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| 1 | Human amnion epithelial cells can be induced to differentiate into functional insulin-producing cells显示文摘胰腺的小岛移植证明了长期的胰岛素独立可以在受不了糖尿病 mellitus 类型 1 的病人被完成。然而,小岛织物的有限可获得性意味着对葡萄糖应答的生产胰岛素的房间的新来源被要求。这里,我们显示出那人的羊膜上皮的房间(HAEC ) 能被导致在 vitro 区分进功能的生产胰岛素的房间。在区别的正式就职以后, HAEC 表示了多重胰腺的 β-cell 基因,包括胰岛素,胰十二指肠 homeobox-1,配对的盒子基因 6, NK2 抄写因素相关的地点 2,小岛 1, glucokinase,和葡萄糖 transporter-2,和以响应另外的细胞外的刺激的一种调整葡萄糖的方式的释放 C 肽。进导致 streptozotocin 的糖尿病的 C57 老鼠的导致的 HAEC 的移植颠倒了多糖症,恢复了身体重量,并且维持了为 30 d 的 euglycemia。这些调查结果显示 HAEC 可以是为在类型 1 糖尿病的房间代替治疗的新来源。 | Yanan Hou | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 25 |
| 2 | Temporal variations and source apportionment of volatile organic compounds at an urban site in Shijiazhuang, China显示文摘Shijiazhuang,the city with the worst air quality in China,is suffering from severe ozone pollution in summer.As the key precursors of ozone generation,it is necessary to control the Volatile Organic Compounds(VOCs)pollution.To have a better understanding of the pollution status and source contribution,the concentrations of 117 ambient VOCs were analyzed from April to August 2018 in an urban site in Shijiazhuang.Results showed that the monthly average concentration of total VOCs was 66.27 ppbv,in which,the oxygenated VOCs(37.89%),alkanes(33.89%),and halogenated hydrocarbons(13.31%)were the main composite on.Eight major sources were identified using Positive Matrix Factorization modeling with an accurate VOCs emission inventory as inter-complementary methods revealed that the petrochemical industry(26.24%),other industrial sources(15.19%),and traffic source(12.24%)were the major sources for ambient VOCs in Shijiazhuang.The spatial distributions of major industrial activities emissions were identified by using geographic information statistics system,which illustrated the VOCs was mainly from the north and southeast of Shijiazhuang.The inverse trajectory analysis using Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)and Potential Source Contribution Function(PSCF)clearly demonstrated the features of pollutant transport to Shijiazhuang.These findings can provide references for local governments regarding control strategies to reduce VOCs emissions. | Yanan Guan Lei Wang Shujuan Wang Yihao Zhang Jieying Xiao Xiaoli Wang Erhong Duan Li'an Hou | 2020 | Journal of Environmental Sciences2020，32，11： | 19 |
| 3 | The separable Hamiltonian system and complete biorthogonal expansion method of Mindlin plate bending problems显示文摘A separable Hamiltonian system of Mindlin plate bending problems is obtained. Using the equivalence between the differential form and integral form of the separable Hamiltonian system, the biorthogonal relationships of the eigenfunctions are presented. Based on the biorthogonal relationships, a novel complete biorthogonal expansion of the Mindlin plate bending problems with two opposite sides simply supported is proposed through the products of operator matrices. The exact solutions to deflections and bending moments for the Mindlin plate with fully simply supported sides are obtained. A numerical example is illustrated to verify the accuracy and validity of the expansion method. | HOU GuoLin QI GaoWa XU YaNan CHEN Alatancang | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，5： | 5 |
| 4 | KEY TECHNIQUE TO COMPOSITELY SUPPORTING THE ROADWAY DRIVEN ALONG PREVIOUS GOAF WITH BOLTS, BARS AND CHAIN MESHES UNDER COMPLEX CONDITIONS显示文摘Large cross sectional roadways driven along the previous goaf are always in fragmental surrounding rocks, and remarkably deform under the influence of mining disturbance. It can successfully be supported by the composite bolt-bar-chain mesh support. However, success can only be achieved by getting hold of the key techniques as follows: rationally determining the size of the goaf-side rib, adopting bolts with extendible rod, determining rational parameters and strengthening the integral structure of the supporting system. These have proved effective and profitable by the practice at Dongpang colliery, Xingtai Coal Mining Administration, Hebei province,and are now in application | HOU Chaojiong HE Yanan ZHANG Yidong GUAN Xuemao (China University of Mining & Technology Xuzhou, Jiangsu, P.R.China) | 1995 | Journal of Coal Science & Engineering(China)1995，1，1： | 4 |
