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| 1 | Characterization of Hand,Foot,and Mouth Disease in China between 2008 and 2009显示文摘Objective To investigate the epidemiological and clinical features of hand,foot and mouth disease (HFMD) since several outbreaks of HFMD caused by enteroviruses were documented in China between 2007 and 2008.Methods HFMD cases reported to the National Infectious Disease Information Management System database between May 2008 and April 2009 were assessed.Clinical features in some of the severe and fatal cases were analyzed the etiology of the outbreaks was investigated.Results 89.1% of reported HFMD cases were found in children<5 year‐old with an age‐specific incidence rate of 834.1/100 000 in the first year as the notifiable disease in China from May 2008 to April 2009.The incidence,mortality and percentage of severe cases were studied for three regions of China and found to be highest in the central region.The incidence of severe cases and mortality in rural population were significantly higher than those in urban population.Among the laboratory confirmed EV17 positive cases there were 52.6% mild,83.5% severe,and 96.1% fatal cases.More myoclonic jerks were found in the severe case group than in group that died.Tachypnea,lip purpling,pink foaming and low limb temperature occurred more frequently in the fatal cases than in the severe cases.Conclusion The epidemic of HFMD in China was characterized predominantly by EV71 infections,had relatively high mortality rates especially in the central region,and was most prevalent in young,rural populations. | ZHANG Jing SUN JunLing CHANG ZhaoRui ZHANG WeiDong WANG ZiJun FENG ZiJian | 2011 | Biomedical and Environmental Sciences2011，24，3： | 74 |
| 2 | Assessment of source water contamination by estrogenic disrupting compounds in China显示文摘Detection of estrogenic disrupting compounds(EDCs) in drinking waters around China has led to rising concerns about health risks associated with these compounds.There is,however,a paucity of studies on the occurrence and identification of the main compounds responsible for this pollution in the source waters.To fill this void,we screened estrogenic activities of 23 source water samples from six main river systems in China,using a recombinant two-hybrid yeast assay.All sample extracts induced significant estrogenic activity,with E2 equivalents(EEQ) of raw water ranging from 0.08 to 2.40 ng/L.Additionally,16 samples were selected for chemical analysis by gas chromatography-mass spectrometry.The EDCs of most concern,including estrone(E1),17β-estradiol(E2),17α-ethinylestradiol(EE2),estriol(E3),diethylstilbestrol(DES),estradiol valerate(EV),4-t-octylphenol(4-t-OP),4-nonylphenols(4-NP) and bisphenol A(BPA),were determined at concentrations of up to 2.98,1.07,2.67,4.37,2.52,1.96,89.52,280.19 and 710.65 ng/L,respectively.Causality analysis,involving comparison of EEQ values from yeast assay and chemical analysis identified E2,EE2 and 4-NP as the main responsible compounds,accounting for the whole estrogenic activities(39.74% to 96.68%).The proposed approach using both chemical analysis and yeast assay could be used for the identification and evaluation of EDCs in source waters of China. | Weiwei Jiang YeYan Mei Ma Donghong Wang Qian Luo Zijian Wang Senthil Kumaran Satyanarayanan | 2012 | Journal of Environmental Sciences2012，24，2： | 29 |
| 3 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 4 | Laboratory culture of the freshwater benthic gastropod Bellamya aeruginosa (Reeve) and its utility as a test species for sediment toxicity显示文摘This study aimed to develop original laboratory culture and sediment toxicity testing protocols for the freshwater gastropod Bellamya aeruginosa(Reeve),a new potential species for sediment toxicity testing.B.aeruginosa was successfully cultured with an effective culture system under proposed laboratory conditions.Optimal ad libitum feeding levels for larvae,juveniles,and adults were 2.0,6.0,and 16.0 mg fish food/(snail·day),respectively.Mean survival rates of juveniles were higher than 90%.The snails could be sexed at 9 weeks of age,and their generation time is approximately 4 months.Reproduction continued all year around;the mean fecundity was 0.55 newborn/(female·day).The utility of this species for bioassays was evaluated in both 10-day and 28-day case studies with artificial sediments.The 10-day LC50 of Cu for larvae was 480 μg/g dry weight(dw),and the lowest observed effects concentration of Cu for survival and growth of larvae was 195 μg/g dw.Survival and growth are reliable indicators of acute toxicity.Larvae accumulated more Cu than adults.B.aeruginosa exhibited a higher sensitivity to Cu exposure than standard test species(Hyalella azteca and Chironomus tentans).The 28-day test of sediment toxicity with adults showed that fecundity was a robust endpoint indicator of reproductive toxicity,and the biochemical endpoints of superoxide dismutase,catalase,and glutathione could be used as sensitive biomarkers for Cu-induced oxidative damage.B.aeruginosa can be therefore recommended as a candidate for the standardization of the freshwater sediment toxicity test protocol. | Taowu Ma Shuangjiao Gong Ke Zhou Cheng Zhu Kaidong Deng Qinghua Luo Zijian Wang | 2010 | Journal of Environmental Sciences2010，22，2： | 22 |
