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| 1 | Osteoarthritis:pathogenic signaling pathways and therapeutic targets显示文摘Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide.OA was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction.Currently,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease.Therefore,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development.In this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk factors.We then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of OA.In addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in detail.Finally,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA.Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies. | Qing Yao Xiaohao Wu Chu Tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 11 |
| 2 | Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats显示文摘Glycine is a well-documented cytoprotective agent.However,whether it has a protective effect against myocar-dial ischemia-reperfusion injury in vivo is still unknown.By using an open-chest anesthetized rat model,we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats.The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%,respectively,in glycine-treated rats.The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment.Importantly,administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium,which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase,as well as the Fas ligand.These results suggest that gly-cine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis. | Xiaozheng Zhong Xiaoyu Li Lingling Qiana Yiming Xu Yan Lu Jing Zhang Nan Li Xudong Zhu Jingjing Ben Qing Yang Qi Chen | 2012 | The Journal of Biomedical Research2012，26，5： | 10 |
| 3 | Intergranular corrosion behavior and mechanism of the stabilized ultra-pure 430LX ferritic stainless steel显示文摘Intergranular corrosion(IGC) behavior of the stabilized ultra-pure 430 LX ferritic stainless steel(FSS) was investigated by using double loop electrochemical potentiokinetic reactivation(DL-EPR) and oxalic acid etch tests to measure the susceptibility of specimens given a two-step heat treatment. The results reveal that IGC occurs in the specimens aged at the temperature range of 600–750℃ for a short time. The aging time that is required to cause IGC decreases with the increase of aging temperature. A longer aging treatment can reduce the susceptibility to IGC. The microstructural observation shows that M(23)C6 precipitates form along the grain boundaries, leading to the formation of Cr-depleted zones. The presence of Cr-depleted zones results in the susceptibility to IGC. However, the atoms of stabilizing elements replace chromium atoms to form MC precipitates after long-time aging treatment, resulting in the chromium replenishment of Cr-depleted zones and the reduction of the susceptibility to IGC. | Peize Cheng Ning Zhong Nianwei Dai Xuan Wu Jin Li Yiming Jiang | 2019 | Journal of Materials Science & Technology2019，35，8： | 5 |
| 4 | Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy显示文摘Cartilage-targeting delivery of therapeutic agents is still an effective strategy for osteoarthritis(OA)therapy.Recently,scavenging for reactive oxygen species(ROS)and activating autophagy have been increasingly reported to treat OA effectively.In this study,we designed,for the first time,a dual-drug delivery system based on metal organic framework(MOF)-decorated mesoporous polydopamine(MPDA)which composed of rapamycin(Rap)loaded into the mesopores and bilirubin(Br)loaded onto the shell of MOF.The collagen II-targeting peptide(WYRGRL)was then conjugated on the surface of above nanocarrier to develop a cartilage-targeting dual-drug delivery nanoplatform(RB@MPMW).Our results indicated the sequential release of two agents from RB@MPMW could be achieved via near-infrared(NIR)laser irritation.Briefly,the rapid release of Br from the MOF shell exhibited excellent ROS scavenging ability and anti-apoptosis effects,however responsively reduced autophagy activity,to a certain