| 5 | Endoplasmic reticulum stress contributed to β1-adrenoceptor autoantibody-induced reduction of autophagy in cardiomyocytes显示文摘Autophagy reduction has been confirm ed as an im portant mechanism in apoptosis induction.Our previous study showed that decreased autophagy induced by Pi-adrenoceptor autoantibodies(Pi-AAs)enhanced cardiom yocyte apoptosis and contributed to heart failure progression.Endoplasmic reticulum stress(ERS)is known to be an im portant mechanism in intracellular homeostasis and is closely related to autophagy.However,ERS in pi-AA-induced autophagy dysfunction of cardiom yocytes remains unclear.In this study,we used an active im m unization rat model and H9c2 cardiom yocytes to study the role of ERS in Pi-AA-induced autophagy.Results showed that prolonged action of Pi-AAs significantly reduced the autophagy of myocardial tissues and H9c2 cardiom yocytes,and ERS and its related apoptotic pathways were significantly activated.Moreover,mRFP-GFP-LC3 double-labeled adenoviruses were used to detect cardiom yocyte autophagic flux to confirm that Pi-AAs caused a significant decrease in autophagic flux in H9c2 cardiom yocytes.The ERS inhibitor,4-phenylbutyrate(4-PBA),partially attenuated the β1-AA-induced reduction of cardiom yocyte autophagy,consistent w ith the effect of the m am m alian target of rapam ycin inh ibito r rapamycin(Rapa).Compared to the pretreatm ent with 4-PBA or Rapa alone,pretreatm ent w ith the com bination of 4-PBA and Rapa had a greater effect on attenuating the pi-AA-induced decrease in autophagy and Pi-AA-induced apoptosis in cardiomyocytes.This study provides an experim ental basis fo r the role of Pi-AAs in the homeostatic maintenance of cardiom yocytes in patients w ith heart failure w ith respect to autophagy and ERS. | Li Wang Na Ning Changtu Wang Xiaohong Hou Yuan Yuan Yanan Ren Cong Sun Zi Yan Xiaohui Wang Huirong Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 3 |
| 6 | Net primary productivity and its control of the Middle Jurassic peatlands: An example from the southern Junggar coalfield显示文摘The Jurassic is an important period of global coal formation, including the development of several large coalfields in central Asia and northern China. Individual seams within these peatlands represent sustained periods of terrestrial carbon accumulation and a key environmental indicator attributed to this record is the rate of carbon accumulation. Determining the rate of carbon accumulation requires a measure of time contained within the coal and this study aimed at determining the rate via the identification of Milankovitch orbital cycles using spectral analysis. Spectral analyses of geophysical data from two thick coal seams, No. 43(35.9 m) and No. 3(13.2 m), of the Middle Jurassic of the southern Junggar coalfield were conducted to identify significant signals of variations in ash content. The results showed that the variations in ash content of the coal showed spatial cycles at 0.2, 0.7 and 1.1 m^(-1), which were interpreted to represent 123 ka(eccentricity), 37.1 ka(obliquity), and 21.2 ka(precession) orbital periodicities, respectively. Using this timeframe, the depositional time of the No. 43 and No. 3 coal seams were calculated to be 876–970 and 322–357 ka, respectively. In combination with an understanding of carbon loss during coalification, the carbon accumulation rates of these Middle Jurassic peatlands were calculated to be 58.6–64.9 and60.3–66.8 g C m^(-2) a^(-1) for the No. 43 and No. 3 coal seams, respectively. Given that the net primary productivity(NPP) was 4.3 times the value of the carbon accumulation in a