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| 1 | Stage-progressive distribution pattern of the Lungmachi black graptolitic shales from Guizhou to Chongqing, Central China显示文摘The Lungmachi Formation is widely distributed in Guizhou, Chongqing and the adjacent area. It is important for the study of Silurian biostratigraphy and shale-gas investigation. Based on those biostratigraphically well-studied sections from Guiyang to Huayingshan, we reveal the stage-progressive distribution pattern of the Lungmachi black shales. The distribution of the Lungmachi black shales in the studying area can be subdivided into four geographic belts from the south to the north,reflecting the joint effect of regional and global environmental changes. The graptolite depth zonation model was adopted herein to infer the water depth of major graptolite assemblages from the black shales. The changes in the water depth indicate two major stages. The first stage is named the transgressive distribution stage which ranged from the Persculptograptus persculptus Biozone(LM1, upper Hirnantian) to the Coronograptus cyphus Biozone(LM5, upper Rhuddanian), an interval mostly controlled by global sea-level rise. The second stage, ranging from the Demirastrites triangulatus Biozone(LM6, lower Aeronian) to the Spirograptus guerichi Biozone(LM9, lower Telychian), is named the regressive shrinking stage, during which the black shales were gradually replaced by mixed-facies or carbonate sediments from the south to the north, representing the effects of the persistent uplifting of the Central Guizhou Oldland. | CHEN Xu FAN JunXuan WANG WenHui WANG HongYan NIE HaiKuan SHI XueWen WEN ZhiDong CHEN DongYang LI WenJie | 2017 | Science China Earth Sciences2017，60，6： | 23 |
| 2 | Simulation on dissolute and dust dispersion in comprehensive mechanized heading face with forced-exhaust ventilation显示文摘 | NIE Wen CHENG Wei-min HAN Li ZHOU Sheng-ju YU Yan-bin ZHAO Shan-shan | 2011 | Journal of Coal Science & Engineering(China)2011，17，3： | 21 |
| 3 | Intercontinental disjunctions between eastern Asia and western North America in vascular plants highlight the biogeographic importance of the Bering land bridge from late Cretaceous to Neogene显示文摘这评论在脉管的植物(flowering 植物,裸子植物,蕨纲植物和 lycophytes ) 的主要的系从迟了的白垩纪显示出在东方亚洲和西方的北美洲之间的一个靠近的 biogeographic 连接到迟了的晚第三纪。东方亚洲北方的美国 disjuncts,针叶树展出在东方亚洲和西方的北美洲之间的 disjuncts 的一个高比例。蕨纲植物的几个系也在二个区域显示出一个最近的分离模式。在 flowering 植物,模式通常在适度的元素在之间被显示出东北亚洲和西北的北美洲,以及寡妇 boreotropical 和晚第三纪 mesophytic 和具球果的植物群的元素。在在最近的种系发生的分析支持的植物的东方亚洲和西方的北美洲之间的洲际 biogeographic 分离的许多盒子从迟了的白垩纪越过 Beringian 区域强调 Bering 陆地桥或植物迁居的重要性到迟了的晚第三纪,在特别期间中新世。Beringian 区域允许自从上新世,在白令海峡的开始以后过滤和某些植物 taxa 的移植,作为许多同种的 taxa 或密切相关的种类发生在 Beringia 的双方上。 | Jun Wen Ze-Long Nie Stefanie M. Ickert-Bond | 2016 | Journal of Systematics and Evolution2016，54，5： | 20 |
| 4 | MicroRNAs Involved in Skeletal Muscle Differentiation显示文摘MicroRNAs (miRNAs) negatively regulate gene expression by promoting degradation of target mRNAs or inhibiting their translation. Previous studies have expanded our understanding that miRNAs play an important role in myogenesis and have a big impact on muscle mass, muscle fiber type and muscle-related diseases. The muscle-specific miRNAs, miR-206, miR-1 and miR-133, are among the most studied and best characterized miRNAs in skeletal muscle differentiation. They have a profound influence on multiple muscle differ-entiation processes, such as alternative splicing, DNA synthesis, and cell apoptosis. Many non-muscle-specific miRNAs are also required for the differentiation of muscle through interaction with myogenic factors. Studying the regulatory mechanisms of these miRNAs in muscle differentiation will extend our knowledge of miRNAs in muscle biology and will improve our understanding of the myogenesis regulation. | Wen Luo Qinghua Nie Xiquan Zhang | 2013 | Journal of Genetics and Genomics2013，40，3： | 19 |