extent.Meanwhile,following the NIR irradiation,Rap was rapidly released from MPDA core and further enhanced autophagy activation and chondrocyte protection.RB@MPMW continuously phosphorylated AMPK and further rescued mitochondrial energy metabolism of chondrocytes following IL-1βstimulation via activating SIRT1-PGC-1αsignaling pathway.Additionally,the cartilage-targeting property of peptide-modified nanocarrier could be monitored via Magnetic Resonance(MR)and IVIS imaging.More significantly,RB@MPMW effectively delayed cartilage degeneration in ACLT rat model.Overall,our findings indicated that the as-prepared dual-drug delivery nanoplatform exerted potent anti-inflammation and anti-apoptotic effects,rescued energy metabolism of chondrocytes in vitro and prevented cartilage degeneration in vivo,which thereby showed positive performance for OA therapy. | Song Xue Xiaojun Zhou Weilin Sang Cong Wang Haiming Lu Yiming Xu Yiming Zhong Libo Zhu Chuanglong He Jinzhong Ma | 2021 | Bioactive Materials2021，6，8： | 5 |
| 5 | GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine显示文摘Precisely delivering combinational therapeutic agents has become a crucial challenge for anti-tumor treatment. In this study, a novel redox-responsive polymeric prodrug(molecular weight,MW: 93.5 k Da) was produced by reversible addition-fragmentation chain transfer(RAFT) polymerization. The amphiphilic block polymer-doxorubicin(DOX) prodrug was employed to deliver a hydrophobic photosensitizer(PS), chlorin e6(Ce6), and the as-prepared nanoscale system [NPs(Ce6)] was investigated as a chemo-photodynamic anti-cancer agent. The glutathione(GSH)-cleavable disulfide bond was inserted into the backbone of the polymer for biodegradation inside tumor cells, and DOX conjugated onto the polymer with a disulfide bond was successfully released intracellularly. NPs(Ce6) released DOX and Ce6 with their original molecular structures and degraded into segments with low MWs of 41.2 k Da in the presence of GSH. NPs(Ce6) showed a chemo-photodynamic therapeutic effect to kill 4 T1 murine breast cancer cells, which was confirmed from a collapsed cell morphology, a lifted level in the intracellular reactive oxygen species, a reduced viability and induced apoptosis. Moreover, ex vivo fluorescence images indicated that NPs(Ce6) retained in the tumor, and exhibited a remarkable in vivo anticancer efficacy. The combinational therapy showed a significantly increased tumor growth inhibition(TGI,58.53%). Therefore, the redox-responsive, amphiphilic block polymeric prodrug could have a great potential as a chemo-photodynamic anti-cancer agent. | Lei Luo Yiming Qi Hong Zhong Shinan Jiang Hu Zhang Hao Cai Yahui Wu Zhongwei Gu Qiyong Gong Kui Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 6 | Cyanobacteria-based self-oxygenated photodynamic therapy for anaerobic infection treatment and tissue repair显示文摘Photodynamic therapy(PDT)is an important technique to deal with drug-resistant bacterial infections in the post-antibiotic era.However,the hypoxic environment in intractable infections such as refractory keratitis and periodontitis,makes PDT more difficult.In this work,spontaneous oxygen-producing cyanobacteria were used as the carrier of photosensitizer(Ce6),and ultrasmall Cu_(5.4)O nanoparticles(Cu_(5.4)O USNPs)with catalase activity for infection and inflammation elimination and rapid tissue repair(CeCycn-Cu_(5.4)O).The loading of Ce6 and Cu_(5.4)O USNPs onto cyanobacteria surface were confirmed by transmission electron microscopy,nano particle size analyzer,scanning electron microscopy.In vitro sterilization and biofilm removal experiments demonstrated that the restriction of hypoxic environment to PDT was significantly alleviated due to the oxygen production of cyanobacteria.Under laser irradiation,the close transfer of energy photons to oxygen produced by cyanobacteria reduced more than 90% of Ce6 dosages(660 nm,200 mW/cm^(2),2 min).It is worth mentioning that both rapid sterilization through PDT and long-term oxidized free radicals elimination were achieved by adjusting the ratio of Ce6 and Cu_(5.4)O USNPs.Both periodontitis and refractory keratitis animal models proved the excellent self-oxygenation enhanced antibacterial property and promotion of tissue repair. | Bailiang Wang Liyang Zhou Yishun Guo Hanwen Guo Yiming Zhong Xiaomin Huang Yifan Ge Qingying Wang Xiaoying Chu Yingying Jin Kaiyue Lan Mei Yang Jia Qu | 2022 | Bioactive Materials2022，7，6： | 3 |