mid-latitude region of 40°–45°N, an NPP of 251.8–279.1 and259.1–287.1 g C m^(-2) a^(-1) was calculated for the No. 43 and No. 3 coal seams, respectively. In the context of the same paleolatitude(40°–45°N) and peat type, the NPP values of the Middle Jurassic strata in the study area were higher than those of the peatlands of the Holocene and Permian, and were similar to the NPP values of Early Cretaceous peatlands. Considering the NPP of a peatland is predominantly controlled by atmospheric CO_2 and O_2 levels and temperature, the lower content of CO_2 and an excessive O_2 level in the temporal atmosphere would lead to a decrease in peatland NPP. Therefore, it is inferred that the CO_2 level during the Middle Jurassic was higher than that of the icehouse Permian and Holocene periods, and it was similar to the CO_2 level of the greenhouse Cretaceous period. The results are consistent with the global CO_2 variation curve of Berner. In conclusion, Milankovitch orbital cycles calculated from geophysical logs can be used to infer the NPP of temporal peatlands during different geological periods, based on which the deep-time paleoclimates can be analyzed. | Yanan LI Longyi SHAO Zhiming YAN Haihai HOU Yue TANG David J.LARGE | 2018 | Science China Earth Sciences2018，61，11： | 2 |
| 7 | A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer显示文摘Protein neddylation is catalyzed by a neddylation activating enzyme(NAE,E1),an E2 conjugating enzyme,and an E3 ligase.In various types of human cancers,the neddylation pathway is abnormally activated.Our previous study validated that the neddylation E2 UBE2F is a promising therapeutic target in lung cancer.Although the NAE inhibitor MLN4924/pevonedistat is currently under clinical investigation as an anti-cancer agent,there are no small molecules available that selectively target UBE2F.Here,we report,for the first time,the discovery,via structure-based virtual screen and chemical optimization,of such a small molecule,designated as HA-9104.HA-9104 binds to UBE2F,reduces its protein levels,and consequently inhibits cullin-5 neddylation.Blockage of cullin-5 neddylation inactivates cullin-RING ligase-5(CRL5)activity,leading to accumulation of the CRL5 substrate,NOXA,to induce apoptosis.Moreover,HA-9104 appears to form the DNA adduct via its 7-azaindole group to induce DNA damage and G2/M arrest.Biologically,HA-9104 effectively suppresses the growth and survival of lung cancer cells and confers radiosensitization in both in vitro cell culture and in vivo xenograft tumor models.In summary,we discovered a small molecule,designated HA-9104,that targets the UBE2F-CRL5 axis with anti-cancer activity alone or in combination with radiation. | Tiantian Xu Qisheng Ma Yanan Li Qing Yu Peichen Pan Yawen Zheng Zhijian Li Xiufang Xiong Tingjun Hou Bin Yu Hongmin Liu Yi Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 2 |
| 8 | NAD^(+) salvage governs the immunosuppressive capacity of mesenchymal stem cells显示文摘Mesenchymal stem/stromal cells(MSCs)possess robust immunoregulatory functions and are promising therapeutics for inflammatory disorders.This capacity is not innate but is activated or‘licensed’by inflammatory cytokines.The licensing mechanism remains unclear.Here,we examined whether inflammatory cytokines metabolically reprogrammed MSCs to confer this immunoregulatory capacity.In response to stimulation by inflammatory cytokines,MSCs exhibited a dramatic increase in the consumption of glucose,which was accompanied by an enhanced use of nicotinamide adenine dinucleotide(NAD^(+))and increased expression of nicotinamide phosphoribosyltransferase(NAMPT),a central enzyme in the salvage pathway for NAD^(+) production.When NAD^(+) synthesis was blocked by inhibiting or depleting NAMPT,the immunosuppressive function of MSCs induced by inflammatory cytokines was greatly attenuated.Consequently,when NAD^(+) metabolism in MSCs was perturbed,their therapeutic benefit was decreased in mice suffering from inflammatory