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| 1 | DEVELOPMENT OF EXPERIMENTAL METHODS FOR IMPACT TESTING BY COMBINING HOPKINSON PRESSURE BAR WITH OTHER TECHNIQUES显示文摘The split Hopkinson pressure bar(SHPB) technique and the wave propagation inverse analysis(WPIA) technique are both extensively used to experimentally investigate the impact behavior of materials, although neither of them alone provides a fully satisfactory analysis. In the present paper, attention is given to new experimental techniques by incorporating a damagemodified constitutive model into the SHPB technique and combining the Hopkinson pressure bar(HPB) technique with WPIA. First, to distinguish the response due to dynamic constitutive behavior and the response due to dynamic damage evolution, the SHPB method incorporating a damage-modified constitutive model is developed, including an explicit damage-modified Zhu–Wang–Tang model and an implicit damage-modified constitutive model. Second, when the SHPB results become invalid, a method of combining new Lagrange inverse analyses with the HPB technique is developed, including cases of the HPB arranged in front of a long specimen and behind the specimen. As examples of these new methods, typical results are given for nonlinear viscoelastic polymers and concretes considering damage evolution, a super-elastic Ti–Ni alloy with phase transformation and an aluminum foam with shock waves propagating within it. | Lili Wang Shisheng Hu Liming Yang Zijian Sun Jue Zhu Huawei Lai Yuanyuan Ding | 2014 | Acta Mechanica Solida Sinica2014，27，4： | 9 |
| 2 | Bioinspired Unidirectional Liquid Transport Micro-nano Structures:A Review显示文摘Unidirectional liquid transport without any need of external energy has drawn worldwide attention for its potential applications in various fields such as microfluidics,biomedicine and mechanical engineering.In nature,numerous creatures have evolved such extraordinary unidirectional liquid transport ability such as spider sik,Sarracenia's trichomes,and Nepenthes alata's peristome,etc.This review summarizes the current progresses of natural unidirectional liquid transport on 1-Dimensional(1D)linear structure and 2-Dimensional(2D)surface stucture.The driving force of unidirectional liquid transport which is determined by unique structure exist distinct differences in physics.The fundamental understanding of 1D and 2D unidirectionaliquid transport especially about hierarchical structural characteristics and their transport mechanism were concentrated,and various bioinspired fabrication methods are also introduced.The applications of bioinspired directional liquid transport are demonstrated especially in fields of microfluidies,biomedical devices and anti-icing surfaces.With newly developed smart materials,various liquid transport regulation strategies are also summarized for the control of transport speed,direction guiding,etc.Finally,we provide new insights and future perspectives of the directional transport materials. | Liwen Zhang Guang Liu Huawei Chen Xiaolin Liu Tong Ran Yi Zhang Yang Gan Deyuan Zhang | 2021 | Journal of Bionic Engineering2021，18，1： | 4 |
| 3 | Efficient genetic transformation and CRISPR/Cas9-mediated genome editing of watermelon assisted by genes encoding developmental regulators显示文摘Cucurbitaceae is an important family of flowering plants containing multiple species of important food plants,such as melons,cucumbers,squashes,and pumpkins.However,a highly efficient genetic transformation system has not been established for most of these species(Nanasato and Tabei,2020).Watermelon(Citrullus lanatus),an economically important and globally cultivated fruit crop,is a model species for fruit quality research due to its rich diversity of fruit size,shape,flavor,aroma,texture. | Wenbo PAN Zhentao CHENG Zhiguo HAN Hong YANG Wanggen ZHANG Huawei ZHANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 4 |
| 4 | Simultaneous gene editing of three homoeoalleles in self-incompatible allohexaploid grasses显示文摘Clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system has been widely used for precise gene editing in plants.However,simultaneous gene editing of multiple homoeoalleles remains challenging,especially in self-incompatible polyploid plants.Here,we simultaneously introduced targeted mutations in all three homoeoalleles of two genes in the self-incompatible allohexaploid tall fescue,using both CRISPR/Cas9 and LbCas12a(LbCpf1)systems.Loss-of-function mutants of FaPDS exhibited albino leaves,while knockout of FaHSP17.9 resulted in impaired heat resistance in T0 generation of tall fescue.Moreover,these mutations were inheritable.Our findings demonstrate the feasibility of generating loss-of-function mutants in T0 generation polyploid perennial grasses using CRISPR/Cas systems. | Liang Zhang Tao Wang Guangyang Wang Aoyue Bi Misganaw Wassie Yan Xie Liwen Cao Huawei Xu Jinmin Fu Liang Chen Yang Zhao Tao Hu | 2021 | Journal of Integrative Plant Biology2021，63，8： | 3 |
