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| 1 | Three-dimensional guidance law based on adaptive integral sliding mode control显示文摘For the terminal guidance problem of missiles intercepting maneuvering targets in the three-dimensional space, the design of guidance laws for non-decoupling three-dimensional engagement geometry is studied. Firstly, by introducing a finite time integral sliding mode manifold, a novel guidance law based on the integral sliding mode control is presented with the target acceleration as a known bounded external disturbance. Then, an improved adaptive guidance law based on the integral sliding mode control without the information of the upper bound on the target acceleration is developed, where the upper bound of the target acceleration is estimated online by a designed adaptive law. The both presented guidance laws can make sure that the elevation angular rate of the line-of-sight and the azimuth angular rate of the line-of-sight converge to zero in finite time. In the end, the results of the guidance performance for the proposed guidance laws are presented by numerical simulations. Although the designed guidance laws are developed for the constant speed missiles, the simulation results for the time-varying speed missiles are also shown to further confirm the designed guidance laws. | Song Junhong Song Shenmin | 2016 | Chinese Journal of Aeronautics2016，29，1： | 23 |
| 2 | The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies显示文摘Terpenoids,including aromatic volatile monoterpenoids and sesquiterpenoids,function in defense against pathogens and herbivores.Phoebe trees are remarkable for their scented wood and decay resistance.Unlike other Lauraceae species investigated to date,Phoebe species predominantly accumulate sesquiterpenoids instead of monoterpenoids.Limited genomic data restrict the elucidation of terpenoid variation and functions.Here,we present a chromosome-scale genome assembly of a Lauraceae tree,Phoebe bournei,and identify 72 full-length terpene synthase(TPS)genes.Genome-level comparison shows pervasive lineage-specific duplication and contraction of TPS subfamilies,which have contributed to the extreme terpenoid variation within Lauraceae species.Although the TPS-a and TPS-b subfamilies were both expanded via tandem duplication in P.bournei,more TPS-a copies were retained and constitutively expressed,whereas more TPS-b copies were lost.The TPS-a genes on chromosome 8 functionally diverged to synthesize eight highly accumulated sesquiterpenes in P.bournei.The essential oil of P.bournei and its main component,b-caryophyllene,exhibited antifungal activities against the three most widespread canker pathogens of trees.The TPS-a and TPS-b subfamilies have experienced contrasting fates over the evolution of P.bournei.The abundant sesquiterpenoids produced by TPS-a proteins contribute to the excellent pathogen resistance of P.bournei trees.Overall,this study sheds light on the evolution and adaptation of terpenoids in Lauraceae and provides valuable resources for boosting plant immunity against pathogens in various trees and crops. | Xiao Han Junhong Zhang Shuang Han Sun Li Chong Guanliang Meng Minyan Song Yang Wang Shengcai Zhou Chengcheng Liu Luhuan Lou Xiongzhen Lou Longjun Cheng Erpei Lin Huahong Huang Qi Yang Zaikang Tong | 2022 | Plant Communications2022，3，6： | 3 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | The effects of pH, bromide and nitrite on halonitromethane and trihalomethane formation from amino acids and amino sugars显示文摘 | Junhong Shan Jia Hu S. Sule Kaplan-Bekaroglu Hocheol Song Tanju Karanfil | 2011 | Chemosphere2011，，4： | 1 |
| 5 | Research on the Fe-silicon nitride material self-producing N_2 at high temperature显示文摘The Fe-silicon nitride synthesized by flashing combustion process was studied to determine the reaction temperature between Fe and silicon nitride, the account of N_2 given out in the course of the reaction, and the change of the microstructure during calcination. The results showed that at 1127.2℃ the Fe-silicon nitride self-reacts and releases N_2 and under 101.3 kPa the volume of N_2 given out in the course of the reaction is 20 times more than that of the starting material. N_2 is produced quickly, and completes in several decade seconds. With the producing of N_2, the structure of Silicon Nitride around Fe becomes loose and porous, or cracks are formed by the reaction between Fe and silicon nitride. So if it is made use of that Fe-silicon nitride self-producing N_2 at the high temperature, the performance of the material on a base of Fe-silicon nitride could be greatly improved. | Junhong Chen Xueda Wang Jialin Sun Huasheng Zhan Wen Song | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 1 |
| 6 | The effects of pH, bromide and nitrite on halonitromethane and trihalomethane formation from amino acids and amino sugars显示文摘 | Junhong Shan Jia Hu S. Sule Kaplan-Bekaroglu Hocheol Song Tanju Karanfil | 2011 | Chemosphere2011，，4： | 1 |