bowel disease and acute liver injury.Further analysis revealed that NAMPT-driven production of NAD^(+) was critical for the inflammatory cytokine-induced increase in glycolysis in MSCs.Furthermore,the increase in glycolysis led to succinate accumulation in the tricarboxylic acid cycle,which led to hypoxia-inducible factor 1α(HIF-1α)stabilization and subsequently increased the transcription of key glycolytic genes,thereby persistently maintaining glycolytic flux.This study demonstrated that unlike its proinflammatory role in immune cells,NAD^(+) metabolism governs the anti-inflammatory function of MSCs during inflammation. | Jiankai Fang Pengbo Hou Shisong Liu Muqiu Zuo Zhanhong Liu Wangwang Chen Yuyi Han Yanan Li Tingting Wang Chao Feng Peishan Li Changshun Shao Yufang Shi | 2023 | Cellular & Molecular Immunology2023，20，10： | 1 |
| 9 | Performance Analysis of Compound Parabolic Concentration Photothermal and Photoelectricity Device for Soil Heating in Facility Agriculture显示文摘It is difficult for solanum crops to grow continuously during winter in severe cold regions. Thus, a soil heating system for facility agriculture based on solar concentration technology was proposed, and a novel compound parabolic concentration photothermal and photoelectricity device(CTPV) equipped in the system was designed to address this problem. In accordance with the structure of the device, LightTools optical software was selected to analyze the variation trend of the light escape rate of the device with the diff erent incident angles. On the basis of the calculation results, an experimental test system was used to investigate the relationship of the air temperature of the inlet and the outlet, total output power of the solar cells, and photothermal and photoelectricity efficiency of the device with the operation time during a sunny day. Research results reveal that the light escape rate of the device is 5.36% at an incidence angle of 12°. At a velocity of 1.5 m/s, the maximum air temperature of the outlet can reach 55.6 ℃, and the total output power of the solar cells is 474.4 W. The variation of the total power of the solar cells is consistent with the simulation results. The maximum instantaneous heat collection and the maximum photothermal and photoelectricity efficiency of the device are 306 W and 60.4%, respectively, and the average efficiency is 44.9%. This study can serve as a reference for compound parabolic concentration technology applied for soil heating in facility agricultural soil heating systems. | Zehui Chang Yanan Peng Xuedong Liu Jing Hou Shuaijun Guo | 2022 | Transactions of Tianjin University2022，28，2： | 1 |
| 10 | Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy显示文摘Protein neddylation is catalyzed by a three-enzyme cascade,namely an E1 NEDD8-activating enzyme(NAE),one of two E2 NEDD8 conjugation enzymes and one of several E3 NEDD8 ligases.The physiological substrates of neddylation are the family members of cullin,the scaffold component of cullin RING ligases(CRLs).Currently,a potent E1 inhibitor,MLN4924,also known as pevonedistat,is in several clinical trials for anti-cancer therapy.Here we report the discovery,through virtual screening and structural modifications,of a small molecule compound HA-1141 that directly binds to NAE in both in vitro and in vivo assays and effectively inhibits neddylation of cullins 1 e5.Surprisingly,unlike MLN4924,HA-1141 also triggers non-canonical endoplasmic reticulum(ER)stress and PKR-mediated terminal integrated stress response(ISR)to activate ATF4 at an early stage,and to inhibit protein synthesis and mTORC1 activity at a later stage,eventually leading to autophagy induction.Biologically,HA-1141 suppresses growth and survival of cultured lung cancer cells and tumor growth in in vivo xenograft lung cancer models at a well-tolerated dose.Taken together,our study has identified a small molecule compound with the dual activities of blocking neddylation and triggering ER stress,leading to growth suppression of cancer cells. | Yanan Li Chaorong Wang Tiantian Xu Peichen Pan Qing Yu Lei Xu Xiufang Xiong Tingjun Hou Sunliang Cui Yi Sun | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 11 | Human skin temperature and thermal responses in asymmetrical cold radiation environments 显示文摘 | Wang Zhaojun He Yanan Hou Juan | 2013 | Building and Enviromnent2013，67，9： | 1 |