| 5 | Progress and Prospects of Salt Lake Research in China显示文摘China has unique salt lake resources, and they are distributed in the east of Eurasian salt lake subzone of the Northern Hemisphere Salt Lake Zone, mainly concentrated in the regions with modern mean annual precipitation lower than 500 mm. This paper preliminarily reviews the progress made in salt lake research in China for the past 60 years. In the research of Paleoclimate and paleoenvironment from salt lake sediments, a series of salts have been proposed to be indicators of paleoclimate, and have been well accepted by scholars. The chloride-sulfate depositional regions of the west Qaidam and the east Tarim have been revealed to be the drought center of China since the Quaternary, and more than 6 spreading stages of arid climate(salt forming) have been identified. Five pan-lake periods with highstands have been proved to exist during the late Quaternary on the Tibetan Plateau. In mineral resource prospecting and theories of the forming of salt deposits: the atlas(1:2500000) of hydrochemical zoning of salt lakes on the Tibetan Plateau has been compiled for the first time, revealing the zonal distribution and transition from carbonate type to chloride type from south to north and presenting corresponding mineral assemblages for different type of salt lakes; several large continental salt deposits have been discovered and the theory of continental potash deposition has been developed, including the salt deposition in deep basins surrounded by high mountains, the mineral deposition from multistage evolution through chains of moderate or shallow lakes with multilevels, the origin of potassium rich brines in gravel layers, and the forming of potassium deposits through the inheriting from ancient salt deposits, thus establishing the framework of 'Continental Potash Deposition Theory'; several new types of Mg-borate deposits have been discovered, including the ulexite and pinnoite bed in Da Qaidam Lake, Qinghai, the pinnoite and kurnakovite bed in Chagcam Caka, Tibet, the kurnakovite bed in Lake Nyer, and the corresponding model of borate deposition from the cooling and dissolution of boron rich brines was proposed based on principles of geology, physics and chemistry. The anti-floatation-cold crystallization method developed independently has improved the capacity of KCl production to 3 million tons per year for the Qarham, serving the famous brand of potash fertilizer products. One 1.2 million ton K-sulfate production line, the biggest in the world, has been built in Lop Nor, and K-sulfate of about 1.6 million tons was produced in 2015. Supported by the new technology, i.e. brine preparation in winter-cooling-solarization-isolation-lithium deposition from salt gradient solar pond' the highest lithium production base at Zabuye Lake(4421 m), Tibet, has been established, which is the first lithium production base in China that reaches the year production of 5000 tons of lithium carbonate. The concept of Salt lake agriculture(Salt land agriculture) has been established based on the mass growth of Dunaliella and other bacillus-algae and the occurrence of various halophytes in saltmarsh and salt saline-alkali lands, finding a new way to increase arable lands and develop related green industry in salt rich environments. Finally this paper presents some new thoughts for the further research and development on salt science, and the further progress in salt science and technology will facilitate the maturing of the interdisciplinary science 'Salinology'. | ZHENG Mianping ZHANG Yongsheng LIU Xifang NIE Zhen KONG Fanjing QI Wen Jia Qingxian PU Linzhong HOU Xianhua WANG Hailei ZHANG Zhen KONG Weigang LIN Yongjie | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 15 |
