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| 1 | CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer显示文摘(CEACAM6 ) Carcinoembryonic 抗原相关的房间粘附分子 6 证明在许多 humancancers 的增加的表示,和它的在表示上与提高的移植被联系,侵略,并且在 vivo 转移。这里,我们报导 CEACAM6 在房间衬里的胃的癌症(GC ) 和肿瘤纸巾是起来调整的。在 MKN-45 和 SGC-7901 GC 房间的 Over-expressionof CEACAM6 在 athymic 老鼠在 vitro 和转移支持了移植和侵略,而 MKN-28 和 SNU-16 GC 房间的移植和侵略被 knockdownof CEACAM6 压制。当 CEACAM6 是 over-expressedin SGC-7901 房间时,我们也观察到类固醇受体激活剂(C-SRC ) phosphorylation 被增加。一起拿,这些结果建议 CEACAM6 在 GC 作为 oncoprotein 工作并且可以是 importantmetastatic biomarker 和治疗学的目标。 | Yunqiang Zhang Mingde Zang Jianfang Li Jun Ji Jianian Zhang Xiaolei Liu Ying Qu Liping Su Chen Li Yinyan Yu Zhenggang Zhu Bingya Liu Min yan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 5 |
| 2 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 3 | Preparation and Dielectric Properties of Nonstoichiometric β-SiC Powder by Combustion Synthesis显示文摘The nonstoichiometric β-SiC powders were synthesized via combustion reaction of Si and C system in a 0.1 MPa nitrogen atmosphere, using Teflon as the chemical activator. The prepared powders were invistigated by XRD and Raman spectra. The results indicates that the cell parameters of all the prepared β-SiC powder are smaller than the standard value of β-SiC because of generation of CSi defects. The complex permittivity of prepared products was carried out in the frequency range of 8.2-12.4 GHz. It shows that the dielectric property of prepared β-SiC powder decrease with increasing PTFE content. The effect of CSi defects on dielectric property of β-SiC powder has been discussed. | Xiaolei Su Wancheng Zhou Zhimin Li Fa Luo Dongmei Zhu | 2009 | Journal of Materials Science & Technology2009，25，3： | 2 |
| 4 | Enhanced thermoelectric properties of hydrothermally synthesized n-type Se&Lu-codoped Bi2Te3显示文摘N-type Se&Lu-codoped Bi2Te3 nanopowders were prepared by hydrothermal method and sintered by spark plasma sintering technology to form dense samples.By further doping Se element into Lu-doped Bi2Te3 samples,the thickness of the nanosheets has the tendency to become thinner.The electrical conductivity of Lu0.1Bi1.9Te3−xSex material is reduced with the increasing Se content due to the reduced carrier concentration,while the Seeback coefficient values are enhanced.The lattice thermal conductivity of the Lu0.1Bi1.9Te3−xSex is greatly reduced due to the introduced point defects and atomic mass fluctuation.Finally,the Lu0.1Bi1.9Te2.7Se0.3 sample obtained a maximum ZT value of 0.85 at 420 K.This study provides a low-cost and simple low-temperature method to mass production of Se&Lu-codoped Bi2Te3 with high thermoelectric performance for practical applications. | Xiaolei Shi Xin Ai Qihao Zhang Xiaofang Lu Shijia Gu Li Su Lianjun Wang Wan Jiang | 2020 | Journal of Advanced Ceramics2020，9，4： | 2 |
| 5 | The effect of winter impoundment of the Three Gorges Dam: the degradation and convergence of pre-upland vegetation 显示文摘 | SU Xiaolei ZENG Bo HUANG Wenjun | 2013 | Ecological Engineering2013，61，： | 1 |
| 6 | Anelectrochemical sensor for pesticide assays based oncarbon nanotube-enhanced acetycholinesterase artivity显示文摘 | CHEN Haode ZUO Xiaolei SU Shao | 2008 | Analyst2008，133，： | 1 |
| 7 | Effect of La doping on microstructure of SnO 2 nanopowders prepared by co-precipitation method显示文摘 | Chong Fu Junbo Wang Minge Yang Xiaolei Su Jie Xu Bailing Jiang | 2010 | Journal of Non-Crystalline Solids2010，，3： | 1 |
