak); interval 3 records stable values of δ^(15)N around +6‰; and interval 4 is characterized by its higher δ^(15)N values, between +6.7‰ and +7.8‰(the second peak). The values of enrichment factor of Mo decrease from 56.8 to 2.6 with the ascending stratigraphic trend. It indicated that immediately after the Sturtian glaciations, the marine seawater above the transitional zone between the shelf to slope of the southern margin of the Yangtze Platform was stratified, with shallow seawater being oxic but deep water being sulfidic. Subsequently, high denitrification rates prevailed in expanded suboxic areas in spite of a short emergence of an oxic condition in the surface seawater, and the deep seawaters were still anoxic or even euxinic.Wei Wei Dan Wang Da Li Hongfei Ling Xi Chen Guangyi Wei Feifei Zhang Xiangkun Zhu Bin Yan 2016Journal of Earth Science2016,27,2:3
7A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration显示文摘Osteoporosis is one of the most disabling consequences of aging,osteoporotic fractures and higher risk of the subsequent fractures leading to substantial disability and deaths,indicating both local fractures healing and the early anti-osteoporosis therapy are of great significance.Teriparatide is strong bone formation promoter effective in treating osteoporosis,while side effects limit clinical applications.Traditional drug delivery is lack of sensitive and short-term release,finding a new non-invasive and easily controllable drug delivery to not only repair the local fractures but also improve total bone mass has remained a great challenge.Thus,bioinspired by the natural bone components,we develop appropriate interactions between inorganic biological scaffolds and organic drug molecules,achieving both loaded with the teriparatide in the scaffold and capable of releasing on demand.Herein,biomimetic bone microstructure of mesoporous bioglass,a near-infrared ray triggered switch,thermosensitive liposomes based on a valve,and polydopamine coated as a heater is developed rationally for osteoporotic bone regeneration.Teriparatide is pulsatile released from intelligent delivery,not only rejuvenating osteoporotic bone defect,but also presenting strong systemic anti-osteoporosis therapy.This biomimetic bone carrying novel drug delivery platform is well worth expecting to be a new promising strategy and clinically commercialized to help patients survive from the osteoporotic fracture.Lingbin Che Ying Wang Dongyong Sha Guangyi Li Ziheng Wei Changsheng Liu Yuan Yuan Dianwen Song 2023Bioactive Materials2023,,1:3
8Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas.Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang 2022Protein & Cell2022,13,7:2
9Graph Computing Based Security Constrained Unit Commitment in Hydro-thermal Power Systems Incorporating Pumped Hydro Storage显示文摘This paper proposes a graph computing based mixed integer programming(MIP)framework for solving the security constrained unit commitment(SCUC)problem in hydro-thermal power systems incorporating pumped hydro storage(PHS).The proposed graph computing-based MIP framework considers the economic operations of thermal units,cascade hydropower stations and PHS stations,as well as their technical impacts towards the network security.First,the hydro-thermal power system data and unit information are stored in a graph structure with nodes and edges,which enables nodal and hierarchical parallel computing for the unit commitment(UC)solution calculation and network security analysis.A MIP model is then formulated to solve the SCUC problem with the mathematical models of thermal units,cascade hydropower stations and PHS stations.In addition,two optimization approaches including convex hull reformulation(CHR)and special ordered set(SOS)methods are introduced for speeding up the MIP calculation procedure.To ensure the system stability under the derived UC solution,a parallelized graph power flow(PGPF)algorithm is proposed for the hydro-thermal power system network security analysis.Finally,case studies of the IEEE 118-bus system and a practical 2749-bus hydro-thermal power system are introduced to demonstrate the feasibility and validity of the proposed graph computing-based MIP framework.Longfei Wei Guangyi Liu Shen Yan Renchang Dai Yachen Tang 2021CSEE Journal of Power and Energy Systems2021,7,3:2
10Graph Computing Based Distributed Parallel Power Flow for AC/DC Systems with Improved Initial Estimate显示文摘The sequential method is easy to integrate with existing large-scale alternating current(AC)power flow solvers and is therefore a common approach for solving the power flow of AC/direct current(DC)hybrid systems.In this paper,a highperformance graph computing based distributed parallel implementation of the sequential method with an improved initial estimate approach for hybrid AC/DC systems is developed.The proposed approach is capable of speeding up the entire computation process without compromising the accuracy of result.First,the AC/DC network is intuitively represented by a graph and stored in a graph database(GDB)to expedite data processing.Considering