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| 1 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 2 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 3 | Research on crystal growth and properties of a new nonlinear optical crystal:Bismuth borate BiB_3O_6显示文摘BiB3O6 (BIBO) single crystals with sizes of 44 mm × 24 mm × 10 mm and weight of 24.7 g have been successfully grown by the top-seeded method. In this note, the preparation of seed, the growth of crystal and some problems encountered are reported. The lattice parameters of BIBO are a =7.1203(7)A, b = 4.9948(7)A, c = 6.5077(7)A, β= 105.586(8) ', V=222.93(5)A3, which were determined by BRUKER-P4 four-circle diffractometer. BIBO is biaxial crystal and the relative orientation of (X, Y, Z) with regard to (a, b, c) is: X|| b, (Y, c) =47.2°, (Z, a) = 31.6°, determined by the X-ray analysis combined with polarized microscopy. The second-harmonic-generation (SHG) conversion efficiency of the sample for 1.064 μm light is up to 67.7%. We have also obtained the third harmonic generation (THG) of 1.064 μm, namely, 1.064 μm + 0.532 μn →0.355 μm. BIBO crystal is free of moisture and hygroscopy. | TENG Bing, WANG Jiyang, WANG Zhengping, JIANG Huaidong, SONG Renbo, LIU Hong, HU Xiaobo, LIU Yaogang, WEI Jingqian & SHAO ZongshuState Key Laboratory of Crystal Materials, Shandong University, Ji’nan 250100, China | 2001 | Chinese Science Bulletin2001，46，21： | 10 |
| 4 | Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses显示文摘Hematopoietic stem cells(HSCs)in adults are believed to be born from hemogenic endothelial cells(HECs)in mid-gestational embryos.Due to the rare and transient nature,the HSC-competent HECs have never been stringently identified and accurately captured,let alone their genuine vascular precursors.Here,we first used high-precision single-cell transcriptomics to unbiasedly examine the relevant EC populations at continuous developmental stages with intervals of 0.5 days from embryonic day(E)9.5 to E11.0.As a consequence,we transcriptomically identified two molecularly different arterial EC populations and putative HSCprimed HECs,whose number peaked at El 0.0 and sharply decreased thereafter,in the dorsal aorta of the aorta-gonadmesonephros(AGM)region.Combining computational prediction and in vivo functional validation,we precisely captured HSCcompetent HECs by the newly constructed Neurl3-EGFP reporter mouse model,and realized the enrichment further by a combination of surface markers(Procr+Kit+CD44+,PK44).Surprisingly,the endothelial-hematopoietic dual potential was rarely but reliably witnessed in the cultures of single HECs.Noteworthy,primitive vascular ECs from E8.0 experienced two-step fate choices to become HSC-primed HECs,namely an Initial arterial fate choice followed by a hemogenic fate conversion.This finding resolves several previously observed contradictions.Taken together,comprehensive understanding of endothelial evolutions and molecular programs underlying HSC-primed HEC specification in vivo will facilitate future investigations directing HSC production in vitro. | Siyuan Hou Zongcheng Li Xiaona Zheng Yun Gao Ji Dong Yanli Ni Xiaobo Wang Yunqiao Li Xiaochen Ding Zhilin Chang Shuaili Li Yuqiong Hu Xiaoying Fan Yu Hou Lu Wen Bing Liu Fuchou Tang Yu Lan | 2020 | Cell Research2020，30，5： | 8 |
| 5 | A natural variation in Ribonuclease H-like gene underlies Rht8 to confer“Green Revolution”trait in wheat显示文摘Dear Editor,Introduction of gibberellin(GA)-insensitive Reduced height(Rht)genes,Rht-B1b and Rht-D1b,has resulted in the“Green Revolution”in modern wheat cultivars(Triticum aestivum)that has skyrocketed wheat grain yields worldwide since the 1960s(Peng et al.,1999;Velde et al.,2021).However,Rht-B1b/D1b also reduce coleoptiles,which is undesired in dryland regions where deep planting is essential for seedling establishment(Rebetzke et al.,1999,Rebetzke et al.,2001;Ellis et al.,2004). | Lingling Chai Mingming Xin Chaoqun Dong Zhaoyan Chen Huijie Zhai Junhong Zhuang Xuejiao Cheng Naijiao Wang Jia Geng Xiaobo Wang Ruolin Bian Yingyin Yao Weilong Guo Zhaorong Hu Huiru Peng Guihua Bai Qixin Sun Zhenqi Su Jie Liu Zhongfu Ni | 2022 | Molecular Plant2022，15，3： | 8 |