| 12 | Evaluation of grain breakage sensitivity of maize varieties mechanically-harvested by combine harvester显示文摘A high grain breakage rate is the main problem that occurs during mechanical maize harvest in China.The breakage sensitivity of different varieties was significantly different,and the breakage resistance is heritable.Therefore,breakage resistant variety screening can help improve the field production efficiency and provide references for breeding work.In this study,42 varieties of maize were harvested with the same mechanical parameters and the same manipulator on a range of harvest dates at experimental stations in Xinxiang,Henan Province,in 2017 and Changji,Xinjiang Province,in 2018 to determine the sensitivity of grain moisture content on grain breakage rate during machine harvest for different varieties.The integral value of the grain breakage rate curve corresponding to the range of 15%to 30%grain moisture content was used as an index that expressed the sensitivity of maize grains to breakage depending on grain moisture content(BSW).Forty-two varieties were categorized as having weak,intermediate,or strong BSW.Among the same four varieties in the two stations,Lianchuang 825 and Lianchuang 808 were classified as sensitive and fragile varieties,Shandan 650 was classified as an intermediate variety,Zeyu 8911 was divided into weak sensitive and breakage-resistance varieties in Xinxiang and intermediate varieties in Changji.The BSW classification results at the two experimental sites were generally consistent,indicating that breakage sensitivity due to moisture content may be a relatively stable genetic characteristic.This study suggested that the integral method for determining BSW can be used to assess the resistance of different maize varieties to grain breakage during mechanical harvesting.The integral method was used to identify twelve breakage-resistant varieties in Xinxiang Station,and six breakage-resistant varieties in Changji Station.This study provides a method for screening maize varieties that are suited to mechanical grain harvesting and for studying the mechanisms of grain breakage resistance. | Yizhou Wang Lulu Li Shang Gao Yanan Guo Guoqiang Zhang Bo Ming Ruizhi Xie Jun Xue Peng Hou Keru Wang Shaokun Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 1 |
| 13 | Inhibitory Effect of 16 Fungicides on Persimmon Anthracnose Pathogen Colletotrichum horii显示文摘In this research,the inhibitory effect of 16 fungicides on Colletotrichum horri causing persimmon anthracnose was investigated using mycelial growth method and spore germination method. The results showed that among the 16 tested fungicides,10% of Difenoconazole WG,33. 5% of Copper quinolate SC,25%of Bromothalonil EC,70% of Mancozeb WP,430 g/L of Tebuconazole SC,50% of Prochloraz-manganese chloride and 400 g/L of Flusilazole EC achieved the best inhibitory effect on mycelial growth of C. horri,with the inhibition rate of 100%; 70% of Polyram WG,33. 5% of Copper quinolate SC,25% of Bromothalonil EC,70% of Mancozeb WP,50% of Chlorobromoisocyanuric acid AF,50% of Triram WP and 400 g/L of Flusilazole achieved the best inhibitory effect on spore germination of C. horri,with the germination rate of 0. In conclusion,33. 5% of Copper quinolate SC,25% of Bromothalonil EC,70% of Mancozeb WP and 400 g/L of Flusilazole EC achieved the best inhibitory effect both in mycelial growth and spore germination,which could be used as the preference fungicides for the control of persimmon anthracnose,and 70% of Polyram WG and 50% of Triram WP achieved the secondly best inhibitory effect,which could be used as alternative fungicides. The results of this research could provide scientific evidence for the effective control of persimmon anthracnose,and more optional pesticides for utilization in the production practice of persimmon industry. | Xianmei YU Changming HOU Kunpeng ZHANG Hao ZHAI Yanan MA Miao AN Chengxiang AI | 2019 | Agricultural Biotechnology2019，8，1： | 1 |
