|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of measurement uncertainty based on grey system theory for small samples from an unknown distribution显示文摘To evaluate measurement uncertainty for small sample size and measurement data from an unknown distribution, we propose a grey evaluation method of measurement uncertainty based on the grey relation coefficient. The uncertainty of measurement is analyzed using grey system theory, and the defects of the grey evaluation model of measurement uncertainty (GEMU) are studied. We then establish an improved grey evaluation model of measurement uncertainty (IGEMU). Simulations show that the precision of IGEMU is greater than that of GEMU, and that sample size has only a small effect on the precision of IGEVU. In particular, IGEMU is applied to evaluating measurement uncertainty for small sample size and measurement data from an unknown distribution. The measurement uncertainty of total profile deviation, which is measured by the CNC gear measuring center, can be evaluated by a combination of IGEMU and the Monte Carlo method. | HAN LianFu TANG WenYan LIU YongMeng WANG Jun FU ChangFeng | 2013 | Science China(Technological Sciences)2013，56，6： | 18 |
| 2 | FAM19A4 is a novel cytokine ligand of formyl peptide receptor I (FPR 1) and is able to promote the migration and phagocytosis of macrophages显示文摘FAM19A4 是为有顺序类似 19 的家庭的缩写(chemokine (C-C 主题)-like) 成员 A4,它能分泌的蛋白质在正常纸巾在底层被表示。坚定的 FAM19A4 遗体的生物功能,和它的潜在的受体是 unclarified。在这研究,我们证明 FAM19A4 是古典能分泌的蛋白质,我们第一次证实它的成熟蛋白质由 95 氨基酸组成。我们发现这新奇 cytokine 的表示是 upregulated 在里面 lipopolysaccharide (LPS ) 刺激了单核白血球和巨噬细胞并且典型地在极化的 M1。FAM19A4 在巨噬细胞上显示出趋化性的活动并且随蛋白质 kinase B (Akt ) 的 phosphorylation 的显著增加在 vitro 并且在 vivo 提高 zymosan 的巨噬细胞吞噬作用。FAM19A4 能也在 zymosan 刺激之上增加反应的氧种类(ROS ) 的版本。基于受体成为主观,收音机 ligand 绑定试金和受体阻塞,而且,我们第一次证明 FAM19A4 是甲酰肽受体 1 的新奇 ligand (FPR1 ) 。上述数据显示在煽动性的刺激之上, monocyte/macrophage-derived FAM19A4 可以在病原的感染期间在巨噬细胞的移植和激活起一个关键作用。 | Wenyan Wang Ting Li Xiaolin Wang Wanxiong Yuan Yingying Cheng Heyu Zhang Enquan Xu Yingmei Zhang Shuang Shi Dalong Ma Wenling Han | 2015 | Cellular & Molecular Immunology2015，12，5： | 8 |
| 3 | Overexpression of GhPFN2 enhances protection against Verticillium dahliae invasion in cotton显示文摘Growing evidence indicates that actin cytoskeleton is involved in plant innate immune responses,but the functional mechanism remains largely unknown.Here,we investigated the behavior of a cotton profilin gene(GhPFN2) in response to Verticillium dahliae invasion,and evaluated its contribution to plant defense against this soil-borne fungal pathogen.GhPFN2 expression was up-regulated when cotton root was inoculated with V.dahliae,and the actin architecture was reorganized in the infected root cells,with a clear increase in the density of filamentous actin and the extent of actin bundling.Compared to the wild type,GhPFN2-overexpressing cotton plants showed enhanced protection against V.dahliae infection and the actin cytoskeleton organization in root epidermal cells was clearly altered,which phenocopied that of the wild-type(WT) root cells challenged with V.dahliae.These results provide a solid line of evidence showing that actin cytoskeleton reorganization involving GhPFN2 is important for defense against V.dahliae infection. | Wenyan Wang Yongduo Sun Libo Han Lei Su Ouixian Xia Haiyun Wang | 2017 | Science China(Life Sciences)2017，60，8： | 4 |