| 8 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 9 | Plasmonic Refractive Index Sensors Based on One-and Two-Dimensional Gold Grating on a Gold Film显示文摘In this paper,we propose two kinds of composite structures based on the one-and two-dimensional(1D&2D)gold grating on a gold film for plasmonic refractive index sensing.The resonance modes and sensing characteristics of the composite structures are numerically simulated by the finite-difference time-domain method.The composite structure of the 1D gold semi-cylinder grating and gold film is analyzed first,and the optimized parameters of the grating period are obtained.The sensitivity and figure of merit(FOM)can reach 660 RIU/nm and 169 RIU-1,respectively.Then,we replace the 1D grating with the 2D gold semi-sphere particles array and find that the 2D grating composite structure can excite strong surface plasmon resonance intensity in a wider period range.The sensitivity and FOM of the improved composite structure can reach 985 RIU/nm and 298 RIU-1,respectively.At last,the comparison results of the sensing performance of the two structures are discussed.The proposed structures can be used for bio-chemical refractive index sensing. | Jiankai ZHU Xiangxian WANG Yuan WU Yingwen SU Tianxu JIA Hua YANG Liping ZHANG Yunping QI Xiaolei WEN | 2020 | Photonic Sensors2020，10，4： | 1 |
| 10 | A Method to Adjust Dielectric Property of SiC Powder in the GHz Range显示文摘The SiC powders by Al or N doping have been synthesized by combustion synthesis, using Al powder and NH4Cl powder as the dopants and polytetra?uoroethylene as the chemical activator. Characterization by X-ray diffraction, Raman spectrometer, scanning electron microscopy and energy dispersive spectrometer demonstrates the formation of Al doped SiC, N doped SiC and the Al and N co-doped SiC solid solution powders, respectively. The electric permittivities of prepared powders have been determined in the frequency range of 8.2-12.4 GHz. It indicates that the electric permittivities of the prepared SiC powders have been improved by the pure Al or N doping and decrease by the Al and N co-doping. The paper presents a method to adjust dielectric property of SiC powders in the GHz range. | Xiaolei Su Jie Xu Zhimin Li Junbo Wang Xinhai He Chong Fu WanchengZhou | 2011 | Journal of Materials Science & Technology2011，27，5： | 1 |
| 11 | Enhanced microwave absorption property of silver decorated biomass ordered porous carbon composite materials with frequency selective surface incorporation显示文摘Porous carbon(PC)is a promising electromagnetic(EM)wave absorbing material thanks to its light weight,large specific surface area as well as good dissipating capacity.To further improve its microwave absorbing performance,silver coated porous carbon(Ag@PC)is synthesized by one-step hydro-thermal synthesis process making use of fir as a biomass formwork.Phase compositions,morphological structure,and microwave absorption capability of the Ag@PC has been explored.Research results show that the metallic Ag was successfully reduced and the particles are evenly distributed inward the pores of the carbon formwork,which accelerates graphitization process of the amorphous carbon.The Ag@PC composite without adding polyvinyl pyrrolidone(PVP)exhibits higher dielectric constant and better EM wave dissipating capability.This is because the larger particles of Ag give rise to higher electric conductivity.After combing with frequency selective surface(FSS),the EM wave absorbing performance is further improved and the frequency region below-10 d B is located in8.20-11.75 GHz,and the minimal reflection loss value is-22.5 dB.This work indicates that incorporating metallic Ag particles and FSS provides a valid way to strengthen EM wave absorbing capacity of PC material. | Yi Liu Jingnan Qin Linlin Lu Jie Xu Xiaolei Su | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，3： | 1 |
