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| 1 | HPLC–MS and HPLC–MS/MS analysis of seven active constituents of Xiao-Xu-Ming decoction and application to a pharmacokinetic study after oral administration to rat显示文摘Xiao-xu-ming decoction(XXMD)is a traditional Chinese medicine that has been widely used to treat theoplegia and its sequelae.This paper reports the development of three separate assays based on reversed phase high-performance liquid chromatography–mass spectrometry(HPLC–MS)and HPLC–MS/MS for the determination of seven active constituents of XXMD viz oroxylin A-7-O-glucuronide,wogonoside,liquiritigenin,cimifugin,5-O-methylvisammiol,glycyrrhizic acid and glycyrrhetinic acid in rat plasma.All calibration curves were linear(r >0.99)with lower limits of quantitation(LLOQs)<12.4 ng/mL.Intra-and inter-day precisions(as relative standard deviation)were all <10.7% with recoveries in the range of 88.7–113%.In addition,the seven analytes were shown to be stable in rat plasma samples under relevant storage conditions.The validated methods were successfully applied to a pharmacokinetic study in rat after oral administration of XXMD. | Yilin Wang Chunguang Ding Caisheng Wu Kehe Du Jinlan Zhangn Hailin Qin Jinfeng Hou Guanhua Du | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 6 |
| 2 | Timing and structural controls on skarn-type and vein-type mineralization at the Xitian tin-polymetallic deposit, Hunan Province, SE China显示文摘Xitian tin-polymetallic deposit, located in the eastern Hunan Province, SE China, hosts quartz vein and skarn in the contact zone between carbonate and two stages granites. Critical geodynamic questions for South China are whether different types of mineralization form in the same time and how the magmatism–tectonic system controls the ore-forming process. Based on the distribution of the orebodies, six cassiterite samples from different types of mineralization are collected for dating. In-situ LA-MCICP-MS U–Pb isotopic data yielded concordia low intercept ages between 154 and 157 Ma, indicating that different types of mineralization belong to the same magmatism–mineralization system. Coupled with the study of the kinematic indicators, it suggests that the structural control of the wall rocks constrain the types of mineralization. These results provide further evidence of a close temporal link between the structure and the tin-polymetallic mineralization in Xitian deposit. Considering the structure in the district, granite dome plays an important role in the ore-forming process. The age and structural signatures in Xitian deposit are the response to the subduction of Pacific Plate. | Miao He Quanlin Hou Qing Liu Jiheng Zhang Jinfeng Sun Shichong Wu Haofeng Zhu | 2018 | Acta Geochimica2018，37，2： | 4 |
| 3 | Identification of a novel seed size associated locus SW9-1 in soybean显示文摘Seed size is one of the vital traits determining seed appearance, quality, and yield. Untangling the genetic mechanisms regulating soybean 100-seed weight (100-SW), seed length and seed width across environments may provide a theoretical basis for improving seed yield. However, there are few reports related to QTL mapping of 100-SW across multiple ecological regions. In this study, 21 loci associated with seed size traits were identified using a genome-wide association of 5361 single nucleotide polymorphisms (SNPs) across three ecoregions in China, which could explain 8.12%–14.25% of the phenotypic variance respectively. A new locus, named as SW9-1 on chromosome 9 that explained 10.05%–10.93% of the seed weight variance was found significantly related to seed size traits, and was not previously reported. The selection effect analysis showed that SW9-1 locus has a relatively high phenotypic effect (13.67) on 100-SW, with a greater contribution by the accessions with bigger seeds (3.69) than the accessions with small seeds (1.66). Increases in seed weight were accompanied by increases in the frequency of SW9-1T allele, with >90% of the bred varieties with a 100-SW >30 