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| 1 | Global warming, human-induced carbon emissions, and their uncertainties显示文摘In recent decades, there have been a number of debates on climate warming and its driving forces. Based on an extensive literature review, we suggest that (1) climate warming occurs with great uncertainty in the magnitude of the temperature increase; (2) both human activities and natural forces contribute to climate change, but their relative contributions are difficult to quantify; and (3) the dominant role of the increase in the atmospheric concentration of greenhouse gases (including CO 2 ) in the global warming claimed by the Intergovernmental Panel on Climate Change (IPCC) is questioned by the scientific communities because of large uncertainties in the mechanisms of natural factors and anthropogenic activities and in the sources of the increased atmospheric CO 2 concentration. More efforts should be made in order to clarify these uncertainties. | FANG JingYun ZHU JiangLing WANG ShaoPeng YUE Chao SHEN HaiHua | 2011 | Science China Earth Sciences2011，54，10： | 37 |
| 2 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 3 | Simulated and reconstructed winter temperature in the eastern China during the last millennium显示文摘The reconstructed temperature anomalies in the eastern China were compared with the output from a 1000-year model simulation in an attempt to evaluate the model’s regional simulation skills and to understand the causes of climate change in China over the last millennium. The reconstructed data are the winter half-year temperature anomalies in the central region of eastern China (25°-40°N, east of 105°E) for the last 1000 years with a 30-year resolu- tion. The model used is the global atmosphere-ocean coupled climate model, ECHO-G, which was driven by time-varying external forcings including solar radiation, volcanic erup- tions, and greenhouse gas concentrations (CO2 and CH4) for the same period. The correlation coefficient between the simulated and reconstructed time series is 0.37, which is sta- tistically significant at a confidence level of 97.5%. The Me- dieval Warm Period (MWP) during 1000-1300 A.D., the Little Ice Age (LIA) during 1300-1850 A.D. and the modern warming period after 1900 A.D. are all recognizable from both the simulated and reconstructed temperatures. The anomalies associated with the LIA and the modern warming simulated by the model are in good consistency with the re- constructed counterpart. In particular during the Maunder sun-spot minimum (1670-1710 A.D.), both the simulated and reconstructed temperature anomalies reach their min- ima without any phase difference. But in the earlier MWP, significant discrepancies exist between the simulation and the reconstruction, which might reflect the degrading quality of the reconstruction data. The range of the simulated anoma- lies (1.62 K) is comparable with that of reconstructed (2.0 K). Diagnosis of the model results indicates that, during the last millennium, variations in solar radiation and volcanic activ- ity are the main controlling factors on regional temperature change, while in the recent 100 years, the change of the con- centration of greenhouse gases plays most important role in explaining the rapid temperature rising. | LIU Jian H. Storch CHEN Xing E. Zorita ZHENG Jingyun WANG Sumin | 2005 | Chinese Science Bulletin2005，50，24： | 21 |
| 4 | Climate and litter C/N ratio constrain soil organic carbon accumulation显示文摘Soil organic carbon(SOC) plays critical roles in stabilizing atmospheric CO2 concentration, but the mechanistic controls on the amount and distribution of SOC on global scales are not well understood. In turn, this has hampered the ability to model global C budgets and to find measures to mitigate climate change. Here, based on the data from a large field survey campaign with 2600 plots across China’s forest ecosystems and a global collection of published data from forested land, we find that a low litter carbon-to-nitrogen ratio(C/N) and high wetness index(P/PET, precipitation-to-potentialevapotranspiration ratio) are the two factors that promote SOC accumulation, with only minor contributions of litter