| 6 | Stenting versus non-stenting treatment of intermediate stenosis culprit lesion in acute ST-segment elevation myocardial infarction: a multicenter random- ized clinical trial显示文摘在有单个容器中介狭窄犯人损害优点的心肌的梗塞(STEMI ) 病人进一步学习的尖锐圣片断举起的 stenting 的 BackgroundThe 利益 / 风险比率,因此现在的 study.Methods 和 resultsIt 的题目是一未来, multicenter,使随机化的控制试用。在 2012 年 4 月和 2015 年 7 月之间,有单个容器疾病和中介(40%-70%) 的 399 个尖锐 STEMI 病人在渴望 thrombectomy 或 intracoronary tirofiban 前后的犯人损害的狭窄(15 呍眠獡愠獳' 覒 X 整 ? 楷桴猠杩楮楦慣瑮椠灭潲敶敭瑮椠 ? ?癲癩污椠 ? 慰楴湥獴眠瑩 ?? | Jing DAI Shu-Zheng LYU Yun-Dai CHEN Xian-Tao SONG Min ZHANG Wei-Min LI Yang ZHENG Shang-Yu WEN Shao-Ping NIE Yu-Jie ZENG Hai GAO Yi-Tong MA Shu-Yang ZHANG Li-Jun GUO Zheng ZHANG | 2017 | Journal of Geriatric Cardiology2017，14，2： | 13 |
| 7 | Molecular Typing of Leptospira interrogans Strains Isolated from Rattus tanezumi in Guizhou Province,Southwest of China显示文摘Objective To identify and type three leptospires isolated from Rattus tanezumi in Guizhou Province by using three molecular techniques (PFGE, MLVA, and MLST), reveal the molecular characteristic of causative agents of local leptospirosis and evaluate these three molecular methods based on their detection resolution and efficiency. Methods Three Leptospira strains were isolated from the kidney of Rattus tanezumi and cultured with EMJH medium. PFGE, MLVA, and MLST assays were applied to type the three strains isolated from Rattus tanezumi in Guizhou Province. Results PFGE, MLVA, and MLST typing showed that the three leptospiral isolates matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai. The findings of the genotyping methods were consistent. MLVA and MLST defined genotypes, whereas PFGE allowed the recognition of additional subgroups within the genotypes, and the findings of molecular typing were also consistent with those of traditional techniques. Conclusion Three leptospiral isolates from Guizhou Province matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai, and PFGE, MLVA, and MLST, as reliable molecular techniques for identifying and typing of Leptospira interrogans, would contribute to the active surveillance, outbreak investigation and source tracking for leptospirosis in Guizhou Province. | LI Shi Jun ZHANG Cui Cai LI Xiu Wen TIAN Ke Cheng TANG Guang Peng WANG Ding Ming LIU Ying NIE Yi Xin JIANG Xiu Gao | 2012 | Biomedical and Environmental Sciences2012，25，5： | 12 |
| 8 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 9 | Microcrack analysis of Sanya grantite fragments from rockburst tests显示文摘Fractures running along a plane reflect the cracking progress.In this paper uniaxial and rockburst tests on a group of granite specimens from Sanya province are described.Scanning electron microscopic imaging was used to characterize the fragments.Fractal fracture mechanics were used to analyze the microcracks in terms of both the crack type and the mineral constituent.A statistical analysis showed that the area of inter-granular cracking exceeds that of intra-granular cracking.Several types of crack were observed in the cracked areas.The percentage of intra-granular cracks in fragments from rockburst tests exceeds that from uniaxial compression tests.The results also showed that feldspar deformation was the main cause of fracture and that the consolidation along quartz grain boundaries was another weak area in the granite.Cracking along quartz grains had enough energy to enter the quartz crystal in the rockburst samples.All these results contribute to further research on rockburst mechanics. | HE, Manchao NIE, Wen HAN, Liqiang LING, Lijing | 2010 | Mining Science and Technology2010，20，2： | 11 |
