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| 1 | TRANSPORT OF THE SUSPENDED SEDIMENT IN THE CHANGJIANG ESTUARY显示文摘The Changjiang River is characterized by the enormous volume of runoff and the great amount of sediment load with remarkable seasonal variation. The annual runoff sometimes is respondent to the amount of sediment load, and sometimes not. The amount of monthly sediment load after the month of the maximum runoff is larger than those before the month. The sediment concentration and net quantity of sediment transport in the vicinity of the river mouth varies greatly in time between the ebb and flood, spring and neap, and dry seasons and flood seasons. The three bifurcations also have differences in concentration and net quantity in space. Even in the same bifurcation they have differences in and out of the sand bar. At present, the North Channel is the main passage for water and sediment load emptying into the sea from the Changjiang River. More than 50 percent of the sediments from the river basin are deposited nearby the South Branch entrance and the main depositional area is situated in subaqueous delta off the South Channel. Between 122°30’E and 123°E is an important boundary for eastward sediment dispersion from which the suspended sediment are dispersed towards the east by south. | SHEN Huanting Institute of Esturaine and Coastal Research, East China Normal University, Shanghai, China LI Jiufa Institute of Esturaine and Coastal Research, East China Normal University, Shanghai, China ZHU Huifang Institute of Esturaine and Coastal Research, East China Normal University, Shanghai, China HAN Mingbao Institute of Esturaine and Coastal Research, East China Normal University, Shanghai, China ZHOU Fugen Department of Marine Geology, Tongji Univcrsity, Shanghai, China | 1992 | International Journal of Sediment Research1992，7，3： | 37 |
| 2 | All-optical active THz metasurfaces for ultrafast polarization switching and dynamic beam splitting显示文摘Miniaturized ultrafast switchable optical components with an extremely compact size and a high-speed response will be the core of next-generation all-optical devices instead of traditional integrated circuits,which are approaching the bottleneck of Moore’s Law.Metasurfaces have emerged as fascinating subwavelength flat optical components and devices for light focusing and holography applications.However,these devices exhibit a severe limitation due to their natural passive response.Here we introduce an active hybrid metasurface integrated with patterned semiconductor inclusions for all-optical active control of terahertz waves.Ultrafast modulation of polarization states and the beam splitting ratio are experimentally demonstrated on a time scale of 667 ps.This scheme of hybrid metasurfaces could also be extended to the design of various free-space all-optical active devices,such as varifocal planar lenses,switchable vector beam generators,and components for holography in ultrafast imaging,display,and high-fidelity terahertz wireless communication systems. | Longqing Cong Yogesh Kumar Srivastava Huifang Zhang Xueqian Zhang Jiaguang Han Ranjan Singh | 2018 | Light(Science & Applications)2018，7，1： | 15 |
| 3 | Predictive values of multidetector-row computed tomography combined with serum tumor biomarkers in preoperative lymph node metastasis of gastric cancer显示文摘Objective: Multidetector-row computed tomography(MDCT) and serum tumor biomarkers are commonly used to evaluate the preoperative lymph node metastasis and the clinical staging of gastric cancer(GC). This study intends to evaluate the clinical predictive value of MDCT and serum tumor biomarkers in lymph node metastasis of GC.Methods: The clinicopathologic data of 445 GC patients who underwent radical gastrectomy were retrospectively analyzed to evaluate the diagnostic value of MDCT and serum tumor biomarkers in lymph node metastatic staging of GC before surgery.Results: With the multinomial logistic regression analysis, the independent relative factors of lymph node metastasis of GC were identified as tumor size, depth of tumor invasion, vessel invasion, vascular embolus, and soft tissue invasion. The optimal critical value of the short diameter of lymph nodes detected by MDCT scanning for evaluation of preoperative lymph node metastasis was 6.0 mm, with 75.7% as predictive accuracy of lymph node metastasis compared to the postoperative pathological results of GC patients. In addition, the critical value of the short diameter of lymph nodes combined with serum tumor biomarkers [including carbohydrate antigen(CA)-724 and CA-199] could show an enhancement of predictive sensitivity of lymph node metastasis(up to 89.3%) before surgery.Conclusions: MDCT combined with serum tumor biomarkers should be adopted to improve preoperative sensitivity and accuracy of lymph node metastasis for GC patients. | Huihui Bai Jingyu Deng Nannan Zhang Huifang Liu Wenting He Jinyuan Liu Han Liang | 2019 | Chinese Journal of Cancer Research2019，31，3： | 11 |