| 12 | The effect of winter impoundment of the Three Gorges Dam: The degradation and convergence of pre-upland vegetation显示文摘 | SU Xiaolei ZENG Bo HUANG Wenjun et a1 | 2013 | Ecological Engineering2013，，： | 1 |
| 13 | An electrochemical sensor for pesticide assays based on carbon nan- otube-enhanced acetychoinesterase activity 显示文摘 | CHEN Haode ZUO Xiaolei SU Shao | 2008 | A nalyst2008，133，9： | 1 |
| 14 | The controlling factors of high suspended sediment concentration in the intertidal flat off the Huanghe River Estuary显示文摘The Huanghe River(Yellow River)is known by its high suspended sediment concentration(SSC)in its river mouth tidal flat.However,the factors controlling the high SSC over there are not well understood.Therefore,we conducted 7-d hydrodynamic observations(water depth,wave height,and current velocity)and SSC measurements on the tidal flat off the Huanghe River Mouth.The data shows that in most of time,under the calm sea condition,the SSC ranges 0.1–3.5 g/L,and sediment discharge from the river is the main source.However,when hydrodynamics are enhanced in a tidal cycle and large-scale erosion occurs on the seafloor,resuspended sediment becomes the main source,and the SSC in the water column reaches 17.3 g/L.We find the suspended sediment flux is mainly controlled by the tidal current and Stokes drift,while the wave-induced shear stress could also affect the variation of suspended sediment flux.During the observation period,when sea under calm-rippled conditions,the current-induced resuspended sediment concentration(RSC)was greater than the wave-induced RSC.In contrast,in smooth-wavelet sea conditions,the wave-induced RSC was greater than the current-induced RSC,for instance,a single wave event was found to cause 11.8 cm seabed erosion within 6 h.This study reveals different controlling factors for the high SSC near a river-influenced tidal flat,and helps us get a better understanding of a delta's depositional and erosional mechanisms. | Bowen Li Yonggang Jia J.Paul Liu Jianfeng Su Xiaolei Liu Mingzheng Wen | 2020 | Acta Oceanologica Sinica2020，39，10： | 1 |
| 15 | Effects of emulsion sizing with nano-SiO2 on interfacial properties of carbon fibers / epoxy composites显示文摘 | Yu Yang Lu Chunxiang Su Xiaolei | 2007 | J Mater Sci2007，，42： | 1 |
| 16 | Advanced Process and Electron Device Technology显示文摘This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of fin field-effect transistors(FinFET)to its limitations,several processes and device boosters are provided.Then,the three-dimensional(3 D)integration schemes with alternative materials and device architectures will pave paths for future technology evolution.Finally,it could be concluded that Moore’s law will undoubtedly continue in the next 15 years. | Dan Zhang Xiaojing Su Hao Chang Hao Xu Xiaolei Wang Xiaobin He Junjie Li Fei Zhao Qide Yao Yanna Luo Xueli Ma Hong Yang Yongliang Li Zhenhua Wu Yajuan Su Tao Yang Yayi Wei Anyan Du Huilong Zhu Junfeng Li Huaxiang Yin Jun Luo Tianchun Ye Wenwu Wang | 2022 | Tsinghua Science and Technology2022，27，3： | 1 |
| 17 | Assessment of Dependent Performance Shaping Factors in SPAR-H Based on Pearson Correlation Coefficient显示文摘With the improvement of equipment reliability,human factors have become the most uncertain part in the system.The standardized Plant Analysis of Risk-Human Reliability Analysis(SPAR-H)method is a reliable method in the field of human reliability analysis(HRA)to evaluate human reliability and assess risk in large complex systems.However,the classical SPAR-H method does not consider the dependencies among performance shaping factors(PSFs),whichmay cause overestimation or underestimation of the risk of the actual situation.To address this issue,this paper proposes a new method to deal with the dependencies among PSFs in SPAR-H based on the Pearson