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| 1 | The Survey of Birth Defects Rate Based on Birth Registration System显示文摘 | Min Yu Zhiguang Ping Shuiping Zhang Yuying He Rui Dong Xiong Guo | 2015 | Chinese Medical Journal2015，，1： | 10 |
| 2 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 3 | Microscopic inspection and tracking of single upconversion nanoparticles in living cells显示文摘Nanoparticles have become new tools for cell biology imaging1,sub-cellular sensing2,super-resolution imaging3,4 and drug delivery5.Long-term 3D tracking of nanoparticles and their intracellular motions have advanced the understanding of endocytosis and exocytosis as well as of active transport processes6–8.The sophisticated operation of correlative optical-electron microscopy9,10 and scientific-grade cameras is often used to study intercellular processes.Nonetheless,most of these studies are still limited by the insufficient sensitivity for separating a single nanoparticle from a cluster of nanoparticles or their aggregates8,11,12.Here we report that our eyes can track a single fluorescent nanoparticle that emits over 4000 photons per 100 milliseconds under a simple microscope setup.By tracking a single nanoparticle with high temporal,spectral and spatial resolution,we show the measurement of the local viscosity of the intracellular environment.Moreover,beyond the colour domain and 3D position,we introduce excitation power density as the fifth dimension for our eyes to simultaneously discriminate multiple sets of single nanoparticles. | Fan Wang Shihui Wen Hao He Baoming Wang Zhiguang Zhou Olga Shimoni Dayong Jin | 2018 | Light(Science & Applications)2018，7，1： | 9 |
| 4 | Measurement of the echo reduction for underwater acoustic passive materials by using the time reversal technique显示文摘A measuring method of the echo reduction of passive materials by using the time reversal(TR) technique is presented. To measure the echo reduction of a sample with this approach, the received signals are firstly focused according to the TR theory. Then, the sample is removed and the TR processing is again employed to realize the focus of the received signal.Finally, the echo reduction of the sample is evaluated with these focusing signals. Besides, to calibrate the measured echo reduction via the TR technique, a standard sample is employed to measure a constant coefficient that only depends on the measurement environment. An aluminum plate sample and a steel plate sample with the same size of 1.1 mxl.O m x0.005 m axe tested in a wave guide tank. The experimental results show that the calibrated values are well consistent with theoretical results under the free field at the measured frequency range of0.5-20 kHz. The relative errors of all the measured values are less than 10% and the values of the expanded uncertainty are less than 1.5 dB. The TR processing focuses the energy in spatial domain and temporal domain, so it can be used to measure the echo reduction of passive materials in the environments with reflections induced by boundaries and low frequency sources. | YAN Xiaowei LI Jianlong HE Zhiguang | 2016 | Chinese Journal of Acoustics2016，35，3： | 7 |
| 5 | Near-infrared light-driven Janus capsule motors: Fabrication, propulsion, and simulation显示文摘我们报导一没有燃料,在红外线附近(NIR ) 驾驶 Janus microcapsule 马达。Janus microcapsule 马达被帮助模板的聚合电解质 layer-by-layer 汇编制作,由在一个方面上金层喷洒列在后面。NIR 动力的 Janus 马达以 42 /DLHC 的最大的速度完成了高推进合成交付一个高特定的能力(930 mAed nanoparticles,有 81.8% 的轻发射度和 118.62ichia coli 的一个水接触角度(E。coli ) ,肠球菌(ENT ) 和全部的大肠菌(TC ) 被分析。除了 EC 和没有 3, ,结果揭示了低 concentrati 吗?? | Yingjie Wu Tieyan Si Jingxin Shao Zhiguang Wu Qiang He | 2016 | Nano Research2016，9，12： | 6 |
| 6 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 7 | CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant显示文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative reverse transcription-polymerase chain reaction till now,which is time-consuming and requires expensive instrumentation,and the confirmation of variants relies on further sequencing techniques.Herein,we first proposed a robust technique-methodology of electrochemical CRISPR sensing with the advantages of rapid,highly sensitivity and specificity for the detection of SARS-CoV-2 variant.To enhance the sensing capability,gold electrodes are uniformly decorated with electro-deposited gold nanoparticles.Using DNA template identical to SARS-CoV-2 Delta spike gene sequence as model,our biosensor exhibits excellent analytical detection limit(50 fM)and high linearity(R2=0.987)over six orders of magnitude dynamic range from 100 fM to 10 nM without any nucleic-acid-amplification assays.The detection can be completed within 1 h with high stability and specificity which benefits from the CRISPR-Cas system.Furthermore,based on the wireless micro-electrochemical platform,the proposed biosensor reveals promising application ability in point-of-care testing. | Chenshuo Wu Zhi Chen Chaozhou Li Yabin Hao Yuxuan Tang Yuxuan Yuan Luxiao Chai Taojian Fan Jiangtian Yu Xiaopeng Ma Omar AAl-Hartomy SWageh Abdullah GAl-Sehemi Zhiguang Luo Yaqing He Jingfeng Li Zhongjian Xie Han Zhang | 2022 | Nano-Micro Letters2022，14，10： | 2 |