| 4 | Effects of Waxy Maize Relay Intercropping and Residue Retention on Rhizosphere Microbial Communities and Vegetable Yield in a Continuous Cropping System显示文摘Intercropping and residue retention contribute to high yield and quality of crops. However, their coupled effects on rhizospheric microbial communities under a continuous vegetable cropping system have not been adequately addressed. The objective of the present study was to assess the effects on soil microbial community and yields of waxy maize(Zea mays L.) intercropped with or without residue retention in a continuous broccoli(Brassica oleracea L.) cropping system, i.e., relay intercropping of broccoli and waxy maize(B/M-B), relay intercropping of broccoli and waxy maize with residue retention(B/MR-B), and broccoli monoculture(B-B). The biomass yields of spring and autumn vegetables in B/MR-B were 16.3%–32.5% and 30.1%–46.1% higher than those of B-B,respectively. Autumn vegetable economic yields of B/MR-B were 28.2%–40.3% higher than B-B. The average well color development followed the order: B/MR-B > B/M-B > B-B. The Shannon index, Simpson index, and Mc Intosh index were higher in B/MR-B than under monoculture. A principal component analysis showed that microbial communities of B/MR-B soils differed from those of B/M-B and B-B soils. Carbon(C) sources utilized by the rhizosphere microorganisms were mainly carbohydrates, carboxylic acids, amino acids, and polymers; however, the C sources for the soil microbial community differed between intercropping and monoculture. The communities from B/MR-B preferred amino acids and polymers. Available nitrogen(N), potassium(K), and phosphorus(P) had an obvious impact on soil microbial community. Additionally, the C source utilization by microorganisms was significantly affected by p H and available K and P. Cropping system diversification through relay intercropping and residue retention effectively improved the functional diversity of the soil microbial communities and increased the yields of vegetables. | ZHANG Xuepeng NING Tangyuan HAN Huifang SUN Tao LI Geng LI Zengjia Rattan LAL | 2018 | Pedosphere2018，28，1： | 5 |
| 5 | Polarization-independent all-silicon dielectric metasurfaces in the terahertz regime显示文摘Dielectric metasurfaces have achieved great success in realizing high-efficiency wavefront control in the optical and infrared ranges. Here, we experimentally demonstrate several efficient, polarization-independent, all-silicon dielectric metasurfaces in the terahertz regime. The metasurfaces are composed of cylindrical silicon pillars on a silicon substrate, which can be easily fabricated using etching technology for semiconductors. By locally tailoring the diameter of the pillars, full control over abrupt phase changes can be achieved. To show the controlling ability of the metasurfaces, an anomalous deflector, three Bessel beam generators, and three vortex beam generators are fabricated and characterized. We also show that the proposed metasurfaces can be easily combined to form composite devices with extended functionalities. The proposed controlling method has promising applications in developing low-loss, ultra-compact spatial terahertz modulation devices. | HUIFANG ZHANG XUEQIAN ZHANG QUAN XU QIU WANG YUEHONG XU MINGGUI WEI YANFENG LI JIANQIANG GU ZHEN TIAN CHUNMEI OUYANG XIXIANG ZHANG CONG HU JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，9，1： | 4 |
| 6 | Understanding of mineral change mechanisms in coal mine groundwater reservoir and their influences on effluent water quality:a experimental study显示文摘This paper presents results of an experimental study to characterize the law of mineral change of fallen rock in coal mine groundwater reservoir ant its influence on water quality.The minerals of the underground reservoir of Daliuta Coal Mine is taken as the research object.Simulation experiments were designed and conducted to simulate water–rock action in the laboratory.The mineral composition was analyzed by X-ray diffractometer(XRD),the surface morphology of the mineral was analyzed by scanning electron microscope(SEM),and the specific surface area,total pore volume and average pore diameter of the mineral were measured by fast specific surface/pore analyzer(BET).The experimental results show that the sandstone and mudstone in the groundwater reservoir of Daliuta Coal Mine account for 70%and 30%,respectively.The pore diameter is 15.62–17.55 nm,and pore volume is 0.035 cc/g.Its