quantity and soil texture. The field survey data demonstrated that high plant diversity decreased litter C/N and thus indirectly promoted SOC accumulation by increasing the litter quality. We conclude that any changes in plant-community composition, plant-species richness and environmental factors that can reduce the litter C/N ratio, or climatic changes that increase wetness index, may promote SOC accumulation. The study provides a guideline for modeling the carbon cycle of various ecosystem scales and formulates the principle for land-based actions for mitigating the rising atmospheric CO2 concentration. | Guoyi Zhou Shan Xu Philippe Ciais Stefano Manzoni Jingyun Fang Guirui Yu Xuli Tang Ping Zhou Wantong Wang Junhua Yan Gengxu Wang Keping Ma Shenggong Li Sheng Du Shijie Han Youxin Ma Deqiang Zhang Juxiu Liu Shizhong Liu Guowei Chu Qianmei Zhang Yuelin Li Wenjuan Huang Hai Ren Xiankai Lu Xiuzhi Chen | 2019 | National Science Review2019，6，4： | 21 |
| 5 | Regional differences in the timing of recent air warming during the past four decades in China显示文摘Global surface temperature has dramatically increased in the past decades.It is critical to evaluate such a change using appropriate approaches.The previous studies for assessment of the change usually used overall trends of temperature series(i.e.slopes of simple linear regression of temperature versus year based on a least-square analysis) for entire study period.Temperature trends,however,differ among different periods,i.e.there are often breakpoints in the temperature series.Therefore,the overall linear trend of a temperature series may conceal some of the temporal characteristics of the temperature change.To precisely characterize the temporal and spatial patterns of air temperature change in China,we analyze the annual mean temperature series between the year of 1961?2004 for 536 meteorological stations across China,using piecewise linear regression approach.We found remarkable breakpoints in the annual mean temperature during the study period across the country.The annual mean temperature started to increase in 1984 at a rate of 0.058°C/a at the country level.The year when warming started appeared to be gradually later from the north to the south:temperature increased since the 1970s in the north(north of 40°N),and did not rise until the 1980s in most areas of the south(south of 40°N),with warming starting in 1983 in the Tibetan Plateau.The trends in annual mean temperatures showed a large spatial heterogeneity across China:a relatively small rising with a rate of 0.025-0.05°C/a in the Sichuan Basin,Central China and South China;the greatest increase in some parts of northwest China(i.e.Xinjiang) with up to a rate of 0.1°C/a;and rising at a rate of >0.05°C/a for most regions of the country.The feedbacks of cold waves and snow may be responsible for such regional differences in the timing and rates of warming in China. | WANG ShaoPeng WANG ZhiHeng PIAO ShiLong FANG JingYun | 2010 | Chinese Science Bulletin2010，55，19： | 18 |
| 6 | Carbon budgets of three temperate forest ecosystems in Dongling Mt.,Beijing,China显示文摘There is a general agreement that forest ecosystems in the Northern Hemisphere function as signifi-cant sinks for atmospheric CO2; however, their magnitude and distribution remain large uncertainties. In this paper, we report the carbon (C) stock and its change of vegetation, forest floor detritus, and mineral soil, annual net biomass increment and litterfall production, and respiration of vegetation and soils between 1992 to 1994, for three temperate forest ecosystems, birch (Betula platyphylla) forest, oak (Quercus liaotungensis) forest and pine (Pinus tabulaeformis) plantation in Mt. Dongling, Beijing, China. We then evaluate the C budgets of these forest ecosystems. Our results indicated that total C density (organic C per hectare) of these forests ranged from 250 to 300 t C ha-1, of which 35―54 t C ha-1 from vegetation biomass C and 209―244 t C ha-1 from soil organic C (1 m depth, including forest floor detritus). Biomass C of all three forests showed a net increase, with 1.33―3.55 t C ha-1 a-1 during the study period. Litterfall production, vegetation autotrophic respiration, and soil heterotrophic respira-tion were estimated at 1.63―2.34, 2.19―6.93, and 1.81―3.49 t C ha-1 a-1, respectively. Ecosystem gross primary production fluctuated between 5.39 and 12.82 t C ha-1 a-1, about half of which (46%―59%, 3.20―5.89 t C ha-1 a-1) was converted to net primary production. Our results suggested that pine forest fixed C of 4.08 t ha-1 a-1, whereas secondary forests (birch and oak forest) were nearly in balance in CO2 exchange between the atmosphere and ecosystems. | FANG JingYun LIU GuoHua ZHU Biao WANG XiaoKe LIU ShaoHui | 2007 | Science China Earth Sciences2007，50，1： | 17 |