| 14 | Nitrogen-doped hierarchical porous carbon derived from metal–organic aerogel for high performance lithium–sulfur batteries显示文摘Nitrogen-doped three-dimensional(3 D) porous carbon materials have numerous applications due to their highly porous structures, abundant structural nitrogen heteroatom decoration and low densities. Herein,nitrogen doped hierarchical 3 D porous carbons(NHPC) were prepared via a novel metal–organic aerogel(MOA), using hexamethylenetetramine(HMT), 1,3,5-benzenetricarboxylic acid and copper(II) as starting materials. The morphology, porous structure of the building blocks in the NHPC can be tuned readily using different amount of HMT, which makes elongation of the pristine octahedron of HKUST-1 to give rise to different aspect ratio rod-like structures. The as-prepared NHPC with rod-like carbons exhibit high performance in lithium sulfur battery due to the rational ion transfer pathways, high N-doped doping and hierarchical porous structures. As a result, the initial specific capacity of 1341 m A h/g at rate of 0.5 C(1 C = 1675 m A h/g) and high-rate capability of 354 m A h/g at 5 C was achieved. The decay over 500 cycles is 0.08% per cycle at 1 C, highlighting the long-cycle Li–S batteries. | Han Zhang Zongbin Zhao Yang Liu Jingjing Liang Yanan Hou Zhichao Zhang Xuzhen Wang Jieshan Qiu | 2017 | Journal of Energy Chemistry2017，26，6： | 1 |
| 15 | An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis显示文摘Background:Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis(ICAS).The platelet-to-lymphocyte ratio(PLR)has recently emerged as a potential inflammatory biomarker.This study aimed to explore the association of the PLR with ICAS in a Chinese Han population.Methods:A total of 2134 participants(518 with ICAS,1616 without ICAS)were enrolled in this study.ICAS was defined as atherosclerotic stenosis>50%or the occlusion of several main intracranial arteries.Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS.Additional subgroup analyses were performed according to age(<60 vs.≥60 years)and acute ischemic stroke.Results:Multivariate regression analysis showed that a high PLR was associated with a higher risk of ICAS in all participants(P<0.001).Compared with the lowest quartile,the fourth PLR quartile was significantly associated with ICAS(OR 1.705,95%confidence interval 1.278–2.275,P<0.001).In the subgroups stratified by age,an association between the PLR and ICAS was found in the late-life group(P<0.001),but not in the mid-life group(P=0.650).In the subgroups stratified by acute ischemic stroke,the relationship between an elevated PLR and a higher risk of ICAS remained unchanged(stroke group,P<0.001;non-stroke group,P=0.027).Conclusions:An elevated PLR was associated with a higher risk of ICAS in a Chinese Han population.The PLR might serve as a potential biomarker for ICAS in the elderly population. | Yanhua Huang Zuoteng Wang Bing Zhao Yahui Ma Yanan Ou Hao Hu Xiaohe Hou Jintai Yu Lan Tan | 2022 | Chinese Medical Journal2022，，12： | 1 |