| 6 | Development of Geothermal Resources in China: A Review显示文摘Geothermal resources in China are distributed throughout the country, with hydrothermal systems of high temperature in the Tibet Autonomous Region, Yunnan Province and Taiwan Island and hydrothermal systems of low-medium temperature mainly in various sedimentary basins. Development and exploration of geothermal energy in China are below expectations. The purpose of this study is to comparatively review the characteristics(geology, hydrogeology, hydrochemistry and geophysical data) of typical hydrothermal fields/areas and suggest development and utilization approaches in the future. Hydrothermal systems formed by mountain lifting contain a considerable amount of energy for geothermal power generation, especially in the Tibet Autonomous Region, Yunnan Province and Taiwan Island. However, geothermal water in the Tatun geothermal field has high TDS(total dissolved solids), an issue that requires more research to resolve this problem for power generation. The large storage of geothermal resources has been investigated in Meso–Cenozoic sedimentary basins; it is basically used for heating, bathing or greenhouse plantation. Moreover, hydrothermal resources of low-medium temperature can also be used in binary power plants. Although the enhanced geothermal systems(EGS) in China are promising, the resources have not yet been commercially exploited, because the emerging technologies(hydraulic fracturing) and concerns over environmental impacts(induced micro-seismicity) lead to slow development. On the contrary, shallow geothermal energy has been directly utilized mainly for heating and cooling buildings. Cities like Beijing, Tianjin and Shenyang have established a series of ground-source heat-pump systems, which has led to a massive reduction of CO_2 emission of 19.87×10~6 t. | Xiaobo Zhang Qinhong Hu | 2018 | Journal of Earth Science2018，29，2： | 7 |
| 7 | Adiponectin Decreases Plasma Glucose and Improves Insulin Sensitivity in Diabetic Swine显示文摘为了在糖尿病的猪的新陈代谢上调查 recombinant 人 adiponectin 的效果,由喂一本 high-fat/high-sucrose 食谱(HFSD ) 导致了,糖尿病的动物模型被用 HFSD 喂猪 6 个月构造。 recombinant adiponectin 的效果被由商业地可得到的酶的方法测试工具包检测血浆葡萄糖层次的变化并且由测试( OGTT ) .About1.5 g 净化了的口头的葡萄糖忍耐评估胰岛素敏感估计 recombinant adiponectin 用净化的 recombinant 人 adiponectin 的15公升 fermenter.A 单身者注射被生产到糖尿病的猪在传播 adiponectin 导致了2-到3褶层举起,它在基础葡萄糖水平( P<0.05 )触发了短暂减少葡萄糖上的 .Thiseffect 没与胰岛素水平的增加被联系。而且在 adiponectininjection 以后,猪也与控制(P<0.05 ) 相比显示出改进胰岛素敏感, .Adiponectin 可能有潜力因为有势力胰岛素 enhancer Unking 脂肪质的织物和葡萄糖新陈代谢能是有用的对待胰岛素抵抗,是为 metabolicdisease.Adiponectin 的一个葡萄糖阴沉的代理人。 | Xiaobo HU Meihua SHE Hongjie HOU Qinkai LI Qingyun SHEN Yi LUO and Weidong YIN Department of Biochemistry and Biotechnology,School of Life Sciences and Technology,Nanhua University,Hengyang 421001,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，2： | 4 |
| 8 | Fine Machining of Large-Diameter 6H-SiC Wafers显示文摘大直径的 6H-SiC 晶片的三主要用机器制造进程在这篇论文被介绍。这些过程包括切,舔并且擦亮。舔的原因伟人剩余压力和能与随后的擦亮的过程逐渐地被减少的深损坏层。机械擦亮准备的表面(MP ) 出现了有 5-8 nm 的深度的很多擦伤。这些擦伤能被 chemo-mechanicalpolishing (CMP ) 有效地移开。在 CMP 以后,有粗糙 R_a=0.3 nmwas 的极其光滑、低的损坏层表面获得了。原子力量显微镜学(AFM ) 和光显微镜学被用来观察到样品和高分辨率 X 光检查衍射计(HRXRD ) 的表面形态学被用于表面下的区域的水晶格子完美。表面剩余压力的变化被 HRXRD 在用机器制造过程期间调查。 | Xiufang CHEN Juan LI Deying MA Xiaobo HU Xiangang XU Minhua JIANG | 2006 | Journal of Materials Science & Technology2006，22，5： | 4 |