g carrying SW9-1T. Analysis of SW9-1 allelic variation in additional soybean accessions showed that SW9-1T allele accounting for 13.83% of the wild accessions, while in 46.55% and 51.57% of the landraces and bred accessions, respectively, this results indicating that the SW9-1 locus has been subjected to artificial selection during the early stages of soybean breeding, especially the utilization of SW9-1T in edamame for big seed. These results suggest that SW9-1 is a novel and reliable locus associated with seed size traits, and might have an important implication for increasing soybean seed weight in molecular design breeding. Cloning this locus in future may provide new insights into the genetic mechanisms underlying soybean seed size traits. | Jiajia Li Jinghui Zhao Yinghui Li Yali Gao Sunan Hua Muhammad Nadeem Genlou Sun Wenming Zhang Jinfeng Hou Xiaobo Wang Lijuan Qiu | 2019 | The Crop Journal2019，7，4： | 4 |
| 4 | Neuroprotective effects of willed-movement therapy in a rat model of cerebral ischemia/reperfusion显示文摘The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method.Rats performed willed-movement(climbing a ladder or wall in a box) when induced by food and water.Results revealed that Longa scores of neurological deficits significantly de-creased in the willed-movement group at 15 days after reperfusion,while expression of glial fibrillary acidic protein,neurotrophic factor-3,and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion.Results suggested that willed-movement ameliorated neurological deficits by increasing expression of glial fibrillary acidic protein,neurotrophic factor-3,and growth-associated protein-43. | Deren Hou Jianfeng Liu Jinfeng Deng Zhongyang Hu Chao Feng Haixia Zhu | 2011 | Neural Regeneration Research2011，6，35： | 1 |
| 5 | Contrasting Thermoelectric Transport Behaviors of p-Type PbS Caused by Doping Alkali Metals (Li and Na)显示文摘PbS is a latent substitute of PbTe thermoelectric materials,which is on account of its superiority in low cost and earth abundance.Here,the thermoelectric transport properties of p-type PbS by doping alkali metals(Na and Li)are investigated and it is verified that Li is a more effective dopant than Na.By introducing Li,the electrical and thermal transport properties were optimized collectively.The electrical transport properties were boosted remarkably via adjusting carrier concentration,and the maximum power factor(PF_(max))of~11.5μW/cmK^(2) and average power factor(PFave)~9.9μW/cmK^(2) between 423 and 730 K in Pb_(0.99)Li_(0.01)S were achieved,which are much higher than those(~9.5 and~7.7μW/cmK^(2))of Pb0.99Na0.01S.Doping Li and Na can weaken the lattice thermal conductivity effectively.Combining the enlarged PF with suppressed total thermal conductivity,a maximum ZT~0.5 at 730 K and a large average ZT~0.4 at 423-730K were obtained in p-type Pb_(0.99)Li_(0.01)S,which are higher than~0.4 and~0.3 in p-type Pb0.99Na0.01S,respectively. | Zhenghao Hou Dongyang Wang Jinfeng Wang Guangtao Wang Zhiwei Huang Li-Dong Zhao | 2020 | Research2020，，1： | 1 |
| 6 | Interpretation of Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7)显示文摘On March 3,2020,the National Health Commission and the National Administration of Traditional Chinese Medicine of China jointly promulgated the Notice on Printing and Distributing the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7).The content has been revised and supplemented on the basis of the Version 6,including etiological characteristics and pathological changes in lung,heart,kidney,spleen,liver,gallbladder,esophagus,stomach and intestinal mucosal epithelium.In particular,the diagnosis and treatment methods of traditional Chinese medicine are supplemented.It provides an evidence-based diagnosis and treatment protocol for the treatment and recovery of suspected and confirmed cases of novel coronavirus pneumonia with traditional Chinese medicine and Western medicine. | Jinfeng CHEN Zhongyi LEI Chaofeng LIU Hong FAN Peng LEI Xueping WU Xiaoyong YU Yanfen ZHOU Jiejun HOU | 2020 | Medicinal Plant2020，11，3： | 1 |
