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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | An operational two-layer remote sensing model to estimate surface flux in regional scale: Physical background显示文摘Based on the improved interaction mechanism of two-layer model, this paper proposed Pixel Component Arranging and Comparing Algorithm (PCACA) and theoretically positioning algorithm, estimated the true temperature of mixed pixel in four extreme points in combination with the measurements of dry and wet points in calibration fields and improved the reliability of positioning dry and wet line. A new two-layer energy-separation algorithm was proposed,which was simple and direct without resistance network parameters for each pixel. We also proposed a new thought about the effect of advection. The albedo of mixed pixel was also separated with PCACA. In combination with two-layer energy-separation algorithm, the net radiation of mixed pixel was separated to overcome the uncertainty of conventional energy-separation algorithm using Beer's Law. Through the validation of retrieval result, this method is proved to be feasible and operational. At the same time, the uncertainty of this algorithm was objectively analyzed. | ZHANG Renhua SUN Xiaomin WANG Weimin XU Jinping ZHU Zhilin TIAN Jing | 2005 | Science China Earth Sciences2005，48，z1： | 16 |
| 3 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 4 | On Uplink Non-Orthogonal Multiple Access for 5G:Opportunities and Challenges显示文摘In this paper,the concept of grantfree non-orthogonal multiple access(NOMA) for uplink data transmission is elaborated.NOMA in combination with grant-free can be applied to ultra reliability low latency communication(URLLC),massive machine type communication(m MTC),enhanced mobile broadband(e MBB) small packet and two-step random-access channel(RACH) scenarios.The advantages of grant-free NOMA are low latency and signaling overhead,high access capability and efficient resource utilization.Candidate uplink NOMA schemes are summarized and preliminary comparison among a subset of schemes are presented.Furthermore,design aspects for grant-free NOMA are discussed,with special notes on particular issues such as blind UE identification and transmitter/receiver(Tx/Rx) impairments in realistic deployment. | Li Tian Chunlin Yan Weimin Li Zhifeng Yuan Wei Cao Yifei Yuan | 2017 | China Communications2017，14，12： | 9 |
| 5 | Relationship between the number of tapping-induced secondary laticifer lines and rubber yield among Hevea germplasm显示文摘The lack of suitable early selection parameters means that traditional rubber breeding for yield is time consuming and inefficient. Laticifer is a tissue specific fo natural rubber biosynthesis and storage in rubber tree. The number of the secondary laticifers in the trunk bark tissues is positively correlated with rubber yield in the matured rubber trees that are regularly tapped. In the present study the rubber yield from 280 of 4–5 year-old virgin trees from7 cross combinations was compared with the number o newly differentiated secondary laticifers caused by tapping. Results showed that the number of tapping induced lines of secondary laticifers varied in differen germplasm and was positively related to the rubber yield indicating this could be used as a suitable parameter fo early evaluation of yield potential of rubber trees. | Yueyi CHEN Xinsheng GAO Xiaofei ZHANG Weimin TIAN | 2016 | Frontiers of Agricultural Science and Engineering2016，3，4： | 9 |
| 6 | The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of histone acetylation显示文摘The secondary laticifer, a specific tissue in the secondary phloem of rubber tree, is differentiated from the vascular cambia. The number of the secondary laticifer in the trunk bark of rubber tree is positively correlated with rubber yield. Although jasmonates have been demonstrated to be crucial in the regulation of secondary laticifer differentiation, the mechanism for the jasmonate-induced secondary laticifer differentiation remains to be elucidated.By using an experimental morphological technique, the present study revealed that trichostatin A(TSA), an inhibitor of histone deacetylation, could induce the secondary laticifer differentiation in a concentrationdependent manner. The results suggest that histone acetylation is essential for the secondary laticifer differentiation in rubber tree. | Shixin ZHANG Shaohua WU Weimin TIAN | 2016 | Frontiers of Agricultural Science and Engineering2016，3，4： | 6 |