| 7 | Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia显示文摘Aberrant self-renewal of leukemia initiation cells(LICs)drives aggressive acute myeloid leukemia(AML).Here,we report that UHRF1,an epigenetic regulator that recruits DNMT1 to methylate DNA,is highly expressed in AML and predicts poor prognosis.UHRF1 is required for myeloid leukemogenesis by maintaining self-renewal of LICs.Mechanistically,UHRF1 directly interacts with Sin3A-associated protein 30(SAP30)through two critical amino acids,G572 and F573 in its SRA domain,to repress gene expression.Depletion of UHRF1 or SAP30 derepresses an important target gene,MXD4,which encodes a MYC antagonist,and leads to suppression of leukemogenesis.Further knockdown of MXD4 can rescue the leukemogenesis by activating the MYC pathway.Lastly,we identified a UHRF1 inhibitor,UF146,and demonstrated its significant therapeutic efficacy in the myeloid leukemia PDX model.Taken together,our study reveals the mechanisms for altered epigenetic programs in AML and provides a promising targeted therapeutic strategy against AML. | Cheng-Long Hu Bing-Yi Chen Zijuan Li Tianbiao Yang Chun-Hui Xu Ruirui Yang Peng-Cheng Yu Jingyao Zhao Ting Liu Na Liu Bin Shan Qunling Zhang Junhong Song Ming-Yue Fei Li-Juan Zong Jia-Ying Zhang Ji-Chuan Wu Shu-Bei Chen Yong Wang Binhe Chang Dan Hou Ping Liu Yilun Jiang Xiya Li Xinchi Chen Chu-Han Deng Yi-Yi Ren Roujia Wang Jiacheng Jin Kai Xue Ying Zhang Meirong Du Jun Shi Ling-Yun Wu Chun-Kang Chang Shuhong Shen Zhu Chen Sai-Juan Chen Xiaolong Liu Xiao-Jian Sun Mingyue Zheng Lan Wang | 2022 | Cell Research2022，32，12： | 1 |
| 8 | Survey on Immunization Services for Children with Medical Conditions-China, 2022显示文摘Summary What is already known about this topic?Children with medical conditions frequently experience under-immunization.Ensuring high-quality immunization services is crucial for enhancing vaccination coverage levels;nevertheless,the state of immunization service provision for children with medical conditions in China remains unclear.What is added by this report?Immunization support for children with medical conditions in China demonstrates considerable variability and may be inadequate.Primary obstacles to the provision of immunization services include an absence of comprehensive vaccination recommendations and assessment guidelines for specific medical conditions,as well as inconsistencies among vaccine recommendations,package inserts,and expert consensus statements pertaining to the vaccination of children with medical conditions.What are the implications for public health practice?The examination of provincial practices in providing immunization services for children with medical conditions,as well as understanding the barriers faced by National Immunization Program providers in administering vaccinations,can contribute to the improvement of immunization services for this population in China. | Yong Huang Yudan Song Junhong Li Yamin Wang Xiang Zeng Chao Ma Zundong Yin | 2023 | China CDC weekly2023，5，19： | 0 |
| 9 | SCGN deficiency is a risk factor for autism spectrum disorder显示文摘Autism spectrum disorder(ASD)affects 1-2%of all children and poses a great social and economic challenge for the globe.As a highly heterogeneous neurodevelopmental disorder,the development of its treatment is extremely challenging.Multiple pathways have been linked to the pathogenesis of ASD,including signaling involved in synaptic function,oxytocinergic activities,immune homeostasis,chromatin modifications,and mitochondrial functions.Here,we identify secretagogin(SCGN),a regulator of synaptic transmission,as a new risk gene for ASD.Two heterozygous loss-of-function mutations in SCGN are presented in ASD probands.Deletion of Scgn in zebrafish or mice leads to autism-like behaviors and impairs brain development.Mechanistically,Scgn deficiency disrupts the oxytocin signaling and abnormally activates inflammation in both animal models.Both ASD probands carrying Scgn mutations also show reduced oxytocin levels.Importantly,we demonstrate that the administration of oxytocin and anti-inflammatory drugs can attenuate ASD-associated defects caused by SCGN deficiency.Altogether,we identify a convergence between a potential autism genetic risk factor SCGN,and the pathological deregulation in oxytocinergic signaling and immune responses,providing potential treatment for ASD patients suffering from SCGN deficiency.Our study also indicates that it is critical to identify and stratify ASD patient populations based on their disease mechanisms,which could greatly enhance therapeutic success. | Zhe Liu Shuai Tan Lianyu Zhou Li Chen Mingfeng Liu Wang Wang Yingying Tang Qin Yang Sensen Chi Peiyan Jiang Yue Zhang Yonghua Cui Junhong Qin Xiao Hu Shenglong Li Qi Liu Lu Chen Song Li Ezra Burstein Wei Li Xiaohu Zhang Xianming Mo Da Jia | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 