| 16 | Real-time Fluorescence Reverse-transcription Loop-mediated Isothermal Amplification for Detection of Porcine Epidemic Diarrhea Virus显示文摘Porcine epidemic diarrhea,a highly contagious enteric infectious disease caused by the porcine epidemic diarrhea virus( PEDV) with symptoms of vomit,diarrhea,loss of appetite of suckling pig,has led to serious economic loss to the global swine industry. In this study,a real-time fluorescence reverse transcription loop-mediated isothermal amplification( RT-LAMP) assay was developed to detect PEDV RNA. The real-time fluorescence RT-LAMP assay was performed at62 ℃ for 60 min,using a simple and portable device,the ESE-Quant Tube Scanner. The detection limit of RNA was 2. 9 × 10~6 copies/μl,10 times as sensitive as RT-PCR,and the detection was specific only to PEDV. Application of this method to clinical samples yielded a positivity rate of 93%,which was higher than that of RT-PCR. This technique saves time and is efficient,and is thus expected to be useful for the diagnosis of PEDV infection in the field. | yanan li jianchang wang bin li ruiwen li yanhong hou lei zhang yun bai wanzhe yuan | 2018 | Agricultural Biotechnology2018，7，2： | 1 |
| 17 | Type 2diabetes is causally associated with depression: a Mendelian randomization analysis显示文摘Type 2diabetes (T2D)has been associated with a high prevalence of depression.We aimed to determine the causal relation by performing a Mendelian randomization (MR)study using 34T2D risk genetic variants validated in East Asians as the instrumental variable (IV).An MR analysis was performed involving 11506 participants from a large longitudinal study.The T2D genetic risk score (GRS)was built using the 34typical T2D common variants.We used T2D_GRS as the IV estimator and performed inverse-variance weighted (IVW)and Egger MR analysis.The T2D_GRS was found to be associated with depression with an OR of 1.21(95%CI:1.07- 1.37)after adjustments for age,sex,body mass index,current smoking and drinking,physical activity,education, and marital status.Using T2D GRS as the IV,we similarly found a causal relationship between genetically determined T2D and depression (OR:1.84,95%CI:1.25-2.70).Though we found no association between the combined effect of the genetic IVs for T2D and depression with Egger MR (OR:0.95,95%CI:0.42-2.14),we found an association for T2D and depression with IVW (OR:1.75,95%CI:1.31-2.46)after excluding pleiotropic SNPs. Overall,the MR analyses provide evidence inferring a potential causal relationship between T2D and depression. | Liping Xuan Zhiyun Zhao Xll Jia Yanan Hou Tiange Wang Mian Li Jieli Lu Yu Xu Yuhong Chen Lu Qi Weiqing Wang Yufang Bi Min Xu | 2018 | Frontiers of Medicine2018，12，6： | 0 |
| 18 | Coal Seam Correlation in Terrestrial Basins by Sequence Stratigraphy and Its Implications for Paleoclimate and Paleoenvironment Evolution显示文摘Coal correlation cannot only guide coal and coalbed methane exploitation,but may also provide valuable information for the evolution of the paleoclimate and paleoenvironment during coalaccumulation periods.It is difficult to undertake coal correlation in a terrestrial basin due to multiple superimposed coal seams and a lack of effective marker beds.In this study,based on the analyses of coal-bearing sedimentary environments and the observations of field outcrops and drilling cores,three key sequence surfaces of the Middle Jurassic Xishanyao Formation were identified in the middle part of the southern Junggar Basin.Three third-order sequences(S.Ⅲ1,S.Ⅲ2 and S.Ⅲ3)and ten fourth-order sequences were divided within the Xishanyao Formation.Regional coal correlation was finally identified,combined with the layered vertical pattern coal and its interval thickness,coal maceral,and coal quality data.In terms of the coal correlation within a specific sequence set,the interval of the B2–B3 coals was approximately three times thicker than that of the B3–B5 coals,which was the main marker for regional coal correlation in the Lower Xishanyao Formation.Furthermore,the phenomena of steadily developed B4 coal seam(2–3 m in thickness)across the Liuhuanggou coal mining area(eastern study region)and the large-small-large variation for intervals between the B8 and B9,B9 and B10,and B10 and B11 coal seams in the Manasi coal mining(western study region)were also an effective means for local coal correlation.Increasing vitrinite and sulphur content and decreasing inertinite content in a third-order sequence were found,which were likely to be closely related to lake level fluctuations.Based on the variation of coal macerals,the wildfire frequency gradually decreased from the bottom to the top of the Xishanyao Formation.The predicted O2level of the S.Ⅲ1,S.Ⅲ2,and S.Ⅲ3 of the Xishanyao Formation was 26.36%,24.22%,and 22.51%,respectively.Except for global paleoclimate effects,the provenance direction changes caused by the Bogda Mountains uplifts would result in a regular variation of coal maceral and coal quality across the study region. | Haihai Hou Longyi Shao Yue Tang Yanan Li Guodong Liang Yilin Xin Jiaqiang Zhang | 2023 | Journal of Earth Science2023，34，2： | 0 |