| 8 | Achieving a stable COF with the combination of“flat”and“twist”large-size rigid synthons for selective gas adsorption and separation显示文摘A new type of covalent organic framework(COF)was achieved using combination of structrally rigid and conformationally othorganal building blocks.The N-2-aryl-substituted triazole derivative(NAT-CHO)was prepared with co-planar conformation among the three aromatic rings as the“flat”building block.The 4,4,4,4-(ethene-1,1,2,2-tetrayl)tetraaniline)(ETTA)was applied as the“twist”building block.A 2 D sheet of network was obtained through imine formation.The resulting NAT-COF gave excellent thermal and chemical stability,survived aqueous solutions from p H 5 to 13.With large-size building blocks,the porous framework NAT-COF gave efficient gas adsorption with excellent selectivity of C3 propane over C1 me-thane,suggesting its potential application for selective gas capture and separation. | Jingyang Li Ying He Yongcun Zou Yan Yan Zhiguang Song Xiaodong Shi | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 9 | Investigation of swelling induced by heavy ion and neutron irradiation in SiC显示文摘 | Hang Zang Daxi Guo Tielong Shen Chaohui He Zhiguang Wang Lilong Pang Cunfeng Yao Tao Yang | 2013 | Journal of Nuclear Materials . 2013 (1-3)2013，，1： | 1 |
| 10 | MAXIMUM LIKELIHOOD ESTIMATION FOR INSAR IMAGE CO-REGISTRATION显示文摘This paper presents a closed-form robust phase correlation based algorithm for performing image registration to subpixel accuracy.The subpixel translational shift information is directly obtained from the phase of the normalized cross power spectrum by using Maximum Likelihood Estimation(MLE).The proposed algorithm also has slighter time complexity.Experimental results show that the proposed algorithm yields superior registration precision on the Cramér-Rao Bound(CRB) in the presence of aliasing and noise. | Li Xinglin Song Hongjun Robert Wang Shao Yunfeng Zhang Zhiguang Yan He | 2013 | Journal of Electronics(China)2013，30，6： | 1 |
| 11 | Prevalence of diabetes among menand women in China显示文摘 | Yang Wenying Lu Juming Weng Jianping Jia Weiping Ji Linong Xiao Jianzhong Shan Zhongyan Liu Jie Tian Ha- oming Ji Qiuhe Zhu Dalong Ge Jiapu Lin Lixiang Chen Li Guo Xiaohui Zhao Zhigang Li Qiang Zhou Zhiguang Shan Guangliang He Jiang | 2010 | N Engl J Med2010，362，： | 1 |
| 12 | Serum Lipids and Lipoproteins in Chinese Men and Women显示文摘 | Wenying Yang Jianzhong Xiao Zhaojun Yang Linong Ji Weiping Jia Jianping Weng Juming Lu Zhongyan Shan Jie Liu Haoming Tian Qiuhe Ji Dalong Zhu Jiapu Ge Lixiang Lin Li Chen Xiaohui Guo Zhigang Zhao Qiang Li Zhiguang Zhou Guangliang Shan Jiang He | 2012 | Circulation2012，，18： | 1 |
| 13 | Study on 2.0μm fluorescence of Ho-doped water-free fluorotellurite glasses显示文摘 | Jianli He Huan Zhan Zhiguang Zhou Aidong Zhang Aoxiang Lin | 2013 | Optical Materials2013，，12： | 1 |
| 14 | Liquid Metal Swimming Nanorobots显示文摘CONSPECTUS:Room temperature liquid metal gallium-based materials have received tremendous attention owing to their potential promises in various aspects including bioengineering and smart medicine,flexible circuits and electronic skins,transformable activators and triboelectric nanogenerators,etc.Particularly,the usage of gallium-based liquid metals to construct humanoid robots to accomplish diverse dangerous missions leads to the considerable focus on the development of gallium-based flexible robots.Unlike conventional metal materials with rigid properties and responsible mainly for the backbone,room temperature gallium-based liquid metals could serve as a new generation of smart flexible materials for robotic devices with its advantages,such as low toxicity,high fluidity,and plasticity at the micro/nanometer sizes.With the expectation in biomedicine,such as targeted drug delivery,the past decade has led to the scaling down of the swimming robot to the micro-and nanoscales.Swimming