| 7 | Agriculture Development-induced Surface Albedo Changes and Climatic Implications Across Northeastern China显示文摘To improve the understandings on regional climatic effects of past human-induced land cover changes,the surface albedo changes caused by conversions from natural vegetation to cropland were estimated across northeastern China over the last 300 years,and its climatic effects were simulated by using the Weather Research and Forecasting (WRF) model.Essential natural vegetation records compiled from historical documents and regional optimal surface albedo dataset were used.The results show that the surface albedo decreased by 0.01-0.03 due to conversions from grassland to cropland in the Northeast China Plain and it increased by 0.005-0.015 due to conversions from forests to cropland in the surrounding mountains.As a consequence,in the Northeast China Plain,the surface net radiation increased by 4-8 W/m 2,2-5 W/m 2,and 1-3 W/m 2,and the climate was therefore warmed by 0.1℃-0.2℃、0.1℃-0.2℃、 0.1℃-0.3 ℃ in the spring,autumn and winter,respectively.In the surrounding mountain area,the net radiation decreased by less than 1.5 W/m 2,and the climate was therefore cooled too slight to be detected.In summer,effects of surface albedo changes on climate were closely associated with moisture dynamics,such as evapotranspiration and cloud,instead of being merely determined by surface radiation budget.The simulated summer climatic effects have large uncertainties.These findings demonstrate that surface albedo changes resulted in warming climate effects in the non-rainy seasons in Northeast China Plain through surface radiation processes while the climatic effects in summer could hardly be concluded so far. | ZHANG Xuezhen WANG Wei-Chyung FANG Xiuqi YE Yu ZHENG Jingyun | 2012 | Chinese Geographical Science2012，22，3： | 15 |
| 8 | NEECF: a project of nutrient enrichment experiments in China’s forests显示文摘Anthropogenic nitrogen(N)emissions to atmosphere have increased dramatically in China since 1980s,and this increase has aroused great concerns on its ecological impacts on terrestrial ecosystems.Previous studies have showed that terrestrial ecosystems in China are acting as a large carbon(C)sink,but its potential in the future remains largely uncertain.So far little work on the impacts of the N deposition on C sequestration in China’s terrestrial ecosystems has been assessed at a national scale.Aiming to assess and predict how ecological processes especially the C cycling respond to the increasing N deposition in China’s forests,recently researchers from Peking University and their partners have established a manipulation experimental network on the ecological effects of the N deposition:Nutrient Enrichment Experiments in China’s Forests Project(NEECF).The NEECF comprises 10 experiments at 7 sites located from north to south China,covering major zonal forest vegetation in eastern China from boreal forest in Greater Khingan Mountains to tropical forests in Hainan Island.This paper introduces the framework of the NEECF project and its potential policy implications. | Enzai Du Zhang Zhou Peng Li Xueyang Hu Yuecun Ma Wei Wang Chengyang Zheng Jianxiao Zhu Jin-Sheng He Jingyun Fang | 2013 | Journal of Plant Ecology2013，6，5： | 13 |