| 5 | Simultaneous determination of ten taste and odor compounds in drinking water by solid-phase microextraction combined with gas chromatography-mass spectrometry显示文摘Taste and odor(T&O)problems in drinking water frequently occur because of many compounds present in the water,of which trans-1,10-dimethyl-trans-9-decalol(geosmin)and 2-methylisoborneol(MIB)are well-known.In this study,a fast and efective method was established for simultaneous determination of 10 T&O compounds,including geosmin,MIB,2,4,6-trichloroanisole(TCA),2-methylbenzofuran,2-isopropyl-3-methoxypyrazine(IPMP),2-isobutyl-3-methoxypyrazine(IBMP),cis-3-hexenyl acetate,trans,trans-2,4-heptadienal,trans,cis-2,6-nonadienal,and trans-2-decenal in water samples by headspace solid-phase microextraction(SPME)coupled with gas chromatography-mass spectrometry.An orthogonal array experimental design was used to optimize the efects of SPME fiber,extraction temperature,stirring rate,NaCl content,extraction time,and desorption time.The limits of detection ranged from 0.1 to 73 ng/L were lower than or close to the odor threshold concentrations(OTCs).All the 10 T&O compounds were detected in the 14 water samples including surface water,treatment process water and tap water,taken from a waterworks in Lianyungang City,China.MIB and geosmin were detected in most samples at low concentration.Six T&O compounds(IPMP,IBMP,trans,cis-2,6-nonadienal,2-methylbenzofuran,trans-2-decenal,and TCA)were efectively decreased in water treatment process(sedimentation and filtration)that is diferent from cis-3-hexenyl acetate,MIB and geosmin.It is noted that the TCA concentrations at 15.9–122.3 ng/L and the trans,cis-2,6-nonadienal concentrations at 79.9–190.1 ng/L were over 10 times higher than their OTCs in tap water.The variation of the analytes in the all water samples,especially distribution system indicated that distribution system cannot be ignored as a T&O compounds source. | Xichao Chen Qian Luo Shengguang Yuan Zi Wei Hanwen Song Donghong Wang Zijian Wang | 2013 | Journal of Environmental Sciences2013，25，11： | 21 |
| 6 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 7 | Generation of B Cell-Deficient Pigs by Highly Efficient CRISPR/Cas9-Mediated Gene Targeting显示文摘Generating B cell-deficient mutant is the first step to produce human antibody repertoires in large animal models. In this study, we applied the clustered regularly interspaced short palindromic repeat(CRISPR)/CRISPR-associated(Cas) system to target the JHregion of the pig Ig M heavy chain gene which is crucial for B cell development and differentiation. Transfection of Ig M-targeting Cas9 plasmid in primary porcine fetal fibroblasts(PFFs) enabled inducing gene knock out(KO) in up to 53.3% of colonies analyzed, a quarter of which harbored biallelic modification, which was much higher than that of the traditional homologous recombination(HR). With the aid of somatic cell nuclear transfer(SCNT) technology, three piglets with the biallelic Ig M heavy chain gene mutation were produced. The piglets showed no antibody-producing B cells which indicated that the biallelic mutation of the Ig M heavy chain gene effectively knocked out the function of the Ig M and resulted in a B cell-deficient phenotype. Our study suggests that the CRISPR/Cas9 system combined with SCNT technology is an efficient genome-editing approach in pigs. | Fengjiao Chen Ying Wang Yilin Yuan Wei Zhang Zijian Ren Yong Jin Xiaorui Liu Qiang Xiong Qin Chen Manling Zhang Xiaokang Li Lihua Zhao Ze Li Zhaoqiang Wu Yanfei Zhang Feifei Hu Juan Huang Rongfeng Li Yifan Dai | 2015 | Journal of Genetics and Genomics2015，42，8： | 15 |