| 4 | High performance of a unique mesoporous polystyrene-based adsorbent for blood purification显示文摘A multi-functional polystyrene based adsorbent(NKU-9)with a unique mesoporous and a high surface area was prepared by suspension polymerization for removal of therapeutic toxins in blood purification.The adsorbent produced had an almost equal amount of mesopore distribution in the range from 2 to 50 nm.The adsorption of serum toxins with different molecular weights were examined by in vitro adsorption assays and compared with some clinical currently used adsorbents such as HA-330,Cytosorb and BL-300 which are produced by China,America and Japan,respectively.Test results indicated that the adsorption rate for pentobarbital by NKU-9 was 81.24%which is nearly as high as HA-330(81.44%).The latter adsorbent is currently used for acute detoxification treatment in China.To reach adsorption equilibrium,NKU-9 was faster than HA-330,which implies short treatment time.For the removal of middle molecular toxins such as b2-microglobulin(98.88%),NKU-9 performed better adsorptive selectivity than Cytosorb(92.80%).In addition,NKU-9 showed high performance for the removal of albumin-bound toxins(e.g.,bilirubin),and its adsorption rate for total bilirubin(80.79%)in plasma was 8.4%higher than that of anion exchange resin BL-300 which is currently used to eliminate bilirubin in clinic.Therefore,our results indicate that the newly developed adsorbent with a wide distribution and almost equal amount of mesopores is a multifunctional adsorbent for high efficient removal of serum toxins with different molecular weights which might be an excellent blood purification adsorbent especially to treat diseases that conventional medical methods are low or not efficient. | Jian Chen Wenyan Han Jie Chen Wenhui Zong Weichao Wang Yue Wang Guanghui Cheng Chunran Li Lailiang Ou Yaoting Yu | 2017 | Regenerative Biomaterials2017，4，1： | 3 |
| 5 | Soil microbial biomass and activity in Chinese tea gardens of varying stand age and productivity显示文摘 | Wenyan Han Sarah J. Kemmitt Philip C. Brookes | 2007 | Soil Biology and Biochemistry2007，，7： | 2 |
| 6 | Identification and characterization of a novel antibacterial peptide, avian β-defensin 2 from ducks显示文摘 | Deying Ma Ruiqin Wang Wenyan Liao Zongxi Han Shengwang Liu | 2009 | The Journal of Microbiology2009，，5： | 2 |
| 7 | Single cell analysis reveals inhibition of angiogenesis attenuates the progression of heterotopic ossification in Mkx^(−/−)mice显示文摘Tendon heterotopic ossification(HO)is characterized by bone formation inside tendon tissue,which severely debilitates people in their daily life.Current therapies fail to promote functional tissue repair largely due to our limited understanding of HO pathogenesis.Here,we investigate the pathological mechanism and propose a potential treatment method for HO.Immunofluorescence assays showed that the Mohawk(MKX)expression level was decreased in human tendon HO tissue,coinciding with spontaneous HO and the upregulated expression of osteochondrogenic and angiogenic genes in the tendons of Mkx^(−/−)mice.Single-cell RNA sequencing analyses of wild-type and Mkx^(−/−)tendons identified three cell types and revealed the excessive activation of osteochondrogenic genes during the tenogenesis of Mkx^(−/−)tendon cells.Single-cell analysis revealed that the gene expression program of angiogenesis,which is strongly associated with bone formation,was activated in all cell types during HO.Moreover,inhibition of angiogenesis by the small-molecule inhibitor BIBF1120 attenuated bone formation and angiogenesis in the Achilles tendons of both Mkx mutant mice and a rat traumatic model of HO.These findings provide new insights into the cellular mechanisms of tendon HO and highlight the inhibition of angiogenesis with BIBF1120 as a potential treatment strategy for HO. | Junxin Lin Yuwei Yang Wenyan Zhou Chao Dai Xiao Chen Yuanhao Xie Shan Han Huanhuan Liu Yejun Hu Chenqi Tang Varitsara Bunpetch Dandan Zhang Yishan Chen Xiaohui Zou Di Chen Wanlu Liu Hongwei Ouyang | 2022 | Bone Research2022，10，4： | 1 |
| 8 | Soil microbial biomass and activity in Chinses tea gardens of raring stand age and productivity显示文摘 | HAN WENYAN KEMMITT S J BROOKES P C | 2007 | Soil Biology and Biochemistry2007，39，： | 1 |
| 9 | Ionic liquid-containing semipermeable membrane devices for monitoring the polycyclic aromatic hydrocarbons in water显示文摘 | Wenyan Han Meng Dai Shugui | 2006 | Chemosphere2006，62，10： | 1 |