| 10 | Development of a supercritical and an ultra-supercritical circulating fluidized bed boiler显示文摘The supercritical circulating fluidized bed(CFB)boiler,which combines the advantages of CFB combustion with low cost emission control and supercritical steam cycle with high efficiency of coal energy,is believed to be the future of CFB combustion technology.It is also of greatest importance for low rank coal utilization in China.Different from the supercritical pulverized coal boiler that has been developed more than 50 years,the supercritical CFB boiler is still a new one which requires further investigation.Without any precedentor engineering reference,Chinese researchers have con ducted fundamental research,development,design of the supercritical CFB boilers independently.The design theory and key technology for supercritical CFB boiler were proposed.Key components and novel structures were invented.The first 600 MWe supercritical CFB boiler and its auxiliaries were successfully developed and demonstrated in Baima Power Plant,Shenhua Group as well as the simulator,control technology,installation technology,commissioning technology,system integration and operation technology.Compared with the 460 MWe supercritical CFB in Poland,developed in the same period and the only other supercritical one of commercial running in the word beside Baima,the 600 MWe one in Baima has a better performance.Besides,supercritical CFB boilers of 350 MWe have been developed and widely commercialized in China.In this paper,the updated progress of 660 MWe ultra-supercritical CFB boilers under development is introduced. | Junfu LYU Hairui YANG Wen LING Li NIE Guangxi YUE Ruixin LI Ying CHEN Shilong WANG | 2019 | Frontiers in Energy2019，13，1： | 11 |
| 11 | Deep learning applied to two-dimensional color Doppler flow imaging ultrasound images significantly improves diagnostic performance in the classification of breast masses:a multicenter study显示文摘Background:The current deep learning diagnosis of breast masses is mainly reflected by the diagnosis of benign and malignant lesions.In China,breast masses are divided into four categories according to the treatment method:inflammatory masses,adenosis,benign tumors,and malignant tumors.These categorizations are important for guiding clinical treatment.In this study,we aimed to develop a convolutional neural network(CNN)for classification of these four breast mass types using ultrasound(US)images.Methods:Taking breast biopsy or pathological examinations as the reference standard,CNNs were used to establish models for the four-way classification of 3623 breast cancer patients from 13 centers.The patients were randomly divided into training and test groups(n=1810 vs.n=1813).Separate models were created for two-dimensional(2D)images only,2D and color Doppler flow imaging(2D-CDFI),and 2D-CDFI and pulsed wave Doppler(2D-CDFI-PW)images.The performance of these three models was compared using sensitivity,specificity,area under receiver operating characteristic curve(AUC),positive(PPV)and negative predictive values(NPV),positive(LR+)and negative likelihood ratios(LR-),and the performance of the 2D model was further compared between masses of different sizes with above statistical indicators,between images from different hospitals with AUC,and with the performance of 37 radiologists.Results:The accuracies of the 2D,2D-CDFI,and 2D-CDFI-PW models on the test set were 87.9%,89.2%,and 88.7%,respectively.The AUCs for classification of benign tumors,malignant tumors,inflammatory masses,and adenosis were 0.90,0.91,0.90,and 0.89,respectively(95%confidence intervals[CIs],0.87-0.91,0.89-0.92,0.87-0.91,and 0.86-0.90).The 2D-CDFI model showed better accuracy(89.2%)on the test set than the 2D(87.9%)and 2D-CDFI-PW(88.7%)models.The 2D model showed accuracy of 81.7%on breast masses≤1 cm and 82.3%on breast masses>1 cm;there was a significant difference between the two groups(P<0.001).The accuracy of the CNN classifications for the test set(89.2%)was significantly higher than that of all the radiologists(30%).Conclusions:The CNN may have high accuracy for classification of US images of breast masses and perform significantly better than human radiologists.Trial registration:Chictr.org,ChiCTR1900021375;http://www.chictr.org.cn/showproj.aspx?proj=33139. | Teng-Fei Yu Wen He Cong-Gui Gan Ming-Chang Zhao Qiang Zhu Wei Zhang Hui Wang Yu-Kun Luo Fang Nie Li-Jun Yuan Yong Wang Yan-Li Guo Jian-Jun Yuan Li-Tao Ruan Yi-Cheng Wang Rui-Fang Zhang Hong-Xia Zhang Bin Ning Hai-Man Song Shuai Zheng Yi Li Yang Guang | 2021 | Chinese Medical Journal2021，，4： | 11 |
