|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Simultaneous changes in seed size, oil content and protein content driven by selection of SM/EEIhomologues during soybean domestication显示文摘Soybean accounts for more than half of the global production of oilseed and more than a quarter of the protein used globally for human food and animal feed.Soybean domestication involved parallel increases in seed size and oil content,and a concomitant decrease in protein content.However,science has not yet discovered whether these effects were due to selective pressure on a single gene or multiple genes.Here,re-sequencing data from>800 genotypes revealed a strong selection during soybean domestication on GmSWEETlOa.The selection of GmSWEETlOa conferred simultaneous increases in soybean-seed size and oil content as well as a reduction in the protein content.The result was validated using both near-isogenic lines carrying substitution of haplotype chromosomal segments and transgenic soybeans.Moreover,GmSWEETlOb was found to be functionally redundant with its homologue GmSWEETlOa and to be undergoing selection in current breeding,leading the the elite allele GrnSWEETlOb,a potential target for present-day soybean breeding.Both GmSWEETlOa and GmSWEETlOb were shown to transport sucrose and hexose,contributing to sugar allocation from seed coat to embryo,which consequently determines oil and protein contents and seed size in soybean.We conclude that past selection of optimal GmSWEETlOa alleles drove the initial domestication of multiple soybean-seed traits and that targeted selection of the elite allele GmSWEETlOb may further improve the yield and seed quality of modern soybean cultivars. | Shoudong Wang Shulin Liu Jie Wang Kengo Yokosho Bin Zhou Ya-Chi Yu Zhi Liu Wolf BFrommer Jian Feng Ma Li-Qing Chen Yuefeng Guan Huixia Shou Zhixi Tian | 2020 | National Science Review2020，7，11： | 17 |
| 2 | Sequencing of PCR amplified HBV DNA pre-c and c regions in 2.2.15 cells and antiviral action by targeted antisense oligonucleotide directed against sequence显示文摘INTRODUCTIONManystudieshaveshownthatantisenseoligonucleotides(ASONs)canefficientlyinhibitHBVDNAreplicationandexpresioninvitro... | ZHOUG Sen 1, WEN Shou Ming 2, ZHANG Ding Feng 3, WANG Quan Li 4, WANG Seng Qi 4 and REN Hong 3 | 1998 | World Journal of Gastroenterology1998，4，5： | 16 |
| 3 | Synthesis of propylene carbonate from urea and 1,2-propanediol显示文摘从脲和 1,2-propanediol (PG ) 的丙烯碳酸盐(PC ) 的生产在一个批过程被调查。锌氯化物和镁氯化物的催化表演为这个反应系统被调查。PC 收益上的各种各样的操作条件的影响被探索。在这个工作, MgCl 2 和 ZnCl 2 向 PC 合成显示出优秀催化活动,并且丙烯碳酸盐的收益分别地到达了 96.5% 和 92.4% 。最佳反应条件如下:乙醇 / 脲 4 的臼齿的比率, 1.5% 的催化剂集中, 160 ° 的反应温度; C, 3 h 的反应时间分别地。从脲和 1,2-propanediol 的线路显示出优点,例如温和反应状况和安全操作。催化系统是环境联盟者良性。 | Zhi Wen Gao Shou Feng Wang Chun Gu Xia | 2009 | Chinese Chemical Letters2009，20，2： | 9 |
| 4 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 5 | Simultaneous quantification of ginsenoside Rg1 and its metabolites by HPLC–MS/MS:Rg1 excretion in rat bile, urine and feces显示文摘Ginsenoside Rg1(Rg1), the major effective component of ginseng, has been shown to have multiple bioactivities, but low oral bioavailability. The aim of this study was to develop a simple, sensitive and rapid high performance liquid chromatography–tandem mass spectrometry(LC–MS/MS) method, which could be used to validate and quantify the concentrations of Rg1 and its metabolites in Sprague-Dawley rat bile,urine, and feces after oral administration(25 mg/kg). Calibration curves offered satisfactory linearity(r40.995)within the determined ranges. Both intra-day and inter-day variances were less than 15%, and the accuracy was within 80–120%. The excretion recoveries of Rg1, ginsenoside Rh1(Rh1), and protopanaxatriol(Ppt) in bile,urine, and feces combined were all greater than 70%. The fecal excretion recoveries of Rg1, Rh1, and Ppt were40.11%, 22.19%, and 22.88%, respectively, whereas 6.88% of Rg1 and 0.09% of Rh1 were excreted in bile.Urinary excretion accounted for only 0.04% of Rg1. In conclusion, the observed excretion profiles for Rg1 and its metabolites after oral administration are helpful for understanding the poor oral bioavailability of Rg1 and will aid further investigations of Rg1 as a pharmacologically active component. | Chiyu He Ru Feng Yupeng Sun Shifeng Chu Ji Chen Chao Ma Jie Fu Zhenxiong Zhao Min Huang Jiawen Shou Xiaoyang Li Yuzhu Wang Jinfeng Hu Yan Wang Juntian Zhang | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 6 |