| 7 | In situ generation of Li_(3)N concentration gradient in 3D carbon-based lithium anodes towards highly-stable lithium metal batteries显示文摘The uncontrolled dendrite growth of lithium metal anodes(LMAs)caused by unstable anode/electrolyte interface and uneven lithium deposition have impeded the practical applications of lithium metal batteries(LMBs).Constructing a robust artificial solid electrolyte interphase(SEI)and regulating the lithium deposition behavior is an effective strategy to address these issues.Herein,a three-dimensional(3D)lithium anode with gradient Li_(3)N has been in-situ fabricated on carbon-based framework by thermal diffusion method(denoted as CC/Li/Li_(3)N).Density functional theory(DFT)calculations reveal that Li_(3)N can effectively promote the transport of Li^(+)due to the low energy barrier of Li^(+)diffusion.As expected,the Li_(3)N-rich conformal artificial SEI film can not only effectively stabilize the interface and avoid parasitic reactions,but also facilitate fast Li^(+)transport across the SEI layer.The anode matrix with uniformly distributed Li3N can enable homogenous deposition of Li,thus preventing Li dendrite propagation.Benefiting from these merits,the CC/Li/Li_(3)N anode achieves ultralong-term cycling for>1000 h at a current density of 2 m A cm^(-2)and dendrite-free Li deposition at an ultrahigh rate of 20 m A cm^(-2).Moreover,the full cells coupled with LiFePO4cathodes show extraordinary cycling stability for>300 cycles in liquidelectrolyte-based batteries and display a high-capacity retention of 96.7%after 100 cycles in solid-state cells,demonstrating the promising prospects for the practical applications of LMBs. | Wenzhu Cao Weimin Chen Mi Lu Cheng Zhang Du Tian Liang Wang Faquan Yu | 2023 | Journal of Energy Chemistry2023，，1： | 4 |
| 8 | Uncertainty analysis and probabilistic design optimization of hybrid rocket motors for manned lunar landing显示文摘To obtain a conceptual design for a hybrid rocket motor(HRM)to be used as the Ascent Propulsion System in the Apollo lunar module,the deterministic design optimization(DDO)method is applied to the HRM design.Based on the results of an uncertainty analysis of HRMs,an uncertainty-based design optimization(UDO)method is also adopted to improve the design reliability.The HRM design process,which is a multidisciplinary system,is analyzed,and a mathematical model for the system design is established to compute the motor performance from the input parameters,including the input variables and model parameters.The input parameter uncertainties are quantified,and a sensitivity analysis of the model parameter uncertainties is conducted to identify the most important model parameter uncertainties for HRMs.The DDO and probabilistic UDO methods are applied to conceptual designs for an HRM to be used as a substitute for the liquid rocket motor(LRM)of the Ascent Propulsion System.The conceptual design results show that HRMs have several advantages as an alternative to the LRM of the Ascent Propulsion System,including nontoxic propellant combination,small motor volume,and comparable functions,such as restarting and throating.Comparisons of the DDO and UDO results indicate that the UDO method achieves more robust and reliable optimal designs than the DDO method.The probabilistic UDO method can be used to develop better conceptual designs for HRMs. | ZHU Hao TIAN Hui CAI GuoBiao BAO WeiMin | 2015 | Science China(Technological Sciences)2015，58，7： | 4 |
| 9 | Uncertainty analysis and design optimization of hybrid rocket motor powered vehicle for suborbital flight显示文摘In this paper, we propose an uncertainty analysis and design optimization method and its applications on a hybrid rocket motor(HRM) powered vehicle. The multidisciplinary design model of the rocket system is established and the design uncertainties are quantified. The sensitivity analysis of the uncertainties shows that the uncertainty generated from the error of fuel regression rate model has the most significant effect on the system performances. Then the differences between deterministic design optimization(DDO) and uncertainty-based design optimization(UDO) are discussed. Two newly formed uncertainty analysis methods, including the