| 19 | Electrolyte/Structure‑Dependent Cocktail Mediation Enabling High‑Rate/Low‑Plateau Metal Sulfide Anodes for Sodium Storage显示文摘As promising anodes for sodium-ion batteries,metal sulfides ubiquitously suffer from low-rate and high-plateau issues,greatly hindering their application in full-cells.Herein,exemplifying carbon nanotubes(CNTs)-stringed metal sulfides superstructure(CSC)assembled by nano-dispersed SnS_(2) and CoS_(2) phases,cocktail mediation effect similar to that of high-entropy materials is initially studied in ether-based electrolyte to solve the challenges.The high nano-dispersity of metal sulfides in CSC anode underlies the cocktail-like mediation effect,enabling the circumvention of intrinsic drawbacks of different metal sulfides.By utilizing ether-based electrolyte,the reversibility of metal sulfides is greatly improved,sustaining a long-life effectivity of cocktail-like mediation.As such,CSC effectively overcomes low-rate flaw of SnS_(2) and highplateau demerit of CoS_(2),simultaneously realizes a high rate and a low plateau.In half-cells,CSC delivers an ultrahigh-rate capability of 327.6 mAh g^(−1) anode at 20 A g^(−1),far outperforming those of monometallic sulfides(SnS_(2),CoS_(2))and their mixtures.Compared with CoS_(2) phase and SnS_(2)/CoS_(2) mixture,CSC shows remarkably lowered average charge voltage up to ca.0.62 V.As-assembled CSC//Na1.5VPO4.8F0.7 full-cell shows a good rate capability(0.05~1.0 A g^(−1),120.3 mAh g^(−1) electrode at 0.05 A g^(−1))and a high average discharge voltage up to 2.57 V,comparable to full-cells with alloy-type anodes.Kinetics analysis verifies that the cocktail-like mediation effect largely boosts the charge transfer and ionic diffusion in CSC,compared with single phase and mixed phases.Further mechanism study reveals that alternative and complementary electrochemical processes between nano-dispersed SnS_(2) and CoS_(2) phases are responsible for the lowered charge voltage of CSC.This electrolyte/structure-dependent cocktail-like mediation effect effectively enhances the practicability of metal sulfide anodes,which will boost the development of high-rate/-voltage sodium-ion full batteries. | Yongchao Tang Yue Wei Anthony F.Hollenkamp Mustafa Musameh Aaron Seeber Tao Jin Xin Pan Han Zhang Yanan Hou Zongbin Zhao Xiaojuan Hao Jieshan Qiu Chunyi Zhi | 2021 | Nano-Micro Letters2021，13，11： | 0 |
| 20 | Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells显示文摘Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for PCa.Herein,we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients,including gene mutations,mRNA/protein/surface protein distributions,and pharmaceutical responses.The multi-omics analyses identify Anterior Gradient 2(AGR2)as a pre-operative prognostic biomarker in PCa.Through the drug library screening,we describe crizotinib as a selective compound for malignant PCa primary cells.We further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug correlations.Surprisingly,the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft model.Our integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses,allowing for more precise diagnosis and therapies. | Ziruoyu Wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang Jiaqi Wang Jiying Zhu Jianbo Pan Wei Jiang Zengxia Li Mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
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