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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition显示文摘 | Yan Jian Xiaotong Zhao Qian Xiao Qingbo Liu Keshuo Ding Fei Yu Rui Zhang Tao Zhu Gaoxiang Ge | 2014 | Journal of Molecular Cell Biology2014，8，4： | 11 |
| 3 | Highly efficient solution-processed CZTSSe solar cells based on a convenient sodium-incorporated post-treatment method显示文摘In CZTSSe solar cells,a simple sodium-incorporation post-treatment method toward solution-processed Cu2Zn Sn S4precursor films is presented in this work.An ultrathin NaCl film is deposited on Cu2Zn Sn S4precursor films by spin-coating NaCl solution.In subsequent selenization process,the introduction of Na Cl is found to be benefacial for the formation of Cu2-xSe,which can further facilitate the element transportation,leading to dense and smooth CZTSSe films with large grains and less impurity Cu2Sn(S,Se)3phase.SIMS depth profiles confirm the gradient distribution of the sodium element in Na-doped absorbers.Photoluminescence spectra show that the introduction of appropriate sodium into the absorber can inhibit the band tail states.As high as 11.18% of power conversion efficiency(PCE)is achieved for the device treated with 5 mg mL^-1 NaCl solution,and an average efficiency of Na-doped devices is 10.71%,13%higher than that of the control groups(9.45%).Besides,the depletion width and the charge recombination lifetime can also have regular variation with sodium treatment.This work offers an easy modification method for high-quality Na-doped CZTSSe films and high-performance devices,in the meantime,it can also help to further understand the effects of sodium in CZTSSe solar cells. | Biwen Duan Linbao Guo Qing Yu Jiangjian Shi Huijue Wu Yanhong Luo Dongmei Li Sixin Wu Zhi Zheng Qingbo Meng | 2020 | Journal of Energy Chemistry2020，29，1： | 8 |
| 4 | Stability improvement under high efficiency—next stage development of perovskite solar cells显示文摘With efficiency of perovskite solar cells(PSCs) overpassing 23%, to realize their commercialization, the biggest challenge now is to boost the stability to the same level as conventional solar cells. Thus, tremendous effort has been directed over the past few years toward improving the stability of these cells. Various methods were used to improve the stability of bulk perovskites,including compositional engineering, interface adjustment, dimensional manipulation, crystal engineering, and grain boundary decoration. Diverse device configurations, carrier transporting layers, and counter electrodes are investigated. To compare the stability of PSCs and clarify the degradation mechanism, diverse characterization methods were developed. Overall stability of PSCs has become one central topic for the development of PSCs. In this review, we summarize the state-of-the-art progress on the improvement of device stability and discuss the directions for future research, hoping it provides an overview of the current status of the research on the stability of PSCs and guidelines for future research. | Danni Yu Yue Hu Jiangjian Shi Haoying Tang Wenhao Zhang Qingbo Meng Hongwei Han Zhijun Ning He Tian | 2019 | Science China Chemistry2019，62，6： | 7 |
| 5 | Single-source-precursor synthesis and phase evolution of SiC-TaC-C ceramic nanocomposites containing core-shell structured TaC@C nanoparticles显示文摘A novel single-source-precursor for SiC-TaC-C nanocomposites was successfully synthesized by the chemical reaction between a polycarbosilane(allylhydridopolycarbosilane,AHPCS)and tantalum(V)chloride(TaCls),which was confirmed by Fourier transform infrared spectra(FTIR)measurement.After pyrolysis of the resultant single-source-precursors at 900'C,amorphous ceramic powders were obtained.The 900 C ceramics were anncaled at different temperatures in the range of 1200-1600℃ to gain SiC-TaC-C nanocomposites.The phase evolution of ceramic nanocomposites was investigated by X-ray diffraction(XRD)and transmission electron microscopy(TEM).The results indicate that the TaC starts to crystallize at lower temperature