| 6 | Night Sleep Duration and Risk of Cognitive Impairment in a Chinese Population: A Cross-sectional Study显示文摘Objective Although sleep is one of the most important health-related behavioral factors,the association between night sleep duration and cognitive impairment has not been fully understood.A cross-sectional study was conducted with a random sample of 2,514 participants(≥40 years of age;46.6% women) in China to examine the association between night sleep duration and cognitive impairment.Methods Night sleep duration was categorized as ≤ 5,6,7,8,or ≥9 h per night.Cognitive function was measured using the Mini-Mental State Examination.A multivariate regression analysis was used to analyze the association of night sleep duration with cognitive impairment.A total of 122 participants were diagnosed with cognitive impairment.Results A U-shaped association between night sleep duration and cognitive impairment was found.The odds ratios(95% confidence intervals) of cognitive impairment(with 7 h of daily sleep being considered as the reference) for individuals reporting ≤ 5,6,8,and ≥9 h were 2.14(1.20-3.83),1.13(0.67-1.89),1.51(0.82-2.79),and 5.37(1.62-17.80),respectively(P≤0.01).Conclusion Short or long night sleep duration was an important sleep-related factor independently associated with cognitive impairment and may be a useful marker for increased risk of cognitive impairment. | SONG Qiao Feng LIU Xiao Xue HU Wan Ning HAN Xiao Chen ZHOU Wen Hua LU Ai Dong WANG Xi Zhu WU Shou Ling | 2017 | Biomedical and Environmental Sciences2017，30，10： | 5 |
| 7 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 8 | Risk of Treatment Failure in Patients with Drug-susceptible Pulmonary Tuberculosis in China显示文摘The objective of this prospective study of the risks of treatment failure in patients with drug-susceptible pulmonary tuberculosis(PTB)was to provide reference data to help develop a disease control strategy.Participants were recruited in eight provinces of China from October 2008 to December2010.A total of 1447 patients with | WANG Ni MA Yan LIU YU Hong DU Jian ZHANG Hui XIE Shi Heng Zhu Kun LYU Xiao Ya SHU Wei WANG Hong Hong ZHU Guo Feng TAN Shou Yong FU Yan Yong MA Li Ping ZHANG Lian Ying LIU Fei Ying HU Dai Yu ZHANG Yan Ling LI Xiang Qun LI Liang | 2016 | Biomedical and Environmental Sciences2016，29，8： | 3 |
| 9 | Role of Diabetes Mellitus on Treatment Effects in Drug-susceptible Initial Pulmonary Tuberculosis Patients in China显示文摘We assessed the role of diabetes mellitus(DM) on treatment effects in drug‐susceptible initial pulmonary tuberculosis(PTB) patients. A prospective study was conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug‐susceptible initial PTB patients, and all subjects received the treatment regimen(2 H3 R3 E3 Z3/4 H3 R3) as recommended by the national guidelines. Of the 1,313 PTB patients, 157(11.9%) had DM; these patients had more sputum smear‐positive rates at the end of the second month [adjusted odds ratios(aO R) 2.829, 95% confidence intervals(CI) 1.783‐4.490], and higher treatment failure(aO R 2.120, 95% CI 1.565‐3.477) and death rates(aO R 1.536, 95% CI 1.011‐2.628). DM was a contributing factor for culture‐positive rates at the end of the second month and treatment failure and death of PTB patients, thus playing an unfavorable role in treatment effects of PTB. | MA Yan HUANG Mai Ling LI Tao DU Jian SHU Wei XIE Shi Heng WANG Hong Hong ZHU Guo Feng TAN Shou Yong FU Yan Yong MA Li Ping ZHANG Lian Ying LIU Fei Ying HU Dai Yu ZHANG Yan Ling LI Xiang Qun LIU Yu Hong LI Liang | 2017 | Biomedical and Environmental Sciences2017，30，9： | 3 |
| 10 | Micro-Raman investigations on the structures of the surface and the inner of MgSO_4 droplets显示文摘Spherical MgSO4 droplets were deposited by a syringe on the hydrophobic Teflon substrate. Using micro-Raman technique, the laser beam was highly focused twice on the surface and in the center of spherical droplets. The Raman spectra for the surface and the inner of MgSO4 droplets were accord-ingly obtained, suggesting formation of a thin layer of gels on MgSO4 droplets at low relative humidity. The gel layer covered the surface and exhibited a significant delay in response to the change of ambi-ent relative humidity, resulting in the structural difference between the surface and the inner of MgSO4 droplets. | WANG Feng SHOU JingJing ZHANG YunHong | 2008 | Chinese Science Bulletin2008，53，15： | 2 |