| 12 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 13 | TaqMan Real-time RT-PCR Assay for Detecting and Differentiating Japanese Encephalitis Virus显示文摘Objective To detect Japanese encephalitis virus(JEV) rapidly and distinguish its genotypes, a TaqMan-based reverse transcriptase quantitative polymerase chain reaction(RT-PCR) detection system was developed.Methods By aligning the full-length sequences of JEV(G1-G5), six sets of highly specific TaqMan real-time RT-PCR primers and probes were designed based on the highly conserved NS1, NS2, and M genes of JEV, which included one set for non-specific JEV detection and five sets for the detection of specific JEV genotypes. Twenty batches of mosquito samples were used to evaluate our quantitative PCR assay.Results With the specific assay, no other flavivirus were detected. The lower limits of detection of the system were 1 pfu/mL for JEV titers and 100 RNA copies/μL. The coefficients of variation of this real-time RT-PCR were all < 2.8%. The amplification efficiency of this method was between 90% and 103%.Conclusion A TaqMan real-time RT-PCR detection system was successfully established to detect and differentiate all five JEV genotypes. | SHAO Nan LI Fan NIE Kai FU Shi Hong ZHANG Wei Jia HE Ying LEI Wen Wen WANG Qian Ying LIANG Guo Dong CAO Yu Xi WANG Huan Yu | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 14 | Comparison of the performance of the CRUSADE, ACUITY-HORIZONS, and ACTION bleeding scores in ACS patients undergoing PCI: insights from a cohort of 4939 patients in China显示文摘BackgroundThe 十字军,行动和尖酸地平线分数通常被使用预言与急性冠的症候群(交流) 在病人为事件放血的在里面医院专业,但是这些的同类的性质为人口限制建模 ? 简单推测到另外的本地人口。我们试图在中国 patients.MethodsWe 比较三个风险模型的表演评估了三的表演为预言主要流血事件在心肌的梗塞( TIMI )由 thrombolysis 定义的在里面医院预言分数严肃(专业和未成年者)事件,在有 non-ST-elevation 交流(NSTE交流)或圣举起的中国交流病人的一个队心肌的梗塞( STEMI )。三个风险模型的刻度和辨别被 Hosmer-Lemeshow 测试和 C 统计数值分别地评估。我们由严肃的流血率是的 Delong 非参量的 test.ResultsTIMI 比较了风险分数的预兆的精确性 1.1% 外套(1.9% 和 0.86% 为 STEMI 和 NSTE 交流,分别地) 。十字军,行动和 ACUTIY 地平线分数为主要流血显示出一个足够的差别对待的能力:在全面病人, C 统计数值分别地是 0.80, 0.77,和 0.70;在 NSTE 交流病人, C 统计数值分别地是 0.73, 0.72,和 0.64;在 STEMI 病人, C 统计数值分别地是 0.91, 0.92,和 0.75。为尖酸地平线模型的 C 统计数值是比为 TIMI 的预言的 CRUSADE 和行动分数的那些显著地低的在全面病人的严肃的流血(与十字军相比, z = 3.83, P = 0.02;与行动相比, z = 3.51, P = 0.03 ) ;在 NSTE 交流病人(与十字军相比, z = 2.37, P = 0.01;与行动相比, z = 2.11, P = 0.04 ) ,并且在 STEMI 病人(与十字军相比, z = 2.6.77, P = 0.02;与行动相比, z = 7.91, P = 0.002 ) 。当 CRUSADE 和行动模型与对方相比时,没有差别被观察,不管全面病人( z = 0.68 , P = 0.31 )并且两个都交流打字(NSTE交流, z = 0.52 , P = 0.60 ),并且 STEMI 病人( z = 0.36 , P = 0.74 )。然而,三个风险分数都在我们的学习在每风险层化过高估计绝对主要流血风险。例如,在高风险层化的十字军 20 的预言的率是 11.9% 对 5.3%.ConclusionsThe 十字军和行动分数的实际的率为在里面医院专业与尖酸地平线相比流血让更大的刻度和辨别与经历一种总线标准的交流在中国病人得分。然而,他们都为中国人口过高估计流血风险率。这些风险分数的刻度将为在中国人口的归纳是有用的。 | Ran LIU Shu-Zheng LYU Guan-Qi ZHAO Wen ZHENG Xiao WANG Xue-Dong ZHAO Sheng-Hui ZHOU Lei ZHEN Shao-Ping NIE | 2017 | Journal of Geriatric Cardiology2017，14，2： | 9 |