than theβ-SiC.It is particularly worth pointing out that the unique core-shell structured TaC-C nanoparticles were in-situ formed and homogeneously distributed in the ceramic matrix after annealing at 1400 C.Even at a high temperature of 1600 C,the grain sizes ofβ-SiC and TaC are smaller than 30 nm,flilling the definition of nanocomposites.The present study related to SiC-TaC C nanocomposites paves a new road for enriching ultra-high temperature ceramic family suitable for structural/functional applications in harsh environment. | Zhaoju YU Yujing YANG Kangwei MAO Yao FENG Qingbo WEN Ralf RIEDEL | 2020 | Journal of Advanced Ceramics2020，9，3： | 5 |
| 6 | Hydrogen production via steam reforming of bio-oil model compounds over supported nickel catalysts显示文摘The steam reforming of four bio-oil model compounds(acetic acid,ethanol,acetone and phenol) was investigated over Ni-based catalysts supported on Al2O3 modified by Mg,Ce or Co in this paper.The activation process can improve the catalytic activity with the change of high-valence Ni(Ni2O3,NiO) to low-valence Ni(Ni,NiO).Among these catalysts after activation,the Ce-Ni/Co catalyst showed the best catalytic activity for the steam reforming of all the four model compounds.After long-term experiment at 700°C and the S/C ratio of 9,the Ce-Ni/Co catalyst still maintained excellent stability for the steam reforming of the simulated bio-oil(mixed by the four compounds with the equal masses).With CaO calcinated from calcium acetate as CO2 sorbent,the catalytic steam reforming experiment combined with continuous in situ CO2 adsorption was performed.With the comparison of the case without the adding of CO2 sorbent,the hydrogen concentration was dramatically improved from 74.8% to 92.3%,with the CO2 concentration obviously decreased from 19.90% to 1.88%. | Huaqing Xie Qingbo Yu Xin Yao Wenjun Duan Zongliang Zuo Qin Qin | 2015 | Journal of Energy Chemistry2015，24，3： | 5 |
| 7 | 120 mm Single-crystalline perovskite and wafers: towards viable applications显示文摘As the large single-crystalline silicon wafers have revolutionized many industries including electronics and solar cells, it is envisioned that the availability of large single-crystalline perovskite crystals and wafers will revolutionize its broad applications in photovoltaics, optoelectronics, lasers, photodetectors, light emitting diodes(LEDs), etc. Here we report a method to grow large single-crystalline perovskites including single-halide crystals: CH3NH3PbX3(X=I, Br, Cl), and dual-halide ones:CH3NH3Pb(ClxBr1.x)3 and CH3NH3Pb(BrxI1.x)3, with the largest crystal being 120 mm in length. Meanwhile, we have advanced a process to slice the large perovskite crystals into thin wafers. It is found that the wafers exhibit remarkable features:(1)its trap-state density is a million times smaller than that in the microcrystalline perovskite thin films(MPTF);(2) its carrier mobility is 410 times higher than its most popular organic counterpart P3HT;(3) its optical absorption is expanded to as high as910 nm comparing to 797 nm for the MPTF;(4) while MPTF decomposes at 150 °C, the wafer is stable at high temperature up to270 °C;(5) when exposed to high humidity(75% RH), MPTF decomposes in 5 h while the wafer shows no change for overnight;(6) its photocurrent response is 250 times higher than its MPTF counterpart. A few electronic devices have been fabricated using the crystalline wafers. Among them, the Hall test gives low carrier concentration with high mobility. The trap-state density is measured much lower than common semiconductors. Moreover, the large SC-wafer is found particularly useful for mass production of integrated circuits. By adjusting the halide composition, both the optical absorption and the light emission can be fine-tuned across the entire visible spectrum from 400 nm to 800 nm. It is envisioned that a range of visible lasers and LEDs may be developed using the dual-halide perovskites. With fewer trap states, high mobility, broader absorption, and humidity resistance, it is expected that solar cells with high stable efficiency maybe attainable using the crystalline wafers. | Yucheng Liu Xiaodong Ren Jing Zhang Zhou Yang Dong Yang Fengyang Yu Jiankun Sun Changming Zhao Zhun Yao Bo Wang Qingbo Wei Fengwei Xiao Haibo Fan Hao Deng Liangping Deng Shengzhong (Frank) Liu | 2017 | Science China Chemistry2017，60，10： | 5 |