| 10 | Responses of flood peaks to land use and landscape patterns under extreme rainstorms in small catchments-A case study of the rainstorm of Typhoon Lekima in Shandong,China显示文摘Investigations of the formation mechanisms of flood peaks in small catchments facilitate flood prediction and disaster prevention under extreme rainstorms.However,there have been few studies on the re-sponses of flood peaks to land use landscape patterns using field surveys during extreme rainstorm events.Based on field data from 17 small catchments near the rainstorm center of Typhoon Lekima,7 landscape indices were chosen.The flood peak and its sensitivity to the land use landscape were investigated by combining remote sensing interpretation and related analysis.The conclusions are as follows:(1)The peak discharge of the small catchment was 2.36e56.50 m3/s,the peak modulus was 8.00 e48.89 m3/(s$km2),and the flood index K ranged from 3.61 to 4.55.(2)Under similar rainfall conditions,the flood peak modulus,K and the proportion of sloping cropland had significantly positive correlations(p<0.05).The flood peak modulus was significantly negatively correlated with the proportion of forest-grassland and terrace(p<0.05),and K and the proportion of forest-grassland and terraced land exhibited a negative correlation.(3)The flood peak modulus and K were positively correlated with the landscape fragmentation.(4)The sensitivities of small catchments to floods were evaluated to be moderate compared to K values from other studies.The ability of small catchments to cope with extreme rain-storms can be improved by increasing the areas of forest-grassland,and terraces and reducing landscape fragmentation.Our results could be applied to provide a basis for land use planning and support for the response against disasters caused by extreme floods. | Yuanhao Liu Jianqiao Han Juying Jiao Baoyuan Liu Wenyan Ge Qingbin Pan Fei Wang | 2022 | International Soil and Water Conservation Research2022，10，2： | 1 |
| 11 | Scale and causes of lead contamination in Chinese tea显示文摘 | Wenyan Han Fangjie Zhao Yuanzhi Shi | 2006 | Environmental Pollution2006，139，： | 1 |
| 12 | Scale and causes of lead contamination in Chinese tea显示文摘 | HAN Wenyan ZHAO Fangjie SHI Yuanzhi | 2006 | Environmental Pollution2006，139，1： | 1 |
| 13 | Adsorption Mechanism of Acetylene Hydrogenation on the Pd (111) Surface显示文摘First-principles calculations are carried out to examine the adsorption of acetylene over the Pd(111)surface.A hydrogen adsorption system is initially investigated to confirm the reliability of the selected calculation method.Adsorption energies,Mulliken-populations,overlap populations,charge density,and projected density of states(PDOS)are then calculated in the optimised acetylene adsorption system.Results show that C_(2)H_(2) molecule tends to adsorb through the threefold parallel-bridge configuration that is computed to be the most stable.In this structure,the distance of the C-H bond is calculated to be 1.09 Å,and the C-C-H bond angle is 128°.The distance of the C-C bond in acetylene is 1.36 Å,increasing from 1.21 Å in the gas phase.Moreover,the C-C bond overlap population decreases from 1.98 to 1.38,revealing that the carbon configuration in C2H2 rehybridises from sp to sp^(2) and beyond.The obtained results are compared with available experimental studies on acetylene hydrogenation on single-metal surfaces.The PDOS study indicates that a carbonaceous layer may generate on the metal surface during acetylene adsorption.The carbonaceous layer can affect the adsorption and reaction of acetylene,thereby inactivating the metal surface.Our experiments also show that Pd exhibits high catalytic activity. | Xuejia Xie Xiuli Song Wenyan Dong Zhenhai Liang Caimei Fan Peide Han | 2014 | Chinese Journal of Chemistry2014，32，7： | 1 |
| 14 | Estimation of N 2 O emission from tea garden soils, their adjacent vegetable garden and forest soils in eastern China显示文摘 | Wenyan Han Jianming Xu Kang Wei Yuanzhi Shi Lifeng Ma | 2013 | Environmental Earth Sciences2013，，6： | 1 |