| 9 | Toward reverse engineering on secret S-boxes in block ciphers显示文摘It has been widely accepted that the security cryptosystems should be only dependent on the security of their secret keys.However,there are still secret ciphers with unknown components in their commercial applications due to various reasons.The existing reverse engineering analyzes are developed for analyzing specific ciphers,and cannot cope with secret algorithms with diferent structures.By looking into the common characteristics of the secret algorithms of ciphers implemented with unknown S-boxes,we proposed a novel reverse engineering analysis approach referred to as Signed Reverse Engineering based on Diferential Power Analysis(SREDPA).It is a generic reverse engineering analysis and can recover the parameters of the secret S-boxes of the block ciphers in typical structures such as SPN,Feistel,and XFeistel(eXtended Feistel).By identifying the bias of the diferential power analysis(DPA)traces,we build the theoretical model of SREDPA and prove its efectiveness.Experiments are performed on secret algorithms in diferent structures and further validate our SREDPA experimentally.The complexity of SREDPA only relies on the size of S-boxes and the reverse engineering analysis is efcient.As shown in the theoretical analysis and the conducted experiments,our SREDPA approach is readily to be extended for analyzing other secret ciphers with unknown S-boxes.This renders a new challenge on the design and implementation of secret ciphers. | TANG Ming QIU ZhenLong PENG HongBo HU XiaoBo YI Mu ZHANG HuanGuo | 2014 | Science China(Information Sciences)2014，57，3： | 4 |
| 10 | Surface Polishing of 6H-SiC Substrates显示文摘为硅碳化物擦亮的表面(原文如此)底层被调查 andresults 为机械擦亮被介绍( MP )并且chemo机械的擦亮( CMP ) .High qualitysurfaces 在 CMP 期间在物理的 MP anddetailed 和化学过程与擦伤的胶体的 silica.The 移动机制在 CMP 以后被获得是 MP 和 CMP 的 analyzed.The 效果在 thesurface 上,粗糙被光显微镜学( OM )估计,原子力量显微镜学( AFM )和高分辨率 | Xiufang CHEN Xiangang XU Juan LI Shouzhen JIANG Lina NING Yingmin WANG Deying MA Xiaobo HU Minhua JIANG | 2007 | Journal of Materials Science & Technology2007，23，3： | 4 |
| 11 | Spatio-temporal measures of electrophysiological correlates for behavioral multisensory enhancement during visual,auditory and somatosensory stimulation:A behavioral and ERP study显示文摘Multisensory enhancement,as a facilitation phenomenon,is responsible for superior behavioral performance when an individual is responding to cross-modal versus modality-specific stimuli.However,the event-related potential(ERP)counterparts of behavioral multisensory enhancement are not well known.We recorded ERPs and behavioral data from 14 healthy volunteers with three types of target stimuli(modality-specific,bimodal,and trimodal)to examine the spatio-temporal electrophysiological characteristics of multisensory enhancement by comparing behavioral data with ERPs.We found a strong correlation between P3latency and behavioral performance in terms of reaction time(RT)(R=0.98,P<0.001),suggesting that P3 latency constitutes a temporal measure of behavioral multisensory enhancement.In addition,a fast RT and short P3 latency were found when comparing the modality-specific visual target with the modality-specific auditory and somatosensory targets.Our results indicate that behavioral multisensory enhancement can be identified by the latency and source distribution of the P3 component.These findings may advance our understanding of the neuronal mechanisms of multisensory enhancement. | Wuyi Wang Li Hu Hongyan Cui Xiaobo Xie Yong Hu | 2013 | Neuroscience Bulletin2013，29，6： | 4 |