| 15 | Optimal timing of staged percutaneous coronary intervention in ST-segment elevation myocardial infarction patients with multivessel disease显示文摘BackgroundStudies 证明了为非犯人损害的上演经皮的冠的干预(一种总线标准) 为圣片断举起的预后是有益的有 multivessel 的心肌的梗塞(STEMI ) 病人疾病。然而,上演 revascularization 的最佳的预定仍然是争论的。这研究试图 428 STEMI 发现上演 revascularization.MethodsA 的最佳的预定全部经历了主要一种总线标准并且上演了一种总线标准的有 multivessel 疾病的病人被包括。根据在主要、上演的一种总线标准之间的时间间隔,病人们被划分成三个组(在主要一种总线标准以后的 1 个星期, 1-2 星期,和 2-12 星期) 。主要端点是主要不利心血管的事件(向) ,一所有原因死亡,非致命的重新梗塞,重复 revascularization,和击合成。考克斯回归模型被用来估计在预定的上演一种总线标准和 MACE.ResultsDuring 的风险之间的协会后续, 119 个参加者有权标。在在三个组之中的向发生有统计差别(1 个星期:23.0% ;1-2 星期:33.0% ;2-12 星期:40.0% ;P = 0.001 ) 。在 multivariable 调整模型,上演一种总线标准 1 星期和 1-2 星期的预定间隔是显著地与向的更低的风险联系的两个[危险比率(HR ) :0.40, 95% 信心间隔(CI ) :0.24-0.65;HR:0.54, 95% CI:0.31-0.93,分别地] ,主要归因于重复 revascularization 的更低的风险(HR:0.41, 95% CI:0.24-0.70;HR:0.36, 95% CI:0.18-0.7 ) ,与主要 PCI.ConclusionsThe 以后的 2-12 星期的策略相比,为非犯人容器的上演一种总线标准的最佳的预定应该在在为 STEMI 病人的主要一种总线标准以后的二个星期以内。 | Xue-Dong ZHAO Guan-Qi ZHAO Xiao WANG Shu-Tian SHI Wen ZHENG Rui-Feng GUO Shao-Ping NIE | 2018 | Journal of Geriatric Cardiology2018，15，5： | 9 |
| 16 | Regression analysis of major parameters affecting the intensity of coal and gas outbursts in laboratory显示文摘Estimating the intensity of outbursts of coal and gas is important as the intensity and frequency of outbursts of coal and gas tend to increase in deep mining. Fully understanding the major factors contributing to coal and gas outbursts is significant in the evaluation of the intensity of the outburst. In this paper, we discuss the correlation between these major factors and the intensity of the outburst using Analysis of Variance(ANOVA) and Contingency Table Analysis(CTA). Regression analysis is used to evaluate the impact of these major factors on the intensity of outbursts based on physical experiments. Based on the evaluation, two simple models in terms of multiple linear and nonlinear regression were constructed for the prediction of the intensity of the outburst. The results show that the gas pressure and initial moisture in the coal mass could be the most significant factors compared to the weakest factor-porosity. The P values from Fisher's exact test in CTA are: moisture(0.019), geostress(0.290), porosity(0.650), and gas pressure(0.031). P values from ANOVA are moisture(0.094), geostress(0.077), porosity(0.420), and gas pressure(0.051). Furthermore, the multiple nonlinear regression model(RMSE: 3.870) is more accurate than the linear regression model(RMSE: 4.091). | Geng Jiabo Xu Jiang Nie Wen Peng Shoujian Zhang Chaolin Luo Xiaohang | 2017 | International Journal of Mining Science and Technology2017，27，2： | 7 |
| 17 | Feed conversion ratio,residual feed intake and cholecystokinin type A receptor gene polymorphisms are associated with feed intake and average daily gain in a Chinese local chicken population显示文摘Background: The feed conversion ratio(FCR) and residual feed intake(RFI) are common indexes in measuring feed efficiency for livestock. RFI is a feed intake adjusted for requirements for maintenance and production so these two traits are related. Similarly, FCR is related to feed intake and weight gain because it is their ratio. Cholecystokinin type A receptor(CCKAR) plays an important role in animal digestive process. We examined the interplay of these three parameters in a local Chinese chicken population.Results: The feed intake(FI) and body weights(BW) of 1,841 individuals were monitored on a daily basis from 56 to 105 d of age. There was a strong correlation between RFI and average daily feed intake(ADFI) and a negative correlation between the FCR and daily gain(r_g=-0.710). Furthermore, we identified 51 single nucleotide polymorphisms(SNPs) in the CCKAR and 4 of these resulted in amino acid mutations. The C334A mutation was specifically associated with FI and the expected feed intake(EFI)(P < 0.01) and significantly associated with the average daily gain(ADG)(P < 0.05). G1290A was significantly associated with FI and EFI(P < 0.05).Conclusion: FCR is apply to weight selecting, and RFI is more appropriate if the breeding focus is feed intake. And C334A and G1290A of the CCKAR gene can be deemed as candidate markers for feed intake and weight gain. | Zhenhua Yi Xing Li Wen Luo Zhenqiang Xu Congliang Ji Yan Zhang Qinghua Nie Dexiang Zhang Xiquan Zhang | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 7 |