| 15 | Impacts of meteorology and precursor emission change on O_(3) variation in Tianjin, China from 2015 to 2021显示文摘Deterioration of surface ozone (O_(3)) pollution in Northern China over the past few years received much attention.For many cities,it is still under debate whether the trend of surface O_(3)variation is driven by meteorology or the change in precursors emissions.In this work,a time series decomposition method (Seasonal-Trend decomposition procedure based on Loess (STL)) and random forest (RF) algorithm were utilized to quantify the meteorological impacts on the recorded O_(3)trend and identify the key meteorological factors affecting O_(3)pollution in Tianjin,the biggest coastal port city in Northern China.After “removing” the meteorological fluctuations from the observed O_(3)time series,we found that variation of O_(3)in Tianjin was largely driven by the changes in precursors emissions.The meteorology was unfavorable for O_(3)pollution in period of 2015-2016,and turned out to be favorable during 2017-2021.Specifically,meteorology contributed 9.3μg/m^(3)O_(3)(13%) in 2019,together with the increase in precursors emissions,making 2019 to be the worst year of O_(3)pollution since 2015.Since then,the favorable effects of meteorology on O_(3)pollution tended to be weaker.Temperature was the most important factor affecting O_(3)level,followed by air humidity in O_(3)pollution season.In the midday of summer days,O_(3)pollution frequently exceeded the standard level (>160μg/m^(3)) at a combined condition with relative humidity in 40%-50%and temperature>31℃.Both the temperature and the dryness of the atmosphere need to be subtly considered for summer O_(3)forecasting. | Jing Ding Qili Dai Wenyan Fan Miaomiao Lu Yufen Zhang Suqin Han Yinchang Feng | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 16 | Two-Dimensional Parabolic Inverse Source Problem with Final Overdetermination in Reproducing Kernel Space显示文摘A new method of the reproducing kernel Hilbert space is applied to a twodimensional parabolic inverse source problem with the final overdetermination. The exact and approximate solutions are both obtained in a reproducing kernel space. The approximate solution and its partial derivatives are proved to converge to the exact solution and its partial derivatives, respectively. A technique is proposed to improve some existing methods. Numerical results show that the method is of high precision, and confirm the robustness of our method for reconstructing source parameter. | Wenyan WANG Masahiro YAMAMOTO Bo HAN | 2014 | Chinese Annals of Mathematics,Series B2014，35，3： | 0 |
| 17 | Robust optimization design on impeller of mixed-flow pump显示文摘To increase the robustness of the optimization solutions of the mixed-flow pump,the impeller was firstly indirectly parameterized based on the 2D blade design theory.Secondly,the robustness of the optimization solution was mathematically defined,and then calculated by Monte Carlo sampling method.Thirdly,the optimization on the mixed-flow pump′s impeller was decomposed into the optimal and robust sub-optimization problems,to maximize the pump head and efficiency and minimize the fluctuation degree of them under varying working conditions at the same time.Fourthly,using response surface model,a surrogate model was established between the optimization objectives and control variables of the shape of the impeller.Finally,based on a multi-objective genetic optimization algorithm,a two-loop iterative optimization process was designed to find the optimal solution with good robustness.Comparing the original and optimized pump,it is found that the internal flow field of the optimized pump has been improved under various operating conditions,the hydraulic performance has been improved consequently,and the range of high efficient zone has also been widened.Besides,with the changing of working conditions,the change trend of the hydraulic performance of the optimized pump becomes gentler,the flow field distribution is more uniform,and the influence degree of the varia-tion of working conditions decreases,and the operating stability of the pump is improved.It is concluded that the robust optimization method proposed in this paper is a reasonable way to optimize the mixed-flow pump,and provides references for optimization problems of other fluid machinery. | ZHAO Binjuan LIAO Wenyan XIE Yuntong HAN Luyao FU Yanxia HUANG Zhongfu | 2021 | 排灌机械工程学报2021，39，7： | 0 |