| 8 | Evaluation of computed tomography obstruction index in guiding therapeutic decisions and monitoring percutanous catheter fragmentation in massive pulmonary embolism显示文摘In the present study, we evaluated computed tomography pulmonary angiography (CTPA) in guiding therapeutic decisions and monitoring patients undergoing percutaneous catheter fragmentation in acute massive pulmonary embolism. From Jan 2003 to Dec 2009, 35 patients were diagnosed with acute massive pulmonary embolism by CTPA (T0) and treated with percutaneous catheter fragmentation. The severity was assessed by CT obstruction index (Qanadli index) and compared with Miller index. CTPA, oxygen saturation (SaO 2 ) and pulmonary artery pressure were performed as follow-up index. The mean percentage of Qanadli index was (55±13)% (range, 40%-75%), and Miller index was (62±15)% (range, 45%-85%). Correlations between them were statistically signifi- cant (r = 0.867, P < 0.0001). The Qanadli index showed significant reduction [T0: (55±13)%; T1: (12±10)%; P < 0.001] in 33 patients. Significant correlation was observed between the Qanadli index, SaO 2 (r = 0.934), and pulmonary artery pressure (r = 0.813). The Qanadli index provides an accurate method for distinguishing massive pulmonary embolism from sub-massive pulmonary embolism. It can be used to determine therapeutic options and monitor clinical outcomes. | Tongfu Yu Mei Yuan Qingbo Zhang Haibing Shi Dehang Wang | 2011 | The Journal of Biomedical Research2011，25，6： | 4 |
| 9 | Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation显示文摘包括 lysyl oxidase (哈鱼) ,涉及骨胶原生合成的酶为自发的肺的纤维变性作为潜在的治疗学的目标被建议了。哈鱼表示是显著地,在 bleomycin (BLM ) 的 upregulated 导致了肺纤维变性,并且哈鱼表示或哈鱼活动的抑制击倒减轻肺纤维变性。出人意料地,有在煽动性的阶段的哈鱼禁止者的鼠标的治疗,然而并非 fibrogenic 阶段,高效地减少骨胶原免职并且使肺建筑学正常化。哈鱼的抑制损害煽动性的房间渗入,发信号的 TGF- ,和 myofibroblast 累积。而且,哈鱼的宫外的表示敏化纤维变性抵抗的 Balb/c 老鼠到导致 BLM 的发炎和肺纤维变性。这些结果建议那条哈鱼为由在肺损害以后加重煽动性的反应和随后的纤维变性过程的导致 BLM 的试验性的肺纤维变性的前进是不可缺少的。 | Tao Cheng Qingbo Liu Rui Zhang Ying Zhang Jianfeng Chen Ronghuan Yu Gaoxiang Ge | 2014 | Journal of Molecular Cell Biology2014，8，6： | 3 |
| 10 | Prediction of anther-expressed gene regulation in Arabidopsis显示文摘Anther development in Arabidopsis, a popular model plant for plant biology and genetics, is controlled by a complex gene network. Despite the extensive use of this genus for genetic research, little is known about its regulatory network. In this paper, the direct transcriptional regulatory relationships between genes expressed in Arabidopsis anther development were predicted with an integrated bioinformatic method that combines mining of microarray data with promoter analysis. A total of 7710 transcription factor-gene pairs were obtained. The 80 direct regulatory relationships demonstrating the highest confidence were screened from the initial 7710 pairs; three of the 80 were validated by previous experiments. The results indicate that our predicted results were reliable. The regulatory relationships revealed by this research and described in this paper may facilitate further investigation of the molecular mechanisms of anther development. The bioinformatic method used in this work can also be applied to the prediction of gene regulatory relationships in other organisms. | HUANG JiFeng YANG JingJin WANG Guan YU QingBo YANG ZhongNan | 2008 | Chinese Science Bulletin2008，53，20： | 2 |