| 9 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 10 | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection显示文摘(EV71 ) Entero 病毒 71 引起手,脚,和嘴疾病(HFMD ) 并且偶尔导致严重神经病学的复杂并发症甚至死亡。(SCARB2 ) Scavenger 受体班 B 成员 2 是为 EV71 的功能的受体,调停病毒的附件,成为主观,和 uncoating。然而, SCARB2 上的 EV71 的准确有约束力的地点是未知的。在这研究,我们产生了绑在人然而并非老鼠 SCARB2 的 monoclonal 抗体(mAb ) 。它被称为 JL2,并且它能有效地禁止目标房间的 EV71 感染。用人和老鼠 SCARB2 的一套怪物,我们鉴别包含人的 SCARB2 的残余 77-113 的区域显著地作出贡献到 JL2 绑定。SCARB2-JL2 建筑群的结构表明 JL2 绑在包含 -helices 的 SCARB2 的顶端的区域 2, 5,和 14。我们的结果在 SCARB2 和 EV71 入口的分子的机制上为 EV71 提供新卓见进潜在的有约束力的地点。 | Xuyuan Zhang Pan Yang Nan Wang Jialong Zhang Jingyun Li Hao Guo Xiangyun Yin Zihe Rao Xiangxi wang Liguo Zhang | 2017 | Protein & Cell2017，8，8： | 10 |
| 11 | When will China achieve its carbon emission peak?显示文摘Global warming is primarily attributed to the significant increase in atmospheric CO2 concentration,which is caused mainly by carbon emissions generated from fossil fuel combustion[1].Efficient measures are required to control these emissions and reduce global warming. | Tianli Zheng Jiangling Zhu Shaopeng Wang Jingyun Fang | 2016 | National Science Review2016，3，1： | 9 |
| 12 | Scenario analysis on the global carbon emissions reduction goal proposed in the declaration of the 2009 G8 Summit显示文摘A goal of a 50% reduction in global greenhouse gases emissions by 2050, with an 80% reduction by developed countries (hereafter referred to as the G8 Goal), was proposed at the G8 Summit held in L’Aquila, Italy, in July 2009. Here we analyze the scientific and political implications of the G8 Goal and its equity and feasibility by examining four greenhouse gas emissions scenarios. Our results show that (1) the goal to keep atmospheric CO2 concentration of <450 ppmv, stated by G8 nations, can only be achieved under the scenario of a steady, linear emissions reduction by all countries and simultaneously meeting the G8 Goal during the period 2005-2050; (2) under the G8 Goal, the carbon emissions quota for developing countries would not meet their carbon emission demands even if very strict reduction regimes are followed, with a gap of up to >1/3 of emissions demand in the next 45 years; and (3) under the G8 Goal, the cumulative per capita emissions during the period of 2006-2050 for developed and developing countries will be 81 t C and 40-47 t C, respectively, with the former doubling that of the latter, implying that the historical disparity of carbon emissions between developed and developing countries would be widened. Historically, the cumulative per capita emissions from developed countries are 12 times of those from developing countries. We therefore conclude that (1) the G8 Goal seeks to impose binding reduction targets on developing countries that will impede their industrialization process and cause conflicts among developing countries in the allocation of carbon emission rights; (2) the G8 Goal will not only widen the existing disparities of historical carbon emissions between developed and developing countries, but also generate new inequalities in the rights of carbon emissions; and (3) the 450 ppmv threshold of atmospheric CO2 concentration control, which is the basis for the G8 Goal, is impractical and impossible, and should not be accepted as the foundation for international climate negotiation on carbon emission reduction. In summary, the G8 Goal is clearly against the principle of 'common but differentiated responsibilities' and thus is unacceptable for developing countries. | FANG JingYun WANG ShaoPeng YUE Chao ZHU JiangLing GUO ZhaoDi HE CanFei TANG ZhiYao | 2009 | Science China Earth Sciences2009，52，11： | 8 |
| 13 | Reconstruction of temperature series in China for the last 5000 years显示文摘有为在中国的最后 5000 年的 100 年决定的一个温度系列被 using31 重建了从最后 20 年里的最近的出版物的长期的温度代理系列。代理记录包括花粉,石笋,湖沉积,泥炭,冰核心和历史的文件。结果表明在千年的规模温度变化,它在 3050-250 BC,它在 250 BC 是冷的 - 1950 广告。在上述二个时期,有亚规模温度变化的许多阶段。结果也在 2850 BC, 2350 BC, 1350 BC, 950-350 BC, 50-250 广告,和 550 广告在这个世纪显示出明显的温度差异到在东方季风区域, Qinghai- 西藏区域和西北的区域之间的多世纪规模。在这篇论文的重建的系列和某诺思半球温度系列之间的比较显示在长期的规模变化,在中国的温度变化在最后 5000 年期间在有北半球的短语,当在到多世纪的世纪在那里的规模是时,在开始和结束的差别预定,它可以暗示温度变化不在不同区域同时发生。 | GE Quansheng WANG Shunbing ZHENG Jingyun | 2006 | Progress in Natural Science:Materials International2006，16，8： | 8 |