pore structure is a key factor in the occurrence of water–rock interaction.According to the water–rock simulation experiment,the quartz content before the water–rock action is about 34.28%,the albite is about 21.84%,the feldspar is about 17.48%,and the kaolinite is about 8.00%.After the water–rock action,they are 36.14%,17.78%,11.62%,and 16.75%,respectively.The content of albite and orthoclase is reduced while the content of kaolinite is increased,that is,the Na+content becomes higher,and the Ca2+and Mg2+contents become lower.This research builds a good theoretical foundation for revealing the role of water and rock in underground coal reservoirs. | Kai Zhang Huifang Li Jiaming Han Binbin Jiang Ju Gao | 2021 | International Journal of Coal Science & Technology2021，8，1： | 3 |
| 7 | Coupling effects of urea types and subsoiling on nitrogen–water use and yield of different varieties of maize in northern China显示文摘 | Hengyu Hu Tangyuan Ning Zengjia Li Huifang Han Zongzheng Zhang Shujun Qin Yanhai Zheng | 2013 | Field Crops Research2013，，： | 2 |
| 8 | HIV-Related Knowledge, Attitude, and Practices Research Among College Students-Six Chinese Cities, 2021显示文摘Summary What is already known about this topic?The number of newly diagnosed human immunodeficiency virus(HIV)cases among Chinese youth 15–24 years of age shows an upward trend between 2010 and 2019.What is added by this report?This survey is on a larger scale as compared to previous studies.It shows inadequate HIV knowledge—especially on HIV treatment,self-testing,and postexposure prophylaxis—among college students.A significant gap exists between knowledge and behavior as indicated by the low condom use rate despite a high knowledge level. | Hui Liu Qiyu Zhu Lei Zhang Yujing Liu Peng Xu Maohe Yu Jixiang Fan Xiaohong Pan Xi Chen Huifang Xu Qinying He Mengjie Han | 2022 | China CDC weekly2022，4，47： | 2 |
| 9 | All dielectric metasurfaces for spin-dependent terahertz wavefront control显示文摘Metasurfaces consisting of artificial subwavelength structure arrays have shown unprecedented ability to manipulate the phase,amplitude,and polarization of light.Separate and complete control over different spin states,namely the orthogonal circular polarizations,has proven more challenging as compared to the control over orthogonal linear polarizations.Here,we present and experimentally demonstrate several spin-dependent wavefront control metasurfaces in the terahertz regime using all-silicon dielectric structures.Such spin-dependent allsilicon metasurfaces are easy to fabricate and have potential applications in spin-involved ultracompact and miniaturized terahertz optical systems as well as terahertz communication systems. | TONG WU HUIFANG ZHANG SIVALOGANATHAN KUMARAN YUEHONG XU QINGWEI WANG WLADISLAW MICHAILOW XUEQIAN ZHANG HARVEY E.BEERE DAVID A.RITCHIE JIAGUANG HAN | 2022 | Photonics Research2022，10，7： | 1 |
| 10 | Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2显示文摘Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic mutations.Because of the paradoxical activation induced by a single use of BRAF or MEK inhibitors,dual-target RAF and MEK treatment is thought to be a promising strategy.In this work,we evaluated erianin is a novel inhibitor of CRAF and MEK1/2 kinases,thus suppressing constitutive activation of the MAPK signaling pathway induced by BRAF V600E or RAS mutations.KinaseProfiler enzyme profiling,surface plasmon resonance(SPR),isothermal titration calorimetry(ITC),cellular thermal shift assay,computational docking,and molecular dynamics simulations were utilized to screen and identify erianin binding to CRAF and MEK1/2.Kinase assay,luminescent ADP detection assay,and enzyme kinetics assay were investigated to identify the efficiency of erianin in CRAF and MEK1/2 kinase activity.Notably,erianin suppressed BRAF V600E or RAS mutant melanoma and colorectal cancer cell by inhibiting MEK1/2 and CRAF but not BRAF kinase activity.Moreover,erianin attenuated melanoma and colorectal cancer in vivo.Overall,we provide a promising leading compound for BRAF V600E or RAS mutant melanoma and colorectal cancer through dual targeting of CRAF and MEK1/2. | Penglei Wang Xuechao Jia Bingbing Lu Han Huang Jialin Liu Xuejiao Liu Qiong Wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie Xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 11 | Evaluation of Multidisciplinary Collaborative Care in Patients with Acute Coronary Syndrome and Depression and/or Anxiety Disorders显示文摘Objective:To evaluate the effect of multidisciplinary collaborative care(MCC)in patients with both acute coronary syndrome(ACS)and depression and/or anxiety disorders compared with usual physician care(UPC).Methods:Depression and/or anxiety were screened by