Kriging-based Monte Carlo simulation(KMCS) and Kriging-based Taylor series approximation(KTSA), are carried out using a global approximation Kriging modeling method. Based on the system design model and the results of design uncertainty analysis, the design optimization of an HRM powered vehicle for suborbital flight is implemented using three design optimization methods: DDO, KMCS and KTSA. The comparisons indicate that the two UDO methods can enhance the design reliability and robustness. The researches and methods proposed in this paper can provide a better way for the general design of HRM powered vehicles.In this paper,we propose an uncertainty analysis and design optimization method and its applications on a hybrid rocket motor(HRM)powered vehicle.The multidisciplinary design model of the rocket system is established and the design uncertainties are quantified.The sensitivity analysis of the uncertainties shows that the uncertainty generated from the error of fuel regression rate model has the most significant effect on the system performances.Then the differences between deterministic design optimization(DDO)and uncertainty-based design optimization(UDO)are discussed.Two newly formed uncertainty analysis methods,including the Kriging-based Monte Carlo simulation(KMCS)and Kriging-based Taylor series approximation(KTSA),are carried out using a global approximation Kriging modeling method.Based on the system design model and the results of design uncertainty analysis,the design optimization of an HRM powered vehicle for suborbital flight is implemented using three design optimization methods:DDO,KMCS and KTSA.The comparisons indicate that the two UDO methods can enhance the design reliability and robustness.The researches and methods proposed in this paper can provide a better way for the general design of HRM powered vehicles. | Zhu Hao Tian Hui Cai Guobiao Bao Weimin | 2015 | Chinese Journal of Aeronautics2015，28，3： | 4 |
| 10 | Flow field design and process stability in electrochemical machining of diamond holes显示文摘The metal grille, commonly composed of an amount of diamond holes, has been growingly used as a key structure on stealth aircraft. Electrochemical machining(ECM) promises to be increasingly applied in aircraft manufacturing on the condition that process stability is guaranteed.In this work, a flow field model was designed to improve the process stability. This model is endowed with a variety of flow channel features, together with vibrating feeding modes. The flow field distribution on the bottom surface of the diamond hole was discussed and evaluated as well.The numerical results show that a short arc flow channel could significantly enhance the uniformity of electrolyte velocity distribution and a vibrating feeding of the cathode enables to reduce both fluctuations of the electrolyte velocity and pressure on the bottom surface of the diamond hole.Consequently, the flow field mutations were eliminated. It is verified from the experimental results that a short arc flow channel, when combined with vibrating feeding, is capable of improving machining localization and process stability markedly. What is more, the side gap on the bottom surface of the diamond hole could also be reduced by the abovementioned approach. | Zhao Jianshe Wang Feng Liu Zhuang Zhang Xiangli Gan Weimin Tian Zongjun | 2016 | Chinese Journal of Aeronautics2016，29，6： | 3 |
| 11 | Prospect and key techniques of Global Energy Interconnection Zhangjiakou Innovation Demonstration Zone显示文摘In the Background of implementing innovation-driven development strategy and building Global Energy Interconnection, the necessity of building Global Energy Interconnection Zhangjiakou Innovation Demonstration Zone for stimulating economic growth, promoting social development and supporting 2022 Winter Olympics are discussed by analyzing the location advantages of Zhangjiakou and the characteristics of renewable energy in Zhangjiakou. Solutions are put forward in aspects of renewable energy integration in National Wind/Solar/Storage/Transmission Pilot Project, VSC-HVDC transmission of renewable energy and demonstration utilization of renewable energy in the Olympics zone, which could be a reference for problems of large-scale renewable energy in secure integration, outgoing transmission and flexible consumption. And replicable experience for building Global Energy Interconnection will be provided by conducting ±500 kV VSC-HVDC Power Grid Demonstration Project, Virtual Synchronous Generator Demonstration Project, Flexible Substation and AC/DC Power Distribution Network Demonstration Project, EV Battery Secondary Utilization Energy Storage Demonstration Project, Smart Grid Demonstration Project of Low Carbon Winter Olympics and other demonstration projects. | Bo Tian Xiaolin Mo Yu Shen Weimin Lei Pengliang Xu | 2018 | Global Energy Interconnection2018，1，2： | 3 |