the interconnection of AC grids via high-voltage direct current(HVDC)links,the network is subsequently partitioned into independent areas which are naturally fit for distributed power flow analysis.For each area,the fast-decoupled power flow(FDPF)is employed with node-based parallel computing(NPC)and hierarchical parallel computing(HPC)to quickly identify system states.Furthermore,to reduce the alternate iterations in the sequential method,a new decoupled approach is utilized to achieve a good initial estimate for the Newton-Raphson method.With the improved initial estimate,the sequential method can converge in fewer iterations.Consequently,the proposed approach allows for significant reduction in computing time and is able to meet the requirement of the real-time analysis platform for power system.The performance is verified on standard IEEE 300-bus system,extended large-scale systems,and a practical 11119-bus system in China.Wei Feng Chen Yuan Qingxin Shi Renchang Dai Guangyi Liu Zhiwei Wang Fangxing Li 2021Journal of Modern Power Systems and Clean Energy2021,9,2:2
11Experimental study on improving collapsible loess with cement显示文摘The collapsibility of loess ground can directly affect stability of subgrade. Therefore, how to adopt practical technical measures to reduce or eliminate its collapse deformation is an important content in foundation design in collapsible loess zone. Selecting collapsible loess from Fuxin-Chaoyang highway in Liaoning, the authors conducted a series of tests for improving loess with cement. The loess in different water content was mixed with the cement in varying proportions, unconfined compression strength for the samples at four different curing periods were tested, and the relationships of improved soil strength among cement mixture ratio and curing periods were analyzed. When the curing periods are certain, the strength of loess increases along with the mixture ratio increases; when the cement mixture ratio is 5%-15%, the scope of increases is quite obvious; when the mixture ratio is greater than 15%, the tendency of intensity increases turns slow. When the mixture ratio for the specimen is certain, the intensity of the test specimen increases along with the curing period increases, the intensity grows obviously in 28 days, and the growth rate is small in 28-90 days, the intensity tends to be steady in the curing period of 90 days.SHAN Bo WANG Changming DONG Quanyang TANG Ling ZHANG Guangyi WEI Jiaming 2010Global Geology2010,13,2:2
12Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai 2020Engineering2020,6,11:1
13Threshold-Based Adaptive Gaussian Mixture Model Integration(TA-GMMI)Algorithm for Mapping Snow Cover in Mountainous Terrain显示文摘Snow cover is an important parameter in the fields of computer modeling,engineering technology and energy development.With the extensive growth of novel hardware and software compositions creating smart,cyber physical systems’(CPS)efficient end-to-end workflows.In order to provide accurate snow detection results for the CPS’s terminal,this paper proposed a snow cover detection algorithm based on the unsupervised Gaussian mixture model(GMM)for the FY-4A satellite data.At present,most snow cover detection algorithms mainly utilize the characteristics of the optical spectrum,which is based on the normalized difference snow index(NDSI)with thresholds in different wavebands.These algorithms require a large amount of manually labeled data for statistical analysis to obtain the appropriate thresholds for the study area.Consideration must be given to both the high and low elevations in the study area.It is difficult to extract all snow by a fixed threshold in mountainous and rugged terrains.In this research,we avoid relying on a manual analysis for different elevations.Therefore,an algorithm based on the GMM is proposed,integrating the threshold-based algorithm and the GMM.First,the threshold-based algorithm with transferred thresholds from other satellites’analysis results are used to coarsely classify the surface objects.These results are then used to initialize the parameters of the GMM.Finally,the parameters of that model are updated by an expectation-maximum(EM)iteration algorithm,and the final results are outputted when the iterative conditions end.The results show that this algorithm can adjust itself to mountainous terrain with different elevations,and exhibits a better performance than the threshold-based algorithm.Compared with orbit satellites’snow products,the accuracy of the algorithm used for FY-4A is improved by nearly 2%,and the snow detection rate is increased by nearly 6%.Moreover,compared with microwave sensors’snow products,the accuracy is increased by nearly 3%.The validation results show that the proposed algorithm can be adapted to a complex terrain environment in mountainous areas and exhibits good performance under a transferred threshold without manually assigned labels.Yonghong Zhang Guangyi Ma Wei Tian Jiangeng Wang Shiwei Chen 2020Computer Modeling in Engineering & Sciences2020,,9:0