using SDS and SAS,ACS patients with depression and/or anxiety disorders were randomized into MCC and UPC groups.The cardiac outcomes and the life quality were evaluated at1year follow-up.Results:Overall,30.19%(96/318)patients had positive screen results.At1year,Cardiac outcome measures for patients in MCC group were significantly better for composite events of cardiac death and non-fatal MI(6.12% vs23.40%,p=0.016),cardiac function(NYHA functional classifi cation III or IV,0% vs 25%,p=0.05),and angina pectoris(21.28% vs 85%,p<0.0005),than patients in UPC group;the life quality were improved in patients in MCC group.Conclusion:After ACS,30.19% of patients had depression and/or anxiety disorders,MCC had better effects on cardiac outcomes and quality of life in ACS patients with Psychiatric disorders. | Feng Liang Xiuhua Ma Liuzhuang Zhao Chengwei Xing Xin Li Dongjing Zhao Da-Yi Hu Shuoqiang Hu Wenbin Wang Lantang Han Shujun Cao Huifang Liu Zhengyu Bian | 2017 | Cardiovascular Innovations and Applications2017，，B05： | 1 |
| 12 | Single molecular insight into steric effect on C-terminal amino acids with various hydrogen bonding sites显示文摘Amino acids are basic units to construct a protein with the assistance of various interactions.During this building process,steric hindrance derived from amino acid side groups or side chains is a factor that could not be ignored.In this contribution,adsorption behaviors of C-terminal amino acid derivatives with amino acid residues fused in 3,4,9,10-perylenetetracarboxylic dianhydride were investigated by scanning tunneling microscopy(STM)and density functional theory(DFT)calculations at various liquid/solid interfaces.STM results at 1-phenyloctane/HOPG interface show that N,N'-3,4,9,10-perylenedicarboximide(GP)and N,N'-methyl-3,4,9,10-perylenedicarboximide(AP)formed linear and herringbone structures,respectively.The driving force could be attributed to different H-bonding sites induced by steric hindrance at side groups.N,N'-Benzyl-3,4,9,10-perylenedicarboximide(PP)generates both linear and herringbone structures because steric hindrance changes the H-bonding sites between PP molecules,whereas N,N'-isopropyl-3,4,9,10-perylenedicarboximide(LP)failed to be imaged because of strong steric hindrance coming from larger side group.To further investigate the impact of steric hindrance,we utilized octanoic acid(OA)as solvent to capture the adsorption details of LP and PP.We found that OA molecules drag PP and LP molecules in a different direction to generate linear structure,impeding the molecular rotation.The structure–solvent relationship shows that the steric hindrance is brought by the large side group,which makes it easier to recognize OA molecules at the interface.These results demonstrate that steric effect plays a significant role in altering interaction sites of the compounds during the adsorption process at the liquid/solid interface. | Yunzhi Xie Chunhua Liu Linxiu Cheng Yulan Fan Huifang Li Wei Liu Lei Zhu Xun Li Ke Deng Qingdao Zeng Shoufa Han | 2022 | Chinese Chemical Letters2022，33，10： | 1 |
| 13 | IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance显示文摘 | Xueyan Zhang Jiayuan Sun Huimin Wang Yuqing Lou Yanwei Zhang Huifang Sha Jiuxian Feng Baohui Han | 2014 | Tumor Biology2014，，1： | 1 |
| 14 | Coupling effects of urea types and subsoiling on nitrogen–water use and yield of different varieties of maize in northern China显示文摘 | Hengyu Hu Tangyuan Ning Zengjia Li Huifang Han Zongzheng Zhang Shujun Qin Yanhai Zheng | 2013 | Field Crops Research2013，，： | 1 |
| 15 | IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance显示文摘 | Xueyan Zhang Jiayuan Sun Huimin Wang Yuqing Lou Yanwei Zhang Huifang Sha Jiuxian Feng Baohui Han | 2014 | Tumor Biology2014，，： | 1 |
| 16 | Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement显示文摘T cell engaging bispecific antibody(TCB)is an effective immunotherapy for cancer treatment.Through co-targeting CD3 and tumor-associated antigen(TAA),TCB can redirect CD3+T cells to eliminate tumor cells regardless of the specificity of T cell receptor.Tissue factor(TF)is a TAA that involved in tumor progression.Here,we designed and characterized a novel TCB targeting TF(TF-TCB)for the treatment of TF-positive tumors.In vitro,robust T cell activation,tumor cell lysis and T cell proliferation were induced by TF-TCB.The tumor cell lysis activity was dependent upon both CD3 and TF binding moieties of the TF-TCB,and was related to TF expression level of tumor cells.In vivo,in both tumor cell/human peripheral blood mononuclear cells(PBMC)co-grafting model and established tumor models with poor T cell infiltration,tumor growth was strongly inhibited by TF-TCB.T cell infiltration into tumors was induced during the