| 12 | Effect of Microstructure of Composite Powders on Microstructure and Properties of Microwave Sintered Alumina Matrix Ceramics显示文摘Two kinds of different structured alumina—titania composite powders were used to prepare alumina matrix ceramics by microwave sintering.One was powder mixture of alumina and titania at a micron—submicron level,in which fused-and-crushed alumina particles(micrometers) was clad with submicron-sized titania.The other was powder mixture of alumina and titania at nanometer—nanometer level,in which nano-sized alumina and nano-sized titania particles were homogeneously mixed by ball-milling and spray dried to prepare spherical alumina—titania composite powders.The effect of the microstructure of composite powders on microstructure and properties of microwave sintered alumina matrix ceramics were investigated.Nano-sized composite(NC) powder showed enhanced sintering behavior compared with micro-sized composite(MC) powders.The asprepared NC ceramic had much denser,finer and more homogenous microstructure than MC ceramic.The mechanical properties of NC ceramic were significantly higher than that of MC ceramic,e.g.the flexural strength,Vickers hardness and fracture toughness of NC ceramic were 85.3%,130.3%and 25.7%higher than that of MC ceramic,respectively.The improved mechanical properties of NC ceramic compared with that of MC ceramic were attributed to the enhanced densification and the finer and more homogeneous microstructure through the use of the nanostructured composite powders. | Hanmin Bian Yong Yang You Wang Wei Tian Haifu Jiang Zhijuan Hu Weimin Yu | 2013 | Journal of Materials Science & Technology2013，29，5： | 2 |
| 13 | GENERALIZED SIMULATION MODEL FOR MILLED SURFACE TOPOGRAPHY-APPLICATION TO PERIPHERAL MILLING显示文摘Based on analyzing various factors influencing milled surface topography, firstly, a generalized model for milled surface topography is proposed. Secondly, using the principles of transformation matrix and vector operation, the trajectory equation of cutting edge relative to workpiece is derived. Then, a three dimensional topography simulation algorithm is constructed through dividing the workpiece into regular grids. Finally, taking the peripheral milling process as an example, the generalized model is simplified, and the corresponding simulation examples are given. The results indicate that it is very efficient for the generalized model to be used to analyze and simulate the peripherally milled surface topography. | Xu Anping Qu Yunxia Li Weimin School of Mechanical Engineering, Hebei University of Technology Zhang Dawei Huang Tian Tianjin University | 2001 | Chinese Journal of Mechanical Engineering2001，14，2： | 2 |
| 14 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 15 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 16 | A Knowledge Base System for Operation Optimization: Design and Implementation Practice for the Polyethylene Process显示文摘Setting up a knowledge base is a helpful way to optimize the operation of the polyethylene process by improving the performance and the ef ciency of reuse of information and knowledge two critical ele- ments in polyethylene smart manufacturing. In this paper, we propose an overall structure for a knowl- edge base based on practical customer demand and the mechanism of the polyethylene process. First, an ontology of the polyethylene process constructed using the seven-step method is introduced as a carrier for knowledge representation and sharing. Next, a prediction method is presented for the molecular weight distribution (MWD) based on a back propagation (BP) neural network model, by analyzing the relationships between the operating conditions and the parameters of the MWD. Based on this network, a differential evolution algorithm is introduced to optimize the operating conditions by tuning the MWD. Finally, utilizing a MySQL database and the Java programming language, a knowledge base system for the operation optimization of the polyethylene process based on a browser/server framework is realized. | Weimin Zhong Chaoyuan Li Xin Peng Feng Wan Xufeng An Zhou Tian | 2019 | Engineering2019，5，6： | 1 |