| 5 | Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice显示文摘Dear Editor,Hearing loss is the most common sensory disorder in the world.Among cases of non-syndromic hearing loss,which account for 70%of all cases of genetic hearing loss,around 80%of cases arise from autosomal recessive loss-of-function mutations that require repair,rather than disruption,of the mutant allele.1 CRISPR/Cas9-mediated homology-directed repair(HDR)-based therapies have the potential to cure many genetic diseases because this class of therapeutics can achieve arbitrary base changes as well as the insertion or deletion of DNA fragments/However. | Xi Gu Xinde Hu Daqi Wang Zhijiao Xu Fang Wang Di Li Geng-lin Li Hui Yang Huawei Li Erwei Zuo Yilai Shu | 2022 | Cell Research2022，32，7： | 3 |
| 6 | Nitrogen-doped carbon stabilized Li Fe0.5Mn0.5PO4/rGO cathode materials for high-power Li-ion batteries显示文摘Exploring high ion/electron conductive olivine-type transition metal phosphates is of vital significance to broaden their applicability in rapid-charging devices.Herein,we report an interface engineered Li Fe0.5Mn0.5PO4/rGO@C cathode material by the synergistic effects of r GO and polydopamine-derived N-doped carbon.The well-distributed Li Fe0.5Mn0.5PO4nanoparticles are tightly anchored on r GO nanosheet benefited by the coating of N-doped carbon layer.The design of such an architecture can effectively suppress the agglomeration of nanoparticles with a shortened Li+transfer path.Meantime,the high-speed conducting network has been constructed by r GO and N-doped carbon,which exhibits the face-to-face contact with Li Fe0.5Mn0.5PO4nanoparticles,guaranteeing the rapid electron transfer.These profits endow the Li Fe0.5Mn0.5PO4/rGO@C hybrids with a fast charge-discharge ability,e.g.a high reversible capacity of 105 m Ah·g^-1at 10 C,much higher than that of the Li Fe0.5Mn0.5PO4@C nanoparticles(46 mA·h·g^-1).Furthermore,a 90.8%capacity retention can be obtained even after cycling 500 times at 2 C.This work gives a new avenue to fabricate transition metal phosphate with superior electrochemical performance for high-power Li-ion batteries. | Haifeng Yu Zhaofeng Yang Huawei Zhu Hao Jiang Chunzhong Li | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 3 |
| 7 | Phase structure of sputtered Ta coating and its ablation behavior by laser pulse heating(LPH)显示文摘Phase structure of sputtered Ta coating in the negative glow space and LPH effect were explored.The whole coating/substrate system is substrate→physically gas-absorbed Fe surface→oxygen-enriched TaOx layer→amorphous Ta→αandβdual phase→singleαphase.After LPH course,micro structure of Ta coating shows intact,only a few cracks emerge after 100 laser pulses,exhibiting thin HAZ but thick Fe/Ta ICZ,without martensitic transformation.For the electrodeposited Cr coating,continuous thermal stresses produce many extra micro-crack,substrate oxidation and martensitic transformation,leading to crack propagations and final bulk delamination,without any ICZ. | Yunsong Niu Lingling Xing Feng Yang Huawei Li Minghui Chen Shenglong Zhu Fuhui Wang | 2021 | Journal of Materials Science & Technology2021，，6： | 2 |
| 8 | The detection of micrometastases in the peripheral blood of patients with breast cancer for hSBEM mRNA and CD44V6 mRNA显示文摘Objective: Successful treatment of breast cancer greatly depends on the early detection of its metastasis, there- fore a sensitive and specific biomarker for detecting dissemination of the cancer cells will help to achieve this goal. This study was to evaluate the prognostic significance of human small breast epithelial mucin (hSBEM) and CD44V6 in breast cancer. Methods: The expressions of hSBEM mRNA and CD44V6 mRNA were detected with nested reverse transcription polymerase chain reaction (nested RT-PCR) in 67 samples of breast cancer and adjacent normal breast tissue, 16 samples of breast benign lesions tissue, and 67 specimens of peripheral