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| 1 | Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrowderived macrophage显示文摘Macrophages play critical roles in renal fibrosis.However,macrophages exhibit ontogenic and functional heterogeneities,and which population of macrophages contributes to renal fibrosis and the underlying mechanisms remain unclear.In this study,we genetically targeted Notch signaling by disrupting the transcription factor recombination signal binding protein-JK(RBP-J),to reveal its role in regulation of macrophages during the unilateral ureteral obstruction(UUO)-induced murine renal fibrosis.Myeloid-specific disruption of RBP-J attenuated renal fibrosis with reduced extracellular matrix deposition and myofibroblast activation,as well as attenuated epithelial-mesenchymal transition,likely owing to the reduced expression of TGF-β.Mean while,RBP-J deletion significantly hampered macrophage infiltration and activation in fibrotic kidney,although their proliferation appeared unaltered.By using macrophage clearance experiment,we found that kidney resident macrophages made negligible contribution,but bone marrow(BM)-derived macrophages played a major role in renal fibrogenesis.Further mechanistic analyses showed that Notch blockade reduced monocyte emigration from BM by down-regulating CCR2 expression.Finally,we found that myeloid-specific Notch activation aggravated renal fibrosis,which was mediated by CCR2^+macrophages infiltration.In summary,our data have unveiled that myeloid-specific targeting of Notch could ameliorate renal fibrosis by regulating BM-derived macrophages recruitment and activation,providing a novel strategy for intervention of this disease. | Yali Jiang Yuanyuan Wang Pengfei Ma Dongjie An Junlong Zhao Shiqian Liang Yuchen Ye Yingying Lu Peng Zhang Xiaowei Liu Hua Han Hongyan Qin | 2019 | Protein & Cell2019，10，3： | 10 |
| 2 | Loop-mediated isothermal amplification (LAMP) method based on two species-specific primer sets for the rapid identification of Chinese Babesia bovis and B. bigemina显示文摘 | Aihong Liu Guiquan Guan Pengfei Du Huitian Gou Zhijie Liu Junlong Liu Milin Ma Jifei Yang Youquan Li Qinli Niu Qiaoyun Ren Qi Bai Hong Yin Jianxun Luo | 2012 | Parasitology International2012，，4： | 1 |
| 3 | Detecting and differentiating Theileria sergenti and Theileria sinensis in cattle and yaks by PCR based on major piroplasm surface protein (MPSP)显示文摘 | Aihong Liu Guiquan Guan Zhijie Liu Junlong Liu Neil Leblanc Youquan Li Jinliang Gao Milin Ma Qinli Niu Qiaoyun Ren Qi Bai Hong Yin Jianxun Luo | 2010 | Experimental Parasitology2010，，4： | 1 |
| 4 | Baseflow Separation and Its Response to Meteorological Drought in a Temperate Water-limited Basin,North China显示文摘Baseflow,a component of the total streamflow,plays a key role in maintaining aquatic habitats,particularly during extreme drought events.This study investigated baseflow response to a prolonged and extreme meteorological drought event in the Baiyangdian Basin(BYD basin),a temperate water-limited basin in North China.Applying a precipitation series,piecewise regression was used to determine this extreme meteorological drought event,while the Automatic Baseflow Identification Technique(ABIT)was used to estimate a recession parameter(α),which was used to isolate baseflow from total streamflow.Results showed that:1)annual precipitation exhibited significant decreasing trends(P<0.05)with an average change of–1.81 mm/yr^(2).The precipitation deficit revealed that the start and end date of the extreme meteorological drought event was from August 1996 to May 2011,respectively,persisting for a total of 178 months(roughly 15 yr);2)hydrological drought(including streamflow and baseflow)lagged behind meteorological drought while predictably persisting longer than extreme meteorological drought(i.e.,precipitation);and 3)baseflow decreased dramatically under meteorological drought at both seasonal and annual scales,resulting in significantly decreasing trends during drought periods.Findings from this study confirmed that hydrological events caused by extreme meteorological drought can alter the magnitude and duration of baseflow and total streamflow,which will have an inevitable influence on aquatic ecosystems. | LIU Qiang YAN Sirui LI Miao MA Kiaojing LIANG Liqiao ZHANG Junlong PAN Jihua | 2021 | Chinese Geographical Science2021，31，5： | 1 |
| 5 | Copper(I)-Catalyzed Intramolecular N-N Coupling of Cyclopropyl O-Acyl Ketoximes: Synthesis of Spiro-fused Pyrazolin-5-ones显示文摘一条方便催化铜的途径经由 intramolecular NN 契约形成反应从容易地可得到的 cyclopropyl O 酰 ketoximes 为代替的熔化 spiro 的 pyrazolin-5-ones 的合成被开发了。这些催化反应在优秀收益继续一个宽广范围。 | Zhiguo Zhang Junlong Li Guoqing Huang Kai Sun Guisheng Zhang Nana Ma Qingfeng Liu Tongxin Liu | 2016 | Chinese Journal of Chemistry2016，34，12： | 1 |