| 17 | Molecular characterization, expression profiles, and association analysis with hematologic parameters of the porcine HPSE and HPSE2 genes显示文摘 | Cong Tao Weimin Wang Ping Zhou Tian Xia Xiang Zhou Cuiping Zeng Qingde Zhang Bang Liu | 2013 | Journal of Applied Genetics2013，，1： | 1 |
| 18 | Tribological properties of SiO2 nanoparticle filled-phthalazine ether sulfone/phthalazine ether ketone ( 50/50mol% ) copolymer composites 显示文摘 | Shao Xin Tian Jun Liu Weimin | 2002 | J Appl Polym Sci2002，85，： | 1 |
| 19 | A case of large-cell neuroendocrine carcinoma harboring rare ALK fusion with initial response to the ALK inhibitor crizotinib and acquired F1174L mutation after resistance显示文摘A 51-year-old,male,non-smoker with a 3.4 cm mass in the right middle lobe was diagnosed with large cell neuroendocrine carcinoma(LCNEC).Fluorescence in situ hybridization revealed anaplastic lymphoma kinase(ALK)gene translocation,in agreement with the immunohistochemistry result obtained with use of ALK-Ventana.Radiographic examinations showed both bone and brain metastasis.After two cycles of chemotherapy consisting of etoposide and cisplatin,the patient achieved stable disease,and was subsequently switched to crizotinib.Both computed tomography and magnetic resonance imaging revealed partial response after 4 months of crizotinib,but progressed after treatment for 10 months,when several hard lymph nodes were palpable in the left supraclavicular fossa.Lymph node biopsy showed similar histology of tumor cells and targeted next-generation sequencing revealed ALK F1174L on exon 23 with two rare forms of ALK rearrangements.This case provides evidence of responsiveness of ALK inhibitors for a rare pattern of ALK-rearranged LCNEC,and suggests that F1174L,a common resistant mutation found in non-small-cell lung cancer,also causes crizotinib resistance in LCNEC. | Ye Wang Panwen Tian Weiya Wang Yalun Li Yu Wang Weimin Li | 2019 | Precision Clinical Medicine2019，2，1： | 1 |
| 20 | Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits显示文摘Tissue engineering provides a promising avenue for treating cartilage defects.However,great challenges remain in the development of structurally and functionally optimized scaffolds for cartilage repair and regeneration.In this study,decellularized cartilage extracellular matrix(ECM)and waterborne polyurethane(WPU)were employed to construct WPU and WPU-ECM scaffolds by water-based 3D printing using low-temperature deposition manufacturing(LDM)system,which combines rapid deposition manufacturing with phase separation techniques.The scaffolds successfully achieved hierarchical macro-microporous structures.After adding ECM,WPU scaffolds were markedly optimized in terms of porosity,hydrophilia and bioactive components.Moreover,the optimized WPU-ECM scaffolds were found to be more suitable for cell distribution,adhesion,and proliferation than the WPU scaffolds.Most importantly,the WPU-ECM scaffold could facilitate the production of glycosaminoglycan(GAG)and collagen and the upregulation of cartilage-specific genes.These results indicated that the WPU-ECM scaffold with hierarchical macro-microporous structures could recreate a favorable microenvironment for cell adhesion,proliferation,differentiation,and ECM production.In vivo studies further revealed that the hierarchical macro-microporous WPU-ECM scaffold combined with the microfracture procedure successfully regenerated hyaline cartilage in a rabbit model.Six months after implantation,the repaired cartilage showed a similar histological structure and mechanical performance to that of normal cartilage.In conclusion,the hierarchical macro-microporous WPU-ECM scaffold may be a promising candidate for cartilage tissue engineering applications in the future. | Mingxue Chen YangYang Li Shuyun Liu Zhaoxuan Feng Hao Wang Dejin Yang Weimin Guo Zhiguo Yuan Shuang Gao Yu Zhang Kangkang Zha Bo Huang Fu Wei Xinyu Sang Qinyu Tian Xuan Yang Xiang sui Yixin Zhou Yufeng Zheng Quanyi Guo | 2021 | Bioactive Materials2021，6，7： | 1 |
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