| 14 | Hippocampal ischemia causes deficits in local field potential and synaptic plasticity显示文摘The long-term enhancement in glutamate receptor mediated excitatory responses has been observed in stroke model.This pathological form of plasticity,termed post-ischemic long-term potentiation(i-LTP),points to functional reorganization after stroke.Little is known,however,about whether and how this i-LTP would affect subsequent induction of synaptic plasticity.Here,we first directly confirmed that i-LTP was induced in the endothelin-1-induced ischemia model as in other in vitro models.We also demonstrated increased expression of NR2 B,CaMKII and p-CaMKⅡ,which are reminiscent of i-LTP.We further induced LTP of field excitatory postsynaptic potentials(fEPSPs) on CA1 hippocampal neurons in peri-infarct regions of the endothelin-1-induced mini-stroke model.We found that LTP of fEPSPs,induced by high-frequency stimulation,displayed a progressive impairment at 12 and 24 hours after ischemia.Moreover,using in vivo multi-channel recording,we found that the local field potential,which represents electrical property of cell ensembles in more restricted regions,was also dampened at these two time points.These results suggest that i-LTP elevates the induction threshold of subsequent synaptic plasticity.Our data helps to deepen the knowledge of meta-synaptic regulation of plasticity after focal ischemia. | Shaoli Wang Jingyun Zhang Tao Sheng Wei Lu Dengshun Miao | 2015 | The Journal of Biomedical Research2015，29，5： | 8 |
| 15 | Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine显示文摘Mesenchymal stem cell(MSC)-mediated immunomodulation has been harnessed for the treatment of human diseases,but its underlying mechanism has not been fully understood.Dead cells,including apoptotic cells have immunomodulatory properties.It has been repeatedly reported that the proportion of nonviable MSCs in a MSC therapeutic preparation varied from 5-50%in the ongoing clinical trials.It is conceivable that the nonviable cells in a MSC therapeutic preparation may play a role in the therapeutic effects of MSCs.We found that the MSC therapeutic preparation in the present study had about 5%dead MSCs(DMSCs),characterized by apoptotic cells.Namely,1×10^(6) MSCs in the preparation contained about 5×10^(4) DMSCs.We found that the treatment with even 5×10^(4) DMSCs alone had the equal therapeutic effects as with 1×10^(6) MSCs.This protective effect of the dead MSCs alone was confirmed in four mouse models,including concanavalin A(ConA)-and carbon tetrachloride(CCI4)-induced acute liver injury,LPS-induced lung injury and spinal cord injury.We also found that the infused MSCs died by apoptosis in vivo.Furthermore,the therapeutic effect was attributed to the elevated level of phosphatidylserine(PS)upon the injection of MSCs or DMSCs.The direct administration of PS liposomes(PSLs)mimic apoptotic cell fragments also exerted the protective effects as MSCs and DMSCs.The Mer tyrosine kinase(MerTK)deficiency or the knockout of chemokine receptor C-C motif chemokine receptor 2(CCR2)reversed these protective effects of MSCs or DMSCs.These results revealed that DMSCs alone in the therapeutic stem cell preparation or the apoptotic cells induced in vivo may exert the same immunomodulatory property as the'living MSCs preparation'through releasing PS,which was further recognized by MerTK and participated in modulating immune cells. | Xuemei He Weiqi Hong Jingyun Yang Hong Lei Tianqi Lu Cai He Zhenfei Bi Xiangyu Pan Yu Liu Lunzhi Dai Wei Wang Canhua Huang Hongxin Deng Xiawei Wei | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 6 |
| 16 | Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment显示文摘The Hedgehog(HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment(TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance.The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6(IL-6) and interferon-g(IFN-g), macrophages, and T cell-dependent immune responses, play a vital role in tumor growth by affecting the HH signaling pathway. Moreover, inhibition of proliferating cancer-associated fibroblasts(CAFs) and inflammatory factors can normalize the TME by suppressing HH signaling. Furthermore, aberrant HH signaling activation is favorable to both the proliferation of cancer stem cells(CSCs) and the drug resistance of gastrointestinal tumors. This review discusses the current understanding of the role and mechanism of aberrant HH signaling activation in gastrointestinal carcinogenesis, the gastrointestinal TME,tumor immune tolerance and drug resistance and highlights the underlying therapeutic opportunities. | Jinghui Zhang Jiajun Fan Xian Zeng Mingming Nie Jingyun Luan Yichen Wang Dianwen Ju Kai Yin | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 17 | Spatial and temporal distribution of large volcanic eruptions from 1750 to 2010显示文摘用 Smithsonian 机构全球火山作用节目提供的数据集,我们从时期提取了大暴烈的爆发(暴烈的 explosivity 索引 4 ) 17502010 并且自从 1750 ,然后根据他们的地理纬度分析了大暴烈的爆发的主要特征,他们的举起,并且他们在发生了的年和月。