14The complete and fully-phased diploid genome of a male Han Chinese显示文摘Since the release of the complete human genome,the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity.Here,we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual(CN1),in which the assemblies of both haploids achieve the telomere-to-telomere(T2T)level.Comparison of this diploid genome with the CHM13 haploid T2T genome revealed significant variations in the centromere.Outside the centromere,we discovered 11,413 structural variations,including numerous novel ones.We also detected thousands of CN1 alleles that have accumulated high substitution rates and a few that have been under positive selection in the East Asian population.Further,we found that CN1 outperforms CHM13 as a reference genome in mapping and variant calling for the East Asian population owing to the distinct structural variants of the two references.Comparison of SNP calling for a large cohort of 8869 Chinese genomes using CN1 and CHM13 as reference respectively showed that the reference bias profoundly impacts rare SNP calling,with nearly 2 million rare SNPs miss-called with different reference genomes.Finally,applying the CN1 as a reference,we discovered 5.80 Mb and 4.21 Mb putative introgression sequences from Neanderthal and Denisovan,respectively,including many East Asian specific ones undetected using CHM13 as the reference.Our analyses reveal the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies.This complete genome will serve as an alternative reference for future genomic studies on the East Asian population.Chentao Yang Yang Zhou Yanni Song Dongya Wu Yan Zeng Lei Nie Panhong Liu Shilong Zhang Guangji Chen Jinjin Xu Hongling Zhou Long Zhou Xiaobo Qian Chenlu Liu Shangjin Tan Chengran Zhou Wei Dai Mengyang Xu Yanwei Qi Xiaobo Wang Lidong Guo Guangyi Fan Aijun Wang Yuan Deng Yong Zhang Jiazheng Jin Yunqiu He Chunxue Guo Guoji Guo Qing Zhou Xun Xu Huanming Yang Jian Wang Shuhua Xu Yafei Mao Xin Jin Jue Ruan Guojie Zhang 2023Cell Research2023,33,10:0
15Understanding the excretion rates of methylmercury and inorganic mercury from human body via hair and fingernails显示文摘Effective biomarkers are necessary to better understand the human mercury(Hg) exposure levels. However, mismatched biomarker sampling method causes extra uncertainty in assessing the risk of Hg exposure. To compare the differences between hair and fingernail, and further understand the excretion rates of methylmercury(MeHg) and inorganic mercury(IHg) via hair and fingernails, the total mercury(THg), Me Hg, and IHg concentrations in paired hair and fingernail samples were investigated through paired samples collected from two typical mining areas, Wanshan mercury mine area(WMMA) and Hezhang zinc smelting area(HZSA). The positive correlation in THg, MeHg, and IHg concentrations( p < 0.01) between hair and fingernail samples indicated that those two biomarkers can be corrected in application of assessing human Hg exposure. Compared to fingernails, the hair was suggested to be a more sensitive biomarker as the concentration of THg, MeHg and IHg were 2~4 times higher than those in fingernails. Furthermore, the amounts of THg, MeHg, and IHg excreted via hair were 70~226 times higher than that excreted via fingernails, and the hair plays a more important role than fingernails in the excretion of Hg from human bodies. Present study therefore provides some new insights to better understand the fate of human assimilated Hg.Wei Zhang Fen Li Lingjian Gao Guangyi Sun Zikang Cui Fengfeng Chen Ping Li Xinbin Feng Lihai Shang 2022Journal of Environmental Sciences2022,34,9:0
16Distribution and Sources of Polycyclic Aromatic Hydrocarbons(PAHs) in Meizhou Bay Sewage Outfall and the Surrounding Ocean Area显示文摘To further clarify the distribution mechanism of polycyclic aromatic hydrocarbons (PAHs) which cause damage to human and ecosystem health,the differences between 15 kinds of PAHs in Meizhou Bay coastal zones in terms of the concentration,spatial distribution and sources,especially the ocean area around drainage outlets of sewage treatment plants,were fully investigated.The results indicated that the total concentration of 15 kinds of PAHs at each sampling station ranged from 27.2 to 774.2 ng/L.PAHs in Meizhou Bay coastal zones decreased as follows:4-ring>3-ring>5-ring>6-ring.As for the ∑PAHs,the concentration increased from the reference ocean area,affected ocean area to the mixed ocean area.Furthermore,the concentration of PAHs in the bottom area was obviously larger than that in the surface layer,indicating that the concentration of PAHs with various rings varied significantly in different ocean areas.The concentration of ∑PAHs had no significant correlation with water quality parameters such as temperature,salinity,pH and so on.In addition,PAHs in the mixed ocean area derived from fossil fuel,while PAHs in the affected ocean area and reference ocean area were mainly from fossil fuel and oil.Zheng Chongrong Liu Baoqing Wu Huikai Yang Fan Yao Rui Jiang Hao Li Guangyi Wang Wei 2019Meteorological and Environmental Research2019,10,3:0
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