| 8 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 9 | Isolated Cases of Plague--Inner Mongolia-Beijing, 2019显示文摘What is already known about this topic?Plague is an acute infectious disease caused by Yersinia pestis(Y.pestis)and is primarily transmitted by rodents.Human can be infected by bites of bacterium-bearing fleas or direct contact with diseased or dead plagueinfected animals.In 2004,the last human plague case was reported in Inner Mongolia Autonomous Region due to skinning a dead hare.What is added by this report?This is the first case of pneumonic plague imported into a major city since the founding of the People's Republic of China.Two primary pneumonic plague cases(Patients A and B)found in residents of Inner Mongolia were confirmed in Beijing on November 12,2019.Another case(Patient C)of Y.pestis was identified as bubonic plague on November 14.Patient A most likely became infected from aerosol exposure to infective droplets while digging on his farm,located in an Meriones unguiculatus(M.unguiculatus)natural plague focus.Patient B became infected from contact with Patient A(her husband).Patient C became infected after skinning a dead hare.There was no epidemiological relationship between the Patient A/B and Patient C.What are the implications for public health practice?When epizootic plague is detected,local health-care providers and the public should be alerted about any possible risks.Public education efforts should focus on promoting personal protection measures. | Yumeng Wang Lei Zhou Mengguang Fan Quanyi Wang Jianyun Li Qun Li Zijian Feng George FGao Cheng Xu Lijuan Chen Wei Li Yanping Zhang | 2019 | China CDC weekly2019，1，1： | 13 |
| 10 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 11 | Relevant experience learning:A deep reinforcement learning method for UAV autonomous motion planning in complex unknown environments显示文摘Unmanned Aerial Vehicles(UAVs)play a vital role in military warfare.In a variety of battlefield mission scenarios,UAVs are required to safely fly to designated locations without human intervention.Therefore,finding a suitable method to solve the UAV Autonomous Motion Planning(AMP)problem can improve the success rate of UAV missions to a certain extent.In recent years,many studies have used Deep Reinforcement Learning(DRL)methods to address the AMP problem and have achieved good results.From the perspective of sampling,this paper designs a sampling method with double-screening,combines it with the Deep Deterministic Policy Gradient(DDPG)algorithm,and proposes the Relevant Experience Learning-DDPG(REL-DDPG)algorithm.The REL-DDPG algorithm uses a Prioritized Experience Replay(PER)mechanism to break the correlation of continuous experiences in the experience pool,finds the experiences most similar to the current state to learn according to the theory in human education,and expands the influence of the learning process on action selection at the current state.All experiments are applied in a complex unknown simulation environment constructed based on the parameters of a real UAV.The training experiments show that REL-DDPG improves the convergence speed and the convergence result compared to the state-of-the-art DDPG algorithm,while the testing experiments show the applicability of the algorithm and investigate the performance under different parameter conditions. | Zijian HU Xiaoguang GAO Kaifang WAN Yiwei ZHAI Qianglong WANG | 2021 | Chinese Journal of Aeronautics2021，34，12： | 10 |
| 12 | Generation of graphene-based aerogel microspheres for broadband and tunable high-performance microwave absorption by electrospinning-freeze drying process显示文摘 | Fanbin Meng Huagao Wang Wei Zijian Chen Tian Li Chunyuan Li Yu Xuan Zuowan Zhou | 2018 | Nano Research2018，11，5： | 9 |
| 13 | Concentration level and geographical distribution of nitrobenzene in Chinese surface waters显示文摘Nitrobenzene was reported to occur at relatively high concentrations in some Chinese surface water and to cause an environmental pollution event in 2005.To map the distribution of nitrobenzene in the Chinese surface water throughout China,surface water samples were collected from over 600 sites in the 7 major watersheds and three drainage areas.The samples were analyzed for concentration of nitrobenzene.Overall,nitrobenzene was more frequently detected at higher concentrations in the rivers of North Chin... | Jijun, Gao Linghua, Liu Xiaoru, Liu Huaidong, Zhou Zijian, Wang Shengbiao, Huang | 2008 | Journal of Environmental Sciences2008，20，7： | 9 |
| 14 | DEVELOPMENT OF EXPERIMENTAL METHODS FOR IMPACT TESTING BY COMBINING HOPKINSON PRESSURE BAR WITH OTHER TECHNIQUES显示文摘The split Hopkinson pressure bar(SHPB) technique and the wave propagation inverse analysis(WPIA) technique are both extensively used to experimentally investigate the impact behavior of materials, although neither of them alone provides a fully satisfactory analysis. In the present paper, attention is given to new experimental techniques by incorporating a damagemodified constitutive model into the SHPB technique and combining the Hopkinson pressure bar(HPB) technique with WPIA. First, to distinguish the response due to dynamic constitutive behavior and the response due to dynamic damage evolution, the SHPB method incorporating a damage-modified constitutive model is developed, including an explicit damage-modified Zhu–Wang–Tang model and an implicit damage-modified constitutive model. Second, when the SHPB results become invalid, a method of combining new Lagrange inverse analyses with the HPB technique is developed, including cases of the HPB arranged in front of a long specimen and behind the specimen. As examples of these new methods, typical results are given for nonlinear viscoelastic polymers and concretes considering damage evolution, a super-elastic Ti–Ni alloy with phase transformation and an aluminum foam with shock waves propagating within it. | Lili Wang Shisheng Hu Liming Yang Zijian Sun Jue Zhu Huawei Lai Yuanyuan Ding | 2014 | Acta Mechanica Solida Sinica2014，27，4： | 9 |