结果证明很大的暴烈的爆发在太平洋的边缘和苏门答腊和 Java 的岛附近被定位,特别在赤道的区域(10 汰獵?? ㈠ ? 猯'T??????? ￡蔴?蔴 吗?? | HAO Zhixin WANG Huan ZHENG Jingyun | 2014 | Journal of Geographical Sciences2014，24，6： | 4 |
| 18 | Altitudinal patterns of stand structure and herb layer diversity of Picea schrenkiana forests in the central Tianshan Mountains,Northwest China显示文摘Altitude is a useful indicator to examine patterns of forest structure and species diversity in relation to environmental factors.In this study,the altitude patterns of forest stand structure and species diversity were analyzed across 20 plots in the Tianchi Nature Reserve,Northwest China.The results showed that mean stem height(Hm),maximum stem height(Hmax) and mean stem diameter at breast height(Dm) of Picea schrenkiana trees all decreased significantly with increasing altitude.Potential tree height(H*) decreased while stem taper increased significantly as altitude increased,suggesting remarkable altitudinal changes in biomass allocation between the diameter and height growth of Picea schrenkiana.Understory herbaceous richness increased significantly with increasing altitude,or with decreasing total basal area(TBA),Hm and stand volume(Volume).High light availability for understory herbs might account for the higher species richness at high altitude.Sorensen Index decreased significantly with the increase in altitude intervals,while the Cody Index demonstrated a converse pattern,suggesting greater differences in species composition with larger distances. | LiPing LI XiangPing WANG Stefan ZERBE LiYun ZHANG JingYun FANG | 2011 | Journal of Arid Land2011，3，4： | 3 |
| 19 | Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production显示文摘Metal chalcogenide solid solution,especially ZnCdS,has been intensively investigated in photocatalytic H_(2) generation due to their cost-effective synthetic procedure and adjustable band structures.In this work,we report on the defect engineering of ZnCdS with surface disorder layer by simple room temperature Li-ethylenediamine(Li-EDA)treatment.Experimental results confirm the formation of unusual Zn and S dual vacancies,where rich S vacancies(Vs)served as electron trapping sites,meanwhile Zn vacancies(Vzn)served as hole trapping sites.The refined structure significantly facilitates the photo charge carrier transfer and improves photocatalytic properties of ZnCdS.The disordered ZnCdS shows a highest photocatalytic H_(2) production rate of 33.6 mmol·g^(-1)·h^(-1) under visible light with superior photocatalytic stabilities,which is 7.3 times higher than pristine ZnCdS and 7 times of Pt(1 wt.%)loaded ZnCdS. | Enna Ha Shuhong Ruan Danyang Li Yuanmin Zhu Yanping Chen Jiangyuan Qiu Zhaohui Chen Tingting Xu Jingyun Su Luyang Wang Junqing Hu | 2022 | Nano Research2022，15，2： | 3 |
| 20 | A turn-on fluorescent probe for Au^(3+) based on rodamine derivative and its bioimaging application显示文摘A new fluorescent probe RY was synthesized for the detection of Au3+ions based on a rhodamine B derivative.The fluorescent probe showed good selectivity and sensitivity to Au3+ions.Obvious color and fluorescence changes could be observed with the naked eye while the fluorescent probe reacted with the Au3+ions.The detection limit of the probe was determined to be 36 ppb by the fluorescence titration.The excellent linear relationship suggests that the probe is potentially useful for quantitative detection of Au3+in vitro.We also demonstrated its bioimaging application in both living cells and mice.This was the first time that a fluorescent probe was successfully applied to imaging Au3+in living animals. | SONG FengLing NING HouFu SHE HaiYing WANG JingYun PENG XiaoJun | 2014 | Science China Chemistry2014，57，7： | 3 |
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