blood from patients with breast cancer, 16 specimens of benign breast lesions, 20 specimens of healthy volunteers, and 25 (each five cases) other carcinomas tissue samples, including those of gastric carcinoma, colorectal carcinoma, esophageal carcinoma, lung carcinoma, and ovary carcinoma, were ana- lyzed for hSBEM mRNA expression by nested RT-PCR. Results: hSBEM mRNA expression was observed in 62/67 (92.54%) of breast cancer, 14/16 (87.50%) of breast benign lesions and 59/67 (88.05%) of normal breast tissue, with no significant differences between them (P > 0.05). None of the samples from other cancer tissues were positive. In peripheral blood the expression of hSBEM mRNA was detected in 34/67 (50.75%) from patients with breast cancer, with significant increasing (P < 0.05) in the cases of metastatic disease (stage IV) and those with lymph node metastasis compared with localized disease (stage I, II and III) and without lymph node metastasis, but its expression was not found in peripheral blood of patients with benign breast lesions or healthy volunteers. Although CD44V6 mRNA was significantly higher in breast cancer than in benign breast lesions tissue and normal breast tissue, its expression in peripheral blood show no significant difference (P > 0.05) in the patients with breast cancer (82.09%), benign breast lesion (75.00%), or healthy volunteers (70.00%). The expressions of hSBEM mRNA and CD44V6 mRNA had no correlation with the age of the patients, size of primary tumor, histological type and estrogen or progestin receptor status (P > 0.05). Conclusion: hSBEM mRNA, as assessed by nested RT-PCR, shows a mammary-specific and mammary-sensitive expression, and is a sensitive indicator of hematogeneous spread of breast cancer cell, while CD44V6 shows low sensitivity and specificity in detecting dissemination of breast cancer cell in peripheral blood. hSBEM mRNA is a promising molecular biomarker for detecting breast cancer micrometastases. | Jianlun Liu Huawei Yang Ji Cao Nanwu Yang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，1： | 2 |
| 9 | Enrichment of CO from syngas with Cu(I)Y adsorbent by five-bed VPSA显示文摘Cu (I) Y 吸附物被被离子交换在之间准备的 Cu (II ) Y 的减小准备否沸石和 Cu (II ) 的一个答案氯化物。为公司的 Cu (I) Y 的动态吸附能力被在 30o | Shuna LI Huawei YANG Donghui ZHANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，4： | 1 |
| 10 | Electrostatic assembly functionalization of poly(γ-glutamic acid)for biomedical antibacterial applications显示文摘Poly(γ-glutamic acid)(γ-PGA)has been found widespread applications in biomedical field because of its excellent water solubility,biocompatibility,and bioactivity.Herein,a water-insoluble γ-PGA antibacterial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate(ELA).The functionalized γ-PGA compound(γ-PGA-ELA)ethanol solution can facilely produce colorless and transparent coatings on various inorganic,metal,and polymeric substrates,especially for the lumen of slender catheters(length up to 2 m,and inner diameter down to 1 mm).The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo.In addition,the γ-PGA compound is used as antibacterial additives of polyolefin via melting extrusion,and the asprepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy.More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility,low cytotoxicity,and satisfactory histocompatibility.The as-proposed γ-PGA compound has a great potential to serve as a safe and multifunctional antibacterial candidate to combat biomedical devices-related infections. | Xiaodan Wang Hengchong Shi Haoyu Tang Huan Yu Qiuyan Yan Huawei Yang Xu Zhang Shifang Luan | 2020 | Journal of Materials Science & Technology2020，59，24： | 1 |
| 11 | A large insert Thellungiella halophila BIBAC library for genomics and identification of stress tolerance genes显示文摘 | Weiquan Wang Yaorong Wu Yin Li Jiaying Xie Zhonghui Zhang Zhiyong Deng Yiyue Zhang Cuiping Yang Jianbin Lai Huawei Zhang Hongyan Bao Sanyuan Tang Chengwei Yang Peng Gao Guixian Xia Huishan Guo Qi Xie | 2010 | Plant Molecular Biology (-)2010，，1： | 1 |
| 12 | Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates显示文摘 | Jinrong Li Hong Li Huawei Mao Meixing Yu Ting Feng Fan Yang Yingying Fan Qiao Lu Chongyang Shen Zhongwei Yin Wenwei Tu Meng Mao | 2013 | Cellular & Molecular Immunology2013，10，3： | 1 |