| 12 | Ectopic expression of VRT-A2 underlies the origin of Triticum polonicum and Triticum petropavlovskyi with long outer glumes and grains显示文摘Polish wheat (Triticum polonicum) is a unique tetraploid wheat species characterized by an elongated outer glume. The genetic control of the long-glume trait by a single semi-dominant locus, P1 (from Polish wheat), was established more than 100 years ago, but the underlying causal gene and molecular nature remain elusive. Here, we report the isolation of VRT-A2, encoding an SVP-clade MADS-box transcription factor, as the P1 candidate gene. Genetic evidence suggests that in T. polonicum, a naturally occurring sequence rearrangement in the intron-1 region of VRT-A2 leads to ectopic expression of VRT-A2 in floral organs where the long-glume phenotype appears. Interestingly, we found that the intron-1 region is a key ON/OFF molecular switch for VRT-A2 expression, not only because it recruits transcriptional repressors, but also because it confers intron-mediated transcriptional enhancement. Genotypic analyses using wheat accessions indicated that the P1 locus is likely derived from a single natural mutation in tetraploid wheat, which was subsequently inherited by hexaploid T. petropavlovskyi. Taken together, our findings highlight the promoter-proximal intron variation as a molecular basis for phenotypic differentiation, and thus species formation in Triticum plants. | Jing Liu Zhaoyan Chen Zhihui Wang Zhaoheng Zhang Xiaoming Xie Zihao Wang Lingling Chai Long Song Xuejiao Cheng Man Feng Xiaobo Wang Yanhong Liu Zhaorong Hu Jiewen Xing Zhenqi Su Huiru Peng Mingming Xin Yingyin Yao Weilong Guo Qixin Sun Jie Liu Zhongfu Ni | 2021 | Molecular Plant2021，14，9： | 4 |
| 13 | A five-fold pig bacterial artificial chromosome library:a resource for positional cloning and physical mapping显示文摘一个猪用绳子拖的平底渡船图书馆从一头 maleErhualian 猪与 genomic DNA 被构造。在有后部的 III 片 384 井盘子的部分消化以后(20 个盘子每超级水池) 。屏蔽系统的二拍子的圆舞 4 尺寸 PCR 被建立屏蔽积极克隆。一般水准插入 128 kb 的尺寸从 105 随机孤立的克隆被估计,它显示图书馆是超过五次 genomic 范围。为概率到的示范从图书馆选出任何唯一的基因或 DNA 标记, 10 单个拷贝的基因外面被屏蔽,积极克隆与 3.6 的一般水准在 1 和 8 之间被产出。积极超级水池为从猪染色体的不同区域选择的 32 个微卫星标记被获得。为每个标记的积极超级水池的数字与 4.78 的一般水准从 1 ~ 9 变化。这个用绳子拖的平底渡船图书馆为猪提供一个另外的资源物理印射和基因鉴定。 | LIU Wei ZHANG Ying LIU Zhaoliang GUO Li WANG Xiaobo FEI Jing FENG Jidong ZHAO Rui HU Xiaoxiang LI Ning | 2006 | Progress in Natural Science:Materials International2006，16，8： | 4 |
| 14 | Experimental and numerical investigation of the influence of roughness and turbulence on LUT airfoil performance显示文摘Vertical-axis wind turbines(VAWTs)have been widely used in urban environments,which contain dust and experience strong turbulence.However,airfoils for VAWTs in urban environments have received considerably less research attention than those for horizontal-axis wind turbines(HAWTs).In this study,the sensitivity of a new VAWT airfoil developed at the Lanzhou University of Technology(LUT)to roughness was investigated via a wind tunnel experiment.The results show that the LUT airfoil is less sensitive to roughness at a roughness height of<0.35 mm.Moreover,the drag bucket of the LUT airfoil decreases with increasing roughness height.Furthermore,the loads on the LUT airfoil during dynamic stall were studied at different turbulence intensities using a numerical method at a tip-speed ratio of 2.Before the stall,the turbulence intensity did not considerably affect the normal or tangential force coefficients of the LUT airfoil.However,after the stall,the normal force coefficient varied obviously at low turbulence intensity.Moreover,as the turbulence intensity increased,the normal and tangential force coefficients decreased rapidly,particularly in the downwind region of the VAWT. | Shoutu Li Ye Li Congxin Yang Xiaobo Zheng Qing Wang Yin Wang Deshun Li Wenrui Hu | 2019 | Acta Mechanica Sinica2019，35，6： | 3 |