| 11 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 12 | Therapeutic Effectiveness of Sustained Low‐Efficiency Hemodialysis Plus Hemoperfusion and Continuous Hemofiltration Plus Hemoperfusion for Acute Severe Organophosphate Poisoning显示文摘 | Shou‐liang Hu Dan Wang Hong Jiang Qing‐feng Lei Xiao‐hua Zhu Jun‐zhang Cheng | 2014 | Artificial Organs2014，，2： | 2 |
| 13 | Baeyer-Villiger oxidation of ketones with hydrogen peroxide catalyzed by Sn-aniline complex显示文摘Sn-aniline complex was prepared by a simple procedure.Cyclic and acyclic ketones were oxidized into lactones or esters with very high selectivity and yield with 30% hydrogen peroxide in the presence of Sn-aniline complex. | Qing Hua Zhang Shou Feng Wang Zi Qiang Lei | 2007 | Chinese Chemical Letters2007，18，1： | 2 |
| 14 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 15 | Sedimentary records of metal speciation in the Yangtze Estuary: Role of hydrological events显示文摘 | Chenghong Feng Shou Zhao Dongxin Wang Junfeng Niu Zhenyao Shen | 2014 | Chemosphere2014，，： | 1 |
| 16 | Spinal Microglia Initiate and Maintain Hyperalgesia in a Rat Model of Chronic Pancreatitis显示文摘 | Pei–Yi Liu Ching–Liang Lu Chia–Chuan Wang I–Hui Lee Jen–Chuen Hsieh Chun–Chia Chen Hsing–Feng Lee Han–Chieh Lin Full–Young Chang Shou–Dong Lee | 2012 | Gastroenterology2012，，1： | 1 |
| 17 | Microporous Silica-supported Polyoxometalate Catalyst H_3PW_(12)O_(40)/SiO_2 with High Activity for Acetal Reaction between Benzaldehyde and Ethylene Glycol显示文摘 | YANG Yu lin 1,2 , WANG Yong hui 1, HU Chang wen 1,** , WANG En bo 1 and FENG Shou hua 2 (1. Institute of Polyoxometalate Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China 2. State Key Laboratory | 2002 | Chemical Research in Chinese Universities2002，18，2： | 1 |
| 18 | Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice显示文摘 | Ying-xia GONG Wen-ting SHOU Bo FENG Wei-ping ZHANG Hui-juan WANG Hiroshi OHTSU Zhong CHEN | 2010 | Acta Pharmacologica Sinica2010，31，11： | 1 |
| 19 | Laser-induced damage thresholds of ultrathin targets and their constraint on laser contrast in laser-driven ion acceleration experiments显示文摘Single-shot laser-induced damage threshold(LIDT)measurements of multi-type free-standing ultrathin foils were performed in a vacuum environment for 800 nm laser pulses with durationsτranging from 50 fs to 200 ps.The results show that the laser damage threshold fluences(DTFs)of the ultrathin foils are significantly lower than those of corresponding bulk materials.Wide band gap dielectric targets such as SiN and formvar have larger DTFs than semiconductive and conductive targets by 1–3 orders of magnitude depending on the pulse duration.The damage mechanisms for different types of targets are studied.Based on the measurement,the constrain of the LIDTs on the laser contrast is discussed. | Dahui Wang Yinren Shou Pengjie Wang Jianbo Liu Zhusong Mei Zhengxuan Cao Jianmin Zhang Pengling Yang Guobin Feng Shiyou Chen Yanying Zhao Joerg Schreiber Wenjun Ma | 2020 | High Power Laser Science and Engineering2020，8，4： | 1 |
| 20 | Optical 2-benzyl-5-hydroxy-4-oxopentanoic acids against carboxypeptidase A:Synthesis,kinetic evaluation and X-ray crystallographic study显示文摘2-Benzyl-5-hydroxy-4-oxopentanoic acid 1 and its enantiomers were designed,synthesized and assayed for inhibitory activity against carboxypeptidase A(CPA,EC 3.4.17.1).To verify the role of the terminal hydroxyl group in 1 binding to CPA,2-benzyl-5- benzyloxy-4-oxopentanoic acid 2 was also synthesized and evaluated.The inhibition constants show that both L-1 and D-1 were shown to have strong binding affinity with L-1 being more potent than its enantiomer by 165-fold.On the other hand,the inhibition consta... | Wang, Shou Feng Jin, Jing-Yi Zeng, Zong Hao Tian, Guan Rong | 2010 | Chinese Chemical Letters2010，21，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员