| 13 | The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population显示文摘MNS16A,a variable number of tandem repeats polymorphism in the TERT gene,has been suggested to regulate telomerase activity.As telomerase activity has been reported to be related to life-span,we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere.To test this hypothesis,we collected 446 unrelated pericentenarian individuals(age≥90,mean 94.45±3.45 years)and 332 normal controls(age 22-53,mean 35.0±12.0 years)from Dujiangyan,Sichuan,China.We typed the MNS16A polymorphism in both groups,and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test.There was no significant difference between the peri-centenarian and control groups.Thus,the MNS16A polymorphism in TERT might not influence human life-span,at least in the Han Chinese population studied here. | LIU LiNa WANG ChengYe LU Xiang XIAO FuHui WANG HuaWei YANG LiQin XU LiangYou KONG QingPeng | 2014 | Science China(Life Sciences)2014，57，10： | 1 |
| 14 | Cryptochrome 1 Inhibits Shoot Branching by Repressing the Self-Activated Transciption Loop of PIF4 in Arabidopsis显示文摘Cryptochrome 1(CRY1)is an important light receptor essential for de-etiolation of Arabidopsis seedlings.However,its function in regulating plant architecture remains unclear.Here,we show that mutation in CRY1 resulted in increased branching of Arabidopsis plants.To investigate the underlying mechanism,we analyzed the expression profiles of branching-related genes and found that the mRNA levels of Phytochrome Interaction Factor 4(PIF4)and PIF5 are significantly increased in the cry1 mutant.Genetic analysis showed that the pif4 or pif4pif5 mutant is epistatic to the cry1 mutant,and overexpression of PIF4 conferred increased branching.Moreover,we demonstrated that PIF4 proteins physically associate with the G-box motif within the PIF4 promoter to form a self-activated transcriptional feedback loop,while CRY1 represses this process in response to blue light.Taken together,this study suggests that the CRY1–PIF4 module regulates gene expression via forming a regulatory loop and shoot branching in response to ambient light conditions. | Huawei Zhai Lu Xiong Hongyu Li Xiangguang Lyu Guodong Yang Tao Zhao Jun Liu Bin Liu | 2020 | Plant Communications2020，1，3： | 1 |
| 15 | An electrocatalyst with anti-oxidized capability for overall water splitting显示文摘 | Chang Yu Huawei Huang Si Zhou Xiaotong Han Changtai Zhao Juan Yang Shaofeng Li Wei Guo Bowen An Jijun Zhao Jieshan Qiu | 2018 | Nano Research2018，11，6： | 1 |
| 16 | Thermally conductive composites obtained by flake graphite filling immiscible Polyamide 6/Polycarbonate blends显示文摘 | Shengtai Zhou Yang Chen Huawei Zou Mei Liang | 2013 | Thermochimica Acta2013，，： | 1 |
| 17 | Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1–RAGE and AKT pathways显示文摘 | Ping Cheng Weiqi Dai Fan Wang Jie Lu Miao Shen Kan Chen Jingjing Li Yan Zhang Chengfen Wang Jing Yang Rong Zhu Huawei Zhang Yuanyuan Zheng Chuan-Yong Guo Ling Xu | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 18 | Mineral characteristics and their geological significance of black shales in southeastern Ordos Basin by X-ray diffraction analysis显示文摘X-ray diffraction analysis of black shale of Upper Triassic Member Chang 7 of the Yanchang Formation in southeastern Ordos Basin showed that black shales were deposited in brackish, strongly reducing, semi-deep-deep lacustrine facies, and mainly composed of quartz, feldspar, carbonate(dolomite), clay minerals(illite and illite/smectite) and a certain amount of pyrite. The mineral composition characteristics of this set of black shales are similar to those of highly productive shale gas in North America, for example shallow burial, low clay mineral and abundant brittle mineral, so the strata are conducive to the development of cracks and fractures. Thus, this area is favorable for shale oil/gas exploration and development. | YAO Zhigang YANG Yang YING Huawei DONG Yunpeng | 2014 | Chinese Journal Of Geochemistry2014，33，1： | 1 |
| 19 | Thermally conductive composites obtained by flake graphite filling immiscible polyamide 6/polycarbonate blends显示文摘 | Shengtai Zhou Yang Chen Huawei Zou | 2013 | Thermochimica Acta2013，566，： | 1 |
| 20 | Diagnostic Performance of Des- γ -carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis显示文摘 | Rong Zhu Jing Yang Ling Xu Weiqi Dai Fan Wang Miao Shen Yan Zhang Huawei Zhang Kan Chen Ping Cheng Chengfen Wang Yuanyuan Zheng Jingjing Li Jie Lu Yingqun Zhou Dong Wu Chuanyong Guo Fabio Farinati | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
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