| 18 | O-GlcNAc修饰与疾病病理学的联系(英文)显示文摘O-连接的N-乙酰葡萄糖胺(O-GlcNAc)修饰是一种发生于蛋白质丝氨酸或苏氨酸残基上的蛋白翻译后修饰,它能动态地发生在细胞的任何部位,如细胞质、线粒体、细胞核等。O-GlcNAc修饰的供体尿苷二磷酸-N-乙酰葡萄糖胺(UDP-GlcNAc)是己糖胺生物合成途径(HBP)的终产物。GlcNAc在蛋白上的添加和移除分别需要O-GlcNAc转移酶(OGT)和O-GlcNAc水解酶(OGA)的介导。被O-GlcNAc修饰的蛋白包括转录因子、代谢酶、细胞信号传导因子等。O-GlcNAc通过调控这些蛋白的功能参与到许多重要的生物进程中,如转录、翻译、代谢、信号传导、自噬等。此外,O-GlcNAc修饰的失调还与许多重要疾病息息相关,包括癌症、糖尿病、神经退行性疾病和心血管疾病。更好地了解O-GlcNAc修饰在这些疾病生理病理学进程中所起的作用将有助于开发新的治疗策略。本文介绍了O-GlcNAc与疾病病理联系的最新研究,并揭示O-GlcNAc可作为潜在的临床治疗靶点。 | Hao NIE Wen YI | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，5： | 7 |
| 19 | Major clades and a revised classification of Magnolia and Magnoliaceae based on whole plastid genome sequences via genome skimming显示文摘With more than 300 species,the Magnoliaceae family represents a major Magnolid lineage that is disjunctly distibuted in Asia and the New World,.The classifcation of Magnolia s.L.has been highly controversial among taxonomists,varying from one genus with several subgenera,sections,and subsections to several(up to 16)genera.We conducted a comprehensive phylogenetic study of Magnoliaceae on the basis of sequences of the complete chloroplast genomes with a broad jaxon sampling of 86 species.The phylogenetic analyses strongly support 15 major clades within Magnolia si.due to the non-monophyly of subgen.Mgnolia,the previous subgeneric treatment that recognizes three subgenera,is not supported.Based on the phylogenetic,morphological,and geographic evidence,we recognize two subfamilies in Magollaceae:Liriodendroideae and Magnolioideae,each with one genus,Liriodendron and Magnolla,respectively.Magnolla Is herein lassfed into 15 sections:sects.Mognolia,Manglietia,Micheila,willimia,Gynopodium,Kmerla,Maingola,Oyama,Rytidospermum,Splendentes,Talouma,Tulparla,Macophylla,Tllpastrum,and Yulanla. | Yu-Bing Wang Bin-Bin Liu Ze-Long Nie Hong-Feng Chen Fa-Ju Chen Richard B.Figlar Jun Wen | 2020 | Journal of Systematics and Evolution2020，58，5： | 6 |
| 20 | Effect of suppressing dust by multi-direction whirling air curtain on fully mechanized mining face显示文摘A combined method of numerical simulation and field testing was adopted in this study in the interest of solving the problem of hard to control high concentrate dusts on a fully mechanized mining face.In addition,the dust suppression effect of a multi-direction whirling air curtain was studied in this paper.Under the influence of the wall attachment effect,the compressed air which blows out from the two-phase or three-phase radial outlets on the generator of the air curtain can form a multi-direction whirling air curtain,which can cover the whole roadway section of a fully mechanized mining face.The traditional method of controlling dust is a forcing system with exhaust overlap which has the major disadvantage of lacking a jet effect and consequently results in poor dust control.It is difficult to form the air flow field within the range of L_p5Sr^(1/2).However,due to the effect of this novel system,the radial airflow can be turned into axial airflow allowing fresh air to flow through the length of the heading.The air flow field which is good at controlling dust diffusion can be formed 12.8 m from the heading face.Furthermore,the field measurement results show that before the application of a multi-direction whirling air curtain,the dust concentration is 348.6 mg/m^3 and 271.4 mg/m^3 respectively at the roadway cross-section measurement points which are 5 m and 10 m from the heading face.However,after the application of the multi-direction whirling air curtain,the dust concentration is only 61.2 mg/m^3 and 14.8 mg/m^3,respectively.Therefore,the dust control effect of a multi-direction whirling air curtain is obvious. | Nie Wen Liu Yanghao Wei Wenle Hu Xiangming Ma Xiao Peng Huitian | 2016 | International Journal of Mining Science and Technology2016，26，4： | 6 |
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