| 7 | New Lignans from the Leaves and Stems of Schisandra chinensis and Their Anti-HIV-1 Activities显示文摘Six new lignans(1-6),as well as five known ones(7-11)were isolated from the leaves and stems of Schisandra chinensis.The structures of 1-6 were established on the basis of spectroscopic methods including 1D-and 2D-NMR techniques and CD experiments.Compound 1 was the first example of naturally occurring N-containing lignans featuring a nicotinoyl group.All the new compounds were evaluated for their anti-HIV-1 activities and showed EC50 values in the range 17.89-138.23μg/mL. | Yiming Shi Weimao Zhong Huan Chen Ruirui Wang Shanzhai Shang Chengqin Liang Zhonghua Gao Yongtang Zheng Weilie Xiao Handong Sun | 2014 | Chinese Journal of Chemistry2014，32，8： | 3 |
| 8 | A mathematical modeling study of the HIV epidemics at two rural townships in the Liangshan Prefecture of the Sichuan Province of China显示文摘Background:As a response to a severe HIV epidemic in the Liangshan Prefecture,one of the worst in China,population based HIV interventions,including two population-wide HIV screening,have been carried out since 2005 at two townships in a remote mountainous region of Liangshan.The objective of our mathematical modeling study is to assess the temporal dynamics of the HIV epidemic in the two townships based on the data collected in the study area during the period 2005e2010.Methods:A mathematical model was set up to describe the population dynamics of HIV transmission in study area.The model was calibrated by fitting it to the HIV testing and treatment data from 2005 to 2008.Validation of the model was done by comparing its predicted value of HIV prevalence in 2010 to the prevalence data obtained in the 2010 population wide HIV testing.The validated model was used to produce estimation of HIV incidence,prevalence and death.Results:Our model estimations show that population-based HIV interventions have significantly slowed down the rise of the HIV epidemic in the two townships.Over the five-year period from 2005 to 2010,the year-over-year rate of increase in HIV incidence,prevalence,and death has declined by 91.5%,28.7%,and 52.3%,respectively.Conclusion:Mathematical models,when integrated with epidemiological and surveillance data,can be an effective tool for predicting the temporal dynamics of HIV and assessing the impacts of HIV interventions. | Zhimin Su Caiting Dong Ping Li Hongxia Deng Yuhan Gong Shiyong Zhong Min Wu Yuhua Ruan Guangming Qin Wen Yang Yiming Shao Michael Li | 2016 | Infectious Disease Modelling2016，1，1： | 2 |
| 9 | Pitting corrosion behaviour of stainless steel in ultrasonic cell 显示文摘 | SUN Daoming JIANG Yiming TANG Yu XIANG Qiuwei ZHONG Cheng LIAO Jiaxing LI Jin | 2009 | Electrochimica Acta2009，54，： | 1 |
| 10 | Investigation of selective corrosion resistance of as-aged lean duplex stainless steel 2101 by non-destructive electrochemical teehniques显示文摘 | GAO Juan JIANG Yiming DENG Bo ZHANG Wei ZHONG Cheng LI Jin | 2009 | Electrochimica Acta2009，54，： | 1 |
| 11 | Oxidation kinetics of nanoscale copper thin films at low temperature characterized by sheet resistance and optical transmittance显示文摘 | ZHONG Cheng JIANG Yiming SUN Daoming | 2009 | Chin J Phys2009，47，3： | 1 |
| 12 | Abnormal growth transport in oxide scales on Fe-16Cr steels in water vapor显示文摘 | GONG Jia JIANG Yiming DENG Bo ZHONG Cheng SUN Daoming LI Jin | 2009 | Metall Mater Trans A2009，，： | 1 |
| 13 | A modified data normalization method for GC-MS-based metabolomics to minimize batch variation显示文摘 | Mingjie Chen R Shyama Prasad Rao Yiming Zhang Cathy Xiaoyan Zhong Jay J Thelen | 2014 | SpringerPlus2014，，1： | 1 |