| 7 | Conductive metal-organic frameworks: Recent advances in electrochemical energy-related applications and perspectives显示文摘Metal-organic frameworks(MOFs),typically constructed with metallic nodes and organic linkers,have influenced the development of modular solid materials.Their adjustable molecular structure provides a remarkable variety of MOF-based solid-state structures towards diverse applications.However,the low conductivity of traditional MOFs extremely hinders their applications in electronic and electrochemical devices.The emerging conductive MOFs,generally possessing twodimensional layered structures,are endowed with both the structural merits of common MOFs and exceptional electronic/ionic conductivities.Besides,the selection and optimization of ligands and metal centers,as well as synthetic methods enormously affects the intrinsic conductivity of conductive MOFs.The distinctive crystal structures and superb conductivity promise their appealing applications in electrochemical energy-related fields.In the review,we mainly summarize representative crystal features,conducting mechanisms and recent advances in rational design and synthesis of conductive MOFs,along with their versatile applications as electrodes for electrochemical capacitors and rechargeable batteries,and as catalysts towards electrocatalysis.Finally,the involved challenges and future trends/prospects of the conductive MOFs for electrochemical energyrelated applications are further proposed. | Lingzhi Guo Jinfeng Sun Jingxuan Wei Yang Liu Linrui Hou Changzhou Yuan | 2020 | Carbon Energy2020，2，2： | 1 |
| 8 | Doping profile modification approach of the optimization of HfO_x based resistive switching device by inserting AlO_x layer显示文摘Hf Ox based resistive switching devices with thin Al Ox layer inserted between Hf Ox and Ti N top electrode(TE) and Pt bottom electrode(BE) were fabricated respectively. Both devices show robust bipolar resistive switching phenomenon. Experimental result reveals that Ti N/Al Ox/Hf Ox/Pt device with appropriately thick Hf Ox film shows significant enhancement in performance as compared with other samples, having lower voltage and excellent uniformity. The role of inserted Al Ox layer and thickness of Hf Ox film on resistive switching properties are discussed and clarified through comparative experiments, which is considered to be a doping effect. The experimental result is consistent with the model where resistive switching happens near Ti N top electrode(TE) due to partial rupture and reconstruction of conducting filaments(CFs) assisted by the doping. The different doping profiles near top electrode of the samples were confirmed by XPS depth analysis.This work provides detailed information about the optimization of Hf Ox based resistive switching device by a doping profile modification approach. | HOU Yi CHEN Bing CHEN Zhe ZHANG FeiFei LIU LiFeng KANG JinFeng CHENG YuHua | 2015 | Science China(Information Sciences)2015，58，6： | 1 |
| 9 | Quantitative Investigation of the Velocity Overshoot Overestimation's Impact on Predicting Device Characteristics in HD Model显示文摘 | HOU Danqiong XIA Zhiliang DU Gang LIU Xiaoyan WANG Yi KANG Jinfeng HAN Ruqi | 2006 | Chinese Journal of Electronics2006，15，2： | 0 |
| 10 | Discussion on the Selection of ACEI and ARB for the Patients with COVID-19 and Hypertension from ACE2显示文摘With the wide spread of COVID-19,some studies have confirmed that novel coronavirus enters the cell through the binding of spike protein and ACE2 protein,which has the risk of causing the virus to enter the cell to accelerate its transmission.ACEI and ARB are the key drugs for the treatment of hypertension and are widely used in clinic.They are good for ventricular and vascular remodeling in patients with hypertension,coronary heart disease and heart failure.ACEI and ARB drugs may increase the expression of ACE2 in lung tissue and increase the risk of aggravation of the disease.According to the advice of hypertension experts:for mild ordinary COVID-19 patients with hypertension,we can consider discontinuing ACEI and ARB drugs,while for severe COVID-19 patients with hypertension,ACEI and ARB drugs should be stopped immediately.During the discontinuation period,temporary replacement therapy with diuretics,dipine and vasodilatation hypotensive drugs can be considered. | Jinfeng CHEN Zhongyi LEI Chaofeng LIU Hong FAN Peng LEI Xueping WU Xiaoyong YU Yanfen ZHOU Jiejun HOU | 2020 | Medicinal Plant2020，11，4： | 0 |