| 18 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 19 | Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1显示文摘Many circular RNAs(circRNAs)are reported to be abnormally expressed during the progression of various tumors,and these circRNAs can be used as anti-tumor targets.Therefore,it is important to identify circRNAs that can be used effectively for the clinical diagnosis and treatment of colorectal cancer(CRC).Here,we report that hsa_Circ_0000826(Circ_0000826),a circ RNA with significantly reduced expression level in CRC tissues,is associated with a poor prognosis in patients.The silencing of Circ_0000826 promotes the proliferation of CRC cells.Conversely,the overexpression of Circ_0000826 restricted CRC cell proliferation both in vitro and in vivo.Furthermore,Circ_0000826 could target AU-rich element RNA-binding protein 1(AUF1).AUF1,known as heterogeneous nuclear ribonucleoprotein D(hnRNP D),could bind to the c-MYC 3’-UTR and promote c-MYC expression.When Circ_0000826 binds to AUF1,it competitively inhibits the binding of AUF1 to the c-MYC 3’-UTR,which inhibits the c-MYC expression and cell proliferation.These results provide novel insights into the functional mechanism of Circ_0000826 action in CRC progression and indicate its potential use as a therapeutic target in CRC. | Zheying Zhang Wenyan Fan Qingzu Gao Yifei Han Jingyu Ma Wuji Gao Yuhan Hu Huifang Zhu Rui Yang Haijun Wang Baoshun Du Zuoyang Zhang Jiateng Zhong | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 20 | Durability of Hepatitis B surface antigen seroclearance in patients experienced nucleoside analogs or interferon monotherapy: A real-world data from Electronic Health Record显示文摘Little is known about the difference in durability of HBsAg seroclearance induced by nucleoside analogs (NAs) or by interferon (IFN). A real-world, retrospective cohort study was conducted. Patients were assigned into two groups: NAs monotherapy-induced HBsAg seroclearance subjects and IFN monotherapy induced-HBsAg seroclearance subjects. A total of 198 subjects, comprised by 168 NAs monotherapy-induced and 30 IFN monotherapy-induced, who achieved HBsAg seroclearance were included in this study. The one-year probabilities of confirmed HBsAg seroclearance were significantly different in patients with NAs monotherapy and IFN monotherapy (0.960 (with 95% CI 0.922–0.999) vs. 0.691 (with 95% CI 0.523–0.913), log-rank-P = 4.04e-4). 73.3% (11 of 15) HBsAg recurrence occurred within one year after HBsAg seroclearance. The one-year probabilities of confirmed HBsAg seroclearance were higher in IFN monotherapy patients with anti-HBs than in IFN monotherapy patients without anti-HBs (0.839 (with 95% CI 0.657–1.000) vs. 0.489 (with 95% CI 0.251–0.953), log-rank test, P = 0.024). Our study thus provided novel insights into the durability of HBsAg seroclearance induced by NAs or IFN monotherapy. In particular, the HBsAg seroreversion rate was relatively high in IFN monotherapy subjects. The presence of anti-HBs was significantly correlated with a longer durability of functional cure induced by IFN treatment. And one-year follow-up in HBsAg seroclearance achieved individuals is proper for averting HBsAg seroreversion and other liver disease. | Zongqi Shi Huizhi Zheng Miaomiao Han Jieli Hu Yuan Hu Xiaosong Li Wenyan Zhu Xinjun He Haijun Deng Quanxin Long Ailong Huang | 2023 | Genes & Diseases2023，10，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员