| 15 | Criteria for hypersonic airbreathing propulsion and its experimental verification显示文摘Hypersonic airbreathing propulsion is one of the top techniques for future aerospace flight, but there are still no practical engines after seventy years’ development. Two critical issues are identified to be the barriers for the ramjet-based engine that has been taken as the most potential concept of the hypersonic propulsion for decades. One issue is the upstream-traveling shock wave that develops from spontaneous waves resulting from continuous heat releases in combustors and can induce unsteady combustion that may lead to engine surging during scramjet engine operation.The other is the scramjet combustion mode that cannot satisfy thrust needs of hypersonic vehicles since its thermos-efficiency decreases as the flight Mach number increases. The two criteria are proposed for the ramjet-based hypersonic propulsion to identify combustion modes and avoid thermal choking. A standing oblique detonation ramjet(Sodramjet) engine concept is proposed based on the criteria by replacing diffusive combustion with an oblique detonation that is a unique pressure-gain phenomenon in nature. The Sodramjet engine model is developed with several flow control techniques, and tested successfully with the hypersonic flight-duplicated shock tunnel.The experimental data show that the Sodramjet engine model works steadily, and an oblique detonation can be made stationary in the engine combustor and is controllable. This research demonstrates the Sodramjet engine is a promising concept and can be operated stably with high thermal efficiency at hypersonic flow conditions. | Zonglin JIANG Zijian ZHANG Yunfeng LIU Chun WANG Changtong LUO | 2021 | Chinese Journal of Aeronautics2021，34，3： | 9 |
| 16 | MdATG18a overexpression improves basal thermotolerance in transgenic apple by decreasing damage to chloroplasts显示文摘High temperature is an abiotic stress factor that threatens plant growth and development.Autophagy in response to heat stress involves the selective removal of heat-induced protein complexes.Previously,we showed that a crucial autophagy protein from apple,MdATG18a,has a positive effect on drought tolerance.In the present study,we treated transgenic apple(Malus domestica)plants overexpressing MdATG18a with high temperature and found that autophagy protected them from heat stress.Overexpression of MdATG18a in apple enhanced antioxidase activity and contributed to the production of increased beneficial antioxidants under heat stress.Transgenic apple plants exhibited higher photosynthetic capacity,as shown by the rate of CO_(2) assimilation,the maximum photochemical efficiency of photosystem II(PSII),the effective quantum yield,and the electron transport rates in photosystems I and II(PSI and PSII,respectively).We also detected elevated autophagic activity and reduced damage to chloroplasts in transgenic plants compared to WT plants.In addition,the transcriptional activities of several HSP genes were increased in transgenic apple plants.In summary,we propose that autophagy plays a critical role in basal thermotolerance in apple,primarily through a combination of enhanced antioxidant activity and reduced chloroplast damage. | Liuqing Huo Xun Sun Zijian Guo Xin Jia Runmin Che Yiming Sun Yanfei Zhu Ping Wang Xiaoqing Gong Fengwang Ma | 2020 | Horticulture Research2020，7，1： | 9 |
| 17 | Isolation of 2019-nCoV from a Stool Specimen of a Laboratory- Confirmed Case of the Coronavirus Disease 2019 (COVID-19)显示文摘The novel coronavirus(2019-nCoV)is spreading very fast in Hubei Province of China.As of February 14,2020,51,986 confirmed cases(including laboratory-confirmed cases and clinically-confirmed cases)were reported in Hubei Province,and 1,318 of them died.Respiratory droplets and contact transmission are considered to be the most important routes of transmission of 2019-nCoV,but do not fully account for the occurrence of all coronavirus disease 2019(COVID-19)cases,previously known as novel coronavirus pneumonia(NCP),and the reasons for the rapid spread of this virus(1). | Yong Zhang Cao Chen Shuangli Zhu Chang Shu Dongyan Wang Jingdong Song Yang Song Wei Zhen Zijian Feng Guizhen Wu Jun Xu Wenbo Xu | 2020 | China CDC weekly2020，2，8： | 9 |