| 6 | Experimental transmission of Theileria uilenbergi infective for small ruminants by Haemaphysalis longicornis and Haemaphysalis qinghaiensis显示文摘 | Youquan Li Jianxun Luo Guiquan Guan Miling Ma Aihong Liu Junlong Liu Qiaoyun Ren Qingli Niu Bingyi Lu Jinliang Gao Zhijie Liu Zhisheng Dang Zhancheng Tian Bao Zhang Zonglin He Qi Bai Hong Yin | 2009 | Parasitology Research2009，，5： | 1 |
| 7 | A new ovine Babesia species transmitted by Hyalomma anatolicum anatolicum显示文摘 | Guiquan Guan Miling Ma Emmanuelle Moreau Junlong Liu Bingyi Lu Qi Bai Jianxun Luo Wayne Jorgensen Alain Chauvin Hong Yin | 2009 | Experimental Parasitology2009，，4： | 1 |
| 8 | Study on the disaster caused by the linkage failure of the residual coal pillar and rock stratum during multiple coal seam mining:mechanism of progressive and dynamic failure显示文摘Multi-seam mining often leads to the retention of a significant number of coal pillars for purposes such as protection,safety,or water isolation.However,stress concentration beneath these residual coal pillars can significantly impact their strength and stability when mining below them,potentially leading to hydraulic support failure,surface subsidence,and rock bursting.To address this issue,the linkage between the failure and instability of residual coal pillars and rock strata during multi-seam mining is examined in this study.Key controls include residual pillar spalling,safety factor(f.),local mine stiffness(LMS),and the post-peak stiffness(k)of the residual coal pillar.Limits separating the two forms of failure,progressive versus dynamic,are defined.Progressive failure results at lower stresses when the coal pillar transitions from indefinitely stable(f,>1.5)to failing(f,<1.5)when the coal pillar can no longer remain stable for an extended duration,whereas sud-den(unstable)failure results when the strength of the pillar is further degraded and fails.The transition in mode of failure is defined by the LMS/k ratio.Failure transitions from quiescent to dynamic as LMS/k.<1,which can cause chain pillar instability propagating throughout the mine.This study provides theoretical guidance to define this limit to instability of residual coal pillars for multi-seam mining in similar mines. | Yunliang Tan Qing Ma Xiaoli Liu Xuesheng Liu Derek Elsworth Ruipengg Qian Junlong Shang | 2023 | International Journal of Coal Science & Technology2023，10，3： | 0 |
| 9 | Oxygen-vacancy-containing cerium oxide nanoparticle-decorated nanonetwork-structured carbon toward high-performance lithium–sulfur batteries显示文摘Lithium-sulfur(Li-S)batteries have been regarded as promising next-generation energy-storage devices owing to their inherently high theoretical energy density.Unfortunately,the poor capacity and cycling life caused by severe polysulfide shuttle effect and sluggish redox kinetics in sulfur cathodes greatly impede the practical application of Li-S batteries.Herein,a new class of nanonetworkstructured carbon decorated with oxygen-vacancy-containing cerium oxide nanoparticles(NSC-CeO_(2−x)),in which carbon skeleton is composed of highly conductive carbon nanotube core welded by hybrid carbon shell,has been developed via one-step heating treatment of hybrid molecular brush and further employed as functional interlayer to modify separator of Li-S battery.Owing to the synergistic effect of the highly active CeO_(2−x)nanoparticles and the threedimensional carbon nanonetwork in enhancing the preservation of the soluble polysulfides and boosting the redox kinetics of sulfur species,the NSC-CeO_(2−x)significantly promotes the electrochemical performance of sulfur cathode.As a result,the as-constructed Li-S batteries exhibit an ultrahigh initial sulfur utilization of 92.9%and an extremely large capacity of 751mA h g^(−1) at a high rate of 5 C.Remarkably,a stable capacity of 728 mA h g^(−1)over 300 cycles at 1 C is also achieved. | Chuanfa Li Pengwei Ma Shenghao Lin Zongheng Cen Junlong Huang Yin Cui Shimei Li Shaohong Liu Ruowen Fu Dingcai Wu | 2023 | SusMat2023，3，1： | 0 |
| 10 | Acupuncture attenuates the development of diabetie peripheral neuralgia by regulating spinal microglia in rats显示文摘Diabetic peripheral neuropathy(DPN)is a chronic microvascular complication of diabetes.However,studies on effect of acupuncture in DPN are rare.The purpose of this study was to research the mechanism of acupuncture in DPN rats.Rats rendered diabetic with a single injection of 35 mg/kg STZ.The STZ-diabetic rats were randomly divided into two groups:DPN model and acupuncture groups.After 14 days treatment,the therapeutic efficacy of acupuncture was assessed using MWT and TWI evaluation of rats. | Tang Heyong Wang Fanjing Ma Junlong Wang Hao Shen Guoming Jiang Aijuan | 2021 | 解剖学杂志2021，44，S01： | 0 |
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