| 11 | Si-based polymer-derived ceramics for energy conversion and storage显示文摘Since the 1960s,a new class of Si-based advanced ceramics called polymer-derived ceramics(PDCs)has been widely reported because of their unique capabilities to produce various ceramic materials(e.g.,ceramic fibers,ceramic matrix composites,foams,films,and coatings)and their versatile applications.Particularly,due to their promising structural and functional properties for energy conversion and storage,the applications of PDCs in these fields have attracted much attention in recent years.This review highlights the recent progress in the PDC field with the focus on energy conversion and storage applications.Firstly,a brief introduction of the Si-based polymer-derived ceramics in terms of synthesis,processing,and microstructure characterization is provided,followed by a summary of PDCs used in energy conversion systems(mainly in gas turbine engines),including fundamentals and material issues,ceramic matrix composites,ceramic fibers,thermal and environmental barrier coatings,as well as high-temperature sensors.Subsequently,applications of PDCs in the field of energy storage are reviewed with a strong focus on anode materials for lithium and sodium ion batteries.The possible applications of the PDCs in Li–S batteries,supercapacitors,and fuel cells are discussed as well.Finally,a summary of the reported applications and perspectives for future research with PDCs are presented. | Qingbo WEN Fangmu QU Zhaoju YU Magdalena GRACZYK-ZAJAC Xiang XIONG Ralf RIEDEL | 2022 | Journal of Advanced Ceramics2022，11，2： | 2 |
| 12 | Defect engineering on all-inorganic perovskite solar cells for high efficiency显示文摘Perovskite solar cells based on organic–inorganic hybrid perovskite materials have become a research hotspot in photovoltaics field due to their outstanding power conversion efficiency (PCE)[1]. Nonetheless, the organic cations are volatile and have rotation freedom, which is not good for photoand thermal-stability of the devices. | Bingcheng Yu Chuantian Zuo Jiangjian Shi Qingbo Meng Liming Ding | 2021 | Journal of Semiconductors2021，42，5： | 2 |
| 13 | Recent Progress of Counter Electrodes in Nanocrystalline Dye-sensitized Solar Cells显示文摘敏化染料的太阳能电池(DSC ) 在于有 nanoparticulated 半导体, sensitizers,电解质和相反的电极(CE ) 的几 differentmaterials:photoanodes 的联合。每材料为 CE 的主要功能是把电子转移到氧化还原作用电解质和 regenerate 碘化物离子的太阳能 intoelectricity.The 的变换执行特定的任务。GE 的工作主要集中于运动表演的研究和传统的 CE 的稳定性改进 DSC 的全面效率,寻求新奇设计概念或新材料。在这评论,发展和研究不同 CE 材料和他们的电气化学的表演进行,并且这些问题被讨论。 | Kexin LI Zhexun YU Yanhong LUO Dongmei LI Qingbo MENG | 2007 | Journal of Materials Science & Technology2007，23，5： | 2 |
| 14 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 15 | Duplication and expression analysis of multicopy miRNA gene family members in Arabidopsis and rice显示文摘理解扩大多拷贝 microRNA (miRNA ) 在植物的家庭,我们局部性从到他们的染色体的 Arabidopsis 和米饭的报导 miRNA 基因,分别地并且从 Arabidopsis 观察了 117 miRNA 基因中的那 37% 个,从米饭的 173 miRNA 基因中的 35% 个是在染色体的部分复制。为了描绘表示多样化是否多发生在植物之中,拷贝 miRNA 家庭成员,我们设计了在 Arabidopsis 和米饭从 10 个家庭指向 48 位预言的 miRNA 先锋的 PCR 教材。从 RT-PCR 数据的结果建议在一样的 miRNA 家庭以内的成员的抄录先锋在不同表示层次是在场的。另外,尽管 miR160 和 miR162 序列在 Arabidopsis 和米饭被保存,我们发现这些基因的表示模式在二种之间不同。这些数据建议那表达式多样化发生了在多拷贝 miRNA 家庭,在植物增加我们 miRNAs 的表达式规定的理解。 | Danhua Jiang Changsong Yin Aiping Yu Xiaofan Zhou Wanqi Liang Zheng Yuan Yun Xu Qingbo Yu Tieqiao Wen Dabing Zhang | 2006 | Cell Research2006，16，5： | 2 |
| 16 | Bio-oil production by fast pyrolysis from agriculture residue in northeastern China显示文摘 | Xie Huaqing Yu Qingbo Qin Qin | 2013 | Journal of Renewable and Sustainable Energy2013，5，1： | 1 |
| 17 | Environmental and Economic Evaluation of Cathode Ray Tube (CRT) Funnel Glass Waste Management Options in the United States显示文摘 | Qingbo Xu Mengjing Yu Alissa Kendall Wenzhi He Guangming Li Julie M. Schoenung | 2013 | Resources Conservation & Recycling2013，，： | 1 |
| 18 | Experimental investigation of liquid disintegration by rotary cups显示文摘 | Junxiang Liu Qingbo Yu Qiang Guo | 2012 | Chemical Engineering Science2012，，： | 1 |
| 19 | Environmental and economic evaluation of cathode ray tube (CRT)funnel glass waste management options in the United States 显示文摘 | XU Qingbo YU Mengjing KENDALL A | 2013 | Resources Conservation and Recycling2013，78，2： | 1 |
| 20 | Experimental investigation of liquid disintegration by rotary cups显示文摘 | LIU Junxiang YU Qingbo GUO Qiang | 2012 | Chemical Engineering Science2012，73，： | 1 |
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