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| 1 | Structural shifts in the intestinal microbiota of rats treated with cyclosporine A after orthotropic liver transplantation显示文摘Understanding the effect of immunosuppressive agents on intestinal microbiota is important to reduce the mortality and morbidity from orthotopic liver transplantation (OLT). We investigated the relationship between the commonly used immunosuppressive agent cyclosporine A (CSA) and the intestinal microbial variation in an OLT model. The rat samples were divided as follows:(1) N group (normal control);(2) I group (isograft LT, Brown Norway [BN] rat to BN);(3) R group (allograft LT, Lewis to BN rat);and (4) CSA group (R group treated with CSA). The intestinal microbiota was assayed by denaturing gradient gel electrophoresis profiles and by using real-time polymerase chain reaction. The liver histopathology and the alanine/aspartate aminotransferase ratio after LT were both ameliorated by CSA. In the CSA group, the numbers of rDNA gene copies of Clostridium cluster I, Clostridium cluster XIV, and Enterobacteriaceae decreased, whereas those of Faecalibacterium prausnitzii increased compared with the R group. Cluster analysis indicated that the samples from the N, I, and CSA groups were clustered, whereas the other clusters contained the samples from the R group. Hence, CSA ameliorates hepatic graft injury and partially restores gut microbiota following LT, and these may benefit hepatic graft rejection. | Junjun Jia Xinyao Tian Jianwen Jiang Zhigang Ren Haifeng Lu Ning He Haiyang Xie Lin Zhou Shusen Zheng | 2019 | Frontiers of Medicine2019，13，4： | 5 |
| 2 | A Case Study of Applying Metagenomic Sequencing in Precise Epidemiology for the COVID-19 Pandemic-Sichuan Province, China, 2020显示文摘Introduction:Determining the transmission chain of a virus in its incipient stages is extremely time consuming in traditional approaches that rely mainly on case incidence and interview-based contact data.With the development of high-throughput sequencing technology,genome-based epidemiology approach is showing promise in detecting viral transmission.However,there is still insufficient evidence for the relationship between the viral genetic variations and real viral transmission.Methods:To explore the possible relationship between transmission chains and viral genetic variations,we combined both epidemiological data and viral genomes of COVID-19 virus collected from Sichuan Province.A phylogenetic approach was used to infer the transmission chain,which was then compared to the transmission chain that came from epidemiological data.Results:We found that the putative transmission chains were highly concordant to the true transmission chains from epidemiological data,suggesting a strong correlation between viral genetic variations and the viral transmission chain.Discussion:Our results showed advantages of viral genomic sequencing in tracking and perceiving pathogen transmission,which allowed for potential improvements in the design and implementation of population-level public health interventions. | Jianan Xu Ye Wang You Li Huiping Yang Ming Pan Jian Liu Lina Shi Yuliang Feng Li Liu Jin Li Li Zhang Shusen He | 2020 | China CDC weekly2020，2，47： | 2 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | The enhancement of henzotriazole on epoxy functionalieed silica sol-gel coating for copper protection 显示文摘 | Peng Shusen Zhao Wenjie Li He | 2013 | Applied Surface Science2013，276，： | 1 |
| 5 | Micro- structural and mechanical characteristics of laser weld- ing of Ti6Al4V and lead metal 显示文摘 | ZHAO SHUSEN YU GANG HE XINLI | 2012 | Journal of Materials Processing Technology2012，212，7： | 1 |
| 6 | Microstructural and mechanical characteristics of laser welding of Ti6Al4V and lead metal显示文摘 | Shusen Zhao Gang Yu Xiuli He Yaowu Hu | 2012 | Journal of Materials Processing Tech2012，，7： | 1 |
| 7 | TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma显示文摘Objective:Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma(HCC).The precise prediction of post-transplant lung metastasis in the early phase is of great value.Methods:The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways.We enrolled 241 HCC patients who underwent liver transplantation from three centers.Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor(TNF),tumor necrosis factor receptor 1(TNFR1),and TNFR2,particularly for post-transplant lung metastasis.Results:Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC.The expression of TNF was degraded in comparison to that in para-tumor tissues(P<0.001).The expression of key receptors in the TNF-dependent signaling pathway,TNFR1 and TNFR2,was higher in HCC tissues than in para-tumor tissues(P<0.001).TNF and TNFR1 showed no relationship with patients’outcomes,whereas elevated TNFR2 in tumor tissue was significantly associated with worse overall survival(OS)and increased recurrence risk(5-year OS rate:31.9%vs.62.5%,P<0.001).Notably,elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis(hazard ratio:1.146;P<0.001).Cox regression analysis revealed that TNFR2,Hangzhou criteria,age,and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis,and a novel nomogram was established accordingly.The nomogram achieved excellent prognostic efficiency(area under time-dependent receiver operating characteristic=0.755,concordance-index=0.779)and was superior to conventional models,such as the Milan criteria.Conclusions:TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC.A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC. | Huigang Li Zuyuan Lin Jianyong Zhuo Modan Yang Wei Shen Zhihang Hu Yichen Ding Hao Chen Chiyu He Xinyu Yang Siyi Dong Xuyong Wei Beicheng Sun Shusen Zheng Ren Lang Di Lu Xiao Xu | 2023 | Chinese Journal of Cancer Research2023，35，1： | 0 |