| 14 | Biomass-based N doped carbon as metal-free catalyst for selective oxidation of D-xylose into D-xylonic acid显示文摘Rational design and facile preparation of low-cost and efficient catalysts for the selective converting of biomass-derived monosaccharides into high value-added chemicals is highly demanded,yet challenging.Herein,we first demonstrate a N doped defect-rich carbon(NC-800-5)as metal-free catalyst for the selective oxidation of D-xylose into D-xylonic acid in alkaline aqueous solution at 100℃ for 30 min,with 57.4%yield.The doped graphitic N is found to be the active site and hydroxyl ion participating in the oxidation of D-xylose.Hydroxyl ion and D-xylose first adsorb on NC-800-5 surface,and the aldehyde group of D-xylose is catalyzed to form germinal diols ion.Then,C–H bond break to yield carboxylic group.Furthermore,NC-800-5 catalyst shows high stability in recycled test. | Zengyong Li Yiming Huang Xiao Chi Di Li Linxin Zhong Xuehui Li Chuanfu Liu Xinwen Peng | 2022 | Green Energy & Environment2022，7，6： | 1 |
| 15 | Wind turbine manufacturing industry in China: Current situation and problems 显示文摘 | Xin Jin Yiming Rong Xiang Zhong | 2014 | Renezoable and Sustainable Energy Reviews2014，，33： | 1 |
| 16 | Microwave frequency upconversion employing a coupling-modulated ring resonator显示文摘We present a method to generate a frequency-doubled microwave signal by employing a coupling-modulated ring resonator. Critical coupling is achieved when the resonator intrinsic loss is perfectly balanced by the external coupling enabled by a Mach–Zehnder interferometer coupler. The high suppression of the carrier leads to a clean two-tone optical signal with the frequency interval two times larger than that of the input microwave frequency.The beating of the two-tone signal at a photodiode generates the frequency upconverted microwave signal.A theoretical model is established to analyze the modulation process and the microwave signal generation.Experimental results show that the electrical harmonic suppression ratio is around ~20 dB(29 dB) for an input microwave signal with 5 dBm(10 dBm) power. | YIMING ZHONG LINJIE ZHOU YANYANG ZHOU YUJIE XIA SIQI LIU LIANGJUN LU JIANPING CHEN XINGJUN WANG | 2017 | Photonics Research2017，5，6： | 1 |
| 17 | THERMAL DEBINDING MECHANISM OF METAL INJECTION MOLDING COMPACTS IN VACUUM显示文摘1INTRODUCTIONDuringthepastfewyears,powderinjectionmolding(PIM)hademergedasanadvancedmanufacturingtechnology[1].Thecombination... | Liu, Shaojun Huang, Baiyun Qu, Xuanhui Zhong, Xiaoxian Yan, Wuhua Li, Yiming | 1999 | 中国有色金属学会会刊:英文版1999，9，2： | 1 |
| 18 | Metabolite variation in hybrid corn grain from a large-scale multisite study显示文摘Metabolite composition is strongly affected by genotype,environment,and interactions between genotype and environment,although the extent of variation caused by these factors may depend upon the type of metabolite.To characterize the complexity of genotype,environment,and their interaction in hybrid seeds,50 genetically diverse non-genetically modified(GM) maize hybrids were grown in six geographically diverse locations in North America.Polar metabolites from 553 harvested corn grain samples were isolated and analyzed by gas chromatography–mass spectrometry and 45 metabolites detected in all samples were used to generate a data matrix for statistical analysis.There was moderate variation among biological replicates and across genotypes and test sites.The genotype effects were detected by univariate and Hierarchical clustering analyses(HCA) when environmental effects were excluded.Overall,environment exerted larger effects than genotype,and polar metabolite accumulation showed a geographic effect.We conclude that it is possible to increase seed polar metabolite content in hybrid corn by selection of appropriate inbred lines and growing regions. | Mingjie Chen R.Shyama Prasad Rao Yiming Zhang Cathy Zhong Jay J.Thelen | 2016 | The Crop Journal2016，4，3： | 0 |