| 15 | Using coupling slabs to tailor surface-acoustic-wave band structures in phononic crystals consisting of pillars attached to elastic substrates显示文摘The propagation of surface acoustic waves(SAWs) in two-dimensional phononic crystals(PnCs) with and without coupling-enhancement slabs was theoretically investigated using a three-dimensional finite element method.Different piezoelectric substrates,for example,lithium niobate(LiNbO_3),gallium nitride(GaN),and aluminium nitride(A1N),were taken into account.Compared to the PnCs without coupling-enhancement slabs,the coupling between each pillar and its nearest neighbor was largely enhanced in the presence of slabs.The bandwidth of the first directional band gap increased markedly compared with its initial value for the PnCs without a slab(within square symmetry).In addition,with increasing thicknesses of the slabs bonded between neighboring pillars,the first directional band-gap and second directional band gap of the PnCs tend to merge.Therefore,the structure with coupling-enhancement slabs can be used as an excellent electrical band elimination filter for most electro-SAW devices,offering a new strategy to realize chip-scale applications in electroacoustic signal processing,optoacoustic modulation,and even SAW microfluidic devices. | Heng Zhang SiYuan Yu FuKang Liu Zhen Wang MingHui Lu XiaoBo Hu YanFeng Chen XianGang Xu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 3 |
| 16 | Important mesoscale phenomena in gas phase fluidized bed ethylene polymerization显示文摘Gas phase fluidized bed processes have been widely applied to polyethylene production.In these processes,the flow,mass transfer,and reaction rate on the microscale and macroscale are strongly coupled because of the multiphase and multiscale nature of the fluidization system.Understanding mesoscale phenomena is therefore essential to the quantitative translation of the knowledge obtained from the microscale to the macroscale.This paper reviews the development of ethylene polymerization gas phase processes while focussing on studies regarding mesoscale phenomena.These include experimental characterizations,mathematical modelling and control strategies.Trends and future developments in this field are also discussed. | Jingyuan Sun Haotong Wang Sihang Tian Xiaoqiang Fan Qiang Shi Ying Liu Xiaobo Hu Yao Yang Jingdai Wang Yongrong Yang | 2020 | Particuology2020，18，1： | 3 |
| 17 | Carbonaceous matter in glacier at the headwaters of the Yangtze River:Concentration,sources and fractionation during the melting process显示文摘Carbonaceous matter has an important impact on glacial retreat in the Tibetan Plateau,further affecting the water resource supply.However,the related studies on carbonaceous matter are still scarce in Geladaindong(GLDD)region,the source of the Yangtze River.Therefore,the concentration,source and variations of carbonaceous matter at Ganglongjiama(GLJM)glacier in GLDD region were investigated during the melting period in 2017,which could deepen our understanding on carbonaceous matter contribution to glacier melting.The results showed that dissolved organic carbon(DOC)concentration of snowpit samples(283±200μg/L)was much lower than that of precipitation samples(624±361μg/L),indicating that large parts of DOC could be rapidly leached from the snowpit during the melting process.In contrast,refractory black carbon(rBC)concentration measured by Single Particle Soot Photometer of snowpit samples(4.27±3.15μg/L)was much higher than that of precipitation samples(0.97±0.49μg/L).Similarly,DOC with high mass absorption cross-section measured at 365 nm value was also likely to enrich in snowpit during the melting process.In addition,it was found that both r BC and DOC with high light-absorbing ability began to leach from the snowpit when melting process became stronger.Therefore,rBC and DOC with high light-absorbing ability exhibited similar behavior during the melting process.Based on relationship among DOC,rBC and K^+ in precipitation,the main source of carbonaceous matter in GLJM glacier was biomass burning during the study period. | Zhaofu Hu Shichang Kang Xiaobo He Fangping Yan Yulan Zhang Pengfei Chen Xiaofei Li Shaopeng Gao Chaoliu Li | 2020 | Journal of Environmental Sciences2020，32，1： | 3 |