10 | Separation process study of liquid phase catalytic exchange reaction based on the Pt/C/PTFE catalysts显示文摘The liquid phase catalytic exchange(LPCE) reaction is an effective process for heavy water detritiation and production of deuterium-depleted potable water. In the current study, hydrophobic carbon-supported platinum catalysts(Pt/C/PTFE) with high efficiency as reported previously for LPCE were prepared and comprehensive performance evaluation method is applied to evaluate the separation behaviors of LPCE systematically. Experimental results indicate that the optimum reaction temperature of 60–80℃ and the molar feed ratio G/L of 1.5–2.5 would lead to higher separation efficiencies. As to the packing method, a random packing mode with a packing ratio of hydrophobic catalysts 0.25 is recommended. In addition, thermodynamic analysis corresponds well with experimental results under lower temperature and G/L, while the suppression of kinetic factors should not be neglected when T > 80℃ and G/L > 1.5. | Peilong Li Li Guo Renjin Xiong Junhong Luo Ming Wen Yong Yao Zhi Zhang Jiangfeng Song Yan Shi Tao Tang | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 0 |
| 11 | Heat and Mass Transfer Enforcement of Vibrating Fluidized Bed显示文摘HeatandMassTransferEnforcementofVibratingFluidizedBed￥ChuZhide;YangJunhong;LiXuhui;SongYang(DepartmentofThermalEnergyEngineer... | Chu Zhide Yang Junhong Li Xuhui Song Yang(Department of Thermal Energy Engineering, Tianjin University, Tianjing 300072, China) | 1994 | Journal of Thermal Science1994，3，4： | 0 |
| 12 | Interactions between ShPP2-1, an F-box family gene, and ACR11A regulate cold toleranee of tomato显示文摘There is a critical need to identify germplasm resources and genes that promote cold tolerance of tomato because global tomato production is threatened by cold stress.We found that the expression of an F-box gene family member named ShPP2-1 from Solanum habrochaites is cold inducible and studied its contribution to cold tolerance.Overexpression of ShPP2-1 in cultivated tomato(AC)reduced cold tolerance by intensifying damage to cell membranes.To explore the underlying molecular mechanism,we conducted a yeast two-hybrid library screen and found that a protein containing ACT domain repeats named ACR11A interacts with PP2-1.Overexpression of SIACR11A in AC enhanced the cold tolerance of seedlings and germinating seeds.Cold tolerance decreased in tomato plants that overexpressed both of these genes.Additionally,we performed seed germination experiments in the cold with 177 tomato accessions and identified two alleles of SlACR11A that differ in one single-nucleotide polymorphism.We found that one of these alleles,SlACR11A G,is significantly enriched in cold-tolerant tomato plants.Taken together,our fi ndings indicate that the combination of low expression levels of PP2-1 and high expression levels of ACR11A can promote cold tolerance.These genes may therefore serve as direct targets for both genetic engineering and improvement projects that aim to enhance the cold tolerance of tomato. | Jianwen Song Lele Shang Shiwei Chen Yongen Lu Yuyang Zhang Bo Ouyang Zhibiao Ye Junhong Zhang | 2021 | Horticulture Research2021，8，1： | 0 |
| 13 | VG,encoding a thylakoid formation protein,regulates the formation of variegated leaves in tomato显示文摘Leaf-color mutations have been studied extensively in plants.However,to better understand the complex mechanisms underlying the formation of leaf color,it is essential to continue discover novel genes involved in the process of leaf color development.In this study,we identified a variegated-leaf(vg)mutant in tomato that exhibited defective phenotypes in thylakoids and photosynthesis.To clone the vg locus,an F2population was constructed from the cross between the vg mutant(Solanum lycopersicum)and the wild tomato LA1589(S.pimpinellifolium).Using the map-based cloning approach,the vg locus was mapped on chromosome 7 and narrowed down to a 128 kb region that contained 21 open reading frames(ORFs).The expression levels of ORF9,ORF10,and ORF13 were significantly lower in vg than in the wild-type plants,while the ORF11 transcript level was elevated in vg.We then mutagenized ORF9,ORF10,and ORF13 by the CRISPR/Cas9 system in the wild-type tomato background and found that only the ORF10 mutation reproduced the phenotype of variegated leaves,indicating that ORF10 represents VG and its down-regulated expression was responsible for the variegated leaf phenotype.ORF10 encodes a thylakoid formation protein and its mutant lines showed reduced levels of chlorophyll synthesis and photosynthesis.Taken together,these results suggest that VG is necessary for chloroplast development,chlorophyll synthesis,and photosynthesis in tomato. | Jianwen Song Lijie Guo Lele Shang Wenqian Wang Chuying Yu Zhibiao Ye Junhong Zhang | 2023 | Horticultural Plant Journal2023，9，1： | 0 |
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