| 18 | In vitro thyroid disrupting effects of organic extracts from WWTPs in Beijing显示文摘It is generally known that there are many endocrine disrupting compounds (EDCs) in the effluents from wastewater treatment plants (WWTPs). Most research has focused on the occurrence of estrogenic or androgenic activities, while ignoring that there are environmental chemicals disrupting thyroid system, which is essential for growth and development in both humans and animals. In the present work, a two-hybrid yeast assay was conducted to evaluate the removal efficiencies of agonistic or antagonistic thyroid receptor (TR) mediated effects in different treatment processes of three WWTPs located in Beijing. We found no TR agonistic, but TR antagonistic activities in all processes from the WWTPs. The TR antagonistic activities in organic extracts of water samples were then calibrated regarding to a known TR-inhibitor, amiodarone hydrochloride (AH). The observed concentration of TR disrupting substances ranged from 2.35 × 10 8 to 6.19 × 10 7 mol/L AH in Gaobeidian WWTP, 3.76 × 10 8 to 8.75 × 10 8 mol/L AH in Lugouqiao WWTP, and 4.80 × 10 9 to 2.55 × 10 8 mol/L AH in Beixiaohe WWTP. Of the three WWTPs, the removal rates were 92.7%, 42.2%, and 23.1% respectively. Industrial sewage may contain more TR disrupting substances compared with domestic sewage. The recipient waters were found to contain considerable concentrations of TR disrupting substances that may cause adverse effects on the exposed organisms. | Na Li Mei Ma Kaifeng Rao Zijian Wang | 2011 | Journal of Environmental Sciences2011，23，4： | 7 |
| 19 | Occurrence and removal of organic micropollutants in the treatment of landfill leachate by combined anaerobic-membrane bioreactor technology显示文摘Organic micropollutants,with high toxicity and environmental concern,are present in the landfill leachate at much lower levels than total organic constituents (chemical oxygen demand (COD),biochemical oxygen demand (BOD),or total organic carbon (TOC)),and few has been known for their behaviors in different treatment processes.In this study,occurrence and removal of 17 organochlorine pesticides (OCPs),16 polycyclic aromatic hydrocarbons (PAHs),and technical 4-nonylphenol (4-NP) in landfill leachate in a combined anaerobic-membrane bioreactor (MBR) were investigated.Chemical analyses were performed in leachates sampled from different treatment processes,using solid-phase extraction and gas chromatography with electron capture detector and mass spectrometry.Concentrations of OCPs,PAHs,and 4-NP in the raw leachate were detected within the range from ND (not detected) to 595.2 ng/L,which were as low as only 10-7-10-5 percentage of TOC (at the concentration of 2,962 mg/L).The removal of 4-NP was mainly established in the MBR process,in agreement with removals of COD,BOD,and TOC.However,the removals of OCPs and PAHs were different,mainly achieved in the anaerobic process.High removal effciencies of both total organic constituents and organic micropollutants could be achieved by the combined anaerobic-MBR technology.The removal effciencies of total organic constituents were in the order of BOD (99%) > COD (89%) > TOC (87%),whereas the removal effciencies of investigated organic micropollutants were as follows: OCPs (94%) > 4-NP (77%) > PAHs (59%). | Yiping XU Zijian WANG | 2008 | Journal of Environmental Sciences2008，20，11： | 7 |
| 20 | Differences in the behavior characteristics between Daphnia magna and Japanese madaka in an on-line biomonitoring system显示文摘It is important to select suitable organisms to adapt the requirement of different environment monitoring purposes.Following our previous study,the behavioral responses of Daphnia magna and Japanese madaka (Oryzias latipes) were investigated and compared under flow-through conditions in an on-line biomonitoring system.The results showed that both D.magna and Japanese madaka had similar biological clock,but the circadian rhythms of Japanese madaka was more clearly recorded than that of D.magna.And the sensitivity of D.magna was about two orders of magnitudes higher than that of Japanese madaka in different types of toxic chemicals (dichlorovos,deltamethrin and cadmium chloride).However,when both animals were used in an on-line biomonitoring system,the life span of D.magna was less than 7 days and Japanese madaka could last for more than one month without feeding.Therefore,D.magna was proposed to be a more sensitive bioindicator and was suitable for short term monitoring the pollution events at concentration level closing to the water quality standard,while Japanese madaka was more suitable for the long-term monitoring for accidental discharges. | Zongming Ren Zijian Wang | 2010 | Journal of Environmental Sciences2010，22，5： | 7 |
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