| 11 | Solid-state template-free fabrication of uniform Mo2C microflowers with lithium storage towards Li-ion batteries显示文摘Herein,we first report one-step synthesis of uniform Mo2 C microflowers(MCMFs)from low-cost precursors via industrialized solid-state strategy.With fine optimization in precursor ratio and pyrolysis temperatures,the as-fabricated MCMFs are assembled well with interconnected single-crystalline nanosheet subunits.More encouragingly,the resultant MCMFs are further highlighted as a competitive anode with robust and long-duration lithium-storage behaviors towards high-performance Li-ion batteries. | Jinfeng Sun Lingzhi Guo Miaomiao Gao Xuan Sun Jinyang Zhang Longwei Liang Yang Liu Linrui Hou Changzhou Yuan | 2020 | Chinese Chemical Letters2020，31，6： | 0 |
| 12 | Discussion on the Prevention and Treatment of COVID-19 Causing Lung Disease and Heart Damage Based on Lei Zhongyi's Theory of Intermingled Phlegm,Blood Stasis and Toxin显示文摘Novel coronavirus infection not only damages lung function,but also causes myocardial injury,elevated myocardial enzymes and heart failure,especially for patients with basic heart diseases who develop COVID-19,the first consideration should be the protection of cardiac function.Based on the theory of intermingled phlegm,blood stasis and toxin of heart disease put forward by Master Lei Zhongyi,the dialectical treatment thinking of COVID-19 patients from the concept of damage of phlegm,blood stasis and toxin to the heart were discussed.During the diagnosis,critical stage and recovery period of COVID-19,expectorant and blood-activating agents,heat and detoxification agents can be added to promote lung and asthma,free Bizheng and remove blood stasis,calm the heart and calm the mind,and promote the recovery of cardiopulmonary functions. | Jinfeng CHEN Zhongyi LEI Chaofeng LIU Hong FAN Peng LEI Xueping WU Xiaoyong YU Yanfen ZHOU Jiejun HOU | 2020 | Medicinal Plant2020，11，6： | 0 |
| 13 | Targeting HSPA1A in ARID2-deficient lung adenocarcinoma显示文摘Somatic mutations of the chromatin remodeling gene ARID2 are observed in~7%of human lung adenocarcinomas(LUADs).However,the role of ARID2 in the pathogenesis of LUADs remains largely unknown.Here we find that ARID2 expression is decreased during the malignant progression of both human and mice LUADs.Using two Kras^(G12D)-based genetically engineered murine models,we demonstrate that ARID2 knockout significantly promotes lung cancer malignant progression and shortens overall survival.Consistently,ARID2 knockdown significantly promotes cell proliferation in human and mice lung cancer cells.Through integrative analyses of Ch IP-Seq and RNA-Seq data,we find that Hspa1 a is up-regulated by Arid2 loss.Knockdown of Hspa1 a specifically inhibits malignant progression of Arid2-deficient but not Arid2-wt lung cancers in both cell lines as well as animal models.Treatment with an HSPA1 A inhibitor could significantly inhibit the malignant progression of lung cancer with ARID2 deficiency.Together,our findings establish ARID2 as an important tumor suppressor in LUADs with novel mechanistic insights,and further identify HSPA1 A as a potential therapeutic target in ARID2-deficient LUADs. | Xue Wang Yuetong Wang Zhaoyuan Fang Hua Wang Jian Zhang Longfu Zhang Hsinyi Huang Zhonglin Jiang Yujuan Jin Xiangkun Han Shenda Hou Bin Zhou Feilong Meng Luonan Chen Kwok-Kin Wong Jinfeng Liu Zhiqi Zhang Xin Zhang Haiquan Chen Yihua Sun Liang Hu Hongbin Ji | 2021 | National Science Review2021，8，10： | 0 |
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