| 8 | Diagnosis of knee osteoarthritis by OCT and surface-enhanced Raman spectroscopy显示文摘In this paper,optical coherence tomography(OCT)and surface-enhanced Raman spectroscopy(SERS)were used to characterize normal knee joint(NKJ)tissue and knee osteoarthritis(KOA)tissue ex vivo.OCT images show that there is a clear hierarchical structure in NKJ tissue,including surface layer,transitional layer,radiation layer and cartilage matrix calcification layer tissue structure,while the hierarchical structure of KOA tissue is not clear and unevenly distributed,and the pathological tissues at different stages also show significant di®erences.SERS shows that NKJ tissue and mild osteoarthritic knee cartilage(MiKOA)tissue have strong characteristic Raman peaks at 964,1073(1086),1271,1305,1442,1660 and 1763 cm^(-1).Compared with the Raman spectrum of NKJ tissue,the Raman characteristic peaks of MiKOA tissue have some shifts,moving from 1073 cm^(-1)to 1086 cm^(-1)and from 1542 cm^(-1)to 1442 cm^(-1).There is a characteristic Raman peak of 1271 cm^(-1)in MiKOA tissue,but not in NKJ tissue.Compared with NKJ tissue,severely degenerated cartilage(SdKOA)tissues show some new SERS peaks at 1008,1245,1285,1311 and 1321 cm^(-1),which are not seen in SERS spectra of NKJ tissue.Principal component analysis(PCA)was used to analyze the Raman spectra of 1245–1345 cm^(-1)region.The results show that PCA can distinguish NKJ,MiKOA and SdKOA tissues and the accuracy is about 90%.These results indicate that OCT can clearly distinguish NKJ,MiKOA,moderate osteoarthritic knee cartilage(MoKOA)and SdKOA tissue,while SERS can provide further judgment basis.The results also prove that the contents of protein and polysaccharide in knee tissue are changed during the pathological process of knee tissue,which is the cause of pain caused by poor friction in knee joint during movement. | Ran An Huaimin Gu Zhouyi Guo Huiqing Zhong Huajiang Wei Guoyong Wu Yonghong He Shusen Xie Hongqin Yang | 2022 | Journal of Innovative Optical Health Sciences2022，15，5： | 0 |
| 9 | Spectroscopic analysis of the interaction between tetra-(p-sulfoazophenyl-4-aminosulfonyl)-substituted aluminum(Ⅲ)phthalocyanines and serum albumins显示文摘The binding interaction between tetra-(p-sulfoazophenyl-4-aminosulfonyl)-substituted aluminum(Ⅲ)phthalocyanine(AIPc),and two-serum albumins(bovine serum albumin(BSA)and human serum albumin(HSA))has been investigated.AlPc could quench the intrinsic fuorescence of BSA and HSA through a static quenching process.The primary and secondary binding sites of AlPc on BSA were domainⅠandⅢof BSA.The primary binding site of AIPc on HSA was domainⅠ,and the secondary binding sites of AlPc on HSA were found at domainsⅠandⅡ.Our results suggest that AIPc readily interact with BSA and HSA implying that the amphiphilic substituents AIPc may contribute to their transportation in the blood. | Liqin Zheng Yipeng He Pingping Lin Lina Liu Hongqin Yang Yiru Peng Shusen Xie | 2017 | Journal of Innovative Optical Health Sciences2017，，2： | 0 |
| 10 | An Outbreak of Poisoning from Penicillium cyclopium Contaminated Dried Persimmon显示文摘It is the first report of an outbreak of 114 food-poisoning cases due to consuption of Penicillium cyclopium contaminated dried persimmon.Gastralgia,diarrhea,dizziness and general malaise are chief symptoms on the poisoning,with incubation period of 2-6 hr generally and a short disease period(generally recovered within 2-3 days).No enteropathogenic organism,pathogenic coccus and Campylobacter jejuni were detected.Surface fungi counts were 49,000/g,21.3times of that discovered in the markted dried persimmon. Penicillium cyclopium Westling was the dominant fungus isolated.Mouse toxicity tests were carried out with the crude extracts of the fungus culture .Diarrhea,tremor and convulsion were observed before death.During autopsy,necrosis and hemorrhagic foci were observced in G.I.tract after intra-peritoneal injection and intubation.in histo-pathological examination,different degree of necrosis and scaling of gastro-intestinal mucous membrane,lymphocyte infiltration,and necrosis of liver cells and renal tubule epithelial cells could be seen. | HE SHUNZHONG, JIU YIQUAN, BIAN HUARONG, HUANG JIANPING,YE SHUSEN, LAN ZHEN, AND XIN YOUCHUANSanitary and Anti-epidemic Station of Shuang Liu County, Chengdu, Sichuan Province Sanitary and Anti-epidemic Station of Chengdu City, Sichuan province College forHealth Administration Staffs of Sichuan Province Institute of FoodSafety Control and Inspection, Sichuan Province | 1992 | Biomedical and Environmental Sciences1992，5，2： | 0 |
| 11 | Implementing termination analysis on quantum programming显示文摘Termination analysis is an essential part in programming. Especially quantum programming concerning measurement, entanglement and even superposition are the foundations of bizarre behaviours in quantum programs. In this paper, we analyse and extend the theoretical theorems on termination analysis proposed by Ying et al. into computational theorems and algorithms. The new algorithm without the Jordan decomposition process has a significant acceleration with polynomial complexity both on terminating and almost-surely terminating programs. Moreover, the least upper bound of termination programs steps is studied and utilized to output the substituted matrix representation of quantum programs. We also implement four groups of experiments to illustrate the advantages of the new algorithm in case of processing a simplified quantum walk example comparing with the original counterpart. | Shusen LIU Kan HE Runyao DUAN | 2019 | Science China(Information Sciences)2019，62，12： | 0 |
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