nanorobots,which are defined as devices that can convert chemical energy in the surrounding environment and externally physical field into their own kinetic energy at the micro/nanoscale and achieve self-propulsion,have shown widespread potential in the field of in vivo applications.Despite the great promises,gallium-based liquid metal robots are primarily limited to the millimeter and subcentimeter scales.Moving toward clinical medical practices,however,these gallium-based liquid metal swimming robots are facing the biocompatible problem caused by their large sizes and propulsion approaches.Particularly,the manufacture,selfpropulsion,and navigation of nanoscale liquid metal swimming robots,ensuring the penetration though various tissues toward the disease area,is still challenging.Construction of gallium-based swimming nanorobots is of vital importance both for fundamental research,such as the dynamics of individual nanorobots and emergence of nanorobotic swarms,as well as for engineering and bioapplications,for instance,active target delivery.When applied as an in vivo surgical agent,the gallium-based liquid metal nanorobots will not only gather into the disease site at a higher targeting ratio but also behave in an emerged collective means that transform and infuse to destroy the lesion by photothermal and photodynamic therapy,and so on.Compared with the large-scale liquid metal robots,gallium-based swimming nanorobots offer the advantages in treatment of tumors with lower intensity,navigation with higher precision,and surgical therapies with minor invasion. | Zesheng Li Jie Xu Zhiguang Wu Bin Guo Qiang He | 2022 | Accounts of Materials Research2022，3，1： | 0 |
| 15 | 3-15 First-principle Investigation of LiTaO3显示文摘As an important multi-functional material applied in surface acoustic wave devices, optical communications,laser and optoelectronics due to its good photoelectric and piezoelectric properties, lithium tantalate (LiTaO3) hasdrawn extensive interests[1]. Numerous physical properties of LiTaO3, such as acoustical, electronic structures,optical properties and effective mass, thermodynamic properties, have been reported in several papers.Point defects will affect the electronic structure which should be responsible for many physical properties,especially optical properties. | He Wenhao Gao Xing Wang Zhiguang | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 16 | 3-17 Corrosion Studies of MAX Phase in Liquid Pb-Bi Alloy显示文摘As one of candidates for the fuel cladding or structure material used in fourth generation fission and fusiondemonstrate reactor, MAX phase has the properties of both ceramic and metal, such as high melting point, hightemperaturestability, good erosion resistance and radiation-damage tolerance[1;2]. Max phase is a series of ceramicsof nanolamellar and hexagonal structure. M represents transition element. A represents the third or fourth maingroup element. X represent N and C. In the design of lead-cooled fast reactor, it is required that the materialshould endure the corrosion of liquid Pb-Bi alloy. Therefore, understanding of the oxide layers and their growthmechanisms in LBE is fundamentally important for the development of candidate materials. | Deng Tianyu Sun Jianrong Wang Zhiguang Song Peng Shen Tielong Pang Lilong Zhu Yabin Cui Minghuan Wang Ji Zhu Huiping Wang Dong Du Yangyang He Wenhao | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 17 | Simple and rapid determination of dioxin in fish and sea food using a highly sensitive reporter cell line,CBG 2.8D显示文摘Food,especially animal origin food is the main source of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs),and dioxin-like polychlorinated biphenyls(dl-PCBs)for human exposure.So,a simple,rapid and cheap bioassay method is needed for determination of dioxins in food samples.In this study,we used a new highly sensitive reporter cell line to determine the concentration of dioxins in 33 fish and seafood samples.The samples were extracted by shaking with water/isopropanol(1:1 v/v)and hexane and cleaned-up by a multi layered silica gel column and an alumina column,then analyzed using CBG 2.8 D cell line.We compared the results obtained from the CBG 2.8 D cell assay to those obtained from conventional High-Resolution Gas Chromatography-High Resolution Mass Spectrometry(HRGC-HRMS)analysis.Good correlations were observed between these two methods(r^2=0.93).While the slope of regression line was 1.76,the bioanalytical equivalent(BEQ)values were 1.76 folds higher than WHO-TEQ values and the conversion coefficient was 0.568(the reciprocal of 1.76).In conclusion,CBG 2.8 D cell assay was an applicable method to determine dioxins levels in fish and sea food samples. | Gangdou Ding Lingyun Wang Songyan Zhang Shuaizhang Li Qunhui Xie Li Xu Zhiguang Zhou YinFeng He Bin Zhao | 2021 | Journal of Environmental Sciences2021，33，2： | 0 |