| 19 | In-situ coupling construction of interface bridge to enhance electrochemical stability of all solid-state lithium metal batteries显示文摘Polymer-based composite electrolytes composed of three-dimensional Li_(6.4)La_(3)Zr_(2)Al_(0.2)O_(12)(3D-LLZAO)have attracted increasing attention due to their continuous ion conduction and satisfactory mechanical properties.However,the organic/inorganic interface is incompatible,resulting in slow lithium-ion transport at the interface.Therefore,the compatibility of organic/inorganic interface is an urgent problem to be solved.Inspired by the concept of“gecko eaves”,polymer-based composite solid electrolytes with dense interface structures were designed.The bridging of organic/inorganic interfaces was established by introducing silane coupling agent(3-chloropropyl)trimethoxysilane(CTMS)into the PEO-3D-LLZAO(PL)electrolyte.The in-situ coupling reaction improves the interface affinity,strengthens the organic/inorganic interaction,reduces the interface resistance,and thus achieves an efficient interface ion transport network.The prepared PEO-3D-LLZAO-CTMS(PLC)electrolyte exhibits enhanced ionic conductivity of 6.04×10^(-4)S cm^(-1)and high ion migration number(0.61)at 60℃and broadens the electrochemical window(5.1 V).At the same time,the PLC electrolyte has good thermal stability and high mechanical properties.Moreover,the Li Fe PO_(4)|PLC|Li battery has excellent rate performance and cycling stability with a capacity decay rate of 2.2%after 100 cycles at 60℃and 0.1 C.These advantages of PLC membranes indicate that this design approach is indeed practical,and the in-situ coupling method provides a new approach to address interface compatibility issues. | Qianwei Zhang Rong Yang Chao Li Lei Mao Bohai Wang Meng Luo Yinglin Yan Yiming Zou Lisheng Zhong Yunhua Xu | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 20 | Graphene quantum dots as sulfiphilic and lithiophilic mediator toward high stability and durable life lithium-sulfur batteries显示文摘The development of lithium-sulfur(Li-S) battery as one of the most attractive energy storage systems among lithium metal batteries is seriously hindered by low sulfur utilization, poor cycle stability and uneven redeposition of Li anode. It is necessary to propose strategies to address the problems as well as improve the electrochemical performance. One of the effective solutions is to improve the sulfiphilicity of sulfur cathode and the lithiophilicity of the Li anode. Herein, we reported that a synergistic functional separator(graphene quantum dots(GQDs)-polyacrylonitrile(PAN) @polypropylene(PP) separator)improved the electrochemical activity of sulfur cathode as well as the stability of Li anode. GQDs induced uniform Li^(+)nucleation and deposition, which slowed down the passivation of Li anode and avoided shortcircuit. Further, three-dimensional network constructed by electrospinning nanofibers and the polar functional groups of GQDs could both effectively inhibit the shuttle of LiPSs and improve the sulfur utilization. The stability of Li-S battery was improved by the synergistic effect. In addition, GQDs and electrospinning nanofibers protector increased lifetime of separators. Benefiting from the unique design strategy, Li//Li symmetric battery with GQDs-PAN@PP separators exhibited stably cycling for over 600 h. More importantly, the Li-S full batteries based GQDs-PAN@PP separators enabled high stability and desirable sulfur electrochemistry, including high reversibility of 558.09 mA h g^(-1)for 200 cycles and durable life with a low fading rate of 0.075% per cycle after 500 cycles at 0.5 C. Moreover, an impressive areal capacity of 3.23 mA h cm^(-2)was maintained under high sulfur loading of 5.10 mg cm^(-2). This work provides a new insight for modification separator to improve the electrochemical performance of Li-S/Li metal batteries. | Chaojiang Fan Rong Yang Yong Huang Lei Mao Yuanyuan Yang Le Gong Xin Dong Yinglin Yan Yiming Zou Lisheng Zhong Yunhua Xu | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
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