| 18 | A new sodium iron phosphate as a stable high-rate cathode material for sodium ion batteries显示文摘Low-cost room-temperature sodium-ion batteries (SIBs) are expected to promote the development of stationary energy storage applications.However,due to the large size of Na+,most Na+ host structures resembling their Li+ counterparts show sluggish ion mobility and destructive volume changes during Na ion (de)intercalation,resulting in unsatisfactory rate and cycling performances.Herein,we report a new type of sodium iron phosphate (Na0.71Fe1.07PO4),which exhibits an extremely small volume change (~ 1%) during desodiation.When applied as a cathode material for SIBs,this new phosphate delivers a capacity of 78 mA·h·g-1 even at a high rate of 50 C and maintains its capacity over 5,000 cycles at 20 C.In situ synchrotron characterization disclosed a highly reversible solid-solution mechanism during charging/discharging.The findings are believed to contribute to the development of high-performance batteries based on Earth-abundant elements. | Xiaobo Zhu Takashi Mochiku Hiroki Fujii Kaibin Tang Yuxiang Hu Zhenguo Huang Bin Luo Kiyoshi Ozawa Lianzhou Wang | 2018 | Nano Research2018，11，12： | 3 |
| 19 | 1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway显示文摘Endoplasmic reticulum(ER)stress plays a critical role in pancreaticβcell destruction which leads to the pathogenesis of type 1 diabetes mellitus(T1DM).Vitamin D(VD)has been reported to reduce the risk of T1DM;however,it remains unknown whether VD affects ER stress in pancreaticβcells.In this study,we investigated the role of the active form of VD,1,25-dihydroxyvitamin D3[1,25-(OH)2D3],in ER stress-inducedβcell apoptosis and explored its potential mechanism in mouse insulinoma cell line mouse insulinoma 6(MIN6).The results of cell counting kit-8(CCK8)and flow cytometric analyses showed that 1,25-(OH)2D3 caused a significant increase in the viability of MIN6 cells injured by H2O2.The protein kinase like ER kinase(PERK)signal pathway,one of the most conserved branches of ER stress,was found to be involved in this process.H2O2 activated the phosphorylation of PERK,upregulated the activating transcription factor 4(ATF4)and C/EBP homologous protein(CHOP)expression,and subsequently initiated cell apoptosis,which were significantly reversed by 1,25-(OH)2D3 pretreatment.In addition,GSK2606414,a specific inhibitor of PERK,suppressed PERK phosphorylation and reduced the expressions of ATF4 and CHOP,leading to a significant decrease inβcell apoptosis induced by H2O2.Taken together,the present findings firstly demonstrated that 1,25-(OH)2D3 could prevent MIN6 cells against ER stress-associated apoptosis by inhibiting the PERK-ATF4-CHOP pathway.Therefore,our results suggested that 1,25-(OH)2D3 might serve as a potential therapeutic target for preventing pancreaticβcell destruction in T1DM. | Xiaobo Hu Cong Hu Jun Liu Zhuan Wu Tingting Duan Zhaohui Cao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 3 |
| 20 | Low-Angle Grain Boundaries in Sublimation Grown 6H-SiC Crystals显示文摘High-resolution X-ray diffractometry (HRXRD) was used to assess the quality of 6H-SiC crystals grown by sublimation method. The results show the occurrence of low-angle grain boundaries (LB) is close relative to the inclination of the crystal interface. At the central faceted region with 0° inclination the crystal is of high structural perfection. However, at the region close to the facet with less than 5° inclination LB occurs slightly and at the region close to the peripheral polytype ring with more than 5° inclination LB defect occurs heavily. The density of LB can be drastically reduced by decreasing radial temperature gradient that determines the shape of the crystal growth interface. | Jiang Shouzhen Li Xianxiang Dong Jie Chen Xiufang Xu Xiangang Hu Xiaobo | 2006 | Journal of Rare Earths2006，24，z1： | 3 |
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