| 18 | Private banking development in China under two organizational structures:Economic analysis from an organizational innovation perspective显示文摘This paper investigates optimal decisions for private banking development in China under two innovative organizational structures—the big retail mode(BRM)and the independent development mode(IDM).Under the BRM,the retail and private banking divisions form a cooperative relationship wherein the former transfers highnet-worth customers to the latter.In addition,retail banking receives a share of private banking revenues.We investigate the optimal revenue-sharing ratio between the two divisions and the optimal effort by private banking to serve transferred customers within the cooperative relationship.The analytical results show that as the private banking division becomes more developed,the optimal revenue-sharing ratio decreases,and the private banking division’s optimal effort to serve transferred customers decreases because it puts more effort into acquiring new customers.Under the IDM,the two divisions form a competitive relationship since they compete to acquire customers independently.We investigate customer acquisition efforts in this interdivisional competition.Optimal customer acquisition efforts by both divisions increase in potential assets and rates of return.This paper contributes to the literature by(1)analyzing financial innovation by private banks from an organizational perspective;(2)providing an economic analysis for private banking development in China. | He Liu Yun Bai Zhiguang Huang Han Qiao Shouyang Wang | 2023 | Financial Innovation2023，9，1： | 0 |
| 19 | 透射电子显微镜研究低能高剂量氦离子辐照引起非晶6H-SiC微观结构演化过程显示文摘Silicon carbide(SiC)is regarded as an important material in nuclear energy system and semiconductor industry,because of its excellent physical,electronic and optical properties.It is inevitable that dense atomic He atoms produced by(n,)nuclear transmutation reaction.Due to the low solubility of He atoms in SiC,He atoms are easy to be trapped by vacancies to form helium-vacancy clusters.After thermal annealing,helium atoms will escape from vacancies,to form cavities.In semiconductor technology,He implantation-induced cavities have lots of important applications.Therefore,the study of He-implanted SiC is critical.He-implantation-induced cavities have been extensively investigated.He-implantation-induced dislocation loops also have been investigated.Chen et al.observed interstitial-type dislocation loops associated with He bubbles due to the release of bubble interior pressure via emitting interstitials[1].These interstitials agglomerate into dislocation loops.It is consistent with previous results observed in the case of He-implanted 6H-SiC[2].What’s more,Barbot et al.regarded that the growth of the Frank loops lead to the formation of stacking faults,which do not result from the agglomeration of interstitials[3]. | Li Bingsheng Han Yi Wang Zhiguang Wei Kongfang Shen Tielong Sun Jianrong Yao Cunfeng Gao Ning Gao Xing Pang Lilong Zhu Yabin Chang Hailong Cui Minghuan Luo Peng Sheng Yanbin Zhang Hongpeng Fang Xuesong Zhao Sixiang Jin Jin Huang Yuxuan Liu Chao Tai Pengfei Wang Dong He Wenhao Qi Ming | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 20 | Fe和He离子注入如TiALC_(2)研究显示文摘In this work,we have used the Fe-ion irradiation and He-ion implantation successively(Fe+He)to produce an environment with lower appm He/dpa than the single He-ion implantation.Samples of Ti_(3)AlC_(2) were irradiated by 3.5 MeV Fe-ions to the fluences of 1.0×10^(16) ions/cm^(2),to produce amount of defects in advance.Then,irradiated samples were implanted with 500 keV He-ion to the fluence of 1.0×10^(17) ions/cm^(2).We have used the SRIM 2008 code[1]with the“Kinchin-Pease quick calculation”mode to simulate damage caused by Fe-ion irradiation and He-ion depositional concentration,as shown in Fig.1.The damage near the peak is about 10 dpa. | Pang Lilong Li Bingsheng Shen Tielong Gao Xing Fang Xuesong Gao Ning Yao Cunfeng Wei Kongfang Cui Minghuan Sun Jianrong Chang Hailong He Wenhao Wang Zhiguang | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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