correlation coefficient.First,the dependence between every two PSFs is measured by the Pearson correlation coefficient.Second,the weights of the PSFs are obtained by considering the total dependence degree.Finally,PSFs’multipliers are modified based on the weights of corresponding PSFs,and then used in the calculating of human error probability(HEP).A case study is used to illustrate the procedure and effectiveness of the proposed method. | Xiaoyan Su Shuwen Shang Zhihui Xu Hong Qian Xiaolei Pan | 2024 | Computer Modeling in Engineering & Sciences2024，138，2： | 0 |
| 18 | 大型水库消落带中西来稗种子耐淹性沿高程梯度的种内分化显示文摘在水文节律稳定、每年蓄水时间很长且水位涨落落差很大的水库中,生长在水库库岸消落带不同高程区域中的植物每年要面对长时间的不同强度的水淹,这种每年发生持续的水淹胁迫可能会导致水库库岸消落带中生长的植物的种子耐淹能力发生种内分化。西来稗(Echinochloa crusgalli var.zelayensis)是在三峡水库消落带中自然生长的优势一年生植物,在三峡水库消落带植被及消落带生态环境保护中发挥着重要作用。本研究的目的在于探究三峡水库消落带中生长的西来稗种子的耐淹能力是否已发生种内分化,以及此分化的发生是否与较弱的种子扩散能力有关。在本研究中,采集来自三峡水库消落带不同高程区域中生长的西来稗种子,在三峡水库即将蓄水时将所有采集的种子放置于三峡水库消落带中4个不同高程位置接受不同深度不同时长的水库蓄水水淹,同时把所有采集的种子也放置于不会被水库蓄水淹没的非消落带河岸上作为对照处理;测定种子在水中的漂浮持续时间和蓄水期间水库水位上涨速度以量化在水库蓄水水位上涨时种子的扩散能力,水库蓄水结束水退后检测放置于水库消落带和非消落带河岸上的种子的种子完好率、种子萌发能力和成苗率。研究结果发现,在经历三峡水库蓄水水淹后,西来稗种子的完好率和最终成苗率随种子母株在消落带中所处的高程的增加而显著降低,表明在三峡水库成库运行七年后,在三峡水库消落带中生长的西来稗的种子耐淹能力已发生了种内分化。三峡水库蓄水水位上涨时西来稗种子在水中较短的漂浮持续时间和水库蓄水时较慢的水位上升速度限制了西来稗种子的水媒传播和扩散距离,从而有利于西来稗种子的耐淹能力发生种内分化。 | Songping Liu Feng Lin Xiaolei Su Qiaoli Ayi Hangang Niu Shaohua Shi Binna Wan Bo Zeng Xiaoping Zhang | 2021 | Journal of Plant Ecology2021，14，1： | 0 |
| 19 | Light-driven soft actuator based on graphene and WSe2 nanosheets composite for multimodal motion and remote manipulation显示文摘Remote controlled soft actuators have attracted ever-increasing interest in industrial,medical,robotics,and engineering fields.Soft actuators are charming than normal tools in executing dedicate tasks due to small volume and flexible body they have.However,it remains a challenge to design soft actuator that can adapt to multi-environments under remote stimuli with promising nano materials.Herein,we have developed a kind of near-infrared laser driven soft actuators with multi locomotive modes based on WSe2 and graphene nanosheets heterojunction.Different locomotion modes are driven by photothermal effect induced deformation to adapt to different working conditions.Moreover,the specially designed gripper driven by pulsed laser can lift a heavy load which is four times of its weight.This work broadens the choice of advanced nanomaterials for photothermal conversion of soft actuators.It is promising to realize applications including photothermal therapy and complex environment detection through the combination of the intelligent robot design and optical fiber system. | Zewen Su Yingjie Zhao Youqiang Huang Chaoyue Xu Xiaolei Yang Binrui Wang Beibei Xu Shiqing Xu Gongxun Bai | 2023 | Nano Research2023，16，1： | 0 |
| 20 | Characterization of kinesin-like proteins in silkworm posterior silkgland cells显示文摘Kinesins 是涉及各种各样的细胞内部的运输的基于微导管的马达。神经原,鞭打的房间,和颜料房间传统地被用作模型系统学习 kinesins 的细胞的功能。这里,我们报导蚕以后的 silkgland (PSG ) ,为细胞内部的运输和丝心蛋白的有效分泌物与一个广泛的 endomembrane 系统专业化房间,,为 kinesin 学习的一个新奇模型。在 PSG 房间调查驾驶 kinesin 的细胞内部的运输,我们克隆五蚕象 kinesin 一样蛋白质(KLP ) , BmKinesin-1, BmKinesin-6, BmKinesin-7, BmKinesin-13,和 BmKinesin-14A。我们由相对即时 PCR 并且西方的弄污决定了他们的表示模式。Immunofluorescence 显微镜学与微导管验证了他们的 colocalization。由联合下拉试金, LC-MS/MS,和西方的弄污分析,我们在 PSG,包括的包含丝心蛋白的小粒和联系 exuperantia 的 ribonucleoprotein (RNP ) 建筑群识别了 BmKinesin-1 的许多潜在的货物。而且, BmKinesin-13 overexpression 在 BmN 细胞破坏了微导管网络,它与在在另外的有机体调整微导管动力学的 Kinesin-13 的一个角色一致。根据这些结果,我们断定 PSG 可能在阐明有优点在能分泌的纸巾的细胞内部的运输的机制并且能为 kinesin 研究担任一个潜在的模型。 | Qiao Wang Junlin Teng Birong Shen Wei Zhang Yige Guo Xiaolei Su Chuanxi Zhang Albert CH Yu Jianguo Chen | 2010 | Cell Research2010，20，6： | 0 |
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