treatment.Furthermore,efficacy of TF-TCB was further improved by combination with immune checkpoint inhibitors.For the first time,our results validated the feasibility of using TF as a target for TCB and highlighted the potential for TF-TCB to demonstrate efficacy in solid tumor treatment. | Zhidi Pan Jie Chen Xiaodong Xiao Yueqing Xie Hua Jiang Baohong Zhang Huili Lu Yunsheng Yuan Lei Han Yuexian Zhou Huifang Zong Lei Wang Rui Sun Jianwei Zhu | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 17 | Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1显示文摘Many circular RNAs(circRNAs)are reported to be abnormally expressed during the progression of various tumors,and these circRNAs can be used as anti-tumor targets.Therefore,it is important to identify circRNAs that can be used effectively for the clinical diagnosis and treatment of colorectal cancer(CRC).Here,we report that hsa_Circ_0000826(Circ_0000826),a circ RNA with significantly reduced expression level in CRC tissues,is associated with a poor prognosis in patients.The silencing of Circ_0000826 promotes the proliferation of CRC cells.Conversely,the overexpression of Circ_0000826 restricted CRC cell proliferation both in vitro and in vivo.Furthermore,Circ_0000826 could target AU-rich element RNA-binding protein 1(AUF1).AUF1,known as heterogeneous nuclear ribonucleoprotein D(hnRNP D),could bind to the c-MYC 3’-UTR and promote c-MYC expression.When Circ_0000826 binds to AUF1,it competitively inhibits the binding of AUF1 to the c-MYC 3’-UTR,which inhibits the c-MYC expression and cell proliferation.These results provide novel insights into the functional mechanism of Circ_0000826 action in CRC progression and indicate its potential use as a therapeutic target in CRC. | Zheying Zhang Wenyan Fan Qingzu Gao Yifei Han Jingyu Ma Wuji Gao Yuhan Hu Huifang Zhu Rui Yang Haijun Wang Baoshun Du Zuoyang Zhang Jiateng Zhong | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 18 | Identifying the Key Nodes of HIV Molecular Transmission Network Among Men Who Have Sex with Men—Guangzhou,Guangdong Province,China,2015–2017显示文摘Summary What is already known about this topic?Identifying the most influential spreaders in human immunodeficiency virus(HIV)transmission networks is crucial for developing effective prevention strategies.What is added by this report?This study identified key nodes of the HIV molecular transmission network among men who have sex with men(MSM)by utilizing linkages between sequences to reconstruct the transmission network at the molecular level. | Juan Yang Zhigang Han Huifang Xu Hui Xing Peng Xu Weibin Cheng Yuzhou Gu Fan Lyu | 2021 | China CDC weekly2021，3，38： | 0 |
| 19 | Bone metastasis of hepatocellular carcinoma:facts and hopes from clinical and translational perspectives显示文摘Patients with hepatocellular carcinoma(HCC)and bone metastasis(BM)suffer from greatly reduced life quality and a dismal prognosis.However,BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades.To date,no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM.Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention.The risk factors,diagnosis,prognosis,and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists.We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions.We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities.Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms,as well as the development of novel effective therapies for HCC patients with BM. | Zhao Huang Jingyuan Wen Yufei Wang Shenqi Han Zhen Li Xuemei Hu Dongling Zhu Zhenxiong Wang Junnan Liang Huifang Liang Xiao-ping Chen Bixiang Zhang | 2022 | Frontiers of Medicine2022，16，4： | 0 |
| 20 | Autologous Transplantation for Parkinson's Disease Patients:Feasibility and Challenge显示文摘Parkinson’s Disease(PD),second only to Alzheimer’s disease,is a neurodegenerative disease,most commonly occurring in people over the age of 65 years and is mostly caused by loss of dopamine neurons[1].Clinically,motor symptoms such as resting tremor,motor retardation,muscular rigidity,and disturbance of postural balance are the main symptoms,followed by non-motor symptoms such as cognitive impairment,autonomic nervous system dysfunction,depression,and sleep disorder[2].In 2016,>6.1 million people were affected with PD globally,2.4 times the number in 1990.The large number of affected people,coupled with the high mortality and disability rates,has placed a great burden on society[3].Traditional treatment methods mainly include drugs and surgery and are supplemented by physical therapy. | Qi Zhang Yanlin Wang Yukai Wang Han Liu Huifang Sun Zhuoya Wang Changhe Shi Jing Yang Yuming Xu | 2021 | Neuroscience Bulletin2021，37，7： | 0 |
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